- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Induced Abortion Provision Among a National Sample of Obstetrician-Gynecologists. (Pubmed Central) - Jan 1, 2020
Compared with the previous national survey in 2008-2009, abortion provision may be increasing among practicing ob-gyns, although important geographic disparities persist. Few provide medication abortion, but uptake might increase if mifepristone could be prescribed.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Generation of Inducible Gene-Switched GAL4 Expressed in the Drosophila Female Germline Stem Cell Niche. (Pubmed Central) - Jan 1, 2020
Since GeneSwitch GAL4 is conveniently activated by the steroid RU486 (mifepristone), we conducted an enhancer-trap screen to isolate GeneSwitch GAL4 lines with expression in the GSC-niche unit...The use of lines #2305 or #2261 to overexpress Drosophila insulin-like peptide 2, which maintains GSC lifespan, in aged niche cap cells significantly delayed age-dependent GSC loss. These results support the notion that insulin signaling is beneficial for maintaining aged stem cells and also validate the utility of our GeneSwitch GAL4 lines for studying stem cell aging.
- |||||||||| methotrexate / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Journal: First Trimester Bleeding: Evaluation and Management. (Pubmed Central) - Dec 26, 2019
The incidence of ectopic pregnancy is 1% to 2% in the United States and accounts for 6% of all maternal deaths. Established criteria should be used to determine treatment options for ectopic pregnancy, including expectant management, medical management with methotrexate, or surgical intervention.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Functional hierarchy of uterotonics required for successful parturition in mice. (Pubmed Central) - Dec 25, 2019
We administered RU486, a progesterone antagonist, to Ptgfr-/-, Oxtr-/-;Ptgfr-/-, and Oxt-/-;Ptgfr-/- on gestation day 19...All of the pups that experienced prolonged labor died. We thus revealed that the oxytocin receptor is an upstream regulator of COX-2 and connexin43 in the uterus during parturition and that both oxytocin/oxytocin receptor and PGF2α receptor are major components for successful parturition.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Mifepristone alleviates cerebral ischemia-reperfusion injury in rats by stimulating PPAR γ. (Pubmed Central) - Dec 23, 2019
Because GR antagonism can reverse expression of these genes, we propose that addition of a GR antagonist to chemotherapy may improve outcome of these high-risk patients. Mifepristone acts as a PPAR γ agonist, and relieves cerebral ischemia-reperfusion injury by restoring the balance between MMPs and TIMPs and inhibiting inflammatory cytokines.
- |||||||||| AG1478 / IDT Australia, Mifeprex (mifepristone) / Danco Laboratories
Journal: Expression and regulation of high mobility group AT-hook 1 (HMGA1) during ovulation and luteinisation in rat ovary. (Pubmed Central) - Dec 23, 2019
Furthermore, Hmga1 mRNA expression in rat granulosa cell cultures was inhibited by AG1478, whereas NS398 and RU486 had no effect, suggesting that Hmga1 expression was regulated, in part, by the epidermal growth factor pathway. In summary, the findings of this study suggest that induction of Hmga1 may be important for theca and granulosa cell differentiation into luteal cells.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Snapshot of medication abortion provision in the primary health care setting of regional and rural Victoria. (Pubmed Central) - Dec 23, 2019
Most identified barriers to service uptake are addressable and relate to a lack of local support services, including the absence of a 24-hour contact advice service, insufficient follow-up access and a lack of local ultrasound facilities. These barriers require educational programs at professional, organisational and community level to ensure that interested rural and regional primary health care providers can start offering medication abortion for their patients.
- |||||||||| Decadron (dexamethasone) / Merck (MSD), sirolimus / Generic mfg.
