- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Molecular characterization of PRM associated endometrial changes, PAEC, following mifepristone treatment. (Pubmed Central) - Oct 16, 2019
More broadly, these results shed light on the effects of immune activation on the HPG axis and help elucidate the mechanisms controlling energy allocation and reproduction. PAEC features may be explained by the altered genes and their networks affecting tissue architecture although not involved in endometrial cancer signaling pathways and thus treatment with mifepristone at this dosage does not show any adverse effect at endometrial level.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Gestational dating using last menstrual period and bimanual exam for medication abortion in pharmacies and health centers in Nepal. (Pubmed Central) - Oct 16, 2019
PAEC features may be explained by the altered genes and their networks affecting tissue architecture although not involved in endometrial cancer signaling pathways and thus treatment with mifepristone at this dosage does not show any adverse effect at endometrial level. Routine bimanual exams may not be essential for safe medication abortion provision by trained clinicians in pharmacies and health facilities in low resource settings like Nepal.
- |||||||||| dexamethasone / generics
Journal: Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo. (Pubmed Central) - Oct 11, 2019
The suppression of Wnt16 by GCs was GC-receptor-dependent as co-treatment of mBMSCs with DEX and the GR antagonist RU-486 abrogated the GC-mediated suppression of Wnt16...Finally, recombinant Wnt16 restored DEX-induced suppression of bone formation in mouse calvaria. Thus, this study identifies Wnt16 as a novel target of GC action in GC-induced suppression of bone formation.
- |||||||||| Korlym (mifepristone) / Corcept Therapeutics, Mifeprex (mifepristone) / Danco Laboratories
Journal: Functionally significant, novel GATA4 variants are frequently associated with Tetralogy of Fallot. (Pubmed Central) - Oct 8, 2019
Homology modeling and tertiary structure comparison show conformational changes in these variants. Interestingly, GATA4 variants are more frequently associated with ToF (45%; p = 0.0046)) and PS (22.7%; p < 0.0001) in spite of abundance of septal defects in our study cohort.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD), Mifeprex (mifepristone) / Danco Laboratories
Enrollment closed, Metastases: Study of Pembrolizumab and Mifepristone in Patients With Advanced HER2-negative Breast Cancer (clinicaltrials.gov) - Oct 8, 2019
P2, N=74, Active, not recruiting,
Interestingly, GATA4 variants are more frequently associated with ToF (45%; p = 0.0046)) and PS (22.7%; p < 0.0001) in spite of abundance of septal defects in our study cohort. Recruiting --> Active, not recruiting
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Enrollment open: Assessing Medical Menstrual Regulation in the United States (clinicaltrials.gov) - Oct 3, 2019
P2, N=284, Recruiting,
The results demonstrate that the SCN is sensitive to stressful stimuli early after birth in pups maintained under light/dark conditions and the effect is mediated via glucocorticoid-dependent pathways. Not yet recruiting --> Recruiting
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: C1q/TNF-α--Related Protein 1 (CTRP1) Maintains Blood Pressure Under Dehydration Conditions. (Pubmed Central) - Oct 2, 2019
Spatiotemporal regulation of DAF in the uterus and preimplantation embryos suggest that DAF functions as an immune modulator for embryo implantation and early pregnancy in mice. The increase in CTRP1 under dehydration conditions was mediated by glucocorticoids, and the antagonist mifepristone prevented the increase in CTRP1 and attenuated BP recovery...For the first time, we provide evidence that CTRP1 contributes to the regulation of BP homeostasis by preventing dehydration-induced hypotension.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Two controls of cell proliferation underlie cancer relapse. (Pubmed Central) - Sep 28, 2019
To selectively kill the cancer stem cells conventional cancer therapies could be followed with a therapy based on inactivating human chronic gonadotrophin (HCG). For example chemically modified prostaglandins like RU486 prevent binding of the unmodified steroid to hCG and inactivate hCG.
