Novaferon (recombinant anti-tumor and anti-virus protein) / Genova 
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10 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Novaferon (recombinant anti-tumor and anti-virus protein) / Genova
ChiCTR2000030000: An open, controlled clinical trial for evaluation of ganovo combined with ritonavir and integrated traditional Chinese and Western medicine in the treatment of novel coronavirus infection (COVID-19)

Recruiting
4
50
 
Ganovo/ ritonavir oral ;Pegasys injection ;Novaferon intramuscular injection+Spray inhalation ;Coriolus oral ;TCM+Spray inhalation
Nanchang Ninth Hospital; Nanchang Ninth Hospital, Ascletis Pharmaceuticals CO., LTD.
Pneumonia caused by new coronavirus
 
 
ChiCTR-TRC-10000982: Novaferon for chronic hepatitis B: a phase Ⅰrandomized open-label control trial

Completed
4
40
 
Novaferon, 10ug intramuscular injection, once daily in the first day; Day 2 to day 7 not given the medication; followed injection 10ug a day, during week 2 to week 7 ;Novaferon, 10ug intramuscular injection, thrice weekly for week 1-6 ;Novaferon, 10ug intramuscular injection, once daily for the first week; followed by 20ug, thrice weekly for week 2-6
Beijing YouAn Hospital, Capital Medical University; Genova Biotech Company, Ltd, Genova Biotech Company, Ltd. , National Novel Drug Development plan
Chronic Hepatitis B
 
 
ChiCTR2000029573: A multicenter, randomized, open, controlled clinical study to evaluate the efficacy and safety of recombinant cytokine gene-derived protein injection in combination with standard therapy in patients with novel coronavirus infection

Recruiting
4
480
China
antiviral therapy and Chinese medicine treatment ;antiviral therapy, Chinese medicine treatment, and Novaferon atomization ;antiviral therapy and Chinese medicine treatment ;antiviral therapy, Chinese medicine treatment, and Novaferon atomization
The First Affiliated Hospital of Medical College of Zhejiang University; The First Affiliated Hospital of Medical College of Zhejiang University, coordinater
novel coronavirus pneumonia
 
 
ChiCTR2000029496: A randomized, open label, parallel controlled trial of evaluating the efficacy of recombinant cytokine gene-derived protein injection for clearing novel coronavirus in patients with novel coronavirus pneumonia (COVID-19)

Recruiting
4
90
 
On the basis of routine medical treatment, the patients were given Novaferon Atomization inhalation, 20ug each time, twice a day, 7-14 days. ;On the basis of routine medical treatment, the patients were given lopinavir / ritonavir tablets (Kaletra) twice a day, twice each time, 7-14 days. ;On the basis of routine medical treatment, combined with Novafron and Kaletra, the usage and course of treatment are the same as above.
The First Hospital of Changsha; The Second Xiangya Hospital of Central South University; The First Hospital of Changsha, Self financing and application for scientific research funds
Novel Coronavirus Pneumonia (COVID-19)
 
 
ChiCTR2100041835: Antiviral Therapy and Long-term Outcome of Chronic Hepatitis B Patients in China (CATLOB study): a National Multicenter, Prospective, Observational Real-World Study (Shan Dong Province)

Recruiting
4
100
 
Treatment with Novaferon
Huashan Hospital of Fudan University; Qingdao Municipal Hospital, Self-paying from patients
chronic hepatitis B
 
 
NCT02349984: Recombinant Anti-tumor and Anti-virus Protein for Injection in Treatment of Metastatic Colorectal Cancer

Recruiting
2/3
105
RoW
Recombinant anti-tumor and anti-virus protein for injection, Novaferon, Saline Injection, Brand name: Novaferon
Beijing Genova Biotech Company, Ltd.
Metastatic Colorectal Cancer
05/15
05/15
ChiCTR-TRC-10001000: A pahse II trial of Novafenon for Locally Advanced Pancreatic Adenocarcinoma

Suspended
2
40
 
Novaferon, intramuscular injection, 10ug, thrice weekly for week 1-13 ;Novaferon, intramuscular injection, 10μg, thrice weekly for week 1; followed by 20μg, thrice weekly for week 2-13 ;Scheme A or Scheme B according to the first stage result
Shanghai Changhai Hospital; Genova Biotech Company, Ltd, Genova Biotech Company, Ltd. , National Novel Drug Development plan
Locally Advanced Pancreatic Adenocarcinoma.
 
 
ChiCTR-TRC-10000984: Randomized double-blinding controlled multicenter trial of Novaferon for Chronic hepatitis B

Completed
1/2
360
 
Novaferon, intramuscular injection ;interferon alpha 2b, intramuscular injection
The XiangYa Hospital, ZhongNan University; Genova Biotech Company, Ltd, National Novel Drug Development plan
Chronic hepatitis B
 
 
NCT04380545: Nivolumab, Fluorouracil, and Interferon Alpha 2B for the Treatment of Unresectable Fibrolamellar Cancer

Suspended
1/2
15
US
Fluorouracil, 5 Fluorouracil, 5 Fluorouracilum, 5 FU, 5-Fluoro-2,4(1H, 3H)-pyrimidinedione, 5-Fluorouracil, 5-Fluracil, 5-Fu, 5FU, AccuSite, Carac, Fluoro Uracil, Fluouracil, Flurablastin, Fluracedyl, Fluracil, Fluril, Fluroblastin, Ribofluor, Ro 2-9757, Ro-2-9757, Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo, Recombinant Interferon Alpha 2b-like Protein, Novaferon, Recombinant IFN Alfa-2b-like Protein
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Stage III Hepatocellular Carcinoma AJCC v8, Stage IIIA Hepatocellular Carcinoma AJCC v8, Stage IIIB Hepatocellular Carcinoma AJCC v8, Stage IV Hepatocellular Carcinoma AJCC v8, Stage IVA Hepatocellular Carcinoma AJCC v8, Stage IVB Hepatocellular Carcinoma AJCC v8, Unresectable Fibrolamellar Carcinoma
07/25
07/25
ChiCTR-TNRC-09000448: A PhaseⅠStudy of Novaferon in Patients with Advanced Cancer

Completed
N/A
120
 
Percutaneous coronary intervention ;Percutaneous coronary intervention ;Percutaneous coronary intervention ;Percutaneous coronary intervention
the First Hospital, Jilin University; Genova Biotech Company, Ltd, Genova Biotech Company, Ltd. , National Novel Drug Development plan
Advanced malignant tumors including, but not limited to, pancreatic cancer, colorectal cancer, liver cancer, gastric cancer, non-small cell lung cancer, breast cancer, etc.
 
 

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