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94 Diseases |  |
58 Trials |
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58 Trials |  |
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- | Mifeprex (mifepristone) / Danco Laboratories
Journal: The Future of Abortion is Now: Mifepristone by Mail and In-Clinic Abortion Access in the United States. (Pubmed Central) - Jul 14, 2021
Although remote medication abortion improves access for many, those who need or want in-clinic care, such as people later in pregnancy, people for whom abortion at home is not safe or feasible, or people who are not eligible for medication abortion, will need comprehensive support to access safe and appropriate care. To understand how we may adapt to remote abortion without leaving people behind, we can look outside of the U.S. to become familiar with emerging and alternative models of abortion care.
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Federal, State, and Institutional Barriers to the Expansion of Medication and Telemedicine Abortion Services in Ohio, Kentucky, and West Virginia during the COVID-19 Pandemic. (Pubmed Central) - Jul 14, 2021
Permanently lifting federal regulations on in-clinic distribution of mifepristone would only advantage abortion seekers in states without restrictive telehealth and medication abortion policies. State policies that limit access to comprehensive abortion services should be central in larger efforts toward dismantling barriers that impinge upon reproductive autonomy.
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: "It was close enough, but it wasn't close enough": a qualitative exploration of the impact of direct-to-patient telemedicine abortion on access to abortion care. (Pubmed Central) - Jul 14, 2021
Medication abortion by mail can increase access to abortion with the added benefits of increased perceived privacy and decreased logistical burdens. Removing the in-person dispensing requirement for mifepristone would allow direct-to-patient telemedicine abortion to be implemented outside of a research setting without compromising the patient experience.
- | Mifeprex (mifepristone) / Danco Laboratories
Enrollment open: Assessing Use Of Mifepristone After Progestin Priming For Use As "Missed Period Pills" (clinicaltrials.gov) - Jul 14, 2021
P2, N=139, Recruiting, Sponsor: Gynuity Health Projects
Removing the in-person dispensing requirement for mifepristone would allow direct-to-patient telemedicine abortion to be implemented outside of a research setting without compromising the patient experience. Not yet recruiting --> Recruiting
- | dexamethasone / Generic mfg.
Journal: Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress. (Pubmed Central) - Jul 13, 2021
In HEI-OC1 cells, dexamethasone was shown to significantly reduce the tunicamycin-induced expression of ATF4 and CHOP in the context of sustained viability and proliferation, a therapeutic effect that was reversible by co-treatment with a glucocorticoid antagonist. Dexamethasone can protect hair-cell-like HEI-OC1 cells from ERS damage, which may be one of the mechanisms of action for GCs in SNHL treatment.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Corticosterone Inhibits LPS-Induced NLRP3 Inflammasome Priming in Macrophages by Suppressing Xanthine Oxidase. (Pubmed Central) - Jul 11, 2021
Finally, the effects of a CORT antagonist (RU486) on XO expression and activity and NLRP3 expression in macrophages were further analyzed...In conclusion, our results suggested that CORT inhibits LPS-induced NLRP3 inflammasome priming in macrophages. The underlying mechanism is related to the modulation of XO expression and activity, which may be involved in priming and activating the NLRP3 inflammasome.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Epidermal ROCK2-induces AKT1/GSK3β/β-catenin, NFκB and dermal tenascin-C; but enhanced differentiation and p53/p21 inhibit papilloma. (Pubmed Central) - Jul 10, 2021
ROCK2 roles in epidermal differentiation and carcinogenesis have been investigated in mice expressing an RU486-inducible, 4HT-activated ROCK2 transgene (K14.creP/lslROCKer)...Alongside an altered ECM, these latent tenascin C-positive dermal fibroblasts may become putative pre-cancer associated fibroblasts (pre-CAFs) and establish a susceptibility that subsequently contributes to tumour progression. However, anomalous differentiation was also accompanied by an immediate increase in basal-layer p53/p21 expression; suggesting that whilst ROCK2/AKT1/β-catenin activation increased keratinocyte proliferation resulting in hyperplasia, compensatory p53/p21 and accelerated differentiation helped inhibit papillomatogenesis.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Perspectives Among Canadian Physicians on Factors Influencing Implementation of Mifepristone Medical Abortion: A National Qualitative Study. (Pubmed Central) - Jul 10, 2021
Health Canada's removal of mifepristone restrictions facilitated the implementation of abortion care in the primary care setting. Our results are unique because Canada is the first country to facilitate provision of medical abortion in primary care via evidence-based deregulation of mifepristone.
