- |||||||||| fexofenadine / Generic mfg.
Journal: Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants. (Pubmed Central) - Oct 25, 2022
This study aimed to investigate the inhibitory effects of naringenin, its monosaccharide glycoside prunin, and its disaccharide glycosides naringin and narirutin on fexofenadine (FEX) uptake by OATP1A2 variants (Ile13Thr, Asn128Tyr, Ala187Thr, and Thr668Ser)...These results suggest that the Ala187Thr variant is less vulnerable to inhibition by naringenin and its glycosides. Moreover, greater glycosylation of naringenin reduces its inhibitory potency against OATP1A2.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
An Unusual Case of Chronic Rhinosinusitis (Exhibit Hall (Upper Concourse); Monitor 04) - Oct 10, 2022 - Abstract #ACAAI2022ACAAI_1018;
She was trialed on diphenhydramine, loratidine, fexofenadine, cetirizine, and intranasal budesonide without significant relief...Additional history was notable for mild eosinophilia of 300 cells/μL and vomiting and nasal congestion to tramadol and naproxen - though tolerated other NSAIDs...A referral to Allergy was made for consideration of dupilumab therapy...Her symptoms were very suggestive of chronic sinusitis with nasal polyposis, but treatment was resistant. Other etiologies of nasal polyps, including malignancy, should be on differential of recalcitrant nasal symptoms.
- |||||||||| Nucala (mepolizumab) / GSK
Case of Chronic Eosinophilic Pneumonia in a Pregnant Patient (Exhibit Hall (Upper Concourse); Monitor 05) - Oct 10, 2022 - Abstract #ACAAI2022ACAAI_917;
She was a candidate for mepolizumab, but had become pregnant; therefore, biologic therapy was held...Discussion While CEP is an increasingly studied entity, pregnancy in the setting of a known CEP diagnosis is not well documented. Management of such patients is challenging in view of their uncontrolled obstructive airways symptoms and systemic steroid requirement.
- |||||||||| famotidine / Generic mfg., fexofenadine / Generic mfg., cetirizine oral / Generic mfg.
Primary Hyperparathyroidism As A Rare Intrinsic Cause Of Chronic Urticaria And Angioedema (Exhibit Hall (Upper Concourse); Monitor 04) - Oct 10, 2022 - Abstract #ACAAI2022ACAAI_900;
Our patient's clinical manifestations, treatment course, and improved outcomes after surgery, suggest hyperparathyroidism induced CUA. Previous reported similar presentations of primary hyperparathyroidism induced CUA resolved after partial parathyroidectomy.3 Our aim is to increase awareness of hyperparathyroidism as a potential cause of CUA and curative treatment with parathyroidectomy.
- |||||||||| Xolair (omalizumab) / Roche, Novartis
Severe Atopic Dermatitis Improved With Omalizumab Treatment Of Cholinergic Urticaria (Exhibit Hall (Upper Concourse); Monitor 04) - Oct 10, 2022 - Abstract #ACAAI2022ACAAI_895;
Case Description A 17-year-old girl with longstanding AD, on dupilumab for two years, presented for recurrent hives and anaphylaxis...With one episode, she received intramuscular epinephrine and returned to baseline; others resolved after cooling...Urticaria treatment was escalated to maximal daily doses of fexofenadine, famotidine, and montelukast, with minimal improvement...Anaphylaxis may occur in advanced cases. In patients unresponsive to antihistamines, omalizumab has proven effective.
- |||||||||| Zyflo (zileuton) / Chiesi
A Case Of Difficult To Diagnose C1INH Normal HAE. (Exhibit Hall (Upper Concourse); Monitor 04) - Oct 10, 2022 - Abstract #ACAAI2022ACAAI_885;
Despite this regimen, she continued her thrice weekly episodes, so cyclosporine was added without improvement in flare frequency or severity...Discussion C1INH normal HAE continues to be difficult to diagnose with currently available assays. For patients with recurrent swells, not responding to mast cell stabilizers or antihistamines, a trial of recombinant C1INH or a bradykinin receptor antagonist, may aid in the diagnosis of C1INH Normal HAE.
- |||||||||| Journal, Adverse events: Use of tracking drugs for the search of intra-hospital adverse reactions: a pharmacovigilance study. (Pubmed Central) - Oct 9, 2022
For patients with recurrent swells, not responding to mast cell stabilizers or antihistamines, a trial of recombinant C1INH or a bradykinin receptor antagonist, may aid in the diagnosis of C1INH Normal HAE. This study indicates that the use of trackers can be a tool to estimate the occurrence of adverse drug reactions and to establish adverse events related to the use of medications, which should be reported to the pharmacovigilance service, with a view to patient safety.
