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[VIRTUAL] A Case of Diabetic Ketoacidosis in Medical Management of Miscarriage () - Jun 7, 2021 - Abstract #AACE2021AACE_224; Women may have an elective first-trimester miscarriage through a non-surgical treatment approach either with Misoprostol alone, a prostaglandin analog, or in combination with Mifepristone, a glucocorticoid progesterone receptor antagonist. We present a case of a 31-year-old female with type 1 diabetes mellitus (DM) who underwent medical abortion with Misoprostol and Mifepristone and developed Diabetic Ketoacidosis (DKA).
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[VIRTUAL] A Case of Cushing Syndrome and Pituitary Microadenoma Managed with Mifepristone () - Jun 7, 2021 - Abstract #AACE2021AACE_223; The causes of Cushing syndrome include exogenous steroids, growth of the pituitary gland (Cushing disease), a benign or malignant growth within the adrenal gland or ectopic production. Our objective is to report a case of Cushing Syndrome and Pituitary Microadenoma in a patient who refused surgical intervention, and was managed medically.
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Preclinical, Journal: Conflicting Nongenomic Effects of Progesterone in the Myometrium of Pregnant Rats. (Pubmed Central) - May 28, 2021 In addition, FPL64176, an activator of L-type voltage-dependent calcium channels, enhanced high-KCl-induced contractions and rescued the decrease in high-KCl-induced contractions caused by progesterone. Together, these results suggest that progesterone exerts conflicting nongenomic effects on the contractions of pregnant myometrium via putative L-type voltage-dependent calcium channels.
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Journal: Glucocorticoid and β-adrenergic regulation of hippocampal dendritic spines. (Pubmed Central) - May 27, 2021 The effects of co-application of corticosterone and isoproterenol on spines could be prevented by blocking the glucocorticoid receptor (GR)-antagonist RU486. Taken together, both corticosterone and β-adrenergic receptor activation increase spine number, and they exert additive effects on spine number for which activation of GRs is permissive.
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Journal: Medical abortion. (Pubmed Central) - May 27, 2021 Medical abortion (using mifepristone followed by misoprostol to end an early pregnancy) is a more accessible and less invasive option than surgical termination and can be provided in primary care settings...Provision of medical abortion is well within the scope of community general practice and improves the comprehensiveness of women's sexual and reproductive health services that GPs can deliver. This article will help GPs to better understand the process involved in providing medical abortion, including the practical considerations for patients; be better equipped to support patients who have decided that medical abortion is an appropriate choice for them; and make an informed decision as to whether to become a provider of medical abortion.
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Clinical, Journal: Preoperative treatment of uterine fibroids with low-dose mifepristone: a multicenter, randomized, double-blind, placebo-controlled, parallel-group study (Pubmed Central) - May 27, 2021 Abdominal pain was the most common adverse event in the study group [9% (6/65)], but the incidence was not significantly increased compared with the control group [3% (2/64); P>0.05]. Compared with placebo, oral mifepristone 10 mg/day is significantly superior to placebo in reducing the size of uterine fibroids and improving anemia, without significant adverse reactions, and could be used as a drug treatment for patients with of uterine fibroids before surgery.
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Journal, Checkpoint inhibition, PD(L)-1 Biomarker, IO biomarker: Enhanced antitumor immunity via endocrine therapy prevents mammary tumor relapse and increases immune checkpoint blockade sensitivity. (Pubmed Central) - May 21, 2021 Treatment with the antiprogestin mifepristone (MFP) inhibited growth of 59-2-HI tumors with similar kinetics in both animal models...Finally, MFP treatment increased the sensitivity of HR+ 59-2-HI tumor to PD-L1 blockade, suggesting that antiprogestins may improve immunotherapy response rates. These results contribute to a better understanding of the mechanisms underlying the antitumor effect of hormonal treatment and the rational design of therapeutic combinations based on endocrine and immunomodulatory agents in HR+ breast cancer.
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Review, Journal: Medication to Manage Abortion and Miscarriage. (Pubmed Central) - May 15, 2021 We discuss clinical considerations and resources for integrating mifepristone and misoprostol into clinical practice. By learning to prescribe mifepristone and misoprostol, clinicians can expand access to time-sensitive health services for vulnerable populations.
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Preclinical, Journal: Effect of Glucocorticoid Receptor Antagonism on Alcohol Self-Administration in Genetically-Selected Marchigian Sardinian Alcohol-Preferring and Non-Preferring Wistar Rats. (Pubmed Central) - May 13, 2021 Once a stable alcohol SA baseline was reached, we tested the effect of the GR antagonists mifepristone (0.0, 10, 30 and 60 mg/kg; i.p.) and CORT113176 (0.0, 10, 30 and 60 mg/kg) on alcohol SA...Overall, these findings indicate that selective blockade of GR selectively reduces alcohol SA, and genetically selected msP rats are less sensitive to this pharmacological manipulation compared to heterogeneous Wistars. Moreover, results suggest sex differences in response to GR antagonism and the ability of alcohol to regulate GR transmission.