- | Mifeprex (mifepristone) / Danco Laboratories
Biomarker, Journal: H3K9ac of TGFβRI in human umbilical cord: a potential biomarker for evaluating cartilage differentiation and susceptibility to osteoarthritis via a two-step strategy. (Pubmed Central) - Jul 10, 2021
WJ-MSCs from IUGR individuals displayed a poor capacity of chondrogenic differentiation and an increased susceptibility to osteoarthritis-like phenotype, which was attributed to the decreased H3K9ac level of TGFβRI and its expression induced by high cortisol through GR/HDAC4. The H3K9ac of TGFβRI in human umbilical cord could be a potential early-warning biomarker for predicting neonatal cartilage dysplasia and osteoarthritis susceptibility.
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: The use of an osmotic dilator for induction of miscarriage in patients with the second trimester missed miscarriage. (Pubmed Central) - Jul 9, 2021
Combined management of antenatal pregnancy loss in the second trimester including intracervical insertion of dilapan-S and conventional induction with miscarriage may be considered a valuable clinical strategy. However, future studies should focus on ways to prevent postprocedural complications in this group of women.
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: A comparison between labor induction with only Dilapan-S and a combination of mifepristone and Dilapan-S in nulliparous women: a prospective pilot study. (Pubmed Central) - Jul 9, 2021
The results revealed that this combined method is safe and has no immediate adverse effects on newborns. More studies are needed to evaluate what clinical cases are the most appropriate for the application of this combined method, considering the parity, degree of cervical ripening, and indication for labor induction.
- | Mifeprex (mifepristone) / Danco Laboratories, Rydapt (midostaurin) / Novartis
Journal: A method for overcoming plasma protein inhibition of tyrosine kinase inhibitors. (Pubmed Central) - Jul 8, 2021
In a mouse model of AGP drug inhibition, mifepristone restores midostaurin activity. This suggests combinatorial methods for overcoming plasma protein inhibition of existing TKIs for leukemia as well as providing a platform for investigating the drug-protein interaction space for developing more potent small-molecule agents.
- | cyclosporine / Generic mfg.
Journal: Glucocorticoid guides mobilization of bone marrow stem/progenitor cells via FPR and CXCR4 coupling. (Pubmed Central) - Jul 7, 2021
Their two-sided changes regulated by glucocorticoid are involved in the egress of MSCs and EPCs from BM, which is helpful for wound healing. MSCs, mesenchymal stem cells; EPCs, endothelial progenitor cells.
- | dexamethasone / Generic mfg.
Preclinical, Journal: By Regulating the NLRP3 Inflammasome Can Reduce the Release of Inflammatory Factors in the Co-Culture Model of Tuberculosis H37Ra Strain and Rat Microglia. (Pubmed Central) - Jul 7, 2021
By intervening the NLRP3 inflammasome pathway, it can significantly reduce the inflammatory response and mortality of microglia during the tuberculosis H37Ra strain infection. This research can help us further understand the inflammatory response mechanism of the central nervous system during tuberculosis infection and improve its treatment.
- | Mifeprex (mifepristone) / Danco Laboratories
Retrospective data, Journal: Comparison between radiofrequency ablation combined with mifepristone and radiofrequency ablation for large uterine fibroids. (Pubmed Central) - Jul 7, 2021
Quality of life and symptom scores improved in both groups but to a greater extent in the combined treatment group. US-guided RFA combined with mifepristone might be a simple, safe and effective alternative for the treatment of large uterine fibroids.
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Mifepristone in primary care: no impediments against its use in management of missed miscarriage (Pubmed Central) - Jul 3, 2021
However, there are clear indications that medical treatment in women with a non-vital pregnancy is greatly improved when mifepristone is prescribed in addition to misoprostol. The authors state that this treatment is also justified in primary care.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Barriers and Facilitators to the Implementation of first Trimester Medical Abortion With Mifepristone in the Province of Québec: A Qualitative Investigation. (Pubmed Central) - Jul 2, 2021
The authors state that this treatment is also justified in primary care. Despite Health Canada's approval of mifepristone in Canada and supportive federal policies for provision of MA in primary care, physicians in the Province of Québec face onerous barriers to the practice of mifepristone MA.
