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34 News |  |
- || etazolate (SQ-20009) / Eurobio Scientific
Review, Journal: Clerodane Diterpenes from Casearia corymbosa as Allosteric GABA Receptor Modulators. (Pubmed Central) - May 31, 2022
Compound 8 potentiated GABA-induced currents with both receptor subunit compositions [EC (αβγS) = 43.6 μM; E = 809% and EC (αβ) = 57.6 μM; E = 534%]. The positive modulation of GABA-induced currents was not inhibited by flumazenil, thereby confirming an allosteric modulation independent of the benzodiazepine binding site.
- | sildenafil / Generic mfg.
Preclinical, Journal: Antiallodynic action of phosphodiesterase inhibitors in a mouse model of peripheral nerve injury. (Pubmed Central) - Apr 1, 2022
Rolipram had anti-neuroimmune action, as shown by its impact on levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) in the dorsal root ganglia of mice with peripheral nerve injury, as well as in human peripheral blood mononuclear cells (PBMCs) stimulated with lipopolysaccharides. This study suggests that PDEs, especially PDE4 and 5, may be targets of interest in the treatment of neuropathic pain.
- || etazolate (SQ-20009) / Eurobio Scientific
Biomarker, Clinical, Retrospective data, Journal: Diagnostic accuracy of the BJI InoPlex™ (Diaxonhit) immunoassay on blood samples for periprosthetic joint infection in complex microbiological situations. Preliminary results of 24 cases in a French Reference Center for Complex Bone and Joint Infection (CRIOAC). (Pubmed Central) - Jun 26, 2021
Its spectrum must include other bacterial strains involved in chronic PJI. Knowledge of the specific infectious agent increases its diagnostic value, it could be used to monitor the outcome of a PJI, although other studies would be needed to support this use.
- | etazolate (SQ-20009) / Eurobio Scientific
Preclinical, Journal: Effect of etazolate upon cuprizone induced demyelination in vivo: Behavioral and myelin gene analysis. (Pubmed Central) - May 11, 2021
Altogether, this study shows that the beneficial effect of etazolate upon demyelination does not occur at the gene expression level. Furthermore, our results also highlight the difficulty in revealing functional sequelae following cuprizone intoxication.
- || etazolate (SQ-20009) / Diaxonhit
Ne! 🤬 Dieses 🦠 hat uns Freunden gepflegter Unterhaltung schon den #ESC2020 genommen. Nicht jetzt auch das noch! Freunde, AHA einhalten. Sonst geht 2021 richtig Baden... (Twitter) - Oct 22, 2020
- | etazolate (SQ-20009) / Diaxonhit
Journal: Evaluation of Modulators of cAMP-Response in Terms of Their Impact on Cell Cycle and Mitochondrial Activity of Leishmania donovani. (Pubmed Central) - Jul 17, 2020
Treatment of etazolate at subcytotoxic concentration to infected macrophages significantly reduced parasite burden, and administration of etazolate to Leishmania-infected BALB/c mice showed reduced liver and spleen parasite burden. Collectively, these results imply involvement of cAMP in various crucial processes paving the avenue for developing potent antileishmanial agent.
- | etazolate (SQ-20009) / Diaxonhit
Biomarker, Journal: Molecular Targets for the Interactive Effect of Etazolate during Post-Traumatic Stress Disorder: Role of Oxidative Stress, BDNF and Histones. (Pubmed Central) - Jun 29, 2020
Etazolate treatment, on the other hand, led to prevention of changes in these oxidative stress biomarkers (GSH, GSSG, GPx and TBARS), BDNF levels, and histones acetylation. In conclusion, oxidative stress and modulation of BDNF and histones acetylation induced by PTSD can be prevented by treatment with etazolate.
- | etazolate (SQ-20009) / Diaxonhit
Preclinical, Journal: A novel model of trauma-induced cerebellar injury and myelin loss in mouse organotypic cerebellar slice cultures using live imaging. (Pubmed Central) - Mar 26, 2020
In line with the existing models of focal injury, we characterized trauma-induced cerebellar lesion with an increase of PI fluorescence by live imaging. Our findings describe a novel tool to study trauma-induced myelin damage in cerebellar slices and to test biomolecules of therapeutic interest for myelin protection.