- |||||||||| dexamethasone / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Journal, IO Biomarker: Glucocorticoid and progesterone mechanisms in photoreceptor survival. (Pubmed Central) - Jul 19, 2020
Both dexamethasone and progesterone increased retinal rhodopsin stores, suggesting a link between photoreceptor protection and transduction pathways. Results show that dexamethasone and progesterone induced comparable but not identical protection responses in each model.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Trial completion: Medication Abortion Via Pharmacy Dispensing (clinicaltrials.gov) - Jul 16, 2020
P4, N=260, Completed,
Results show that dexamethasone and progesterone induced comparable but not identical protection responses in each model. Recruiting --> Completed
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Photorearrangement of Quinoline-Protected Dialkylanilines and the Photorelease of Aniline-Containing Biological Effectors. (Pubmed Central) - Jul 8, 2020
Introducing a methyl substituent at the 2-methyl position of the CyHQ core enabled the bypass of the photorearrangement and significantly improved the aniline release efficiency. We successfully applied the strategy to the photoactivation of mifepristone (RU-486), an antiprogestin drug that is also used to induce the LexPR gene expression system in zebrafish and the gene-switch regulatory system based on the pGL-VP chimeric regulator in mammals.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Mifepristone affects fertility and development in the sea urchin Paracentrotus lividus. (Pubmed Central) - Jul 7, 2020
However, mifepristone administered to females caused the decrease of the percentage of normal developed plutei larvae compared to the control, while it did not alter sperm motility parameters and fertilization success in males. The immunohistological localization of progesterone receptor-like immunoreactivity on the plasma membrane of oocytes and ova and the molecular weight of a progesterone receptor-like immunoband identified by western blot, are in agreement with a membrane progesterone receptor deducted from the genome sequence of the sea urchin Strongylocentrotus purpuratus and suggest that in Paracentrotus lividus mifepristone actions may be mediated by a progesterone receptor.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Drug Seller Provision Practices and Knowledge of Misoprostol in Bangladesh. (Pubmed Central) - Jul 7, 2020
The immunohistological localization of progesterone receptor-like immunoreactivity on the plasma membrane of oocytes and ova and the molecular weight of a progesterone receptor-like immunoband identified by western blot, are in agreement with a membrane progesterone receptor deducted from the genome sequence of the sea urchin Strongylocentrotus purpuratus and suggest that in Paracentrotus lividus mifepristone actions may be mediated by a progesterone receptor. NGO-led training and call centers should be considered in other settings in which misoprostol alone is provided off-label for pregnancy termination.
- |||||||||| [VIRTUAL] Non-Genomic Effects of Glucocorticoids Differentially Modulate Glucocorticoid Receptor Site-Specific Phosphorylation (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_3745;
The role of protein synthesis as well as GR was also examined using cycloheximide and RU486, respectively...While SB203580 and LY294002 had little effect on CB-induced pGR-ser226, PD98059 and SP600125 dramatically reduced pGR-ser226...Conclusion Together, our findings show that the non-genomic effects of GC i) differentially affect GR phosphorylation by upregulating pGR-ser226, but not pGR-ser211, in a manner that is GR-independent but ERK/JNK dependent and ii) rapidly activate MAPK pathways. Further studies are still needed to determine the role of GR-independent early events such as nonspecific interactions with the cell membrane in regulating later GC genomic activities.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
Journal: Role of Parkin-mediated mitophagy in glucocorticoid-induced cardiomyocyte maturation. (Pubmed Central) - Jun 28, 2020
The siRNA-mediated inhibition of Parkin expression can inhibit mitochondrial autophagy caused by dexamethasone, thus inhibiting cardiomyocyte maturation. Overall, our study found that dexamethasone can promote embryonic stem cell-derived cardiomyocyte maturation through Parkin-mediated mitophagy.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Trial completion date, Trial primary completion date: Cervical Preparation With Mifepristone Prior to Osmotic Dilators (clinicaltrials.gov) - Jun 25, 2020
P2, N=66, Recruiting,
Targeting this signaling axis may enhance the radiotherapy efficacy in treating PCa. Trial completion date: Jul 2020 --> Jul 2021 | Trial primary completion date: Jun 2020 --> Jun 2021
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
[VIRTUAL] NALCN Expression Is Regulated by Progesterone and Estrogen in Human Myometrial Smooth Muscle Cells () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_1853;
Conversely, treatment with the ER antagonist, ICI 182,780, significantly increased NALCN mRNA expression, while treatment with the PR antagonist RU486 significantly decreased NALCN mRNA expression suggesting E2 and P4 work through their respective receptors to regulate NALCN...This data reveals a new mechanism by which NALCN is regulated in the myometrium and may suggest a novel role for NALCN during pregnancy. Further investigation into these novel roles can provide an insight into potential targets to modulate uterine quiescence and contractility.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Mifepristone Combination Therapy Versus Misoprostol Monotherapy for Early Pregnancy Loss: A Cost Analysis () - Jun 20, 2020 - Abstract #ACOG2020ACOG_609;