- |||||||||| Edsivo (celiprolol) / Acer Therap, Invirase (saquinavir) / Roche, Crixivan (indinavir sulfate) / Merck (MSD)
Review, Journal: Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals. (Pubmed Central) - Sep 29, 2022
Interactions between Pchs and drugs affect the gene expression and enzymatic activity of CYP3A and P-gp transporter, which has an impact on their bioavailability; such that co-administration of drugs with food, beverages and food supplements can cause a subtherapeutic effect or overdose. Therefore, it is important for the clinician to consider these interactions to obtain a better therapeutic effect.
- |||||||||| fexofenadine / Generic mfg.
Enrollment open: Fexofenadine in Patients With Active Rheumatoid Arthritis (clinicaltrials.gov) - Sep 22, 2022
P1/2, N=80, Recruiting,
These observations warrant further investigation of SJP-003 in double-blind, placebo-controlled clinical trials. Not yet recruiting --> Recruiting
- |||||||||| fexofenadine / Generic mfg., tenofovir disoproxil fumarate / Generic mfg., rosuvastatin / Generic mfg.
Journal: P-Gp And Oatp1b/Bcrp Drug Transporters Activity In Pregnant Women Living With Hiv. (Pubmed Central) - Sep 12, 2022
It is suggested that gestation inhibits the hepatic OATP1B1/1B3 and/or BCRP activity but does not alter intestinal P-gp activity. It was not observed the influence of HIV infection in conjunction with use of cART (raltegravir, lamivudine, tenofovir disoproxil fumarate) on OATP1B/BCRP and intestinal P-gp activity.
- |||||||||| fexofenadine / Generic mfg.
Trial completion date, Trial primary completion date: Excipient Effect on Drug Absorption in Humans (clinicaltrials.gov) - Sep 9, 2022
P1, N=12, Not yet recruiting,
It was not observed the influence of HIV infection in conjunction with use of cART (raltegravir, lamivudine, tenofovir disoproxil fumarate) on OATP1B/BCRP and intestinal P-gp activity. Trial completion date: Dec 2022 --> Mar 2023 | Trial primary completion date: Dec 2022 --> Mar 2023
- |||||||||| diphenhydramine / Generic mfg.
Journal: Diphenhydramine: Time to Move on? (Pubmed Central) - Aug 25, 2022
Second-generation antihistamines are also widely available and affordable, with many of the same desired effects as diphenhydramine and fewer, if any, of the undesirable side effects. Because of the negative side effects and wide availability of alternative antihistamine medications, it is definitively time to move on from diphenhydramine.
- |||||||||| Vocabria (cabotegravir oral) / ViiV Healthcare
Journal: Potential COVID-19 Therapies from Computational Repurposing of Drugs and Natural Products against the SARS-CoV-2 Helicase. (Pubmed Central) - Jul 29, 2022
Top hits not previously reported to have SARS-CoV-2 activity included the antiviral agents, cabotegravir and RSV-604; the NK1 antagonist, aprepitant; the trypanocidal drug, aminoquinuride; the analgesic, antrafenine; the anticancer intercalator, epirubicin; the antihistamine, fexofenadine; and the anticoagulant, dicoumarol. These hits from our in silico SARS-CoV-2 helicase screen warrant further testing as potential COVID-19 treatments.
- |||||||||| Tetralysal (lymecycline) / Galderma
Maculopapular cutaneous mastocytosis mimicking seborrhoeic folliculitis () - Jul 15, 2022 - Abstract #BAD2022BAD_756;
This had been widely investigated and managed as follicular eruption with long-term antibiotics in the past (lymecycline and doxycycline)...Urgent skin biopsies were carried out using lidocaine without adrenaline...He was started on fexofenadine 180 mg twice daily with topical mometasone furoate 0·1% cream, which resulted in a slight improvement...Gastrointestinal symptoms are second only to pruritus and seen in 60–80% of patients with systemic disease. This case report highlights the importance of re-evaluation, a high degree of clinical suspicion and clinicopathological correlation in arriving at a diagnosis of a rare skin disease with variable presentations as they are often misdiagnosed and underdiagnosed.
