- |||||||||| Esmya (ulipristal acetate) / ASKA Pharma, Gedeon Richter, AbbVie, Perrigo Company, Mifeprex (mifepristone) / Danco Laboratories
Review, Journal: Hormonal methods for emergency contraception. (Pubmed Central) - Sep 8, 2024
Ulipristal acetate (UPA) and levonorgestrel (LNG) are the recommended oral methods...Mifepristone can also be used for EC but its availability is limited to few countries...Hormonal contraception can be quickstarted immediately following LNG, or five days following UPA. LNG-releasing intrauterine devices and cyclo-oxygenase inhibitors are promising options for EC to be further studied.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Progesterone treatment for women who have changed their minds after taking mifepristone. (Pubmed Central) - Sep 5, 2024
We identify several leads with >99% efficacy as antagonists of GR trans-activation (potency within 10-fold of that of mifepristone) and further characterize examples that also inhibit release of pro-inflammatory cytokines IL-6 and TNF-?. No abstract available
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Abortion Restrictions Threaten Miscarriage Management In The United States. (Pubmed Central) - Sep 3, 2024
We combined vital statistics with life-table parameters to estimate that 1,034,000 miscarriages occur annually, including nearly 400,000 in US states with abortion bans. Attempts to restrict mifepristone access further threaten miscarriage management.
- |||||||||| Metopirone (metyrapone) / Perrigo Company, Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Glucocorticoid signaling mediates stress-induced migraine-like behaviors in a preclinical mouse model. (Pubmed Central) - Sep 1, 2024
These findings demonstrate that while CORT synthesis and receptor activation is necessary for the behavioral responses triggered by repeated stress, it is only sufficient in females. Better understanding of how glucocorticoids contribute to migraine may lead to new therapeutic opportunities.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Medication and procedural abortion uptake during a period of increasing abortion hostility. (Pubmed Central) - Aug 18, 2024
To measure the association between state abortion hostility and mifepristone and procedural abortion rates, we conducted a state-level repeated cross-sectional study using 2010-2020 employer-sponsored insurance claims data from Merative MarketScan...Advocates for abortion access must simultaneously attend to individual abortion policies and the overall political climate. Updated research on the relationship between political climate and the evolving clinical landscape of abortion care is needed to inform this work.
- |||||||||| progesterone / Generic mfg., albendazole / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Journal: The potential prophylactic and therapeutic efficacy of progesterone and mifepristone on experimental trichinellosis with ultra-structural studies. (Pubmed Central) - Aug 14, 2024
There was notable destruction and degeneration of the adult worm tegument by using both drugs. The current study pointed out that progesterone and mifepristone may provide new insights regarding the development of vaccines and drug protocols to treat trichinellosis through their combined action in reducing the inflammation, affecting the intestinal immune cell, and decreasing the adult worm burden, and larval capsule development.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: A validated HPLC-MS/MS method for the quantification of systemic mifepristone after subcutaneous application in mice. (Pubmed Central) - Aug 8, 2024
The presented HPLC-MS/MS method showed high sensitivity with baseline separation of MIF, MET, and the internal standard levonorgestrel within a run time of only 8.0 minutes and comparable limits of quantification for plasma and tissue homogenates ranging from 40 pg ml-1 to 105 pg ml-1 for MIF and MET. The presented study is suitable for murine plasma and tissues and can be easily applied to human samples.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Neural correlates of learning and memory are altered by early-life stress. (Pubmed Central) - Aug 1, 2024
