- |||||||||| dexamethasone / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Journal: Glucocorticoids regulate thrombopoiesis by remodeling the megakaryocyte transcriptome. (Pubmed Central) - Oct 22, 2023
People who self-managed an abortion with medication between 9 and 16 weeks of gestation had high levels of abortion completion and accessed health care to confirm completion or to treat potential complications. Our findings identify glucocorticoids as new regulators of thrombopoiesis.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories, ibuprofen / Generic mfg.
Review, Journal: Medical strategy for abortions between 14 and 16 weeks of gestation (Pubmed Central) - Oct 22, 2023
Registration and availability of medical abortion as an over-the-counter product would likely increase women's access to safe abortion. Medical abortion is a safe and effective method up to 16
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal, HEOR: Medical management of early pregnancy loss is cost-effective compared to office uterine aspiration. (Pubmed Central) - Oct 22, 2023
Although office-based uterine aspiration more often results in treatment completion without further intervention, medical management with mifepristone pretreatment costs less and yields similar quality-adjust life-years, making it an attractive alternative. Our findings provided evidence that increasing access to mifepristone and eliminating unnecessary restrictions will improve early pregnancy care.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Mifepristone inhibits hepatoma growth by enhancing the GR-HSP60-survivin interaction to facilitate survivin degradation. (Pubmed Central) - Oct 20, 2023
Animal models have confirmed the growth inhibitory effects of mifepristone on HCC, including changes in the abundance of HSP60 in mitochondria and cytosol, decreased survivin and Ki-67-positive cells, as well as increased cell apoptosis. In conclusion, the inhibition of HCC growth by mifepristone may be achieved by altering the subcellular distribution of HSP60 to enhance the formation of cytosolic GR-HSP60-survivin complexes in the cells, leading to the degradation of survivin.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Enrollment open, Trial completion date, Trial primary completion date, Head-to-Head: The Use of Letrozole or Mifepristone for Pretreatment of Medical Termination of Pregnancy (clinicaltrials.gov) - Oct 17, 2023
P4, N=144, Recruiting,
In conclusion, the inhibition of HCC growth by mifepristone may be achieved by altering the subcellular distribution of HSP60 to enhance the formation of cytosolic GR-HSP60-survivin complexes in the cells, leading to the degradation of survivin. Not yet recruiting --> Recruiting | Trial completion date: Nov 2023 --> Nov 2024 | Trial primary completion date: Aug 2023 --> Aug 2024
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Review, Journal: The Potential of Hormonal Therapies for Treatment of Triple-Negative Breast Cancer. (Pubmed Central) - Oct 14, 2023
This review highlights current findings regarding the roles of three steroid hormone receptors, estrogen receptor beta, the androgen receptor, and the glucocorticoid receptor, in the progression of TNBC. In addition, we discussed several ongoing and completed clinical trials targeting these hormone receptors in TNBC patients.
- |||||||||| Visanne (dienogest) / Mochida, Bayer, Esmya (ulipristal acetate) / ASKA Pharma, HRA Pharma, Gedeon Richter, AbbVie, Mifeprex (mifepristone) / Danco Laboratories
Review, Journal: The Present and the Future of Medical Therapies for Adenomyosis: A Narrative Review. (Pubmed Central) - Oct 14, 2023
The search was limited to articles in English, with subsequent screening of abstracts. Abstracts were screened to select relevant studies.
- |||||||||| EC313 / Evestra, mesoprogestin (EVE104) / Evestra
Preclinical, Journal: Next step in the development of mesoprogestins: the preclinical profile of EC313. (Pubmed Central) - Oct 2, 2023
For an explanation of these findings, the possibility is discussed that the mixed agonistic/antagonistic feature of EC313 is tissue target-specific based on its super-additive synergism characteristic for active bifunctional agents. In conclusion, the specific pharmacodynamic profile of this compound opens the possibility for the development of a drug with a distinct pharmaco-endocrinological profile against uterine fibroids, endometriosis, and other PR-dependent gynecological diseases.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Quality testing of mifepristone and misoprostol in 11 countries. (Pubmed Central) - Sep 30, 2023
For misoprostol, our findings suggest that historical concerns around primary packaging may have been largely resolved but that manufacturing processes for both finished product and active pharmaceutical ingredient need to be improved. The present study also provides evidence of mifepristone quality issues.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: The role of mifepristone on first trimester miscarriage treatment - A double-blind randomized controlled trial - MiFirsT. (Pubmed Central) - Sep 25, 2023
In summary, we confirmed that oxycodone alleviates mifepristone-induced hEndoSC injury by activating the Keap1/Nrf2/HO-1 signaling pathway. The mifepristone plus vaginal misoprostol combined treatment for medical resolution of first trimester miscarriage resulted in significant higher success rate and lower rate of surgical uterine evacuation comparing to misoprostol-alone treatment, with no relevant differences in adverse events or treatment acceptability.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Preabortion ultrasound - a patient perspective. (Pubmed Central) - Sep 12, 2023
Most women opting for medical abortion through telemedicine did not undergo a pre-abortion ultrasound scan. The main reason stated was that women did not find it necessary, lack of resources and privacy issues.
