fexofenadine / Generic mfg. 
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 28 Diseases   17 Trials   17 Trials   1171 News 


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  • ||||||||||  fexofenadine / Generic mfg.
    Post orgasmic illness syndrome (POIS) (Poster Zone A) -  May 13, 2023 - Abstract #EAACI2023EAACI_2168;    
    Levocetirizine controls the symptoms of AR better as compared to Cetirizine, Loratidine and Fexofenadine and is a better choice due to its cost effectiveness, tolerability and safety profile. Fexofenadine 120 mg bid was started.
  • ||||||||||  Rupex (rupatadine) / Incepta Pharma, Medexus
    Acquired angioedema with C1-inhibitor deficiency (AAE-C1-INH) (Poster Zone A) -  May 13, 2023 - Abstract #EAACI2023EAACI_1980;    
    Skin histopathological assessment revealed smooth epidermis, with segmental vacuole degeneration of the basal layer and basal hyperpigmentation. Moreover, presence of perivascular clusters of inflammatory cells, mainly granulocytes and lymphocytes with additional presence of dispersed neutrophils has been ascertained.
  • ||||||||||  Vekacia (ciclosporin ophthalmic) / Santen
    Journal:  Cyclosporine ophthalmic emulsion (Verkazia) for vernal keratoconjunctivitis. (Pubmed Central) -  May 12, 2023   
    Moreover, presence of perivascular clusters of inflammatory cells, mainly granulocytes and lymphocytes with additional presence of dispersed neutrophils has been ascertained. No abstract available
  • ||||||||||  Xolair (omalizumab) / Roche, Novartis
    Late-onset systemic reactions to omalizumab in two patients with urticaria () -  Apr 30, 2023 - Abstract #EAACI2023EAACI_1676;    
    This may pose challenges to further management; given limited availability of other biologics (which are still in clinical trials) and the side effect profiles of other agents such as ciclosporin. There also needs to be awareness of the risk of late reactions, particularly as omalizumab is licensed for self-administration from the 4th dose onwards.
  • ||||||||||  fexofenadine / Generic mfg.
    Trial completion date, Trial primary completion date:  FEXPRESAR: A Placebo-controlled Study of 2-day Pre-treatment With Fexofenadine in Seasonal Allergic Rhinitis (clinicaltrials.gov) -  Apr 10, 2023   
    P3,  N=106, Active, not recruiting, 
    Subjects ingested placebo (control), 540mg fexofenadine (H1-antihistamine) or 40mg famotidine (H2-antihistamine) 1 hour before the exercise bout...Additionally, this could Trial completion date: Mar 2023 --> Nov 2023 | Trial primary completion date: Mar 2023 --> Nov 2023
  • ||||||||||  fexofenadine / Generic mfg.
    Journal:  Phenotyping Indices of CYP450 and P-Glycoprotein in Human Volunteers and in Patients Treated with Painkillers or Psychotropic Drugs. (Pubmed Central) -  Mar 30, 2023   
    P-gp activity was evaluated by determining AUC for plasma concentrations over time of fexofenadine, a well-known substrate of P-gp...The amplitude of phenotyping indices observed in our patients was much wider than those observed in the literature for healthy volunteers. Our study helps define the range of phenotyping indices with "normal" activities in human volunteers and allows classification of patients for further clinical studies regarding CYP and P-gp activities.
  • ||||||||||  fexofenadine / Generic mfg., dexamethasone injection / Generic mfg., epinephrine / Generic mfg.
    A Curious Case of Croup: Parainfluenza Positive Laryngotracheobronchitis in an Adult (Walter E. Washington Convention Center, Area K, Hall C (Lower Level)) -  Mar 25, 2023 - Abstract #ATS2023ATS_8133;    
    She felt this could be related to seasonal allergies and took fexofenadine with mild improvement of her sore throat...Given the history of croup as a child, findings on x-ray, and a Westley croup score of 5 indicating moderate severity, the patient was immediately treated with racemic epinephrine and intravenous dexamethasone and admitted to the ICU for airway monitoring...The case highlights the need for clinicians to be aware of croup as a differential in adults presenting with dyspnea, cough, or stridor. Early diagnosis with a flexible laryngoscope and close clinical monitoring can prevent escalation of care and result in a favorable outcome.