We propose a tapering protocol in the setting of potentially untreated Cushing’s Syndrome and suggest use as a bridge therapy to surgical intervention rather than destination therapy. Mifepristone combined with misoprostol is overall more cost effective than monotherapy and therefore cost should not be a deterrent to its adoption.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Miscarriage information available on the internet: a content analysis of leading consumer websites. (Pubmed Central) - Jun 19, 2020
The key messages with the most limited or inaccurate information pertained to diagnosis of miscarriage; treatment, including medical management with mifepristone and misoprostol; instructions postmiscarriage and prevention of miscarriage...The missing information points to areas that patients may feel underprepared to discuss with healthcare providers. More effort is needed to ensure that internet-based consumer information about miscarriage reflects the best scientific evidence.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
Journal: Development and Entrainment of the Fetal Clock in the Suprachiasmatic Nuclei: The Role of Glucocorticoids. (Pubmed Central) - Jun 18, 2020
We show that the maternal but not the fetal part of the placenta harbors the autonomous circadian clock, which is reset by dexamethasone (DEX) and rhythmically expresses Hsd11b2...At E17, treatment of the explants with DEX induces phase advances and phase delays of the rhythms depending on the timing of treatments, and the shifts are completely blocked by the GC receptor antagonist, mifepristone...The fetal SCN is sensitive to GCs in vivo because DEX administration to pregnant rats acutely downregulates c-fos expression specifically in the laser-dissected fetal SCN. Our results provide evidence that the rodent fetal SCN clock may respond to changes in GC levels.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: Cholestatic drug induced liver injury caused by mifepristone. (Pubmed Central) - Jun 15, 2020
Mifepristone (also known as RU-486, which has been used historically with misoprostol to induce abortion), is now being used to inhibit excess cortisol activity in adults with endogenous Cushing's Syndrome. To our knowledge, no prior reports of liver injury associated with its use exist.
- |||||||||| Korlym (mifepristone) / Corcept Therap, Mifeprex (mifepristone) / Danco Laboratories
Journal: Polymorphisms of LAP3 gene and their association with the growth traits in the razor clam Sinonovacula constricta. (Pubmed Central) - Jun 11, 2020
Association analysis identified three shared single nucleotide polymorphisms (SNPs), c.1073A > G, c.1139C > T and c.1154A > G in exons of ScLAP3 gene from 177 individuals of two groups, one selective strain and one wild population, which had significant effects on growth traits of S. constricta. The results provided candidate genetic markers to assist selective breeding of razor clams toward improved growth.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Retrospective data, Review, Journal: Clinical interventions that influence vaginal birth after cesarean delivery rates: Systematic Review & Meta-Analysis. (Pubmed Central) - Jun 11, 2020
This systematic review evaluated clinical interventions directed at increasing the rate of vaginal delivery among women with a prior CD and found low to very low certainty in the body of evidence for cervical ripening and/or labor induction techniques. There is insufficient high-quality evidence to inform optimal clinical interventions among women attempting a trial of labor after a prior CD.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: PURL: Early pregnancy loss: Pretreat with mifepristone? (Pubmed Central) - Jun 9, 2020
Yes. While medical management of early pregnancy loss with misoprostol frequently results in treatment failure, pretreating with mifepristone can increase efficacy.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Clinical, Retrospective data, Journal: Clinical investigation in the methods for complete placenta previa labor induction in the second trimester (Pubmed Central) - Jun 9, 2020
Twenty patients in group A were treated with cesarean section, 30 patients in group B were treated with ethacridine and mifepristone combined with uterine artery embolization (UAE), and 35 patients in group C were induced by using ethacridine and mifepristone...As to average hemoglobin level and blood transfusion rate, there were no difference among the three groups (all P>0.05). Prophylactic UAE combined with drug induction in patients with complete placenta previa in the second trimester could significantly reduce the amount of bleeding during induction and reduce the risk of emergency procedures.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
Journal: Compound A inhibits urothelial tumorigenesis via both the androgen receptor and glucocorticoid receptor signaling pathways. (Pubmed Central) - Jun 9, 2020
