- |||||||||| cetirizine oral / Generic mfg., cyclosporine / Generic mfg., dextromethorphan / Generic mfg.
Clinical, Journal: Important considerations for drugs, nutritional, and herbal supplements in pediatric solid organ transplant recipients. (Pubmed Central) - Dec 1, 2021
Over-the-counter medications, such as guaifenesin and dextromethorphan, antihistamine medications, including diphenhydramine, loratadine, cetirizine, and fexofenadine, can be safely used in pediatric solid organ transplant population...Several herbal products can alter immune status of the patients or alter the blood concentration of immunosuppressive drugs or may produce renal or hepatic toxicities and should be avoided in pediatric transplant recipients. It is important to educate pediatric transplant recipients and their families about not only immunosuppressive drug therapy but also about non-prescription drugs, dietary, and herbal supplement use.
- |||||||||| Tagrisso (osimertinib) / AstraZeneca
Trial completion date, Metastases: Study to Assess the Effect of Osimertinib (TAGRISSO (clinicaltrials.gov) - Nov 24, 2021
P1, N=24, Active, not recruiting,
Based on our results, shortening on-site monitoring time may be feasible. Trial completion date: Dec 2021 --> Dec 2022
- |||||||||| Nesina (alogliptin) / Takeda
Journal: Intestinal Absorption of Alogliptin Is Mediated by a Fruit-Juice-Sensitive Transporter. (Pubmed Central) - Nov 24, 2021
In a rat in vivo study, apple juice reduced systemic exposure to orally administered ALG without changing the terminal half-life. These observations suggest that intestinal absorption of ALG is carrier-mediated, and involves a fruit-juice-sensitive transporter other than OATP2B1.
- |||||||||| fexofenadine / Generic mfg.
Journal: 120 mJ, 1 kHz, picosecond laser at 515 nm. (Pubmed Central) - Nov 16, 2021
We report on a 1 kHz, 515 nm laser system, based on a commercially available 230 W average power Yb:YAG thin-disk regenerative amplifier, developed for pumping one of the last optical parametric chirped pulse amplification (OPCPA) stages of the Allegra laser system at ELI Beamlines...Additionally, development of a thermal management system was needed to ensure stable phase matching conditions at high average power. The resulting 515 nm pulses have an energy of more than 120 mJ with SHG efficiency of 60% and an average RMS stability of 1.1% for more than 8 h.
- |||||||||| fexofenadine / Generic mfg.
Journal: Revision of the phylogeny of Placididea (Stramenopiles): Molecular and morphological diversity of novel placidid protists from extreme aquatic environments. (Pubmed Central) - Nov 16, 2021
In this study, we extend the known diversity of Placididea by three new genera (Allegra, Haloplacidia, and Placilonga) compromising nine new species, isolated from athalassic, mostly hypersaline environments (Allegra dunaii, Allegra atacamiensis, Allegra hypersalina, Haloplacidia cosmopolita, Suigetsumonas keniensis) and marine waters (Placilonga atlantica, Placidia azorensis, Placidia abyssalis, Wobblia pacifica) including a description of their morphology and molecular phylogeny...A multigene analysis based on a ten genes dataset revealed a clear separation into marine, athalassic and brackish water clades. Several representatives were found to cope with hypersaline conditions from 20 to 250 PSU, even up to 284 PSU, suggesting that they may form a halotolerant group.
- |||||||||| Skyrizi (risankizumab) / AbbVie, Boehringer Ingelheim
Risankizumab-induced rosacea-like dermatitis () - Nov 11, 2021 - Abstract #ISDS2021ISDS_200;
She had already been treated with phototherapy, methotrexate, cyclosporine, efalizumab 15-year before and was currently using only high-potency topical corticosteroids...It was precribed a single dose of ivermectin, fexofenadine for 7 days, topical 0.75 metronidazole for 3 months, fexofenadine for 7 days and photoprotection...Although there are less common possible triggering factors, the aim of this case is to presente the current knowledge on the association between of certain drugs and rosacea. Moreover, risankizumab improved health-related quality of life for psoriasis control and was generally well tolerated.
- |||||||||| fexofenadine / Generic mfg.