  • ||||||||||  progesterone / Generic mfg., fexofenadine / Generic mfg.
    Preclinical, Journal:  Functioning of P-Glycoprotein during Pregnancy in Rabbits. (Pubmed Central) -  Mar 24, 2023   
    An increase in Pgp content in the jejunum on days 7, 14, 21, and 28 of pregnancy in comparison with this parameter non-pregnant females was revealed by ELISA; in the liver, Pgp content was higher on day 7 and tended to increase on day 14; in the kidney and cerebral cortex, Pgp content was higher on day 28 of pregnancy in parallel with an increase in serum progesterone concentration. We also observed a decrease in Pgp content in the placenta on days 21 and 28 of pregnancy in comparison with day 14 and a decrease in Pgp activity in the placental barrier, which was confirmed by enhanced penetration of fexofenadine (Pgp substrate) through the barrier.
  • ||||||||||  fexofenadine / Generic mfg.
    Trial completion date, Trial primary completion date:  Fexofenadine in Patients With Active Rheumatoid Arthritis (clinicaltrials.gov) -  Mar 23, 2023   
    P1/2,  N=80, Recruiting, 
    For severe symptoms, the addition of oral budesonide may be beneficial. Trial completion date: Apr 2023 --> Nov 2023 | Trial primary completion date: Jan 2023 --> Oct 2023
  • ||||||||||  Preclinical, Journal:  Flupirtine and antihistamines exert synergistic anti-nociceptive effects in mice. (Pubmed Central) -  Mar 14, 2023   
    Flupirtine and antihistamines produced synergistic analgesic effects in all the above pain models. The analgesic effects of antihistamines were partially mediated by Kv7/M channels, and the activation of Kv7/M channels may be partly responsible for the synergistic analgesic effects between flupirtine and antihistamines.
  • ||||||||||  fexofenadine / Generic mfg.
    Journal:  Co-treatment with Fexofenadine and Budesonide Increases FoxP3 Gene Expression in Patients with Allergic Rhinitis. (Pubmed Central) -  Mar 9, 2023   
    Our results showed that combined treatment with fexofenadine and budesonide increased the expression level of the FoxP3 gene, decreased the percentage of peripheral blood eosinophils, and improved the clinical symptoms of AR patients. This regimen appears to improve disease symptoms, at least in part by increasing the Treg population and decreasing the eosinophil population.
  • ||||||||||  fexofenadine / Generic mfg.
    Enrollment open:  Excipient Effect on Drug Absorption in Humans (clinicaltrials.gov) -  Mar 2, 2023   
    P1,  N=12, Recruiting, 
    Therefore, FFD is promising as a therapeutic against cPLA2-involved diseases, particularly ALI. Not yet recruiting --> Recruiting
  • ||||||||||  fexofenadine / Generic mfg.
    Journal:  Similar cortical morphometry trajectories from 5 to 9 (Pubmed Central) -  Feb 28, 2023   
    Patients with coeliac disease may not require consideration for alternative clinical drug management for a number of non-metabolised and transport-mediated medications. Although our results suggest that normal development of cortical morphometry between the ages of 5 and 9
  • ||||||||||  Journal:  Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug Absorption. (Pubmed Central) -  Feb 27, 2023   
    However, analyses of intestinal absorption so far have not been able to accurately consider the concentrations in the epithelial cells where P-glycoprotein and CYP3A4 exert effects. In this study, the limitation was removed by measuring the apical and basal membrane permeability separately and then analyzing these values using new appropriate models.
  • ||||||||||  fexofenadine / Generic mfg.
