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94 Diseases |  |
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- Mifeprex (mifepristone) / Danco Laboratories
[VIRTUAL] In-Vitro Effects of Active Vitamin-D3 and Vitamin-A on Human Melanoma (BLM and1205Lu) Cell Growth (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_2146;
For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- Mifeprex (mifepristone) / Danco Laboratories
[VIRTUAL] Transient Thyrotoxicosis in Molar Pregnancy (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_2013;
She received mifepristone and underwent dilatation and evacuation...Beta-hCG and FT4 levels rapidly trended down in the post-operative setting, and methimazole was discontinued...Atenolol was stopped when her TFTs normalized...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- Korlym (mifepristone) / Corcept Therap, Mifeprex (mifepristone) / Danco Laboratories
[VIRTUAL] Mifepristone (Korlym ®) Use Interferes With Accurate Serum Measurement of Sex Steroids (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_705;
For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- | progesterone / Generic mfg.
Journal, BRCA Biomarker: Targeting progesterone signaling prevents metastatic ovarian cancer. (Pubmed Central) - Feb 2, 2021
Strikingly, mifepristone treatment profoundly improved mouse survival (∼18 human years). Hence, targeting progesterone/PR signaling could offer an effective chemopreventive strategy, particularly in high-risk populations of women carrying a deleterious mutation in the BRCA gene.
- | Mifeprex (mifepristone) / Danco Laboratories
Trial completion date, Trial primary completion date: Mifepristone for the Prevention of Relapses of Alcohol Drinking (clinicaltrials.gov) - Jan 27, 2021
P1/2, N=30, Recruiting, Sponsor: Brown University
Hence, targeting progesterone/PR signaling could offer an effective chemopreventive strategy, particularly in high-risk populations of women carrying a deleterious mutation in the BRCA gene. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
- | exicorilant (CORT125281) / Corcept Therap
Journal: The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity. (Pubmed Central) - Jan 26, 2021
In conclusion, CORT125281 antagonizes GR transcriptional activity in a tissue-dependent manner and improves corticosterone-induced hyperinsulinemia. Tailored dosing of CORT125281 may allow tissue-specific inhibition of GR transcriptional activity.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Task-sharing in menstrual regulation services: Implementation efforts and lessons learned in Bangladesh. (Pubmed Central) - Jan 26, 2021
Tailored dosing of CORT125281 may allow tissue-specific inhibition of GR transcriptional activity. The government needs to implement effective planning for skills building of nonphysician providers and ensuring facility readiness for provision of menstrual regulation services to reduce unsafe abortion in Bangladesh.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Venus. (Pubmed Central) - Jan 23, 2021
The government needs to implement effective planning for skills building of nonphysician providers and ensuring facility readiness for provision of menstrual regulation services to reduce unsafe abortion in Bangladesh. No abstract available
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: BIRC5 Expression is Regulated in Uterine Epithelium During the Estrous Cycle. (Pubmed Central) - Jan 21, 2021
Estrogen-induced Birc5 expression was blocked by treatment with estrogen receptor antagonist, ICI 182, 780 and progesterone-reduced Birc5 expression was inhibited by the progesterone receptor antagonist RU486. These results suggest that Birc5 expression is dynamically regulated by a combination of estrogen and progesterone via their receptor-mediated signaling.
- || methotrexate / Generic mfg.
Clinical, Journal: A rare case of ectopic pregnancy: Posterior ectopic pregnancy of the iliac vessels. (Pubmed Central) - Jan 16, 2021
HCG levels were retested on the first postoperative day and found to be 8670 mIU/mL. Mifepristone (50 mg, q12h) was purchased from New Hualian Pharmaceutical Corporation (Shanghai, China) and was administered along with 75 mg methotrexate intramuscular injection purchased from Huiyu Pharmaceutical Corporation (Sichuan, China).
- || Mifeprex (mifepristone) / Danco Laboratories
I would love to see everyone who's excited about this put their energy into organizing for Mifepristone access! Especially with these both having huge news this week, not surprised abortion care was the one with bad news (Twitter) - Jan 14, 2021
- | dexamethasone / Generic mfg.
Journal: Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy. (Pubmed Central) - Jan 14, 2021
In addition, dexamethasone significantly decreased lysosomal Hsc70. These findings suggest that glucocorticoids negatively regulate CMA and mA in a glucocorticoid receptor-dependent manner, and provide evidence for CMA and mA as novel therapeutic targets for depression.
- | Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Icariin reduces LPS-induced acute lung injury in mice undergoing bilateral adrenalectomy by regulating GRα. (Pubmed Central) - Jan 13, 2021
However, RU486 could partially counteract the protective effect of ICA on lung injury and its downregulating effect on various inflammatory transcription factors and inflammatory cytokines. In conclusion, ICA reduces ALI in mice undergoing bilateral ADX by regulating GRα, and no inhibitory effect on hypothalamic pituitary adrenal (HPA) axis.
- | dexamethasone / Generic mfg.
Preclinical, Journal: Mechanisms of NADPH-cytochrome P450 oxidoreductase induction by dexamethasone in the H4IIE rat hepatoma cell line. (Pubmed Central) - Jan 13, 2021
The half-life for POR mRNA was prolonged by DEX at both 100 nM and 10 μM. GR is more important in DEX-induced POR expression in H4IIE cells compared to rat liver in vivo, calling into question the suitability of this cell model for mechanistic studies.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Clinical association of progesterone receptor isoform A with breast cancer metastasis consistent with its unique mechanistic role in preclinical models. (Pubmed Central) - Jan 13, 2021
Taken together with previous mechanistic studies, the findings provide clinical evidence in support of the role of PR-A in L-BCa metastasis. They also suggest the possibility of developing selective PR-A modulators for future interventions in appropriate clinical situations.
- || Mifeprex (mifepristone) / Danco Laboratories
Retrospective data, Review, Journal: Effectiveness, safety and acceptability of medical abortion at home versus in the clinic: a systematic review and meta-analysis in response to COVID-19. (Pubmed Central) - Jan 12, 2021
Home-based medical abortion is effective, safe and acceptable to women. This evidence should be used to expand women's abortion options and ensure access to abortion for women during COVID-19 and beyond.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Metapristone (RU486-derivative) inhibits endometrial cancer cell progress through regulating miR-492/Klf5/Nrf1 axis. (Pubmed Central) - Jan 9, 2021
This evidence should be used to expand women's abortion options and ensure access to abortion for women during COVID-19 and beyond. Metapristone inhibited the endometrial cancer cell growth through regulating the cell apoptosis-related signaling pathway and decreasing the expression of miR-492 and its downstream target genes (Klf5 and Nrf1), which provided the theoretical basis in clinical treatment of endometrial cancer.
- | dexamethasone / Generic mfg.
Journal: Corticosterone inhibits vagal afferent glutamate release in the Nucleus of the Solitary Tract via retrograde endocannabinoid signaling. (Pubmed Central) - Jan 8, 2021
Pharmacological or genetic elimination of the cannabinoid type 1 (CB1) receptor signaling blocked CORT suppression of glutamate release. Together our results detail a mechanism whereby the NTS integrates endocrine CORT signals with fast neurotransmission to control autonomic reflex pathways.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Determination of mifepristone in workplace air by ultra-performance liquid chromatography (Pubmed Central) - Jan 8, 2021
The sample could be stored stably for 3 days at 4°C. The ultra-high performance liquid chromatography method for determination of mifepristone is easy to operate, and its indicators meet the requirements of GBZ/T 201.4-2008 "Guidelines for the Establishment of Occupational Hygiene Standards Part 4: Methods for Determination of Chemical Substances in Workplace Air", which is suitable for the detection of mifepristone in the air of the workplace.
- | Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Modulation of heroin intake by ovarian hormones in gonadectomized and intact female rats. (Pubmed Central) - Jan 7, 2021
These data suggest that (1) estradiol but not progesterone is responsible for proestrus-associated decreases in heroin intake and (2) estradiol decreases heroin intake relative to progesterone. These data differ from those reported previously with stimulants and suggest that estrogen-based pharmacotherapies may be of value to women with opioid use disorder.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Programming Changes in GLUT1 Mediated the Accumulation of AGEs and Matrix Degradation in the Articular Cartilage of Female Adult Rats after Prenatal Caffeine Exposure. (Pubmed Central) - Jan 6, 2021
Exogenous AGEs can increase the expression of inflammatory factors (IL-6 and TNF-α) and degradation-related genes, and decrease the matrix synthesis-related genes expression in chondrocyte. In conclusion, the GC-IGF1-GLUT1 axis mediated intrauterine dysplasia of articular cartilage, increased accumulation of AGEs and matrix degradation after birth in PCE female offspring, thereby increasing their susceptibility to osteoarthritis in adulthood.
- | Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Preclinical study of the topical anti-inflammatory activity of Cyperus rotundus L. extract (Cyperaceae) in models of skin inflammation. (Pubmed Central) - Jan 6, 2021
In conclusion, the GC-IGF1-GLUT1 axis mediated intrauterine dysplasia of articular cartilage, increased accumulation of AGEs and matrix degradation after birth in PCE female offspring, thereby increasing their susceptibility to osteoarthritis in adulthood. The results here demonstrate for the first time the topical anti-inflammatory and antiproliferative efficacy of C. rotundus extract, suggesting that the extract could be a potential new therapeutic tool for the treatment of inflammatory skin disorders.
- | dexamethasone / Generic mfg.
Journal: Expanding the anti-inflammatory potential of Moringa oleifera: topical effect of seed oil on skin inflammation and hyperproliferation. (Pubmed Central) - Jan 6, 2021
Both MOSO and OA depend on GC activation for anti-inflammatory effect but do not exhibit the same adverse effects seen in topical treatment with dexamethasone. We hereby evidence the use of MOSO as a topical anti-inflammatory agent in inflammatory skin diseases, thus, expanding its therapeutic potential.
- | Thalomid (thalidomide) / Fujimoto, BMS
Preclinical, Journal: Two thalidomide analogs induce persistent estrous behavior and inhibit uterus contractility in rats: the central role of cAMP. (Pubmed Central) - Jan 6, 2021
Tha analogs were equally effective, but 4APDPMe was more potent than 4NOPDPMe. These results strongly suggest the central role of cAMP in both processes, sexual behavior, and uterine relaxation, and suggest that Tha analogs may also act as Ca-channel blockers.
- || Review, Journal: What is the role of medical therapy in adrenal-dependent Cushing's syndrome? (Pubmed Central) - Jan 2, 2021
Mitotane can be used as well but is considered second-line therapy because of its high toxicity...New drugs are tested in prospective trials (levoketoconazole, osilidrostat and relacorilant) and might become effective alternatives to common drugs. Oher drugs - adrenal steroidogenesis inhibitors as well as glucocorticoid receptor antagonists - are currently tested in vitro.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Sex differences in the long-term effects of past stress on alcohol self-administration, glucocorticoid sensitivity and phosphodiesterase 10A expression. (Pubmed Central) - Jan 1, 2021
Control females self-administered less alcohol following glucocorticoid receptor inhibition by mifepristone, which did not significantly alter alcohol consumption in the other groups...Females expressed more synaptic PDE10A than males in basolateral amygdala and dorsolateral striatum, regardless of stress history, whereas dorsomedial prefrontal cortex PDE10A protein levels matched group differences in reacquisition drinking, but also were expressed at much lower levels than all other regions examined. Together, these data show stress history differentially impacts alcohol self-administration and PDE10A expression by sex, with control females consuming alcohol in a glucocorticoid receptor-sensitive fashion that may relate to sex differences in PDE10A expression.
- Mifeprex (mifepristone) / Danco Laboratories
[VIRTUAL] Characterization of Inpatient Mifepristone in an Academic Medical Center for Estimation of Outpatient Clinic Needs () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2527;
The low incidence of adverse events support administration of mifepristone in an outpatient setting in most patients. Use of outpatient mifepristone administration in low risk patients, with prospective evaluations is warranted.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: State and Federal Abortion Restrictions Increase Risk of COVID-19 Exposure by Mandating Unnecessary Clinic Visits. (Pubmed Central) - Dec 22, 2020
Medically unnecessary abortion regulations result in a large number of excess clinical visits and contacts. Policy Implications Repeal of medically unnecessary state and federal abortion restrictions in the United States would allow for evidence-based telemedicine abortion care, thereby lowering risk of SARS-CoV-2 transmission.
- |||||||||| Mifeprex (mifepristone) / Danco Laboratories
New P3 trial: A multi-centre, open-label, single-arm study assessing the safety and efficacy of 5 mg of mifepristone for the treatment of endometriosis in reproductive-age women during two treatment cycles of 24 weeks each (EUDRACT) - Dec 22, 2020
P3, N=300, Ongoing, Sponsor: Litaphar Laboratorios S.L.