Clinical, Review, Journal: Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis. (Pubmed Central) - Nov 5, 2021
Overall, fexofenadine displays a favorable safety profile and results in greater treatment satisfaction in children compared with other second-generation antihistamines. This review aimed to evaluate and compare the safety and efficacy of fexofenadine with other available first- and second-generation antihistamines in children with AR.
- |||||||||| Poteligeo (mogamulizumab) / Kyowa Kirin
SEZARY SYNDROME IN A PATIENT REFERRED FOR REFRACTORY ERYTHEMATOUS RASH AND ANGIOEDEMA (Hall B (1st Floor); Monitor 07) - Nov 2, 2021 - Abstract #ACAAI2021ACAAI_879;
Twice daily fexofenadine and famotidine did not help...Given the disease burden, he was diagnosed with Sezary syndrome and started on Mogamulizumab, an anti-CC chemokine receptor 4 monoclonal antibody, with significant improvement...It is important to maintain strong suspicion given the implications of a delayed diagnosis. Patients may also be at an increased risk for opportunistic infections and secondary malignancies.
- |||||||||| Poteligeo (mogamulizumab) / Kyowa Kirin
SUCCESSFUL REINTRODUCTION OF MOGAMULIZUMAB VIA OUTPATIENT ONE DILUTION DESENSITIZATION PROTOCOLS FOLLOWING RECURRENT DELAYED CUTANEOUS REACTIONS (Hall B (1st Floor); Monitor 02) - Nov 2, 2021 - Abstract #ACAAI2021ACAAI_732;
Case Descriptions: A 65-year-old woman developed recurrent mogamulizumab-associated rash with onset 1 day after each infusion, refractory to oral methylprednisolone 6-day tapers (24-20-16-12-8-4mg) and cetirizine 20mg twice daily...A 73-year-old man developed mogamulizumab-associated rash with onset 1 day after each infusion, refractory to fexofenadine 180mg daily and diphenhydramine 25mg daily but responsive to methylprednisolone 6-day tapers...Desensitization may be a novel approach for reintroduction of mogamulizumab following recurrent delayed cutaneous reactions while minimizing oral steroid requirements. Further investigation into the use of desensitization to prevent delayed cutaneous reactions may allow more patients to continue mogamulizumab treatment.
- |||||||||| levocetirizine / Generic mfg.
MAST CELL ACTIVATION SYNDROME IN THE SETTING OF ACUTE HYPOTENSION AND ALTERED MENTAL STATUS (Hall B (1st Floor); Monitor 01) - Nov 2, 2021 - Abstract #ACAAI2021ACAAI_698;
A broad differential diagnosis should be considered when assessing patients with MCAS during acute decompensation. Symptoms triggered by mast cell mediator release, especially isolated hypotension, have a broad differential and failure to consider other treatable conditions may delay recognition of emergent diagnoses, including sepsis and hemorrhage.
- |||||||||| fexofenadine / Generic mfg.
Trial completion date, Trial primary completion date: Role of Fexofenadine in Diabetic Kidney Disease (clinicaltrials.gov) - Oct 7, 2021
P4, N=60, Recruiting,
The Allegra trans-catheter aortic valve offers optimal hemodynamic results in patients with severely degenerated biological aortic valve. Trial completion date: Jul 2022 --> Feb 2022 | Trial primary completion date: Jul 2021 --> Feb 2022
- |||||||||| Krystexxa (pegloticase) / Horizon Therapeutics
[VIRTUAL] Concomitant Immunomodulation and Pegloticase Therapy: Experiences with a Variety of Immunomodulatory Agents in Two Community Rheumatology Practices () - Sep 21, 2021 - Abstract #ACRCONVERGENCE2021ACR_CONVERGENCE_926;
All patients received pre-infusion prophylaxis (125 mg IV methylprednisolone or 100 mg hydrocortisone, 180 mg oral fexofenadine or 25 mg IVP diphenhydramine)...Immunomodulator co-therapy was initiated prior to (5.3±3.0 weeks, n=32) or at (n=2) first pegloticase infusion and included subcutaneous (subQ) methotrexate (MTX; 15.4±4.9mg/week [range: 10-25 mg/week], n=20), oral MTX (15.3±3.6 mg/week [range: 7.5-20 mg/week], n=9), oral mycophenolate mofetil (MMF; all 1000 mg/day, n=3), and oral azathioprine (AZA; all 100 mg/day, n=2)... These data provide further support for concomitant immunomodulator/pegloticase therapy, showing similar efficacy rates to both an open-label trial with oral MTX (79%) 4 and a systematic literature review of all immunomodulators (83%).