Journal: Endogenous CSE/Hydrogen Sulfide System Regulates the Effects of Glucocorticoids and Insulin on Muscle Protein Synthesis. (Pubmed Central) - Dec 23, 2019
Dexamethasone (DEX) inhibited protein synthesis, downregulated mTOR and p70S6K phosphorylation, and suppressed the expression of the cystathionine γ-lyase (CSE) protein in myoblasts...The CSE inhibitor DL-propargylglycine (PAG) completely abrogated the effects of RU486 on blocking the suppressive effects of DEX...These results demonstrated that CSE/HS regulated protein synthesis in fast-twitch muscle fibres, and glucocorticoids and insulin regulated protein synthesis in an endogenous CSE/HS system-dependent manner. The results from the present study suggest that the endogenous CSE/HS system regulates fast-twitch glycolytic muscle degeneration and regeneration.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Risk factors for surgical intervention of early medical abortion. (Pubmed Central) - Dec 20, 2019
Gestational age, maternal age, previous deliveries, and history of medically and surgically induced abortions all had a significant influence on the risk of surgical intervention of early medical abortion. However, inclusion of all quantified risk factors still left most interventions unpredictable.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Effects of progesterone on glucose uptake in neurons of Alzheimer's disease animals and cell models. (Pubmed Central) - Dec 19, 2019
Present results point to species-differences in CYP3A regulation and the complexity of bovine CYP3A28 regulatory elements, but further confirmatory studies are needed. These results confirm that progesterone significantly improves the glucose metabolism of neurons.One of the mechanisms of this effect is that progesterone upregulates protein expression of GLUT3 and GLUT4 through pathways PGRMC1/CREB/GLUT3 and PGRMC1/PPARγ/GLUT4.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: RU486 Metabolite Inhibits CCN1/Cyr61 Secretion by MDA-MB-231-Endothelial Adhesion. (Pubmed Central) - Dec 12, 2019
The present study, for the first time, demonstrates that co-incubation of MDA-MB-231 with HPMEC secrets CYR61 probably via the CYR61/integrin αβ signaling pathway to promote adhesion-invasion of TNBC (early metastatic step). Metapristone, by interfering the adhesion-invasion process, prevents metastasis from happening.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Natural chromones as potential anti-inflammatory agents: Pharmacological properties and related mechanisms. (Pubmed Central) - Dec 6, 2019
Furthermore, treatment with RU486, a glucocorticoid receptor (GR) antagonist, partially prevented the inhibitory effect of 3 on macrophages, indicating that this chromone exerts its anti-inflammatory effects in part through the activation of GR. The results presented herein demonstrate the pharmacological potential of natural chromones, highlighting 3 as a possible candidate for the drug discovery process targeting new anti-inflammatory drugs.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Enrollment open: DoMy: Pain Assessment in MToP Up to 7 WA (during 5h After Misoprostol Intake) (clinicaltrials.gov) - Dec 3, 2019
P=N/A, N=364, Recruiting,
The results presented herein demonstrate the pharmacological potential of natural chromones, highlighting 3 as a possible candidate for the drug discovery process targeting new anti-inflammatory drugs. Not yet recruiting --> Recruiting
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Natural and synthetic glucorcorticoids induce therapy resistance in breast cancer in vitro (Hall 1) - Dec 2, 2019 - Abstract #SABCS2019SABCS_2087;
Given our results, it is difficult to conclude whether the primary detrimental effect of GCs is on cell viability and apoptosis. We cannot rule out the possibility that GCs my enhance resistance to chemotherapeutic drugs by modifying inflammation, angiogenesis or cell migration.
- |||||||||| lithium / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Progesterone Receptor Regulation of Seizures (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1322;
Basal seizure frequency was monitored for 2 weeks and then the animals were treated with progesterone (P, 50 mg/kg/day, ip) for a week; RU-486 (RU, 10 mg/kg/day) or vehicle (V) were administered 30 min before progesterone...Finally, the susceptibility of female rats with global deletion of PRs to lithium-pilocarpine-induced SE was assessed...Conclustions PR activation regulates recurrent spontaneous seizures and contributes to progesterone withdrawal-induced seizure exacerbation. Deletion of PRs reduced the severity of SE.
- |||||||||| Tresiba (insulin degludec) / Novo Nordisk, Lantus (insulin glargine) / Sanofi, Mifeprex (mifepristone) / Danco Laboratories
Journal: Hypokalemia associated with mifepristone use in the treatment of Cushing's syndrome. (Pubmed Central) - Nov 22, 2019
Patients on mifepristone require anticipation of toxicity, especially when the dose is escalated. The half-life of mifepristone is 85 h, requiring prolonged monitoring for toxicity, even after the medication is held.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Glucocorticoids and checkpoint tyrosine kinase inhibitors stimulate rat pancreatic beta cell proliferation differentially. (Pubmed Central) - Nov 19, 2019
Our data using glucocorticoids in combination with a receptor antagonist, mifepristone, show that 48h exposure is sufficient to allow beta cells to pass the cell cycle restriction point and to become committed to cell division regardless of sustained glucocorticoid-signaling...Glucocorticoids, but not the kinase inhibitors, were also found to induce changes in the expression of checkpoint regulators. Our data, using checkpoint kinase-specific inhibitors further point to a role for Chk1 and Cdk1 in G1/S transition and progression of beta cells through the cell cycle upon stimulation with glucocorticoids.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Trial initiation date: Mail Order Mifepristone Study (clinicaltrials.gov) - Nov 18, 2019
P4, N=425, Not yet recruiting,
Our data, using checkpoint kinase-specific inhibitors further point to a role for Chk1 and Cdk1 in G1/S transition and progression of beta cells through the cell cycle upon stimulation with glucocorticoids. Initiation date: Sep 2019 --> Dec 2019
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Enrollment closed: MIPRA: Mifepristone for Breast Cancer Patients With Higher Levels of Progesterone Receptor Isoform A Than Isoform B. (clinicaltrials.gov) - Nov 15, 2019
P=N/A, N=20, Active, not recruiting,
Identification of facilitators and barriers to implementation of mifepristone practice in Canada and knowledge translation has the potential to inform regulatory and health system changes to support and scale up facilitators and mitigate barriers to equitable medical abortion provision. Recruiting --> Active, not recruiting
- |||||||||| Jakafi oral (ruxolitinib) / Novartis, Incyte, Imbruvica (ibrutinib) / AbbVie, J&J
Journal: Ibrutinib reprograms the glucocorticoid receptor in chronic lymphocytic leukemia cells. (Pubmed Central) - Nov 14, 2019
P1/2
In contrast to normal B and T cells, transcription of GC-regulated genes was not rhythmic and the synthetic GC dexamethasone (DEX) could not inhibit toll-like receptor (TLR)-responses in CLL cells...Ibrutinib increased transcription of the GR-signature gene GILZ in circulating CLL cells along with GR(pS211)/GR(pS226) ratios and lytic sensitivity to DEX that were not reversed by the competitive antagonist mifepristone in vitro...Addition of the janus kinase inhibitor ruxolitinib to block ibrutinib-insensitive signals increased GILZ transcription in pseudofollicle conditions in vitro and in a clinical trial (NCT02912754), and also increased GR(S211)/GR(S226) ratios and DEX-mediated killing in patient samples in vitro. These observations suggest that intrinsic resistance to endogenous GCs is characteristic of CLL cells and ibrutinib may help increase the therapeutic activity of GCs by non-canonical activation of GR.
