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94 Diseases |  |
58 Trials |
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58 Trials |  |
2914 News |  |
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- Mifeprex (mifepristone) / Danco Laboratories
A randomized phase II trial of nab-paclitaxel with or without mifepristone for advanced triple-negative breast cancer. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_4321;
P2
Nonetheless, in this subset of patients, the addition of mif to nab-pac did not significantly improve PFS compared to nab-pac alone. There was a trend towards improvement in OS, primarily driven by one long-term responder.
- Keytruda (pembrolizumab) / Merck (MSD), Mifeprex (mifepristone) / Danco Laboratories
Phase II study of pembrolizumab plus mifepristone in patients with advanced HER2-negative breast cancer. (On Demand | Hall A; Poster Bd # 316) - Apr 26, 2023 - Abstract #ASCO2023ASCO_3287;
P2
In addition, a higher than anticipated rate of skin toxicity, possibly related to mifepristone enhancing the activity of ICI, was observed in the study, leading to early closure. While the benefit/risk analysis of this combination does not support further evaluation, additional investigation of alternative chemotherapy-free, immunomodulatory strategies is warranted.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Court Intrusion Into Science and Medicine-the Mifepristone Decisions. (Pubmed Central) - Apr 26, 2023
While the benefit/risk analysis of this combination does not support further evaluation, additional investigation of alternative chemotherapy-free, immunomodulatory strategies is warranted. No abstract available
- | NN1213 / Novo Nordisk, Mifeprex (mifepristone) / Danco Laboratories
Enrollment change, Trial termination: Medication Enhanced Rapid Therapy (clinicaltrials.gov) - Apr 26, 2023
P1, N=15, Terminated, Sponsor: Washington University School of Medicine
No abstract available N=90 --> 15 | Suspended --> Terminated; COVID and staffing issues
- | Mifeprex (mifepristone) / Danco Laboratories, SCH-23390 / Boehringer Ingelheim, Bijuva (estradiol/progesterone) / TherapeuticsMD, Knight Therap
Journal: Spinal dopaminergic D-and D-like receptors have a sex-dependent effect in an experimental model of fibromyalgia. (Pubmed Central) - Apr 25, 2023
N=90 --> 15 | Suspended --> Terminated; COVID and staffing issues Ovariectomy abated the antiallodynic effect of SCH-23390 (30
- | Mifeprex (mifepristone) / Danco Laboratories
Enrollment open, Trial completion date, Trial primary completion date: MIST: Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial (clinicaltrials.gov) - Apr 25, 2023
P4, N=30, Recruiting, Sponsor: Washington University School of Medicine
Ovariectomy abated the antiallodynic effect of SCH-23390 (30 Not yet recruiting --> Recruiting | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Apr 2023 --> Dec 2023
- ||| sildenafil / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Clinical: Data shows mifepristone is even safer than some common, low-risk prescription drugs, including penicillin & Viagra. There were 5 deaths associated with mifepristone use for every 1 million people in the U.S. who've used the drug since its approval in 2000 https://t.co/i42OHCawMU (Twitter) - Apr 24, 2023
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Judicial interference with mifepristone. (Pubmed Central) - Apr 24, 2023
Not yet recruiting --> Recruiting | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Apr 2023 --> Dec 2023 No abstract available
- || Mifeprex (mifepristone) / Danco Laboratories
Supreme Court protects access to #Mifepristone (Twitter) - Apr 22, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
Case will be back in courts. For now Supreme Court protects access to #Mifepristone (Twitter) - Apr 22, 2023
- ||| Mifeprex (mifepristone) / Danco Laboratories
Kudos @JackResneckMD @AmerMedicalAssn for an excellent piece in @nytimes that lays bare what’s at stake in the mifepristone decision: so much more than just #AbortionRights https://t.co/BunhSwXZGl (Twitter) - Apr 20, 2023
- | Mifeprex (mifepristone) / Danco Laboratories
US FDA’s Califf Responds To, And Deflects, Senators’ Mifepristone Questions https://t.co/zpJX8KSLzN #PinkSheet (Twitter) - Apr 19, 2023
- | Mifeprex (mifepristone) / Danco Laboratories
Journal, Surgery: Stress induces prolonged pain recovery after surgery: involvement of glucocorticoid related pathway. (Pubmed Central) - Apr 19, 2023
No abstract available This finding indicates that stress-induced GR change may result in dysfunction of GR-related neuroprotective pathway.
