aceclofenac / Generic mfg. 
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  • ||||||||||  Review, Journal:  Control of neuropathic pain in lumbosacral dorsalgia (Pubmed Central) -  Dec 18, 2024   
    The severity of musculotonic pain syndrome is significantly reduced when using tolperizone (Midocalm-long). The results of the analyzed studies confirm the effectiveness and safety of the combination.
  • ||||||||||  aceclofenac / Generic mfg.
    Journal:  Water dynamics on the structural properties of some NSAID's with leucine in the picosecond region using time domain spectroscopy. (Pubmed Central) -  Nov 29, 2024   
    Concentration-dependent dielectric response for non-steroidal anti-inflammatory drugs (NSAIDs): Aceclofenac (ACF) and Diclofenac (DCF) in the aqueous leucine solution have been reported at different concentrations and temperatures (298.15?K to 283.15?K)...To give more insights into the structural dynamics of drug-induced amino acids, the study includes molar enthalpy of activation (?H), entropy of activation (?S), and free energy of activation (?F). The overall study concludes that the drug (DCF) having a potent inhibitor of cyclooxygenase found a higher static dielectric constant (?) than that of the drug (ACF) having more carbon (C), hydrogen (H), and oxygen (O) in the chain, which is more efficient in controlling pain.Communicated by Ramaswamy H. Sarma.
  • ||||||||||  aceclofenac / Generic mfg.
    Journal:  Tarlock K, Gerbing RB, Ries RE, et (Pubmed Central) -  Oct 15, 2024   
    Based on the current findings, it appears that OS may be a better choice for managing arthritis and related inflammations. No abstract available
  • ||||||||||  metformin / Generic mfg., clotrimazole topical / Generic mfg., aceclofenac / Generic mfg.
    Journal:  A Case Report With Dual Diagnosis of Candidiasis in a Patient With Uncontrolled Diabetes Mellitus. (Pubmed Central) -  Sep 2, 2024   
    The underlying condition was treated by a general physician who prescribed the tablet metformin 500mg. The patient was educated about the predisposing condition, and motivated to make some lifestyle changes and to maintain a proper diet.
  • ||||||||||  methotrexate / Generic mfg., aceclofenac / Generic mfg.
    Journal:  Therapeutic Potential of Nanocarriers in the Management of Rheumatoid Arthritis. (Pubmed Central) -  Jul 31, 2024   
    By overcoming the limitations of traditional therapies, these technologies have the potential to improve patient outcomes and quality of life. Future research should focus on optimizing nanocarrier design, evaluating long-term safety, and conducting clinical trials to validate their efficacy in RA management.
  • ||||||||||  etoricoxib / Generic mfg., aceclofenac / Generic mfg.
    The effect of aceclofenac and etoricoxib on platelet aggregation activity in bone trauma (Exhibition Hall) -  May 17, 2024 - Abstract #ISTH2024ISTH_1395;    
    By 7th day, aggregation activity in ACF group decreased again relative to the control. In ETC group, aggregation did not differ from the control during entire study period, and no postoperative reactive thrombocytosis was detected.
  • ||||||||||  aceclofenac / Generic mfg.
    Journal:  Re-assessment of monoclonal antibodies against diclofenac for their application in the analysis of environmental waters. (Pubmed Central) -  May 14, 2024   
    Relevant cross-reactivity occurred only with an amide derivative of DCF, 6-aminohexanoic acid (DCF-Ahx), aceclofenac (ACF) and DCF methyl ester (DCF-Me) with 150%, 61% and 44%, respectively...In sewage treatment plant effluents, concentrations in the range of 1.9-5.2 ?g L-1 were determined directly, with recoveries compared to HPLC-MS/MS averaging 136%. Concentrations in lakes ranged from 3 to 4.4 ng L-1 and were, after pre-concentration, determined with an average recovery of 100%.
  • ||||||||||  aceclofenac / Generic mfg.