- |||||||||| Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech
Reaction after COVID-19 mRNA Booster Vaccination (Ponce Foyer) - Jun 26, 2022 - Abstract #EAC2022EAC_58;
This case illuminates a delayed urticarial reaction post COVID-19 Booster vaccination. This case prompts awareness to find other patients who may have had similar reactions and also help the medical community develop a management protocol to control the hives and furthermore, perhaps a protocol prior to future booster shots if needed
- |||||||||| Humira (adalimumab) / Eisai, AbbVie, Tetralysal (lymecycline) / Galderma
Enteral nutrition in the management of refractory orofacial Crohn disease (M1) - Jun 23, 2022 - Abstract #BAD2022BAD_544;
The patient started a cinnamon and benzoate-free diet and azathioprine 50 mg twice daily...This spread to involve the contralateral side, despite treatment including topical betamethasone, tacrolimus and mometasone, and systemic medications, including short-courses of prednisolone, fexofenadine, azithromycin, lymecycline and doxycycline...Adalimumab was started in 2020 owing to the refractory orofacial disease and ongoing abdominal pain...This case demonstrates the need for ongoing gastroenterology review in children who present with OFG due to the potential risk of developing intestinal CD. It also highlights the possible role for EEN in the management of orofacial CD.
- |||||||||| fexofenadine / Generic mfg., cetirizine oral / Generic mfg., loratadine / Generic mfg.
Journal: Analysis of degradation and pathways of three common antihistamine drugs by NaClO, UV, and UV-NaClO methods. (Pubmed Central) - Jun 22, 2022
There were 9, 8, and 10 chloride oxidation products of loratadine, fexofenadine, and cetirizine, respectively, and 8 photolysis products of cetirizine were identified. For cetirizine, it was found that there were three identical intermediates produced by photodegradation and NaClO oxidation.
- |||||||||| fexofenadine / Generic mfg.
Journal, IO biomarker: High-fat diet promotes prostate cancer growth through histamine signaling. (Pubmed Central) - Jun 22, 2022
Administration of fexofenadine, a histamine H1 receptor antagonist, suppressed tumor growth in HFD-fed mice by reducing the number of myeloid-derived suppressor cells and suppressing IL6/STAT3 signaling...In conclusion, HFD promotes PCa growth through histamine signaling via mast cells. Dietary high-fat induced gut dysbiosis might be involved in the inflammatory cancer growth.
- |||||||||| fexofenadine / Generic mfg.
Journal: Effect of Nitric Oxide on the Functioning of the P-Glycoprotein Transporter. (Pubmed Central) - Jun 9, 2022
It was shown that GSNO in concentrations of 10 and 50 μM increased the content and activity of Pgp. Increasing the GSNO concentration to 500 μM led to the development of nitrosative stress and a decrease in the content and activity of the transporter protein.
- |||||||||| fexofenadine / Generic mfg.
Journal: Design of xerogel pill with good swallowing performance through wet milling and drop freeze-drying processes. (Pubmed Central) - Jun 8, 2022
Fexofenadine hydrochloride (FXF) was used as a poorly water-soluble model drug...The relative standard deviation (RSD) of the FXF amount were varied in the range of around 3-10%, suggesting that the content uniformity would be acceptable as a composite dosage unit containing five or more pills. It was assumed that further improvements of the physical strength and drug content uniformity would be required to introduce the xerogel pills to practical use.
- |||||||||| fexofenadine / Generic mfg.
Journal: Ultrasound Study of Magnetic and Non-Magnetic Nanoparticle Agglomeration in High Viscous Media. (Pubmed Central) - May 30, 2022
In particular, the use of Epstein-Carhart-Allegra-Hawley's (ECAH) ultrasound scattering theory, along with experimental data of ultrasound velocity or attenuation, provide the method of estimation for the particle or droplet size from nanometers to millimeters...The fitting of theoretical model to experimental ultrasound spectra was used to determine the real size of objects suspended in a high viscous medium that differed from the size distributions provided by electron microscopy imaging. The ultrasound spectroscopy technique demonstrated a greater tendency of magnetic particles toward agglomeration when compared with silica particles whose sizes were obtained from the combination of experimental and theoretical ultrasonic data and were more consistent with the electron microscopy images.
- |||||||||| Journal: Suppressing leukocyte Kv1.3-channels by commonly used drugs: A novel therapeutic target for schizophrenia? (Pubmed Central) - May 22, 2022
In our previous basic studies, in addition to nonsteroidal anti-inflammatory drugs (NSAIDs) and statins, antibiotics (clarithromycin, chloroquine), anti-hypertensive drugs (nifedipine, benidipine, diltiazem, verapamil) and anti-allergic drugs (cetirizine, fexofenadine, azelastine, terfenadine) strongly suppressed the Kv1.3-channel activity and pro-inflammatory cytokine production from lymphocytes. Given such pharmacological properties of these commonly used drugs, they may be useful in the treatment of schizophrenia, in which the enhanced cellular immunity and the subsequent release of excessive cytokines are responsible for the pathogenesis.
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