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Journal: Expression analysis of progesterone‑regulated miRNAs in cells derived from human glioblastoma. (Pubmed Central) - May 11, 2021 The possible mRNA targets of the miRNAs regulated by P4 could participate in the regulation of proliferation, cell cycle progression and cell migration of GBMs. The present study provided insight for understanding epigenetic modifications regulated by sex hormones involved in GBM progression, and for identifying potential therapeutic strategies for these brain tumors.
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Preclinical, Journal: Progesterone-induced RNA Hand2os1 regulates decidualization in mice uteri. (Pubmed Central) - May 8, 2021 Concurrently, Hand2os1 significantly promoted the decidual process in vitro and dramatically increased decidualization markers Prl8a2 and Prl3c1. Our results provide a valuable catalog for better understanding of the functional roles of lncRNAs in pregnant mouse uteri, as it relates to decidualization.
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Review, Journal: Expulsion at home for early medical abortion: A systematic review with meta-analyses. (Pubmed Central) - Apr 29, 2021 Women who are having a medical abortion and will be taking the mifepristone up to and including 10 weeks' gestation should be offered the option of expulsion at home after they have taken the misoprostol. Further research needs to determine if the gestational limit for home expulsion can be extended beyond 10 weeks.
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Clinical, Journal: Analysis of medication data of women with uterine fibroids based on data mining technology. (Pubmed Central) - Apr 28, 2021 Based on the analysis of the frequency of drug, treatment effect and adverse drug reactions, it was found that the clinical application of mifepristone in the treatment of uterine fibroids was relatively common, with significant drug effect and mild adverse reactions, which was worthy of clinical promotion and application. Therefore, the results of this study provide a new basis for the clinical and basic research of traditional Chinese medicine in the treatment of uterine fibroids, but it still needs the verification of expert interpretation, experimental research and other methods.
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Journal: A new trick for an old dog: The application of mifepristone in the treatment of adenomyosis. (Pubmed Central) - Apr 23, 2021 We also found that mifepristone treatment decreases the uterine volume, CA125 concentration and increases the haemoglobin concentration in serum for adenomyosis patients. Therefore, we demonstrate that mifepristone could serve as a novel therapeutic drug in the treatment of adenomyosis, and therefore, the old dog can do a new trick.
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Journal: Mifepristone and Misoprostol for Early Pregnancy Loss and Medication Abortion. (Pubmed Central) - Apr 23, 2021 Ongoing pregnancy, infection, hemorrhage, undiagnosed ectopic pregnancy, and the need for unplanned uterine aspiration are rare complications. Clinical history, combined with serial quantitative beta human chorionic gonadotropin levels, urine pregnancy testing, or ultrasonography, is used to establish complete passage of the pregnancy tissue.
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Journal: Palliative Benefits of Oral Mifepristone for the Treatment of Metastatic Fibroblastic Osteosarcoma. (Pubmed Central) - Apr 14, 2021 High-frequency TENS offers an effective nonpharmacologic option for pain management during medication abortion. Thus, osteosarcoma can be added to the list of cancers, not necessarily associated with the classic nuclear progesterone receptor, that seem to respond to progesterone receptor antagonist therapy.
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Journal: Structural insights into the ligand binding domain of the glucocorticoid receptor: a molecular dynamics study. (Pubmed Central) - Apr 10, 2021 On the other hand, our results describe the H12 as a dynamic ensemble of conformations whose relative population is in the end determined by the interacting ligand: while dexamethasone privileges only a few poses (determined by a potential energy surface with a deep minimum), RU486 favors a wider H12 conformational amplitude, as indicated by a flatter potential landscape. By characterizing the H12 conformation in different conditions, we provide novel GR LBD models that represent potential targets for rational glucocorticoid drugs design, in aim to accurately modulate GR activity.
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Preclinical, Journal: The effect of steroid hormone on the expression of the calcium-processing proteins in the immature female rat brain. (Pubmed Central) - Apr 7, 2021 In summary, calcium-processing proteins are widely expressed in the immature rat brain, and expressions of calcium-processing proteins in CT and HY indicated that they may regulate by E2, P4, and/or DEX and can be attenuated by antagonist treatment. These results indicate that steroid hormone regulation of TRPV5, TRPV6, NCX1, and PMCA1 proteins may serve as a critical regulator of cytosolic calcium absorption and release in the brain.
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Clinical, Journal: Thunder-fire moxibustion combined with mifepristone for ovarian chocolate cyst dysmenorrhea with kidney deficiency and blood stasis: a randomized controlled trial (Pubmed Central) - Apr 7, 2021 These results indicate that steroid hormone regulation of TRPV5, TRPV6, NCX1, and PMCA1 proteins may serve as a critical regulator of cytosolic calcium absorption and release in the brain. Thunder-fire moxibustion combined with mifepristone could significantly improve dysmenorrhea symptoms, shorten dysmenorrhea time and promote atrophy of ovarian heterotopic cyst in patients with ovarian chocolate cyst dysmenorrhea of kidney deficiency and blood stasis, and the mechanism may be related to the reduction of serum levels of TGF-β1 and IL-17.
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