    Journal:  Assessment of Malondialdehyde Belonging to Modulators and Substrates of the P-Glycoprotein Transporter Protein. (Pubmed Central) -  Feb 14, 2023   
    In this study, it was shown that MDA at concentrations of 10 and 50 ?M and exposure duration of 24 h increases the relative amount and activity of Pgp by acting through CAR and PXR, and MDA can be transported by Pgp. The induction of Pgp under the action of MDA during the development of OS can have a protective significance, ensuring the removal of the peroxidation product from cells into the extracellular space and thereby increasing the viability of cells.
  • ||||||||||  fexofenadine / Generic mfg.
    Trial completion date, Trial primary completion date:  Effect of Antihistamines on Ureteral Stent-Related Symptoms (clinicaltrials.gov) -  Feb 8, 2023   
    P2,  N=78, Recruiting, 
    It is important to monitor these PPCPs in the Potomac River and its tributaries because of its significance as a large drinking water source for the Washington D.C., Maryland, and Virginia area. Trial completion date: Mar 2022 --> Jun 2023 | Trial primary completion date: Mar 2022 --> Jun 2023
  • ||||||||||  fexofenadine / Generic mfg.
    Enrollment open:  FEXPRESAR: A Placebo-controlled Study of 2-day Pre-treatment With Fexofenadine in Seasonal Allergic Rhinitis (clinicaltrials.gov) -  Jan 31, 2023   
    P3,  N=96, Recruiting, 
    These novel and translational findings provide mechanistic evidence on the critical role of BBB transporters in delivery of stroke drugs to the ischemic brain, information that can facilitate therapeutic advancement in clinical trials. Not yet recruiting --> Recruiting
  • ||||||||||  chlorpheniramine / Generic mfg., fexofenadine / Generic mfg., levocetirizine / Generic mfg.
    Journal:  Old versus new antihistamines: Effects on cognition and psychomotor functions. (Pubmed Central) -  Jan 10, 2023   
    In bepotastine group, arousal calm and positive tired scores increased at 4 week as compared to baseline. Patients with dermatological illnesses can be prescribed fexofenedine and bepotastine, as compared to chlorpheniramine and levocetirizine, and their cognitive and psychological functions should be evaluated periodically with suitable tests.
  • ||||||||||  fexofenadine / Generic mfg.
    Journal:  Gut microbiome and fecal metabolic alteration in systemic lupus erythematosus patients with depression. (Pubmed Central) -  Dec 13, 2022   
    A downregulation of the metabolite fexofenadine involved in bile secretion was positively correlated with the genus Faecalibacterium, Subdoligranulum and Agathobacter...This study identified specific fecal microbes and their metabolites that may participate in the development of SLE-d. Our findings provide a new perspective for improving depression in SLE patients by regulating the gut-brain axis.
  • ||||||||||  fexofenadine / Generic mfg.
    Trial completion date, Trial primary completion date:  Excipient Effect on Drug Absorption in Humans (clinicaltrials.gov) -  Dec 1, 2022   
    P1,  N=12, Not yet recruiting, 
    Trial primary completion date: Dec 2024 --> Aug 2024 Trial completion date: Mar 2023 --> Aug 2023 | Trial primary completion date: Mar 2023 --> Aug 2023
  • ||||||||||  Tagrisso (osimertinib) / AstraZeneca
    Trial completion, Metastases:  Study to Assess the Effect of Osimertinib (TAGRISSO (clinicaltrials.gov) -  Nov 14, 2022   
    P1,  N=24, Completed, 
    This influence on T cell-mediated NHR was excluded from the pharmacological effects of antihistamines. Active, not recruiting --> Completed
  • ||||||||||  tramadol hydrochloride / Generic mfg.
    Preclinical, Journal:  Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat. (Pubmed Central) -  Oct 28, 2022   
    Our findings do not support the involvement of serotoninergic, histaminergic, dopaminergic, norepinephrine or opioidergic pathways in tramadol-induced seizures in overdose, but they strongly suggest a tramadol-induced allosteric change of the benzodiazepine-binding site of GABA receptors. Management of tramadol-poisoned patients should take into account that tramadol-induced seizures are mainly related to a GABAergic pathway.