- | Mifeprex (mifepristone) / Danco Laboratories
No evidence it's dangerous, especially compared to pregnancy (33 deaths per 100,000 vs 0.35 per 100,000 for Mifepristone). But you do you, I guess. (Twitter) - Apr 19, 2023
- | lithium carbonate ER / Generic mfg.
Journal: An update on potential pharmacotherapies for cognitive impairment in bipolar disorder. (Pubmed Central) - Apr 17, 2023
Traditional treatments, such as lithium, anticonvulsants (lamotrigine), antipsychotics (aripiprazole, asenapine, cariprazine, lurasidone, and olanzapine), antidepressants (vortioxetine, fluoxetine, and tianeptine) and psychostimulants (modafinil), and emerging interventions, such as acetylcholinesterase inhibitors (galantamine and donepezil), dopamine agonists (pramipexole), erythropoietin, glucocorticoid receptor antagonists (mifepristone), immune modulators (infliximab, minocycline and doxycycline), ketamine, metabolic agents (insulin, metformin, and liraglutide), probiotic supplements, and Withania somnifera are discussed...In the past, methodological pitfalls in BD cognition trials have also been a critical limiting factor. Expanding on the existing literature and identifying novel pharmacological and non-pharmacological treatments for cognitive impairment in BD should be a priority.
- | Journal: GENETICALLY ENGINEERED HUMAN PITUITARY CORTICOTROPH TUMOR ORGANOIDS EXHIBIT DIVERGENT RESPONSES TO GLUCOCORTICOID RECEPTOR MODULATORS. (Pubmed Central) - Apr 17, 2023
Relacorilant sensitized PitNET organoid responsiveness to Pasireotide. Therefore, our study identified the potential therapeutic use of relacorilant in combination with somatostatin analogs and demonstrated the advantages of relacorilant over Mifepristone, supporting its further development for use in the treatment of CD patients.
- || Mifeprex (mifepristone) / Danco Laboratories
I wonder how many doses of mifepristone and misoprostol Aid Access shipped out. (Twitter) - Apr 16, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
Roughly two in three respondents in a new poll said that the #abortion drug mifepristone should remain available. https://t.co/6LhLwQlp7A (Twitter) - Apr 16, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
Anti-mifepristone court decisions rely on medical misinformation about #abortion and questionable legal reasoning. https://t.co/4e0eed7yCx (Twitter) - Apr 15, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
.#Abortion providers rush to make backup plans as Supreme Court decides whether to keep limits on mifepristone. https://t.co/SuyJdwm77l (Twitter) - Apr 15, 2023
- ||| Mifeprex (mifepristone) / Danco Laboratories
FDA event: What the Supreme Court's decision in the legal fight over abortion pills means for access to #mifepristone. The Supreme Court has temporarily blocked a federal judge's ruling that the FDA's approval of the abortion pill mifepristone be put on hold. https://t.co/uknRa6Xr6b (Twitter) - Apr 15, 2023
- ||| Mifeprex (mifepristone) / Danco Laboratories
Clinical, Adverse events: .@NicolleDWallace, anti-choice🦆s claim that treating a patient with a failed abortion/side effects from mifepristone is “emotionally taxing” & violates their conscience🙄perform the SAME care for a naturally occurring incomplete miscarriage🤷🏼♀️@danielleholley @lipiroy @meganranney (Twitter) - Apr 14, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
The Supreme Court on Friday temporarily blocked a lower court's ruling preventing access to #mifepristone by mail. https://t.co/tVMrLv0df8 (Twitter) - Apr 14, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
Looking forward to joining @wolfblitzer @CNNSitRoom in a few minutes to discuss the medical facts about #mifepristone - and the potential effects of the dueling decisions on pregnant people & families. Tune in! (Twitter) - Apr 14, 2023
- ||| Mifeprex (mifepristone) / Danco Laboratories
Clinical: A federal appeals court decision that declined to suspend approval of the #abortion pill mifepristone, but kept in place restrictions that would prevent it from being sent to patients by mail has teed up a high-stakes showdown at the Supreme Court. https://t.co/fKcUmgkt1n (Twitter) - Apr 13, 2023