Furthermore, we examined the potential of RU38486 (RU486), a glucocorticoid receptor antagonist, to mitigate ELS-induced memory deficits by blocking stress signalling during adolescence...Altered correlated activity during training and changes in IEG expression over time were also found in ELS animals. In conclusion, this study shows that ELS alters neuronal activation patterns after fear acquisition and retrieval, which may provide mechanistic insights into enduring impact of early-life stress on the processing of fear memories, possibly via changes in cell (co-) activation and engram cell allocation.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Mifepristone Blocks the Anxiolytic- and Antidepressant-like Effects of Allopregnanolone in Male Rats. (Pubmed Central) - Aug 1, 2024
The current study provides evidence for the first time that progestin or glucocorticoid receptors are involved in the acute anxiolytic and antidepressant effects of allopregnanolone. Understanding the mechanism of action of allopregnanolone will help us design better therapeutic strategies to treat neuropsychiatric diseases such as depression and anxiety.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Cytoarchitectural differences in reproductive organs of some polycystic ovary-like induced animal models. (Pubmed Central) - Jul 28, 2024
Each of the subgroups also had a comparison control group. Following the completion of administration, the Wistar rats were euthanized, and their ovaries and uterus were collected for histological analysis.Increased proliferation of ovarian follicles was noted in the treated groups compared to control, as well as thickening of the endometrial layer.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Bushen Zhuyun Decoction Improves Endometrial Receptivity by Inhibiting NF-?B/NLRP3 Signaling Pathway. (Pubmed Central) - Jul 18, 2024
The present systematic review did not find data to support mifepristone being implicated as a teratogen. BSZY can improve endometrial receptivity, potentially by improving mitochondrial morphology and function to inhibit the activation of NF-?B/NLRP3 signaling pathway in endometrial cells, thus regulate inflammation to improve endometrial receptivity.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
New P1 trial: Mifepristone vs Misoprostol (clinicaltrials.gov) - Jul 15, 2024
P1, N=94, Not yet recruiting,
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: The Role of Glucocorticoid and Nicotinic Acetylcholine Receptors in the Reward-Enhancing Effects of Nicotine in the ICSS Procedure in Male and Female Rats. (Pubmed Central) - Jul 15, 2024
In this study, we investigated the effects of the GR antagonist mifepristone and the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine on the reward-enhancing effects of nicotine using the intracranial self-stimulation (ICSS) procedure in adult male and female rats...These findings indicate that the rewarding effects of nicotine are mediated via the activation of nAChRs, and that the activation of GRs does not contribute to the acute rewarding effects of nicotine. These studies enhance our understanding of the neurobiological mechanisms underlying tobacco use disorder.
- |||||||||| progesterone / Generic mfg.
Journal: Participation of kisspeptin, progesterone, and GnRH receptors on lordosis behavior induced by kisspeptin. (Pubmed Central) - Jul 13, 2024
Results demonstrated a significant reduction in the facilitation of lordosis behavior by Kiss at 60 and 120 min when Kiss-234, RU486, or antide were administered. These findings suggest that Kiss stimulates lordosis expression by activating GPR54 receptors on GnRH neurons and that Kiss/GPR54 system is an essential intermediary by which progesterone activates GnRH.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: To Evaluate the Efficacy and Safety of Mifepristone in Reducing the Size & Symptoms of Uterine Leiomyoma/Fibroids. (Pubmed Central) - Jul 8, 2024
Pain intensity, assessed using the Visual Analog Scale (VAS) score, gradually decreased from baseline to three-month, with all 20 patients reporting the complete absence of pelvic pain by six months. This prospective study highlights mifepristone's promise as a non-surgical approach to effectively reduce uterine fibroid volume, improve hemoglobin levels, and mitigate uterine blood loss in patients.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Effect of Oral Mifepristone on Modified Bishop's Score in Term Pregnancy. (Pubmed Central) - Jul 8, 2024
In our study, we found that mifepristone is a safe and effective cervical ripening agent in term pregnancy with unfavorable cervix. It is well tolerated and leads to significant cervical ripening with improvement in Bishop's score favoring vaginal delivery.