- | Mifeprex (mifepristone) / Danco Laboratories
Retrospective data, Journal, HEOR: A Retrospective Cost-Effectiveness Analysis of Mifepristone-Misoprostol Medical Abortions in the First Year at the Regina General Hospital. (Pubmed Central) - Jul 2, 2021
Patients from Regina were more likely to receive medical abortion during both time periods. Mife/miso had a >50% probability of cost-effectiveness over both surgical and MTX/miso options.
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Mifepristone in Fibroids: Comparative Study of Safety and Efficacy of Biweekly Dosage Vs Daily Dosage Schedule. (Pubmed Central) - Jul 1, 2021
The side effects were mild and tolerable. Mifepristone in both dosages is highly efficacious in causing amenorrhea, improving anemia, and enhancing the quality of life, and hence 50 mg biweekly dosage shows potential for being cost efficient.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: The Supreme Court's Abortion Exceptionalism - Judicial Deference, Medical Science, and Mifepristone Access. (Pubmed Central) - Jul 1, 2021
Mifepristone in both dosages is highly efficacious in causing amenorrhea, improving anemia, and enhancing the quality of life, and hence 50 mg biweekly dosage shows potential for being cost efficient. No abstract available
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Review, Journal: Systematic Review of the Effectiveness, Safety, and Acceptability of Mifepristone and Misoprostol for Medical Abortion in Low- and Middle-Income Countries. (Pubmed Central) - Jun 30, 2021
No abstract available Mifepristone and misoprostol is highly effective, safe, and acceptable to women in low- and middle-income countries, making it a feasible option for reducing maternal morbidity and mortality worldwide.
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Inhibition of progesterone receptor activity during development increases reelin-immunoreactivity in Cajal-Retzius cells, alters synaptic innervation in neonatal dentate gyrus, and impairs episodic-like memory in adulthood. (Pubmed Central) - Jun 30, 2021
In contrast, the same RU486 treated rats were impaired in an episodic-like memory task compared to controls, failing to integrate object identity ('what'), time ('when'), and object position ('where'). These findings reveal a novel role for PR in regulating CR cell function within the MOL, thereby altering development of DG connectivity and behavioral function.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Regulation of the early expression of MAFbx/atrogin-1 and MuRF1 through membrane-initiated cortisol action in the skeletal muscle of rainbow trout. (Pubmed Central) - Jun 30, 2021
Using RU486 to selectively block glucocorticoid receptor (GR), we found that early downregulation of murf1 is potentially mediated by membrane GR signaling in myotubes. Considering the results of both the in vivo and in vitro approaches, we suggest that membrane-initiated cortisol action regulates the early expression of atrophy-related processes in teleosts.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Uterine Rupture During Medical Induction for Second Trimester Abortion. (Pubmed Central) - Jun 26, 2021
Medical induction is an alternative to dilatation and evacuation (D and E) in second trimester abortion, though it has higher risk of minor complications compared to D and E. Combination of mifepristone and misoprostol is commonly used for the medical abortion...After 63 doses of misoprostol, she had to undergo unintended major intra-abdominal surgery for partial uterine rupture. Keywords: Dilatation and evacuation; medical induction; second trimester abortion; uterine rupture.
- ||| Mifeprex (mifepristone) / Danco Laboratories
Clinical, Clinical guideline, Reimbursement, Review, Journal: Cervical priming before surgical abortion up to 13 weeks' gestation: a systematic review and metaanalyses for the National Institute for Health and Care Excellence-new clinical guidelines for England. (Pubmed Central) - Jun 26, 2021
Cervical priming with misoprostol decreases the force needed to dilate the cervix for first trimester surgical abortion and reduces the risk of incomplete abortion. Considered alongside clinical expertise, this evidence supports the use of routine cervical priming before first trimester surgical abortion with 400 µg misoprostol or, if misoprostol cannot be used, 200 mg oral mifepristone.