- | Mifeprex (mifepristone) / Danco Laboratories
New P2 trial: Assessing Use Of Mifepristone After Progestin Priming For Use As "Missed Period Pills" (clinicaltrials.gov) - Dec 20, 2020
P2, N=139, Not yet recruiting, Sponsor: Gynuity Health Projects
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal, HEOR: Treatment With Mifepristone Allows a Patient With End-stage Pancreatic Cancer in Hospice on a Morphine Drip to Restore a Decent Quality of Life. (Pubmed Central) - Dec 20, 2020
Policy Implications Repeal of medically unnecessary state and federal abortion restrictions in the United States would allow for evidence-based telemedicine abortion care, thereby lowering risk of SARS-CoV-2 transmission. It is hoped that this case report will influence others to prescribe mifepristone off-label and hopefully substantiate this finding of marked palliative benefit in the majority of a larger series of patients.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Chemical Fingerprint Analysis and Ultra-Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics Study of the Protective Effect of Buxue Yimu Granule in Medical-Induced Incomplete Abortion Rats. (Pubmed Central) - Dec 19, 2020
An incomplete abortion rat model was induced by intragastric administration of mifepristone (8.3 mg·kg) combined with misoprostol (100.0 μg·kg) during early pregnancy...Moreover, 19 potential biomarkers, including N-lactoylleucine, 2-piperidinone, isobutyryl-l-carnitine, eicosapentaenoylcholine, LysoPC(14:0), LysoPC(20:5), physagulin C, LysoPC(18:3), leukotriene D5, deoxycholic acid 3-glucuronide, glycine, pregnanediol 3-O-glucuronide, LysoPC(18:2), LysoPC(17:0/0:0), N-acetyl-leukotriene E4, LysoPC(18:0), platelet-activating factor, LysoPA(24:1), and LysoPC(18:1), which were mainly related to the amino acids metabolism, lipids metabolism, and bile acid biosynthesis, were identified. Consequently, BYG exerts a potential protective role in the intervention of incomplete abortion by anti-inflammatory, promote endometrial repair, and regulate the metabolic disorders.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: A new role for RU486 (mifepristone): it protects sperm from premature capacitation during cryopreservation in buffalo. (Pubmed Central) - Dec 19, 2020
Also, we demonstrated that RU 486 treated sperm underwent normal capacitation, zona pellucida binding and zygote cleavage indicating normal fertilizing ability of sperm. In conclusion, we report a new role of RU 486 in protecting buffalo sperm from premature capacitation during cryopreservation.
- | Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Modulation of IL10 and Its Receptor Subunits in Normal and Progesterone-Prolonged Gestation in the Mouse. (Pubmed Central) - Dec 18, 2020
Treatment with RU486 did not modulate the expression of IL10 or IL10Rα, but showed a significant decrease in the level of IL10Rβ (p < 0.05). Progesterone functions at least in part through the IL10 signaling pathway to prolong gestation.
- || ibuprofen / Generic mfg.
Clinical, Journal: Pain during medical abortion in early pregnancy in teenaged and adult women. (Pubmed Central) - Dec 18, 2020
More effective analgesics than ibuprofen and paracetamol should be offered to all women undergoing early medical abortion, especially to those with history of dysmenorrhea. Also, routine use of antiemetics might be advisable.
- | fulvestrant / Generic mfg.
Preclinical, Journal: Non-genomic actions of sex hormones on pregnant uterine contractility in rats: An in vitro study at term. (Pubmed Central) - Dec 18, 2020
Their actions are mediated by a G-protein coupled receptor that can be blocked by mifepristone. A single and high dose of T or E2 might be considered in premature contractions, however, further preclinical and clinical studies are required for the approval of such a therapeutic intervention.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Mifepristone decreases chronic voluntary ethanol consumption in rhesus macaques. (Pubmed Central) - Dec 16, 2020
Significance Statement Mifepristone reliably decreases average daily ethanol self-administration in a non-human primate model. This effect was mediated by cortisol, was most effective during open-access conditions, and did not prevent or reduce relapse drinking.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Adoption of no-test and telehealth medication abortion care among independent abortion providers in response to COVID-19. (Pubmed Central) - Dec 12, 2020
Clinics can strive for a culture shift towards simplifying the provision of medication abortion and routinely avoiding preabortion tests and in-person visits. Such changes in practice could have positive benefits for public health and patient-centered care.
- Mifeprex (mifepristone) / Danco Laboratories
[VIRTUAL] Surgery for retained products of conception () - Dec 10, 2020 - Abstract #ESGELIVE2020ESGE_LIVE_86;
We need to look and analyze the different factors and baseline characteristics in all misoprostol-cycles for miscarriage. A more tailored management like adding mifepristone or direct surgery could be offered in order to prevent RPOC.