    Preclinical, Journal:  Delivery of nano-emulgel carrier: optimization, evaluation and in vivo anti-inflammation estimations for osteoarthritis. (Pubmed Central) -  Feb 15, 2024   
    Aim: Optimization and evaluation of Aceclofenac nanoemulgel for treatment for rheumatoid arthritis and reduction of GI irritation and enhancement of bioavaibility...Concluded that emulgels had better (nearly twice as good) anti-inflammatory action as the commercial product. Compared with the commercial gel, the emulgel's anti-inflammatory effect had a quicker onset and a longer duration of action.
  • ||||||||||  aceclofenac / Generic mfg.
    Journal:  Drug Polymeric Carrier of Aceclofenac Based on Amphiphilic Chitosan Micelles. (Pubmed Central) -  Dec 25, 2023   
    In the carrageenan-induced inflammation model of paw edema in rats, it has been demonstrated that the injection of ACF-loaded PMs (at a dose of 10 mg/kg) resulted in a strengthened inflammatory activity compared to the injection of free ACF at equivalent dosages as well as at time intervals. However, the use of ACF-loaded PMs for a duration of 6 h displayed a notable reduction of paw edema, with an inhibition percentage of 85.09%, in contrast to the 74.9% inhibition percentage observed for the free ACF medication.
  • ||||||||||  aceclofenac / Generic mfg.
    Preclinical, Journal:  Development and In vitro Evaluation of Aceclofenac Buccal Film. (Pubmed Central) -  Oct 9, 2023   
    Buccal films can be formulated using different polymers either individually or in combination to obtain the drug release profile required to achieve a desired treatment goal. Furthermore, the property of the buccal films depends on the type and concentration of the polymer used.
  • ||||||||||  aceclofenac / Generic mfg.
    Journal:  Optimization and Production of Aceclofenac-Loaded Microfiber Solid Dispersion by Centrifugal Spinning. (Pubmed Central) -  Sep 28, 2023   
    In vitro dissolution studies revealed an instantaneous disintegration of the fibrous structure and a rapid release of the active substance, with the microfibrous webs greatly outperforming the crystalline active substance, especially in the early time-points. This implies that centrifugal spinning offers a viable scale-up production process to prepare drug-loaded fiber-based solid dispersions.
  • ||||||||||  ilaprazole / Generic mfg., aceclofenac / Generic mfg.
    Trial completion, Trial completion date:  Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Ilaprazole and Aceclofenac (clinicaltrials.gov) -  Jun 28, 2023   
    P1,  N=24, Completed, 
    In conclusion, we propose the study of the immunological signaling pathways in experimental humanized RA mice. Recruiting --> Completed | Trial completion date: Dec 2023 --> Dec 2022
  • ||||||||||  oxaliplatin / Generic mfg., cisplatin / Generic mfg., aceclofenac / Generic mfg.