- |||||||||| Tamoxis (tamoxifen) / Bioprofarma, Mifeprex (mifepristone) / Danco Laboratories
Journal: Tamoxifen- and mifepristone-inducible versions of CRISPR effectors, Cas9 and Cpf1. (Pubmed Central) - Sep 28, 2019
We demonstrate their low background activity and robust activation with drugs, by using gRNAs to target them to TetR, in a cell carrying a Tet-repressed reporter gene. As well as being useful in their own right, the research tools generated here will pave the way to making further drug-controlled effector proteins.
- |||||||||| pregabalin / generics, ibuprofen / generics
Clinical, Journal: Prophylactic Pregabalin to Decrease Pain During Medication Abortion: A Randomized Controlled Trial. (Pubmed Central) - Sep 26, 2019
P4
Compared with placebo, 300 mg pregabalin coadministered with misoprostol during medication abortion did not significantly decrease maximum pain scores. Women who received pregabalin were less likely to require any ibuprofen or narcotic and were more likely to report higher satisfaction with analgesia, despite an increase in dizziness, sleepiness, and blurred vision.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Inhibition of adenovirus infection by mifepristone. (Pubmed Central) - Sep 26, 2019
Mifepristone showed significant in vitro anti-HAdV activity at low micromolar concentrations with little cytotoxicity. Our mechanistic assays suggest that this drug could affect the microtubule transport, interfering with the entry of the virus into the nucleus and therefore inhibiting HAdV infection.
- |||||||||| Proellex (telapristone oral) / Repros
Prevention of BRCA1-associated mammary cancers by selective progesterone receptor modulators (SPRM) in mice (Hall 1 - Poster Session 1) - Sep 25, 2019 - Abstract #SABCS2019SABCS_1940;
The reason for the lack of efficacy of MFP may relate to its strong affinity to GR, resulting in mixed effects on both PR and GR as a reason for its failure in this model. Understanding mechanisms underlying the different anti-tumor efficacy of UPA and MFP in our model will provide important insights that will aid the clinical development of PR-directed strategies for breast cancer prevention in both BRCA1 mutation carriers.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure. (Pubmed Central) - Sep 22, 2019
In vitro, hippocampal neuronal cell line (HT22) cells were incubated with or without mifepristone (RU486) for 1 h, then treated with 400 μM cortisol (CORT) for 3 h. In vivo, autophagy was measured by western blotting...In addition, autophagy in male mice was more severe. The study would provide new insight into the mechanisms and the negative effect of the cold stress response, which can inform the development of new strategies to combat the effects of hypothermia.
- |||||||||| ondansetron ultra-low dose (AD04) / ADial
Clinical, Review, Journal: Anticraving therapy for alcohol use disorder: A clinical review. (Pubmed Central) - Sep 20, 2019
Then, the author addressed on the underused issues of those recommended, and suggested anticraving drugs by the practice guideline of the American Psychiatric Association. The author urges that clinicians should be more "adventurous" in prescribing those promising drugs because benefits of those anticraving drugs are far-outweighing the possible side effects of anticraving drugs, or the harms of untreated AUD itself.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Mifepristone and Misoprostol vs Misoprostol Alone in Second Trimester Termination of Pregnancy. (Pubmed Central) - Sep 20, 2019
Mifepristone and misoprostol combined together is now an established, highly effective and safe method for medical method of second trimester termination. However, when mifepristone is not available or affordable, misoprostol alone can also be used effectively, although a higher total dose is needed and side effects are higher than with the combined regimen.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Involvement of cortisol and sirtuin1 during the response to stress of hypothalamic circadian system and food intake-related peptides in rainbow trout, Oncorhynchus mykiss. (Pubmed Central) - Sep 18, 2019