- |||||||||| fexofenadine / Generic mfg., colchicine / Generic mfg.
A Rare Case of Lymphocytic Esophagitis in a Patient With Recurrent and Severe Oral Ulcers (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_429;
The patient was placed on fexofenadine once daily and a second biopsy of the oral ulcers revealed connective tissue focally surfaced by fragments of squamous epithelium, erosive lichen planus and a robust influx of mixed chronic inflammation including non-necrotizing granulomas...Management considerations by rheumatology included genetic testing for HLA-B51, steroids and colchicine...Pyogenic granulomatous esophagitis is typically managed with systemic corticosteroids or endoscopic resection. In our case, evaluation for Crohn’s disease was unremarkable and the presence of pathergy and involvement of non-keratinized squamous mucosa is suggestive of an oral manifestation of Behcet’s disease despite absent genital ulcers and join pain.
- |||||||||| Ocrevus (ocrelizumab) / Roche
Trial completion date, Trial primary completion date, Head-to-Head: DanNORMS: Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis (clinicaltrials.gov) - Sep 5, 2021
P3, N=594, Recruiting,
In our case, evaluation for Crohn’s disease was unremarkable and the presence of pathergy and involvement of non-keratinized squamous mucosa is suggestive of an oral manifestation of Behcet’s disease despite absent genital ulcers and join pain. Trial completion date: Jan 2028 --> Apr 2028 | Trial primary completion date: Jan 2025 --> Apr 2025
- |||||||||| methamphetamine / Generic mfg.
Preclinical, Journal: In vivo evaluation of effects of histamine H receptor antagonists on methamphetamine-induced hyperlocomotion in mice. (Pubmed Central) - Sep 3, 2021
These observations suggest that pretreatment with histamine H receptor antagonists attenuate METH-induced hyperlocomotion via releasing histamine after blocking H receptors, which then bind to the post-synaptic histamine receptor H (but not H or H). It is likely that activation of brain histamine systems may be a good strategy for the development of agents, which treat METH abuse and dependence.
- |||||||||| fexofenadine / Generic mfg.
Trial initiation date: Excipient Effect on Drug Absorption in Humans (clinicaltrials.gov) - Aug 22, 2021
P1, N=12, Not yet recruiting,
This may be partly due to our strengthened pre-medication strategy. Initiation date: May 2021 --> Oct 2021
- |||||||||| tamoxifen / Generic mfg.
Journal: Evaluation of Human Liver Microtissues for Drug Screening on Schistosoma mansoni Schistosomula. (Pubmed Central) - Aug 4, 2021
Despite only one drug, praziquantel, being available, the drug pipeline against schistosomiasis is empty, and drug screening tools have limitations...Cytotoxicity was observed at high concentrations of flutamide and tamoxifen citrate. An in vitro platform containing hLiMTs could serve as an advanced drug screening tool for Schistosoma mansoni, providing information on reduced or increased activity and toxicity.
- |||||||||| famotidine / Generic mfg., fexofenadine / Generic mfg.
Trial completion, Trial completion date: Histamine H1/H2 Receptors and Training Adaptations (clinicaltrials.gov) - Jul 30, 2021
P=N/A, N=20, Completed,
An in vitro platform containing hLiMTs could serve as an advanced drug screening tool for Schistosoma mansoni, providing information on reduced or increased activity and toxicity. Active, not recruiting --> Completed | Trial completion date: Sep 2020 --> Apr 2021
- |||||||||| rivaroxaban / Generic mfg., midazolam hydrochloride / Generic mfg.