    Journal:  Multi-action platinum(IV) prodrugs conjugated with COX-inhibiting NSAIDs. (Pubmed Central) -  Jun 19, 2023   
    In this work, a series of novel cisplatin and oxaliplatin-based Pt(IV) complexes comprising non-steroidal anti-inflammatory drugs (NSAIDs) and their carboxyl ester analogues as axial moieties were synthesized...For the most potent complex 26, comprising two aceclofenac (AFC) moieties, the formation of Pt(II)-9-methylguanine (9-MeG) adducts after activation with ascorbic acid (AsA) was proven. Additionally, a significant inhibition of cyclooxygenase (COX) activity and prostaglandin E (PGE) production was observed, as well as increased cellular accumulation, depolarization of mitochondrial membranes, and strong proapoptotic potencies in SW480
  • ||||||||||  THROUGH THE LOOKING GLASS: GITELMAN AND GORDON () -  Mar 28, 2023 - Abstract #ISNWCN2023ISN_WCN_744;    
    At the time, she was taking prednisone, aceclofenac and omeprazole regularly...The patient's ionic disorders were quickly resolved once indapamide was initiated...The thiazide diuretic counters this cascade by direct NCC blockage. Conclusions Understanding the nephron
  • ||||||||||  Clinical, Retrospective data, Review, Journal, HEOR:  Comparative effectiveness and safety of analgesic medicines for adults with acute non-specific low back pain: systematic review and network meta-analysis. (Pubmed Central) -  Mar 25, 2023   
    Low or very low confidence was noted in evidence for reduced pain intensity after treatment with tolperisone (mean difference -26.1 (95% confidence intervals -34.0 to -18.2)), aceclofenac plus tizanidine (-26.1 (-38.5 to -13.6)), pregabalin (-24.7 (-34.6 to -14.7)), and 14 other medicines compared with placebo...Increased adverse events had moderate to very low confidence with tramadol (risk ratio 2.6 (95% confidence interval 1.5 to 4.5)), paracetamol plus sustained release tramadol (2.4 (1.5 to 3.8)), baclofen (2.3 (1.5 to 3.4)), and paracetamol plus tramadol (2.1 (1.3 to 3.4)) compared with placebo...Until higher quality randomised controlled trials of head-to-head comparisons are published, clinicians and patients are recommended to take a cautious approach to manage acute non-specific low back pain with analgesic medicines. PROSPERO CRD42019145257.
  • ||||||||||  etodolac / Generic mfg., aceclofenac / Generic mfg.
    Cost-Effectiveness Analysis of Etodolac and Aceclofenac in Low Back Pain () -  Mar 9, 2023 - Abstract #ISPOR2023ISPOR_411;    
    Taken together, our results suggests that Etodolac is more cost-effective drug than Aceclofenac for the treatment of low back pain. Etodolac 400 mg OD is more expensive but provides better therapeutic effect, well tolerated relief from low back pain, and has prominent analgesic activity when compared to Aceclofenac 100 mg BD.
  • ||||||||||  Trial completion date, Trial primary completion date:  Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Naproxen, Aceclofenac, Celecoxib and Ilaprazole (clinicaltrials.gov) -  Mar 1, 2023   
    P1,  N=72, Recruiting, 
    Etodolac 400 mg OD is more expensive but provides better therapeutic effect, well tolerated relief from low back pain, and has prominent analgesic activity when compared to Aceclofenac 100 mg BD. Trial completion date: Apr 2023 --> Dec 2023 | Trial primary completion date: Mar 2023 --> Jul 2022
  • ||||||||||  ilaprazole / Generic mfg., aceclofenac / Generic mfg.
    Enrollment open, Trial completion date:  Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Ilaprazole and Aceclofenac (clinicaltrials.gov) -  Mar 1, 2023   
    P1,  N=24, Recruiting, 
    Trial completion date: Apr 2023 --> Dec 2023 | Trial primary completion date: Mar 2023 --> Jul 2022 Not yet recruiting --> Recruiting | Trial completion date: Apr 2023 --> Dec 2023
  • ||||||||||  Journal:  Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD. (Pubmed Central) -  Nov 20, 2022   
    The first-line therapeutic for ADHD, methylphenidate, can cause serious side effects including weight loss, insomnia, and hypertension...Using the previously identified non-stimulants as a positive control, we identified four compounds that matched the effect of atomoxetine: aceclofenac, amlodipine, doxazosin, and moxonidine...In summary, we introduce a genetic model of ADHD in zebrafish and identify five putative therapeutics. The findings offer a novel tool for understanding the neural circuits of ADHD, suggest a novel mechanism for its etiology, and identify novel therapeutics.
  • ||||||||||  aceclofenac / Generic mfg.
    Journal:  Safety and effectiveness of 4-week therapy with aceclofenac controlled release once a day. (Pubmed Central) -  Oct 11, 2022   
    This study confirmed that no severe adverse reactions were observed for aceclofenac CR exceeding those previously reported for safety results of conventional formulation of this drug in routine clinical practice settings. The use of aceclofenac CR might not violate the previously reported information on the safety and effectiveness of aceclofenac.