Mifeprex (mifepristone) / Danco Laboratories 
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  • ||||||||||  enzalutamide capsule / Generic mfg., hydrocortisone / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
    Preclinical, Journal:  Synthesis of hydrocortisone esters targeting androgen and glucocorticoid receptors in prostate cancer in vitro. (Pubmed Central) -  Mar 27, 2023   
    Moreover, binding to receptor's ligand binding domains was assessed by molecular modelling. Lead compound also induced the accumulation of cells in G1 phase and its combination with enzalutamide was shown to be more effective than enzalutamide alone.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  FDA preemption of conflicting state drug regulation and the looming battle over abortion medications. (Pubmed Central) -  Mar 21, 2023   
    Over the past 25 years, Congress and the FDA have determined the safest and most beneficial way to regulate the use of mifepristone (Mifeprex), the medication that accounts for the majority of abortions in the United States...It then sets forth the strong arguments for FDA preemption of each type of state restriction and responses to the 'defenses' of those statutes that have been offered in an effort to avoid FDA preemption under the Supremacy Clause. That review shows that a straight-forward application of the FDCA and the Supreme Court caselaw should result in the preemption of the state restrictions that squarely conflict with the relatively free access to abortion medications which FDA has mandated.
  • ||||||||||  Journal:   (Pubmed Central) -  Mar 20, 2023   
    Access to medication abortion is difficult in Quebec and access through telemedicine is almost non existent. Restrictions imposed by the Coll
  • ||||||||||  Journal:   (Pubmed Central) -  Mar 20, 2023   
    Restrictions imposed by the Coll The information received when calling Qu
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Melanin-concentrating hormone regulation by estradiol and progesterone in the incerto-hypothalamic area. (Pubmed Central) -  Mar 15, 2023   
    The regulation of these hormones over the MCH peptidergic system is established before sexual maturation, once the peripubertal removal of the ovaries changes the serum levels of MCH and the number of MCH-ir neurons in the IHy of adult females. Such results support the inhibitory role of steroid hormones over the MCH system.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Comparison of Early Pregnancy Loss Management Between States With Restrictive and Supportive Abortion Policies. (Pubmed Central) -  Mar 14, 2023   
    Such results support the inhibitory role of steroid hormones over the MCH system. OBGYNs practicing in states with restrictive abortion policies are less likely than those in states with supportive abortion policies to have received abortion training or perceive institutional support for abortion care, and they are less likely to offer mifepristone-misoprostol and office uterine aspiration for early pregnancy loss.
  • ||||||||||  Tagrisso (osimertinib) / AstraZeneca, Mifeprex (mifepristone) / Danco Laboratories
    Increased longevity and quality of life with treatment with a progesterone receptor modulator in a patient with treatment resistant stage IV small cell lung cancer (Section 29; Poster Board #4) -  Mar 14, 2023 - Abstract #AACR2023AACR_4840;    
    The progesterone receptor modulator, mifepristone, has been found to provide extension of life by years and marked palliative benefits in several cases of non-small cell lung cancer (NSCLC) despite progression with platinum-based chemotherapy, check-point inhibitors, and third-generation tyrosine inhibitors...He was treated with single agent osimertinib 80mg once/day...Though clinically suspicious of SCLC, it was not biopsy proven. Hopefully this case will inspire a clinical trial of PR antagonists for SCLC.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    A novel mechanism for therapeutic targeting of the glucocorticoid receptor in triple negative breast cancer (Section 29; Poster Board #2) -  Mar 14, 2023 - Abstract #AACR2023AACR_4838;    
    However, GR antagonists such as RU486 (mifepristone) targeting AF2/coactivators have shown only partial success in TNBC cell lines as well as in animal models...We also found that treatment of MDA-MB-231 cells with PepT results in significant attenuation of cell viability and proliferation. Together, these results support our hypothesis that PepT has potential to kill TNBC cells by blocking GR AF1:co-regulator interactions.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Mechanism of human chorionic gonadotropin in endometrial receptivity via the miR-126-3p/PI3K/Akt/eNOS axis. (Pubmed Central) -  Mar 14, 2023   
    The embryo implantation dysfunction (EID) mouse models were established by administrating mifepristone and human endometrial epithelial cells (EECs) were used for in vivo experiments, both followed by hCG treatment...Both in vivo and in vitro experiments validated that hCG activated the PI3K/Akt/eNOS pathway through the miR-126-3p/PIK3R2 axis. Collectively, hCG improves endometrial receptivity by activating the PI3K/Akt/eNOS pathway via regulating miR-126-3p/PIK3R2.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Targeting the progesterone receptor in breast cancer: mind the short form! (Pubmed Central) -  Mar 2, 2023   
    The results indicate that the anti-estrogen (Clomiphene Citrate) but not anti-progesterone (Mifepristone) induces hypo-spermatogenesis in rats which are associated with a downregulation of expression of two of the steroidogenic enzymes, 3?-HSD and P450arom mRNA and StAR protein. The pre-surgical window of opportunity trial (WOT), MIPRA, provides evidence that neoadjuvant treatment with the progesterone receptor (PR) antagonist Mifepristone (RU486) may benefit patients with ER+ breast cancer characterized by a high ratio of PR-A versus PR-B isoform (>1.5) suggesting that PR may be targeted in a subset of patients.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories, Zelboraf (vemurafenib) / Roche
    Review, Journal, IO biomarker, Metastases:  Survival Mechanisms of Metastatic Melanoma Cells: The Link between Glucocorticoids and the Nrf2-Dependent Antioxidant Defense System. (Pubmed Central) -  Feb 12, 2023   
    Recent studies revealed that VMF/PLX40-32 (vemurafenib, a selective inhibitor of mutant BRAF) increases mitochondrial respiration and reactive oxygen species (ROS) production in BRAF human melanoma cell lines...Thus, it is likely that a glucocorticoid receptor antagonist (RU486) could increase the efficacy of BRAF-related therapy in BRAF-mutated melanoma...Moreover, melanoma resistance was decreased if AKT and NF-?B signaling pathways were blocked. These findings highlight mechanisms by which metastatic melanoma cells adapt to survive and could help in the development of most effective therapeutic strategies.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  In brief: Expanded acess to mifepristone. (Pubmed Central) -  Feb 9, 2023   
    Maternal BMI showed a non-significant trend. No abstract available
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Telemedicine medical abortion service in Georgia: an evaluation of a strategy with reduced number of in-Clinic visits. (Pubmed Central) -  Feb 8, 2023   
    Participants were mailed a study package containing mifepristone, misoprostol, two multi-level pregnancy tests, and instructions for their use...Most participants had a complete abortion without a procedure (95.8%, n?=?114). The adapted telemedicine medical abortion service was feasible and satisfactory to participants and has the potential to make medical abortion more patient-centered where waiting periods are mandated.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Advancing Reproductive Health through Policy-Engaged Research in Abortion Care. (Pubmed Central) -  Feb 7, 2023   
    Mifepristone medication abortion was first approved in China and France more than 30 years ago and is now used in more than 60 countries worldwide...We explore how policy-maker-engaged research advanced reproductive health policy and facilitated this rapid change in Canada. We discuss the implications of these policy advances for self-management of abortion and demonstrate how in Canada patients "self-manage" components of the abortion process within a supportive health care system.