- ||| Mifeprex (mifepristone) / Danco Laboratories
Clinical, Clinical guideline, Reimbursement, Review, Journal: Cervical priming before surgical abortion between 14 and 24 weeks: a systematic review and meta-analyses for the National Institute for Health and Care Excellence-new clinical guidelines for England. (Pubmed Central) - Jun 26, 2021
Considered alongside clinical expertise, the published data support the use of osmotic dilators, misoprostol, or mifepristone before abortion for pregnancies at 14 to 16 weeks' gestation; osmotic dilators or misoprostol for pregnancies at 16 to 19 weeks' gestation; and osmotic dilators alone or with mifepristone for pregnancies at 19 to 24 weeks' gestation. The effectiveness of pharmacologic agents alone beyond 16 weeks' gestation and the optimal timing of dilator placement remain important questions for future research.
- | Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: 5-lipoxygenase- and Glucocorticoid-dependent eosinophilia in a novel surgical model in mice. (Pubmed Central) - Jun 23, 2021
The effectiveness of pharmacologic agents alone beyond 16 weeks' gestation and the optimal timing of dilator placement remain important questions for future research. These findings document glucocorticoid-, allergen- and 5-lipoxygenase-dependent eosinophilia, which makes EWIp carriers an abundant source of pure, nontransgenic eosinophils for immunopharmacological studies.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Elevated expression of EP4 in human decidua is associated with delayed embryo expulsion during medical abortion by promoting decidual cell proliferation. (Pubmed Central) - Jun 22, 2021
Elevated expression level of EP4 in human decidua was significantly associated with delayed embryo expulsion in early medical abortion by promoting decidual cell proliferation. Detailed studies on the nature of roles EP4 plays in human decidua will help us to develop more effective prevention and noninvasive interventions approaches for delayed embryo expulsion during medical abortion.
- || Review, Journal: Oral medications for central serous chorioretinopathy: a literature review. (Pubmed Central) - Jun 22, 2021
Although none of the studies showed robust evidence of efficacy, the mineralocorticoid receptor antagonists, particularly eplerenone, appear to demonstrate the highest quality evidence for use in this condition. The review aims to give the reader an overview of the current available evidence for oral medications used in the treatment of CSCR in order to provide an evidence-based discussion with the patient and guide through possible options for treatment.
- | dexamethasone / Generic mfg.
Preclinical, Journal: In vivo vascular rarefaction and hypertension induced by dexamethasone are related to phosphatase PTP1B activation not endothelial metabolic changes. (Pubmed Central) - Jun 22, 2021
In combination, these results indicate that Dex-induced endothelial dysfunction is mediated by glucocorticoid receptor and PTP1B activation. Moreover, since exercise reduces the expression of PTP1B and normalized insulin resistance in aging rats, our findings indicate that exercise training by reducing PTP1B activity counteracts Dex-induced hypertension in vivo.
- | ciprofloxacin oral / Generic mfg.
Journal: Dexamethasone along with ciprofloxacin modulates S. aureus induced microglial inflammation via glucocorticoid (GC)-GC receptor-mediated pathway. (Pubmed Central) - Jun 22, 2021
This situation was reversed when this combination treatment was applied by keeping GR blocked using GR antagonist RU486. Therefore, it can be concluded that combination treatment of ciprofloxacin and dexamethasone could regulate S. aureus induced microglial activation, in the presence of functional GR via utilizing glucocorticoid (GC)-GR pathway and ultimately confers protection to the host from brain inflammation.
- | dexamethasone / Generic mfg.
Preclinical, Journal, IO biomarker: Intrauterine RAS programming alteration-mediated susceptibility and heritability of temporal lobe epilepsy in male offspring rats induced by prenatal dexamethasone exposure. (Pubmed Central) - Jun 22, 2021
Our results confirmed that PDE-induced H3K27ac enrichment in the ACE promoter and enhanced the RAS classic pathway via activating GR-C/EBPα-p300 in utero, which caused changes of the HMGB1 pathway and glutamate excitatory damage. Intrauterine programming mediated by abnormal histone modification of hippocampal ACE could continue to adulthood and even F2 generation, which induced the heritability of TLE in male offspring rats.
- || Metopirone (metyrapone) / HRA Pharma
Review, Journal: Advances in the Medical Treatment of Cushing Disease. (Pubmed Central) - Jun 22, 2021
All agents require careful monitoring to optimize clinical effectiveness and manage adverse effects. Novel agents in development may expand the armamentarium for management of this condition.