PK/PD data, Journal: Effects of Hypericum perforatum (St. John's wort) on the pharmacokinetics and pharmacodynamics of rivaroxaban in humans. (Pubmed Central) - Jul 28, 2021
The CYP3A4/P-gp inducing Hypericum perforatum extract caused a decrease of rivaroxaban exposure with a proportional decrease of the pharmacodynamic effect. Although the data do not justify a contraindication for the combination or a systematic adjustment of rivaroxaban dosage, avoidance of the combination or laboratory monitoring should be considered in patients taking hyperforin-containing Hypericum perforatum extracts with rivaroxaban.
- |||||||||| fexofenadine / Generic mfg.
Journal: Novel Reflections on the Autonomy and Responsibility of Science. (Pubmed Central) - Jul 27, 2021
The analysis focuses on the multi-layered ways in which social and epistemic interests are treated in Allegra Goodman's Intuition and Jennifer Rohn's The Honest Look...In contrast, Rohn's novel exemplifies the corrosion of the ideal scientific ethos by profit-driven practices in private-sector biomedical sciences. The concluding discussion juxtaposes these findings with pertinent contemporary phenomena in modern science systems to provide a more substantial understanding of the interpenetration between science and other social spheres.
- |||||||||| fexofenadine / Generic mfg.
Enrollment open, Trial initiation date: Effect of Antihistamines on Ureteral Stent-Related Symptoms (clinicaltrials.gov) - Jul 20, 2021
P2, N=78, Recruiting,
The concluding discussion juxtaposes these findings with pertinent contemporary phenomena in modern science systems to provide a more substantial understanding of the interpenetration between science and other social spheres. Not yet recruiting --> Recruiting | Initiation date: Mar 2021 --> Jun 2021
- |||||||||| Journal: Palatability of crushed over-the-counter medications. (Pubmed Central) - Jul 11, 2021
Survey responses indicate pharmacists' opinions of crushed medications changed after this palatability experiment. Clinicians should evaluate the appropriateness of all medications when dysphagia is a concern and deprescribe medications when appropriate to reduce burden for patients and caregivers.
- |||||||||| fexofenadine / Generic mfg.
Journal: The Role of P-Glycoprotein in Decreasing Cell Membranes Permeability during Oxidative Stress. (Pubmed Central) - Jul 4, 2021
The transport of the P-gp substrate fexofenadine was evaluated in a special Transwell system...Hydrogen peroxide at a concentration of 50 µM promoted oxidative stress, which was manifested as a decrease in the content of SH-groups, increase in the concentration of lipid peroxidation products and protein carbonyl derivatives, and decrease in the P-gp level, which led to a significantly increased permeability of the plasma membrane. These results show that the transport and protective roles of P-gp, in particular, reduction of the cell membrane permeability, are affected by the intensity of oxidative stress and can be manifested only if the extent of membrane damage is insignificant.
- |||||||||| Ocrevus (ocrelizumab) / Roche
Enrollment open, Head-to-Head: DanNORMS: Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis (clinicaltrials.gov) - Jul 1, 2021
P3, N=594, Recruiting,
These results show that the transport and protective roles of P-gp, in particular, reduction of the cell membrane permeability, are affected by the intensity of oxidative stress and can be manifested only if the extent of membrane damage is insignificant. Not yet recruiting --> Recruiting
- |||||||||| fexofenadine / Generic mfg.
Clinical, Journal: Validity of automated FreeSurfer segmentation compared to manual tracing in detecting prenatal alcohol exposure-related subcortical and corpus callosal alterations in 9- to 11-year-old children. (Pubmed Central) - Jun 24, 2021
High-resolution T1-weighted images were acquired, using a sequence optimized for morphometric neuroanatomical analysis, on a Siemens 3T Allegra MRI scanner in 71 right-handed, 9- to 11-year-old children (27 fetal alcohol syndrome (FAS) and partial FAS (PFAS), 25 non-syndromal heavily exposed (HE) and 19 non-exposed controls) from a high-risk community in Cape Town, South Africa...PAE-related changes in the NA for which ICC consistency did not reach this minimum were inconsistent across methods and should be interpreted with caution. This is the first study to demonstrate in a pre-adolescent cohort the ability of automated segmentation with FreeSurfer to detect regional volume changes associated with pathology similar to those found using manual tracing.
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