Finally, CpdA was found to reduce AR transactivation and selectively induce GR transrepression (i.e. suppression of NF-κB transactivation and expression of its regulated genes), but not GR transactivation (i.e. activation of glucocorticoid-response element-mediated transcription and expression of its targets) in SVHUC cells. These findings suggest that CpdA suppresses urothelial tumorigenesis via both the AR and GR pathways, which may consequently provide an effective option of chemoprevention for bladder cancer, especially in patients with superficial disease following transurethral surgery.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Mifepristone Treatment in Four Cases of Primary Bilateral Macronodular Adrenal Hyperplasia (BMAH). (Pubmed Central) - Jun 8, 2020
Collectively, our data suggest that miR-196a-2 rs11614913 T/T in pri-miR-196a-2 may be conductive to the genetic predisposition to RSA by disrupting the production of mature miR-196a-3p and reinforcing the expression of DHFR. Mifepristone can be an effective alternative to surgery in patients with hypercortisolism due to BMAH.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
Clinical, Journal: Impaired 11β-Hydroxysteroid Dehydrogenase Type 2 in Glucocorticoid Resistant Patients. (Pubmed Central) - Jun 4, 2020
Collectively, we demonstrate that 11β-HSD2 expression and activity is transcriptionally regulated by GR. In the context of GR haploinsufficiency, these findings provide evidence that defective GR signaling may account for apparent mineralocorticoid excess in glucocorticoid resistant patients.
- |||||||||| SR1001 / Scripps Research Institute, Mifeprex (mifepristone) / Danco Laboratories
Journal: White light emitting diode induces autophagy in hippocampal neuron cells through GSK-3-mediated GR and RORα pathways. (Pubmed Central) - May 23, 2020
SR1001, a specific inhibitor of RORα, protected the cells from light-induced activation of autophagy...GR inhibitor RU486 prevented light-induced up-regulation of RORα and the activation of autophagy...Furthermore, GSK-3 was identified as an upstream regulator of GR/RORα signaling as it was not affected by GR or RORα inhibitors. Taken together, our data demonstrate that GSK-3-mediated GR/RORα signaling pathway is involved in white LED light-induced autophagy in hippocampal neuron cells.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Journal: The piggyBac-based double-inducible binary vector system: A novel universal platform for studying gene functions and interactions. (Pubmed Central) - May 23, 2020
Eukaryotic inducible overexpression systems, including Tet-On and mifepristone-inducible systems, have been widely used to study gene functions by reverse genetics...The system efficiently and stringently induced expression of GFP/mCherry and their co-expressed genes without significant mutual interference, as determined by qRT-PCR and Western blot. This piggyBac-based double-inducible system represents a new genetic tool for studying gene functions and interactions in vitro and in vivo in almost all organisms.
- |||||||||| pyridostigmine Bromide / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Review, Journal: Progression of intervention-focused research for Gulf War illness. (Pubmed Central) - May 23, 2020
After reviewing the published and ongoing registered clinical trials for cognitive-behavioral therapy, exercise therapy, acupuncture, coenzyme Q10, mifepristone, and carnosine in GWI patients, we identified only four treatments (cognitive-behavioral therapy, exercise therapy, CoQ10, and mifepristone) that have progressed beyond a phase II trial.We conclude that progress in the scientific study of therapies for GWI has not followed the NIH Roadmap for Medical Research model. Establishment of a standard case definition, prioritized GWI research funding for the characterization of the pathophysiology of the condition, and rapid replication and adaptation of early phase, single site clinical trials could substantially advance research progress and treatment discovery for this condition.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: No-Test Medication Abortion: A Sample Protocol for Increasing Access During a Pandemic and Beyond. (Pubmed Central) - May 23, 2020
Establishment of a standard case definition, prioritized GWI research funding for the characterization of the pathophysiology of the condition, and rapid replication and adaptation of early phase, single site clinical trials could substantially advance research progress and treatment discovery for this condition. No abstract available
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Late glucocorticoid receptor antagonism changes the outcome of adult life stress. (Pubmed Central) - May 19, 2020
This suggests that GR-mediated processes are part of allostatic regulation after adult stress. The normalization of a number of SPS-effects after RU486 treatment reinforces the potential of targeting GR for treatment of stress-related psychopathologies.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Retrospective data, Review, Journal: Management of first-trimester miscarriage: a systematic review and network meta-analysis. (Pubmed Central) - May 17, 2020
We conducted a systematic review and network meta-analysis to assess the effectiveness and safety of treatment options for first-trimester miscarriage: expectant management (EXP), sharp dilation and curettage (D+C), electric vacuum aspiration (EVAC), manual vacuum aspiration (MVA), misoprostol alone (MISO), mifepristone+misoprostol (MIFE+MISO) and misoprostol plus electric vacuum aspiration (MISO+EVAC)...EXP has lower effectiveness compared to other treatment options. Systematic review registration: Prospero CRD42016048920.