- |||||||||| atosiban / Generic mfg.
Preclinical, Journal, Combination therapy: Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacy. (Pubmed Central) - Sep 11, 2023
A high-throughput combination screen identified that mundulone exhibits synergism with two clinical-tocolytics (atosiban and nifedipine), and MA displayed synergistic efficacy with nifedipine...Importantly, mundulone+atosiban permitted long-term management of PL, allowing 71% dams to deliver viable pups at term (> day 19, 4-5 days post-mifepristone exposure) without visible maternal and fetal consequences. Collectively, these studies provide a strong foundation for the development of mundulone as a single or combination tocolytic for management of PL.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Early pregnancy loss medical management in clinical practice'. (Pubmed Central) - Sep 11, 2023
Medical management of EPL with mifepristone and misoprostol is effective and safe outside of a clinical trial setting. A standardized protocol based on the best available clinical trial evidence can be used in clinical practice for the medical management of EPL.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Voluntary wheel exercise ameliorates cognitive impairment, hippocampal neurodegeneration and microglial abnormalities preceded by demyelination in a male mouse model of noise-induced hearing loss. (Pubmed Central) - Sep 9, 2023
Pretreatment with the glucocorticoid receptor antagonist RU486 before stressful noise exposure partially mitigated the early activation of hippocampal microglia, which were present at 7 days post noise exposure (7DPN), but had no impact on later microglial aberrations, hippocampal neurodegeneration, or cognitive decline exhibited at 1 month post noise exposure (1MPN)...Our results indicated that accelerated cognitive deterioration and hippocampal neuroplastic decline following NIHL are most likely driven by the maladaptive response of hippocampal microglia to myelin damage secondary to hearing loss, and we also demonstrated the potential of voluntary physical exercise as a promising and cost-effective strategy to alleviate the detrimental impact of APHL on cognitive function and thus curtail the high and continuously increasing global burden of dementia. Furthermore, the findings of the present study highlight the contribution of myelin debris overload to microglial malfunction and identify the microglial HIF1?-related pathway as an attractive candidate for future comprehensive investigation to obtain a more definitive picture of the underlying mechanisms linking APHL and dementia.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Enrollment open, Trial completion date, Trial primary completion date: MOLI: Mifepristone Outpatient Labour Induction (clinicaltrials.gov) - Sep 6, 2023
P3, N=400, Recruiting,
Trial completion date: May 2023 --> May 2024 | Trial primary completion date: Apr 2023 --> Apr 2024 Not yet recruiting --> Recruiting | Trial completion date: Mar 2024 --> Oct 2026 | Trial primary completion date: Feb 2024 --> Oct 2025
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Enrollment open: Mifepristone and Misoprostol for Undesired Pregnancy of Unknown Location (clinicaltrials.gov) - Sep 5, 2023
P3, N=50, Recruiting,
Not yet recruiting --> Recruiting | Trial completion date: Mar 2024 --> Oct 2026 | Trial primary completion date: Feb 2024 --> Oct 2025 Not yet recruiting --> Recruiting
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Battles Over Medication Abortion Threaten the Integrity of Drug Approvals in the U.S. (Pubmed Central) - Sep 1, 2023
Legal challenges to the FDA's approval of mifepristone have destabilized patients' ability to access controversial medicines like medication abortion. We argue that federal courts' receptiveness to this litigation undermines the coherence and integrity of prescription drug regulation in the U.S.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Clinical analysis of the regimens for terminating the second-trimester pregnancy in cesarean section women. (Pubmed Central) - Sep 1, 2023
Group A included pregnant women who were administered mifepristone with misoprostol, Group B included those administering mifepristone with misoprostol as well as a transcervical Cook double-balloon catheter, Group C included those receiving mifepristone with an intra-amniotic injection of ethacridine lactate, and Group D included those receiving mifepristone, transcervical Cook double-balloon catheter, and intra-amniotic injection of ethacridine lactate...The four regimens are all effective for the termination of second-trimester pregnancy in women with prior cesareans. The use of transcervical Cook double-balloon could reduce the risks caused by misoprostol, and the combination of these is feasible to induce second-trimester pregnancy termination in women with prior cesareans.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: US federal court upholds limits on abortion drug mifepristone. (Pubmed Central) - Aug 21, 2023