Four cohorts of trout were subjected to 1) normal stocking density (control group), 2) high stocking density for 72 hours (stress group), 3) normal stocking density and implanted with mifepristone, a glucocorticoid receptors antagonist, and 4) mifepristone administered and stressed for 72 hours...Accordingly, cortisol appears to mainly mediate the effect of stress on food intake regulators through binding to specific glucocorticoid receptors within trout hypothalamus, whereas sirtuin1 is apparently mediating such effects on the circadian system in the same brain region. Further research must be performed to clarify those mechanisms through which stress influences food intake and the circadian oscillator within the same brain region, hypothalamus, in rainbow trout, and the interaction among them all.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Trial completion date, Trial primary completion date: IMEGYN: Evaluation of Efficacy of Two Therapeutic Strategies for Cervical Maturation Before Medical Termination (clinicaltrials.gov) - Sep 16, 2019
P=N/A, N=120, Recruiting,
In conclusion, PCE caused podocyte developmental toxicity in male offspring, which was associated with corticosterone-induced low-functional programming of KLF4 through GR/HDAC7/H3K9ac pathway. Trial completion date: Oct 2021 --> May 2022 | Trial primary completion date: Jun 2021 --> May 2022
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Medication abortion: Potential for improved patient access through pharmacies. (Pubmed Central) - Sep 16, 2019
Trial completion date: Oct 2021 --> May 2022 | Trial primary completion date: Jun 2021 --> May 2022 Provision of mifepristone in pharmacies, which involves dispensing and patient counseling, would likely improve access to early abortion in the United States without increasing risks to women.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Mifepristone. (Pubmed Central) - Sep 16, 2019
Provision of mifepristone in pharmacies, which involves dispensing and patient counseling, would likely improve access to early abortion in the United States without increasing risks to women. No abstract available
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Hypercorticism during streptozotocin diabetes and mifepristone administration: the role of cyclic adenosine monophosphate (Pubmed Central) - Sep 13, 2019
In rats with streptozotocin diabetes, both basal and ACTH-stimulated activity of all stages of steroidogenesis increase, which is mediated by the increased formation of cAMP as second messenger mediating the ACTH action on adrenocortical cells. Prolonged administration of mifepristone to control and diabetic rats resulted in increased activity of only late stages of steroidogenesis with predominant elevation of synthesis of physiologically active hormone corticosterone without additional changes in cAMP production level.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Enrollment status, Trial completion date, Trial primary completion date: Triple M: Comparing Two Medical Treatments for Early Pregnancy Failure. (clinicaltrials.gov) - Sep 12, 2019
P4, N=460, Enrolling by invitation,
Prolonged administration of mifepristone to control and diabetic rats resulted in increased activity of only late stages of steroidogenesis with predominant elevation of synthesis of physiologically active hormone corticosterone without additional changes in cAMP production level. Recruiting --> Enrolling by invitation | Trial completion date: Jan 2020 --> Jun 2020 | Trial primary completion date: Jan 2020 --> May 2020
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Review, Journal: Medical treatment for early fetal death (less than 24 weeks). (Pubmed Central) - Sep 10, 2019
Treatment satisfaction was addressed in only a few studies, in which the majority of women were satisfied with the received intervention. Since the quality of evidence is low or very low for several comparisons, mainly because they included only one or two (small) trials; further research is necessary to assess the effectiveness, safety and side effects, optimal route of administration and dose of different medical treatments for early fetal death.
- |||||||||| Avastin (bevacizumab) / Roche, Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Clinical effect of mifepristone on patients with ovarian cancer in pregnancy. (Pubmed Central) - Sep 6, 2019
In conclusion, mifepristone combined with bevacizumab in the treatment of high-risk pregnancy complicated with ovarian cancer can significantly reduce the patient's labor process and the amount of bleeding at different stages after surgery, the incidence of side effects and complications after surgery is significantly reduced, which is conducive to the recovery of the patient's body. .
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Time to Reevaluate U.S. Mifepristone Restrictions. (Pubmed Central) - Aug 29, 2019
However, these conclusions should be interpreted with caution due to the methodological flaws of the included trials. No abstract available
|