- || sildenafil / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
In the U.S. #Viagra causes 50 per million user deaths. #Mifepristone causes 5 per million user deaths. The death rate from pregnancy is 70x as high as the death rate from taking mifepristone. Politicians want less lethal drugs banned to keep their male organs alive. (Twitter) - Apr 12, 2023
- || sildenafil / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
In the U.S. #Viagra causes 50 per million user deaths. #Mifepristone causes 5 per million user deaths. Politicians want less lethal drugs banned to keep their male organs alive. (Twitter) - Apr 12, 2023
- | Mifeprex (mifepristone) / Danco Laboratories
Trial completion date, Trial primary completion date: Mail Order Mifepristone Study (clinicaltrials.gov) - Apr 12, 2023
P4, N=538, Active, not recruiting, Sponsor: Daniel Grossman, MD
Therefore, our study identified the potential therapeutic use of relacorilant in combination with somatostatin analogs and demonstrated the advantages of relacorilant over Mifepristone, supporting its further development for use in the treatment of CD patients. Trial completion date: Jan 2023 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Jun 2023
- || Mifeprex (mifepristone) / Danco Laboratories
A medical ethics expert says a Texas #abortion pill ruling is unprecedented because a federal judge "standing in" for regulators could have far-reaching implications beyond mifepristone. https://t.co/tQgVUVWkCl (Twitter) - Apr 11, 2023
- || paracetamol / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
This is insane. Mifepristone (20 deaths in 18 yrs) is objectively safer than tylenol (500 deaths per yr) or penicillin (500-1000 deaths per yr). It's not about the FDA or regulation it's about banning any and all access to reproductive health care and controlling women's bodies. (Twitter) - Apr 11, 2023
- |||| Mifeprex (mifepristone) / Danco Laboratories
Interview: Two judges have issued conflicting rulings on abortion medication mifepristone. @celinegounder joined @CBSNews to discuss the medical impacts of the rulings. Full interview: https://t.co/JEvJPmuWfq (Twitter) - Apr 11, 2023
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Curcumol, a major terpenoid from Curcumae Rhizoma, attenuates human uterine leiomyoma cell development via the p38MAPK/NF-?B pathway. (Pubmed Central) - Apr 11, 2023
Curcumol suppresses cell proliferation and cell migration while arresting the cell cycle in the G0/G1 phase and inducing cell apoptosis in UMCs via a mechanism related to p38MAPK/NF-?B pathway regulation. Curcumol may be a potential therapeutic and preventive agent in the treatment of benign tumors such as UFs.
- |||| paracetamol / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Clinical: Of course the difference here is mifepristone - used in a procedure that does not fit the personal believe of some & benefits only 50% of the population directly. Tylenol - general use in pain management and anti inflammatory therapy. Also good for men. No religious issues. (Twitter) - Apr 10, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
Unfortunately, the politicians pushing for the ban don't see a difference between an embryo and a fetus and would count each abortion with the mifepristone as death. (Twitter) - Apr 10, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
5/ My math? Mortality from mifepristone is 0.0005% = 5 per 1,000,000 https://t.co/VvAt18rmr6 Maternal mortality in US is 32.9 per 100,000 live births or ~330 per 1,000,000 live births. https://t.co/EnvRngmTc6 330/5 = 66 (or almost 70) (Twitter) - Apr 10, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
4/ The death rate from pregnancy is almost 70x as high as the death rate from taking mifepristone. SEVENTY 7-0 It's bad enough that a woman who wants to have a child has to run those risks. But when she doesn't want a child? (Twitter) - Apr 10, 2023
- ||| Mifeprex (mifepristone) / Danco Laboratories