- |||||||||| indomethacin / PLx Pharma Inc, Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Journal: Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction. (Pubmed Central) - May 16, 2020
Indomethacin treatment at GD15.5 suppressed the PL-II overproduction at GD18.5 in Slco2a1 (-/-) embryo-bearing dams, which promoted progesterone withdrawal and corrected the delayed parturition. These results suggest that extracellular PGE reduction by OATP2A1 at mid-pregnancy would be associated with progesterone withdrawal by suppressing PL-II production, triggering parturition onset.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Effect of Roscovitine and mifepristone in luminal breast cancer cells (Virtual Meeting II: E-Posters) - May 16, 2020 - Abstract #AACRII2020AACR-II_3870;
Whereas both T47D-YA and -YB cells were similarly inhibited by Roscovitine, only in T47D-YA cells the combination of the antiprogestin mifepristone (MFP; 10 nM) and Roscovitine 1 µM in the presence of FGF2 induced a higher inhibitory effect than MFP or Roscovitine single treatments (p<0.01). We conclude that CDK2 inhibitors may be an option for luminal breast cancer treatment independent of the levels of cyclin A, and that they might be used in combination with antiprogestins only in breast cancer cells overexpressing PRA isoform.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Reducing the effects of glucocorticoids on breast cancer outcome in-vitro and in-vivo (Virtual Meeting II: E-Posters) - May 16, 2020 - Abstract #AACRII2020AACR-II_2954;
We cannot rule out the possibility that GCs may enhance resistance to chemotherapeutic drugs by modifying inflammation, angiogenesis or cell migration. Therefore, our current studies are aimed at investigating the possible pathways mediating GCs induced resistance to therapy in vitro and in vivo.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
Improvement in quality and length of life following treatment with mifepristone in women with stage IV non-small cell lung cancer, positive for the epidermal growth factor receptor (EGFR) mutation, that previously progressed on targeted therapy (Virtual Meeting II: E-Posters) - May 16, 2020 - Abstract #AACRII2020AACR-II_1992;
The brain metastasis was treated with palliative radiation therapy and erlotinib was started...She then had a second course of brain radiation and 5 months after stopping afatinib she began osimertinib...More importantly they both feel much better, with no dyspnea, or pain, and remain ECOG-0. Thus, similar to small cell lung cancer and NSCLC devoid of tumor markers, or with the PD-L1 mutation, patients with advanced NSCLC with EGFR mutation also seem to respond to the progesterone receptor modulator, mifepristone.
- |||||||||| doxorubicin hydrochloride / Generic mfg., Mifeprex (mifepristone) / Danco Laboratories
Palliative benefits of oral mifepristone treatment for metastatic fibroblastic osteosarcoma (Virtual Meeting II: E-Posters) - May 16, 2020 - Abstract #AACRII2020AACR-II_1991;
This was followed by a chemotherapy cocktail of doxorubicin, cisplatin and high dosages of methotrexate for 9 months...Since he was also found to have a 1.6x1.3cm upper lung nodule and another right lower lung nodule, he was also treated with ifosamide and etoposide for 5 months...Foundation one testing revealed targeted mutations for CD104, FGRI, and KRAS, leading to treatment with a targeted therapy, regorafenib...Mifepristone, by blocking this membrane P receptor, inhibits PIBF production. Fibroblastic osteosarcoma can be added to the long list of advanced cancers, resistant to standard cancer therapy, yet demonstrating palliative benefits from mifepristone treatment.
|