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Review, Journal: Clinical management of patients with Cushing syndrome treated with mifepristone: consensus recommendations. (Pubmed Central) - Dec 10, 2020
Safe and effective use of mifepristone requires clinical judgment and close patient monitoring to ensure optimal clinical outcomes. These consensus recommendations provide useful, practical guidance to clinicians using mifepristone.
- || medroxyprogesterone injection / Generic mfg.
Review, Journal: Long-acting reversible contraception immediately after medical abortion: systematic review with meta-analyses. (Pubmed Central) - Dec 2, 2020
The contraceptive implant or injectable should be offered on the day of taking mifepristone. Intrauterine methods of contraception should be offered as soon as possible after expulsion of the pregnancy.
- | Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Antiproliferative effect of mifepristone (RU486) on human neuroblastoma cells (SK-N-SH): in vitro and in vivo studies. (Pubmed Central) - Dec 2, 2020
These results indicated a clear effect of RU486 on the growth of SK-N-SH neuroblastoma cells that does not seem to be mediated through the classical steroid receptors. RU486 acted mainly on the more aggressive component of the SK-N-SH cell line and its effect in vivo was achieved at a concentration already used to inhibit oocyte implantation.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Medication Abortion Up to 70 Days of Gestation. (Pubmed Central) - Dec 1, 2020
The purpose of this document is to provide updated evidence-based guidance on the provision of medication abortion up to 70 days (or 10 weeks) of gestation. Information about medication abortion after 70 days of gestation is provided in other ACOG publications (R1).
- | Mifeprex (mifepristone) / Danco Laboratories
Journal, HEOR, Combination therapy, Monotherapy: Mifepristone Combination Therapy Compared With Misoprostol Monotherapy for the Management of Miscarriage: A Cost-Effectiveness Analysis. (Pubmed Central) - Dec 1, 2020
Information about medication abortion after 70 days of gestation is provided in other ACOG publications (R1). Mifepristone combined with misoprostol is, overall, more cost effective than monotherapy, and therefore cost should not be a deterrent to its adoption in the management of miscarriage.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Prolactin peptide (pPRL) induces anti-prolactin antibodies, ROS and cortisol but suppresses specific immune responses in rainbow trout. (Pubmed Central) - Dec 1, 2020
Additionally, through qPCR assay, we determined that the pPRL-VP2 fish group decreased pro-inflammatory transcript expression, and the serum of these (pPRL-VP2) fish stimulated ROS production in untreated fish leukocytes, a phenomenon that was blocked by the pharmacological cortisol receptor inhibitor (RU486). Collectively, this is the first report that indicates that pPRL could modulate both components of immunity in rainbow trout.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Medication Abortion Up to 70 Days of Gestation: ACOG Practice Bulletin Summary, Number 225. (Pubmed Central) - Dec 1, 2020
The purpose of this document is to provide updated evidence-based guidance on the provision of medication abortion up to 70 days (or 10 weeks) of gestation. Information about medication abortion after 70 days of gestation is provided in other ACOG publications ().
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Human and zebrafish nuclear progesterone receptors are differently activated by manifold progestins. (Pubmed Central) - Nov 28, 2020
The potent human PR antagonist mifepristone (RU486) blocked PR-induced luciferase in both cell models but with different potencies...Such zfPR-specific response was further confirmed in zebrafish liver cells (ZFL). This study provides novel information regarding the activity of a large set of progestins on human and zebrafish PR and highlights major interspecies differences in their activity, which may result in differential effects of progestins between fish and humans.
- Mifeprex (mifepristone) / Danco Laboratories
[VIRTUAL] Seizure-induced activation of the HPA axis worsens epilepsy outcomes and comorbidities () - Nov 28, 2020 - Abstract #AES2020AES_392;
We also find that attenuation of HPA axis dysfunction in chronically epileptic mice lessens seizure severity, suggesting a therapeutic intervention that can be utilized alongside anti-seizure medication to slow disease progression, and potentially alleviate comorbid affective states in patients with epilepsy. Funding: NINDS
- || ibuprofen / Generic mfg., dronabinol oral / Generic mfg.
Clinical, Journal: Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial. (Pubmed Central) - Nov 26, 2020
P4
Funding: NINDS Dronabinol does not reduce the maximum level of pain experienced by women undergoing medical abortion.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Study of effects of mifepristone on full-term pregnancies. (Pubmed Central) - Nov 25, 2020
Mifepristone needs to be studied more in term pregnancies as induction of labour is increasingly required in today's scenario for various reasons. However, its role in improving the Bishop score as found in this study helps in decreasing dose of other labour inducing agents.