Mifeprex (mifepristone) / Danco Laboratories 
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  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Missing Mifepristone at Tribal Health Facilities serving Native Americans. (Pubmed Central) -  Oct 20, 2021   
    In order to improve access to medication abortion, the mifepristone Risk Evaluation and Mitigation Strategy should be modified or removed to allow clinicians to prescribe the medication with dispensing by pharmacies, including mail-order pharmacies. No abstract available
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Clinical, Journal:  Mifepristone restrictions and primary care: breaking the cycle of stigma through a learning collaborative model in the United States. (Pubmed Central) -  Oct 20, 2021   
    This cycle successfully excludes mifepristone from many primary care settings, reinforcing the perception that abortion is a tainted and undesirable service that should remain marginalized in specialty settings. The learning collaborative model serves as a potentially valuable framework for primary care physicians to address, understand, and overcome the institutional fears that the REMS program encourages.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  The Mifepristone REMS: A Needless and Unlawful Barrier to Care. (Pubmed Central) -  Oct 20, 2021   
    Removing FDA restrictions is a critical step in reducing primary care barriers to mifepristone provision and improving access to timely, patient-centered medication abortion and EPL care. No abstract available
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  The Disproportionate Burdens of the Mifepristone REMS. (Pubmed Central) -  Oct 20, 2021   
    Most clients do not need healthcare provider support when administering medicines at home or post abortion. No abstract available
  • ||||||||||  spironolactone / Generic mfg.
    [VIRTUAL] SEVERE REFRACTORY HYPERCORTISOLISM FROM ATYPICAL THYMIC CARCINOID TUMOR MANAGED WITH ETOMIDATE INFUSION () -  Oct 13, 2021 - Abstract #CHEST2021CHEST_700;    
    She was initiated on ketoconazole at that time, while closely monitoring ACTH and cortisol levels...Mifepristone (korlym) along with spironolactone and KCl were started...She is currently receiving chemotherapy - carboplatin/etoposide along with mitotane and her cortisol levels have been stable... Low dose etomidate infusion can be used to control severe Cushing's syndrome with life threatening complications as a bridge to long-term definitive management.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Histone H3K9 methylation regulates chronic stress and IL-6-induced colon epithelial permeability and visceral pain. (Pubmed Central) -  Oct 10, 2021   
    Low dose etomidate infusion can be used to control severe Cushing's syndrome with life threatening complications as a bridge to long-term definitive management. Our findings support a novel role for methylation of the repressive histone H3K9 to regulate chronic stress, pro-inflammatory cytokine-mediated reduction in colon TJ protein levels, and increase in paracellular permeability and visceral hyperalgesia.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells. (Pubmed Central) -  Oct 9, 2021   
    Since BPA and BPAF induced RACK1 expression in the presence of glucocorticoid receptor (GR) antagonist mifepristone, a role of G-protein-coupled estrogen receptor (GPER) has been considered due to their known estrogenic profile...Conversely, BPAF induced RACK1 up-regulation via androgen receptor (AR) activation, as confirmed by treatment with AR antagonist flutamide...Altogether, our data suggest that RACK1 could represent an important target of EDCs and serves as a screening tool for their immunotoxic potential. Furthermore, RACK1 can be exploited to unmask multiple molecular interactions of hormone-active substances to better dissect out their mechanisms of action.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Clinical, Journal:  Clinical Efficacy and Safety Study of Mifepristone with Misoprostol Treatment in Patients with Missed Abortion. (Pubmed Central) -  Oct 9, 2021   
    After drug treatment, no abnormal changes in liver and kidney functions were observed in both groups, and the incidence of adverse reactions was at a similar and lower level in both groups. This shows that mifepristone with misoprostol is a safer and more effective drug regimen for the treatment of MA, which can regulate the levels of serum sex hormones and inflammatory factors in the body, promote the shedding of placental tissue, and create conditions for improving the rate of curettage.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Clinical, Journal:  Clinical and diagnostic-imaging findings in patellofemoral instability (Pubmed Central) -  Oct 2, 2021   
    Medical abortion with combined mifepristone and misoprostol is a highly effective, safe, and widely used method for medical termination of pregnancy. In this review, it is shown that self-testing with a urine human chorionic gonadotropin stix (detection limit greater than 25 IU/l) four weeks after administration of medication is a safe, practical, and cheap method to determine successful termination.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    [VIRTUAL] Regulation of lentivirusmediated expression in a human airway model () -  Oct 2, 2021 - Abstract #ESGCT2021ESGCT_255;    
    To establish proofofconcept that lentivirusmediated expression can be regulated, a commercial mifepristoneinducible system (GeneSwitch, Invitrogen) was cloned into a lentiviral backbone and VSVG vectors generated...GMCSF expression increased by 27.8fold in 1V cultures compared to 575.9fold with 2V cultures. In summary, we have demonstrated proofofconcept that lentivirusmediated gene expression can be regulated in a human airway model, with superior induction observed by the 2V system.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories, Rydapt (midostaurin) / Novartis
    Journal:  A method for overcoming plasma protein inhibition of tyrosine kinase inhibitors. (Pubmed Central) -  Oct 1, 2021   
    In a mouse model of AGP drug inhibition, mifepristone restores midostaurin activity. This suggests combinatorial methods for overcoming plasma protein inhibition of existing TKIs for leukemia as well as providing a platform for investigating the drug-protein interaction space for developing more potent small-molecule agents.