- |||||||||| Metopirone (metyrapone) / Perrigo Company, Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Effect of glucocorticoid blockade on inflammatory responses to acute sleep fragmentation in male mice. (Pubmed Central) - Jul 2, 2024
Furthermore, irrespective of sleep fragmentation, mifepristone increased pro-inflammatory cytokine gene expression in heart (IL-1?), pre-frontal cortex (IL-1?), and hypothalamus (IL-1?). The results provide mixed evidence for pro- and anti-inflammatory functions of corticosterone to regulate inflammatory responses to acute sleep loss.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Inhibition of the glucocorticoid receptor attenuates proteinuric kidney diseases in multiple species. (Pubmed Central) - Jun 27, 2024
Thus, across multiple species and proteinuria models, both genetic and pharmacological GR inhibition was at least as effective as pronounced GR activation. While the mechanism remains perplexing, GR inhibition may be a novel and targeted therapeutic approach to treat glomerular proteinuria potentially bypassing adverse actions of steroids.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Retrospective data, Journal: Effects of medical abortion assisted by traditional Chinese medicine: A network meta-analysis of randomized controlled trials. (Pubmed Central) - Jun 26, 2024
While the mechanism remains perplexing, GR inhibition may be a novel and targeted therapeutic approach to treat glomerular proteinuria potentially bypassing adverse actions of steroids. This network meta-analysis showed that Lenge Zhumo decoction and Sancao decoction could have a large beneficial effect on complete abortion rate in medical abortion during early pregnancy, and comfrey and trichosanthin decoction could be the best TCM for shortening the duration of vaginal bleeding.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Expression of human tau in adult Drosophila melanogaster causes a sexually dimorphic sleep phenotype (Exhibit (Pennsylvania Convention Center); In-Person) - Jun 19, 2024 - Abstract #AAIC2024AAIC_845;
Our results indicate that pathological tau expression in Drosophila melanogaster causes neurodegeneration and increase sleep in females. These results indicate that pathological tau may directly contribute to sleep disruption in humans and provides a new model system to further our understanding of the role of tau in neurodegeneration.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Mifepristone: US Supreme Court rejects ban on abortion drug. (Pubmed Central) - Jun 15, 2024
In conclusion, this study highlights the long-lasting consequences of early-life stress on fear memory processing and further illustrates 1) the potential of a glucocorticoid antagonist intervention during adolescence to mitigate these effects and 2) the partial modulation of the auditory retrieval upon post training administration of CORT, with all these effects being sex-dependent. No abstract available
- |||||||||| progesterone / Generic mfg.
Journal, Stroma: Progesterone inactivation in decidual stromal cells: A mechanism for inflammation-induced parturition. (Pubmed Central) - Jun 11, 2024
Pharmacologic inhibition of AKR1C1 activity prevented parturition in a mouse model of inflammation-induced preterm parturition. The data suggest that inflammatory stimuli at the CDI drive labor by inducing AKR1C1-mediated P4 inactivation in DS cells and that inhibiting and/or bypassing of AKR1C1-mediated P4 inactivation is a plausible therapeutic strategy to mitigate the risk of inflammation-associated preterm birth.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Biomarker, Journal, Tumor microenvironment: Enhancing the Inhibition of Breast Cancer Growth Through Synergistic Modulation of the Tumor Microenvironment Using Combined Nano-Delivery Systems. (Pubmed Central) - Jun 10, 2024
The in vivo anti-tumor studies further confirmed the enhanced anti-tumor capabilities of Dox@CLGs + Ber/Ru486@CLPs, including smaller tumor volumes, weak collagen deposition, and low expression levels of ?-SMA and CD31 proteins, leading to a superior anti-tumor effect. In brief, this combination therapy based on Dox@CLGs and Ber/Ru486@CLPs could effectively inhibit tumor development, which provides a promising approach for the treatment of breast cancer.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Local vaginal bioelectrical impedance can predict preterm delivery in mice. (Pubmed Central) - Jun 3, 2024
PTD was induced in ICR mice through the subcutaneous injection of mifepristone or local intrauterine injection of lipopolysaccharide (LPS)...Histological examination of the LPS-treated model 6?hours post-treatment revealed increased expression of sulfomucins and/or sulfated proteoglycans and sialomucins in the cervical endometrium, cervical stroma and vaginal stroma. In conclusion, local VZ values can determine sulfated and sialylated glycocalyx alterations within the uterus and vagina and might be a useful PTD prediction parameter.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Trial completion, Enrollment change: Clinical Evaluation of Cervical Ripening in the Outpatient Setting (clinicaltrials.gov) - May 31, 2024
P=N/A, N=101, Completed,
Our findings highlight the crucial role of PGRMC1 in mediating the immunoregulatory effects of progesterone at the maternal-fetal interface. Recruiting --> Completed | N=200 --> 101
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