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Double-blind, placebo-controlled trial of mifepristone on cognition and depression in alcohol dependence. (Pubmed Central) - Jun 22, 2021
Novel agents in development may expand the armamentarium for management of this condition. Larger trials would be needed to draw conclusions about the efficacy of mifepristone.
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Journal: Self-managed medication abortion outcomes: results from a prospective pilot study. (Pubmed Central) - Jun 22, 2021
Further, the high effectiveness of self-managed medication abortion with accompaniment support reported here is consistent with high levels of effectiveness reported in prior studies. Trial registration ISRCTN95769543.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Cost of goods sold analysis and recommendations to reduce costs of co-packaged mifepristone-misoprostol for medical abortion. (Pubmed Central) - Jun 22, 2021
It is feasible to lower the cost of quality-assured combi-packs, through reducing mifepristone API cost and selection of the manufacturing location. However, manufacturers need to be incentivised to achieve WHO pre-qualification with a carefully built business case and require support in identifying and sourcing competitively priced material and manufacturing products to the necessary standard.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Glucocorticoid receptors involved in melatonin inhibiting cell apoptosis and NLRP3 inflammasome activation caused by bacterial toxin pyocyanin in colon. (Pubmed Central) - Jun 22, 2021
In order to further investigate the molecular mechanism, goblet cells were exposed to MEL and PCN in the presence of luzindole and RU486, inhibitors of MEL receptors and GR respectively...Moreover, we found that MEL mainly upregulated the expression of GR to achieve its anti-inflammatory and anti-apoptotic functions rather than through its own receptor (MT2) in colon goblet cells. Therefore, MEL can reverse the inhibitory effects of PCN on GR/p-GR expression to present its anti-oxidative and anti-apoptotic function.
- || Mifeprex (mifepristone) / Danco Laboratories, Cervidil (dinoprostone) / Ferring
Retrospective data, Review, Journal: Cervical dilatation and preparation prior to outpatient hysteroscopy: A systematic-review and meta-analysis. (Pubmed Central) - Jun 22, 2021
Therefore, MEL can reverse the inhibitory effects of PCN on GR/p-GR expression to present its anti-oxidative and anti-apoptotic function. Cervical preparation reduces pain and improves feasibility associated with outpatient hysteroscopy but increases the risk of side-effects.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Circ6401, a novel circular RNA, is implicated in repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells through regulation of the miR-29b-1-5p/RAP1B axis. (Pubmed Central) - Jun 22, 2021
Cervical preparation reduces pain and improves feasibility associated with outpatient hysteroscopy but increases the risk of side-effects. Our results showed the abundance and regulation profiles of ncRNAs of WJ-MSCs during repair of damaged ESCs and, for the first time, clarified the underlying mechanism by which circ6401 promotes endometrial repair by WJ-MSCs; thus, demonstrating that circ6401 may serve as a potential therapeutic target.
- || dexamethasone / Generic mfg., spironolactone / Generic mfg.
Clinical, Journal: Evaluation of the HPA axis' response to pharmacological challenges in experimental and clinical early-life stress-associated depression. (Pubmed Central) - Jun 22, 2021
Animals submitted to ELS presented altered behavior, as increased immobility time in the forced-swimming test, but no effects were observed in response to GR and MR challenges. It provides insights into the complexity of HPA axis-related mechanisms involved in the long-lasting consequences of ELS in both experimental animals and humans.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Out-of-clinic and self-managed abortion in Bangladesh: menstrual regulation provider perspectives. (Pubmed Central) - Jun 22, 2021
A harm reduction approach to improve counseling about MR/abortion care in pharmacies may improve safety and access. Policy makers should consider increasing training of frontline health workers, such as Family Welfare Visitors to provide evidence-based information about Mifepristone/Misoprostol.
- || Mifeprex (mifepristone) / Danco Laboratories
Clinical, Clinical protocol, Journal: UTAH: Using Telemedicine to improve early medical Abortion at Home: a protocol for a randomised controlled trial comparing face-to-face with telephone consultations for women seeking early medical abortion. (Pubmed Central) - Jun 22, 2021
P=N/A
Early medical abortion (EMA) is a two-stage process of terminating pregnancy using oral mifepristone (a progesterone-receptor antagonist) followed usually 1-2 days later by sublingual, vaginal or buccal misoprostol (a prostaglandin analogue)...Results will be published in peer-reviewed journals, presented at clinical and academic meetings, and shared with participants via the clinic website. NCT04139382.