Clinical: 3/ Taking mifepristone for medication abortion is FAR safer than forcing a woman to carry a pregnancy. To put that into perspective, 330 out of 1M women in the US die from pregnancy-related causes vs 5 out of 1M from taking mifepristone. (Twitter) - Apr 10, 2023
- ||| Clinical: 2/ Mifepristone is safer than many of our most commonly used medications, like ibuprofen & Tylenol. For every 1M women who have used mifepristone, there have been 5 deaths. You compare that to penicillin & Viagra, you’re talking about 20 & 50 deaths per million. (Twitter) - Apr 10, 2023
- |||| Mifeprex (mifepristone) / Danco Laboratories
FDA event: 1/ The courts MAY order the FDA to withdraw its approval of mifepristone, which dates back to 2020. with @tonydokoupil @lilialuciano on @CBSNews https://t.co/11hQAw0uCf There were 10y of data on mifepristone prior to FDA approval + another 23y after. It's SAFE & EFFECTIVE. (Twitter) - Apr 10, 2023
- ||| Mifeprex (mifepristone) / Danco Laboratories
Clinical: “If courts can overturn drug approvals without regard for science or evidence, or for the complexity required to fully vet the safety and efficacy of new drugs, any medicine is at risk for the same outcome as mifepristone,” said the statement.” https://t.co/iBadtIUMhy (Twitter) - Apr 10, 2023
- ||| Mifeprex (mifepristone) / Danco Laboratories
FDA event: 1/ FDA *may* be ordered by the courts to withdraw approval of mifepristone, dating back to 2020. with @tonydokoupil & @lilialuciano on @CBSNews https://t.co/11hQAw0uCf There are 10y of data on mifepristone prior to FDA approval... & another 23y after. It's SAFE & EFFECTIVE. (Twitter) - Apr 10, 2023
- || paracetamol / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Mifepristone: ~14 deaths/year, target of a judicial ban Tylenol: ~500 deaths/year, still readily available on pharmacy shelves for your over-the-counter use right now https://t.co/VWOKmfbSNE. (Twitter) - Apr 10, 2023
- ||| Mifeprex (mifepristone) / Danco Laboratories
Clinical: judges and (vs?) our health: “If courts can overturn drug approvals without regard for science or evidence,” the letter said, “any medicine is at risk for the same outcome as mifepristone.” @NYTHealth https://t.co/L1X9lX3ifU? @PamBelluck @By_CJewett (Twitter) - Apr 10, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
This post explaining the Texas decision on mifepristone was incredibly popular. Worth your time. Fastest explanation of the open regulatory qs https://t.co/spsU5txgbX (Twitter) - Apr 10, 2023
- ||| Mifeprex (mifepristone) / Danco Laboratories
Clinical: With a federal judge in Texas overturning the two-decade-old approval of Mifepristone Friday, Dr. @meganranney provides reassurance of its safety. "It is totally safe. The removal of this option would have devastating consequences for women." https://t.co/gimR9nXXqR (Twitter) - Apr 10, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
Why are they only targeting mifepristone? (Twitter) - Apr 10, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
Analysis: 4 questions answered about the courts and the abortion pill mifepristone. https://t.co/3p2GeXY2sX (Twitter) - Apr 9, 2023
- ||| Defitelio (defibrotide) / IRCCS San Raffaele Hospital, Jazz, Mifeprex (mifepristone) / Danco Laboratories
FDA event: Let’s just say that if the mifepristone ruling stands (which it shouldn’t, of course - it’s utterly lawless and a grotesque overreach) then I will be filing suit against the FDA over their approval of defibrotide. 😇 (Twitter) - Apr 9, 2023
- |||| Mifeprex (mifepristone) / Danco Laboratories
Clinical: FACTS (from a womens🩸 doctor) ✅Postpartum hemorrhage/#bleed risk up to 5% ✅ Severe bleed risk w #mifepristone far lower ✅ Pregnant ppl more likely to bleed/die from unwanted #pregnancy than #abortion @FutureDocs @AOC @PPFA @DrDGrossman @DrJenGunter @DrJenLincoln (Twitter) - Apr 8, 2023
- || Mifeprex (mifepristone) / Danco Laboratories
Two Federal Judges Issued Opposing Rulings on #Abortion Pills. Here’s What’s Going On. One invalidated the F.D.A.’s approval of the abortion pill mifepristone. The other ordered the F.D.A. to do nothing to restrict the pill’s availability. https://t.co/vWyxza9CO4 (Twitter) - Apr 8, 2023