Our findings may explain the proresolving GC actions and offer opportunities for optimizing GC pharmacotherapy and proresolving mediator production. No abstract available
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Review, Journal: GLUCOCORTICOID FEEDBACK PARADOX a homage to Mary Dallman. (Pubmed Central) - Aug 17, 2023
These include the conditional nature of the excitation/inhibition balance in feedback regulation, the role of glucose as a determinant of stress responsivity, and the potential of glucocorticoids in resetting the stress response system. The analysis of the feedback paradox provides also a golden opportunity to review the progress in understanding the role of glucocorticoid hormone in resilience and vulnerability during stress, the science that was burned deeply in Mary Dallman's emotions.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Enhancing Fear Extinction: Pharmacological Approaches. (Pubmed Central) - Aug 16, 2023
The analysis of the feedback paradox provides also a golden opportunity to review the progress in understanding the role of glucocorticoid hormone in resilience and vulnerability during stress, the science that was burned deeply in Mary Dallman's emotions. The process of extinction is also the underlying mechanism for recovery in gold-standard therapies for PTSD, including prolonged exposure, cognitive processing therapy, eye movement desensitization and procession, as well as other empirically-based paradigms.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Mifepristone-Induced Hypothyroidism. (Pubmed Central) - Aug 11, 2023
In conclusion, while the hypothyroidism seems reversible our case highlights the importance of getting baseline thyroid function tests (TFTs) and repeating them while on the medication. Treatment of hypothyroidism is based on symptoms and bloodwork.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Comparison of Two Different Intervals of Misoprostol Administration in Second Trimester Abortions. (Pubmed Central) - Aug 7, 2023
There was no significant difference in side effects in both groups. Based on the results it was observed that shorter interval between mifepristone and misoprostol i.e., 24 hours can be chosen to decrease the hospital stay as there was no significant difference was seen after intravaginal misoprostol in terms of induction abortion interval, number of doses and side effects.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Glucocorticoid receptors regulate central amygdala GABAergic synapses in Marchigian-Sardinian alcohol-preferring rats. (Pubmed Central) - Aug 7, 2023
The GR antagonist mifepristone attenuates craving in AUD patients, alcohol consumption in AUD models, and decreases CeA ?-aminobutyric acid (GABA) transmission in alcohol-dependent rats...In msP rats, GR regulates CeA GABAergic signaling under basal conditions, indicative of intrinsically active GR. Thus, enhanced GR function in the CeA represents a key mechanism contributing to maladaptive behaviors associated with AUD.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Efficacy and safety of medical termination of pregnancy in a regional primary care setting. (Pubmed Central) - Aug 2, 2023
This study is a large Australian example demonstrating high efficacy and safety of nurse-led MToP within regional general practice. The establishment of similar services in rural and regional Australia may address geographical and financial barriers to termination access.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Enrollment change, Trial termination: Mifepristone and Two Doses of Misoprostol for Abortion at 11&12 Weeks (clinicaltrials.gov) - Jul 28, 2023
P4, N=23, Terminated,
The establishment of similar services in rural and regional Australia may address geographical and financial barriers to termination access. N=171 --> 23 | Recruiting --> Terminated; Enrollment
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Trial completion, Trial completion date, Trial primary completion date: DoMy: Pain Assessment in MToP Up to 7 WA (during 5h After Misoprostol Intake) (clinicaltrials.gov) - Jul 27, 2023
P=N/A, N=306, Completed,
N=171 --> 23 | Recruiting --> Terminated; Enrollment Recruiting --> Completed | Trial completion date: Jan 2022 --> Apr 2023 | Trial primary completion date: Jul 2021 --> Mar 2023
- |||||||||| dexamethasone injection / Generic mfg., spironolactone / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Ambiguous Contribution of Glucocorticosteroids to Acute Neuroinflammation in the Hippocampus of Rat. (Pubmed Central) - Jul 18, 2023
The modulation of GR and MR was performed by dexamethasone (GR activation), mifepristone, and spironolactone (GR and MR inhibition, respectively)...In contrast to GR activation, GR or MR inhibition had virtually no influence on LPS-induced inflammatory response. The results suggest glucocorticosteroids ambiguously modulate specific aspects of neuroinflammatory response in the hippocampus of rats at molecular and cellular levels.
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