- |||||||||| ondansetron / generics, ibuprofen / generics
Clinical, Journal: Opioid Analgesia for Medical Abortion: A Randomized Controlled Trial. (Pubmed Central) - Nov 10, 2019
P4
Aggressive concomitant therapy for hypokalemia and hypertension is necessary. Oxycodone does not reduce the maximum level of pain experienced by women undergoing medical abortion up to 10 0/7 weeks of gestation or improve satisfaction.
- |||||||||| Korlym (mifepristone) / Corcept Therapeutics, Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Mutation screening and functional analysis for 8 patients with ectodermal dysplasia (Pubmed Central) - Nov 8, 2019
Oxycodone does not reduce the maximum level of pain experienced by women undergoing medical abortion up to 10 0/7 weeks of gestation or improve satisfaction. This study identified EDA mutations in Chinese ED patients and further verified the pathogenicity of the mutations by functional studies, contributing to the understanding of the pathogenesis of ED.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: 11β-hydroxysteroid dehydrogenase type 1 inhibitor attenuates high-fat diet induced cardiomyopathy. (Pubmed Central) - Oct 29, 2019
The membrane receptor-GR was involved in pituitary somatotroph differentiation induced by glucocorticoids during the embryonic development of geese. 11β-HSD1 acts as an important regulator that controls the cardiac remolding via both GR and MR and the pharmacological inhibition of 11β-HSD1 could be a new therapeutic approach in preventing HFD-induced cardiac hypertrophy.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal, BRCA Biomarker, IO Biomarker: Mifepristone mediates anti-proliferative effect on ovarian mesenchymal stem/stromal cells from female BRCA carriers. (Pubmed Central) - Oct 29, 2019
Our study showed an anti-proliferative effect on ovarian BRCA MSC upon in vitro mifepristone and progesterone combined treatment. These findings suggest that mifepristone or other selective progesterone receptor modulator could be developed as preventive treatment and postpone early use of prophylactic salpingoophorectomy as well as reduce the risk of ovarian cancer.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Clinical application of low-dose misoprostol in the induced labor of 16 to 28 weeks pathological pregnancies (a STROBE-compliant article). (Pubmed Central) - Oct 24, 2019
The successful induced labor rate, complete induced labor rate, and incomplete induced labor rate were also significantly different between the 2 groups (all P < .05).In the induced labor of 16 to 28 weeks pathological pregnancy, low-dose misoprostol can markedly improve the successful induced labor rate and complete induced labor rate, shorten the birth process and hospital day, and decrease uterine curettage rate and uterine rupture risk. Low-dose misoprostol combined with mifepristone is suitable to the induced labor of 16 to 28 weeks pathological pregnancy in Chinese women.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Xiaoyaosan prevents atherosclerotic vulnerable plaque formation through heat shock protein/glucocorticoid receptor axis-mediated mechanism. (Pubmed Central) - Oct 22, 2019
Xiaoyaosan (XYS) and glucocorticoid receptor (GR) antagonist RU 38486 were orally administrated to the mice...Our results inferred that the HSP/GR complex-mediated CD36 axis was involved in the regulation of atherosclerosis development in mice verified by Co-IP assay, EMSA, and Chip-PCR. These findings not only provide the potential therapeutic value of Xiaoyaosan for atherosclerotic vulnerable plaque but also brought forth a novel strategy for preventing the formation and treatment of atherosclerotic vulnerable plaques through the elucidated mechanism of XYS on vulnerable plaque.
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