  • ||||||||||  PT150 / The Pop Test & Palisades Therap
    Preclinical, Journal:  Effects of the glucocorticoid receptor antagonist PT150 on stress-induced fentanyl seeking in male and female rats. (Pubmed Central) -  Sep 30, 2021   
    This suggests combinatorial methods for overcoming plasma protein inhibition of existing TKIs for leukemia as well as providing a platform for investigating the drug-protein interaction space for developing more potent small-molecule agents. The glucocorticoid antagonist PT150 reduces shock-induced fentanyl seeking, suggesting it may be effective against stress-induced relapse, although the sex difference in response may need further exploration.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Clinical, Journal:  Mifepristone improves adipose tissue insulin sensitivity in insulin resistant individuals. (Pubmed Central) -  Sep 29, 2021   
    These results provide a rationale for the use of carotid sinus nerve electrostimulation as a therapeutic approach for immune-mediated inflammatory diseases. Short-term mifepristone administration improves adipose and hepatic insulin sensitivity among obese individuals with hyperglycemia without hypercortisolism.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  GPGMH, a New Fixed Timed-AI Synchronization Regimen for Swamp and River Crossbred Buffaloes (Bubalus bubalis). (Pubmed Central) -  Sep 24, 2021   
    Comparison of four conventional synchronization protocols [pregnant mare gonadotropin-prostaglandin Fα-gonadotropin-releasing hormone (PmPG), gonadotropin-releasing hormone-prostaglandin Fα-gonadotropin-releasing hormone (GPG), prostaglandin Fα-gonadotropin-releasing hormone-prostaglandin Fα-estradiol benzoate (PGPE), and progesterone-pregnant mare gonadotropin-prostaglandin Fα-gonadotropin-releasing hormone (PPmPG)] in crossbred buffaloes showed that the GPG protocol treated buffaloes displayed higher (P 0.05) and pregnancy rates (P > 0.05) than the PGPG and GPG protocols in crossbred buffaloes. The current study supported that new synchronization protocol (modified of GPG protocol; GPGMH) by the inclusion of mifepristone (with a dose of 0.4 mg/kg along second GnRH), AI after 24 h of mifepristone or second GnRH, and human chorionic gonadotropin (hCG at day 5 of AI) enhance the ovulation and pregnancy rates in crossbred buffaloes.
  • ||||||||||  ritonavir / Generic mfg.
    Journal:  Optimized pharmacological control over the AAV-Gene-Switch vector for regulable gene therapy. (Pubmed Central) -  Sep 24, 2021   
    Most importantly, we demonstrate that the GS vector can be efficiently controlled by mifepristone in the presence of its human plasma carrier protein, α1-acid glycoprotein, in a "humanized" rat model. Thus, we have substantially improved the applicability of the GS vector toward therapeutic use in patients.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Medication Abortion up to 70 Days of Gestation. (Pubmed Central) -  Sep 22, 2021   
    The purpose of this document is to provide updated evidence-based guidance on the provision of medication abortion up to 70 days (or 10 weeks) of gestation. Information about medication abortion after 70 days of gestation is provided in other ACOG publications [1].
  • ||||||||||  Metopirone (metyrapone) / HRA Pharma
    Review, Journal:  Medical therapy in severe hypercortisolism. (Pubmed Central) -  Sep 22, 2021   
    When medical therapies fail, are unavailable or contra-indicated, bilateral adrenalectomy should be indicated as a life-saving measure. Adrenal arterial embolization is rarely encountered in routine clinical practice, being a last alternative in specialized centers when all other options fail or are contra-indicated.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Clinical, Observational data, Journal:  Medical Induction for Mid trimester Abortion: A Hospital-based Descriptive Cross-sectional Study. (Pubmed Central) -  Sep 19, 2021   
    KPRa could also improve the transfection of other nonviral vectors used in gene therapy. The combination of Mifepristone and Misoprostol have excellent result for termination of pregnancy if appropriately used after evaluating the patient with minimal complications.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Journal:  Paeoniflorin Enhances Endometrial Receptivity through Leukemia Inhibitory Factor. (Pubmed Central) -  Sep 17, 2021   
    Paeoniflorin significantly improved the embryo implantation rate in a murine model of mifepristone (RU486)-induced implantation failure...Moreover, using the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database of the human endometrium, we confirmed that LIF signaling is a key regulator for improving human endometrial receptivity. Therefore, these results suggest that paeoniflorin might be a potent drug candidate for the treatment of endometrial implantation failure by enhancing endometrial receptivity.
  • ||||||||||  methotrexate / Generic mfg.
    Clinical, Journal:  Clinical characteristics and treatment of different types of cesarean scar pregnancy. (Pubmed Central) -  Sep 15, 2021   
    UAE plus curettage is a more effective treatment option for partial- and complete-type of CSP than mifepristone plus curettage. The cases of mass-type often need surgery and are prone to have longer gestational duration, larger lesions, and more vaginal bleeding.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Preclinical, Journal:  Effects of high temperature and high humidity stress on the negative feedback regulation of hippocampus on HPA axis in rats. (Pubmed Central) -  Sep 11, 2021   
    High temperature and high humidity stress may up-regulate the local expression of iNOS in hippocampus and decrease the activity of glucocorticoids (GC) receptor, then the effective binding of GR-GC would be decreased and the negative feedback regulation of hippocampus on HPA axis would be inhibited. The glucocorticoid receptor antagonist can improve the negative feedback regulation of hippocampus on HPA axis in rat.
  • ||||||||||  Esmya (ulipristal acetate) / ASKA Pharma, HRA Pharma, Gedeon Richter, AbbVie
    Journal:  Liver Injury with Ulipristal Acetate: Exploring the Underlying Pharmacological Basis. (Pubmed Central) -  Sep 11, 2021   
    Different drug properties previously linked to the occurrence of DILI may partially explain the reporting pattern observed with UPA. Our "bedside-to-bench" approach may support regulators in the risk-benefit assessment of UPA.