- | Mifeprex (mifepristone) / Danco Laboratories
Trial completion date, Trial primary completion date: IMEGYN: Evaluation of Efficacy of Two Therapeutic Strategies for Cervical Maturation Before Medical Termination (clinicaltrials.gov) - Jun 21, 2021
P=N/A, N=120, Recruiting, Sponsor: Centre Hospitalier Universitaire de N?mes
NCT04139382. Trial completion date: May 2022 --> Nov 2023 | Trial primary completion date: May 2022 --> Nov 2023
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: "I'll just deal with this on my own": a qualitative exploration of experiences with self-managed abortion in the United States. (Pubmed Central) - Jun 16, 2021
In addition to those who pursue SMA as a last resort (after facing barriers to facility-based care) or as a first resort (because they prefer homeopathic remedies), our findings show that some individuals view SMA as a potential interim step worth trying after suspecting pregnancy and before accessing facility-based care. These people in particular would benefit from a medication abortion product available over the counter, online, or in the form of a missed-period pill.
- | Mifeprex (mifepristone) / Danco Laboratories
Preclinical, Journal: Stress pathway modulation is detrimental or ineffective for functional recovery after spinal cord injury in mice. (Pubmed Central) - Jun 12, 2021
These results suggest that injury-induced stress responses do not interfere with the healing process and hence, pharmacological targeting of stress responses is not a recommended treatment option for SCI. These findings are of great importance for other researchers to avoid unnecessary and potentially futile animal experiments.
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: A ruptured ectopic pregnancy during early termination of pregnancy before ultrasound confirmation (Pubmed Central) - Jun 10, 2021
A new regimen for early termination of pregnancy does not require ultrasound confirmation of intrauterine pregnancy before mifepristone administration...As she was told to expect pain, she awaited follow-up appointment a week later, but before then she collapsed at home, and she was unconscious, when the emergency service arrived. In emergency surgery, 1.3 l of intra-abdominal blood and a right fallopian tube pregnancy were removed.
- | Enbrel (etanercept) / Pfizer, Amgen, Mifeprex (mifepristone) / Danco Laboratories
Trial completion date, Trial primary completion date: TNF and Glucocorticoid Antagonist for GWI Associated Multi-symptom Disease Homeostasis Reset (clinicaltrials.gov) - Jun 10, 2021
P1, N=20, Not yet recruiting, Sponsor: Nova Southeastern University
In emergency surgery, 1.3 l of intra-abdominal blood and a right fallopian tube pregnancy were removed. Trial completion date: Jul 2021 --> Jul 2023 | Trial primary completion date: Apr 2021 --> Apr 2023
- | Mifeprex (mifepristone) / Danco Laboratories
Journal: Pharmacist checklist and resource guide for mifepristone medical abortion: User-centred development and testing. (Pubmed Central) - Jun 10, 2021
Trial completion date: Jul 2021 --> Jul 2023 | Trial primary completion date: Apr 2021 --> Apr 2023 No abstract available
- | progesterone / Generic mfg.
Journal: Assessment of progesterone synthesis and its regulation role on dihydrotestosterone secretion in sheep epididymis. (Pubmed Central) - Jun 8, 2021
Our results indicated that the paracrine and autocrine P4 could affect the secretion of DHT in epididymal cells through PGR. Overall, this study provides new data regarding the involvement of P4 in sperm maturation and functionality in sheep.
- Korlym (mifepristone) / Corcept Therap, Mifeprex (mifepristone) / Danco Laboratories
[VIRTUAL] Use of Mifepristone in a Hypercortisolemic Patient with End Stage Renal Disease on Hemodialysis () - Jun 7, 2021 - Abstract #AACE2021AACE_601;
There is currently no published data on the use of mifepristone (Korlym , Corcept Therapeutics) in patients with End Stage Renal Disease (ESRD) on hemodialysis diagnosed with hypercortisolism. We present a patient case with ESRD demonstrating the safe and efficacious long-term use of mifepristone.