oxcarbazepine / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 51 Diseases   15 Trials   15 Trials   1554 News 


«12345678910111213...1718»
  • ||||||||||  carbamazepine / Generic mfg., oxcarbazepine / Generic mfg.
    Journal:  Recommendations for treatment strategies in people with epilepsy during times of shortage of antiseizure medications (Pubmed Central) -  Aug 4, 2022   
    Finally, when supplies of benzodiazepines or equipment to administer medications intravenously are not available, rectal administration of some ASMs may be an emergency alternative route for treating serial seizures and status epilepticus. Decision-making with regard to treatment and possible options should be driven by what is best for the patient.
  • ||||||||||  oxcarbazepine / Generic mfg.
    Journal:  Crystal Structure and Twisted Aggregates of Oxcarbazepine Form III. (Pubmed Central) -  Aug 3, 2022   
    A crystal structure determination of OXCBZ III from powder X-ray diffraction methods, assisted by crystal structure prediction (CSP), reveals that OXCBZ III, similar to carbamazepine form II, contains void channels in its structure with the channels, aligned along the c crystallographic axis, oriented parallel to the twist axis of the aggregates. The likely role of structural misalignment at the lattice or nanoscale is explored by considering the role of molecular and closely related structural impurities informed by crystal structure prediction.
  • ||||||||||  Proproten-100 / Materia Medica
    Review, Journal:  Management of Post-Acute Alcohol Withdrawal: A Mixed-Studies Scoping Review. (Pubmed Central) -  Jul 23, 2022   
    More cohort studies with a higher sample size concerning oxcarbazepine use in pregnant patients are required to truly assess the in-utero safety profile of the drug. Although there is some evidence for targeted pharmacotherapy for treating specific PAWS symptoms, there are few recent, robust, placebo-controlled trials, and the level of evidence for treatment efficacy is low.
  • ||||||||||  Journal:  Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. (Pubmed Central) -  Jul 15, 2022   
    No increased risk was associated with levetiracetam with lamotrigine (8-year cumulative incidence, 1.6%; aHR, 0.9; 95% CI, 0.3-2.5). No consistently increased risks were observed for neurodevelopmental disorders after prenatal exposure to monotherapy with lamotrigine, levetiracetam, carbamazepin, oxcarbazepine, gapapentin, pregabalin, clonazepam, or phenobarbital.
  • ||||||||||  Journal, Adverse events:  Analyzing excipient-related adverse events in antiseizure drug formulations. (Pubmed Central) -  Jul 15, 2022   
    Our study provides a novel approach to analyzing post-market surveillance reports by including excipients. It may be useful to clinicians when evaluating select patient groups that may be refractory to pharmacological treatment or experience worsening adverse events when switching formulations of the same antiseizure medicine.
  • ||||||||||  Review, Journal:  Impact of Antiseizure Medications on Appetite and Weight in Children. (Pubmed Central) -  Jun 22, 2022   
    The ASM most robustly associated with increased appetite and/or weight gain is valproic acid; however, both pregabalin and perampanel may also lead to modest weight gain or increased appetite in children. Certain ASMs may impact both appetite and weight, which may lead to increased morbidity of the underlying disease and impaired adherence to the treatment regimen.
  • ||||||||||  Review, Journal:  Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide. (Pubmed Central) -  Jun 22, 2022   
    Data on teratogenic risks are also favorable for oxcarbazepine, whereas topiramate tends to have an unfavorable profile...During pregnancy most ASMs (e.g. lamotrigine, oxcarbazepine, and levetiracetam) need to be increased to compensate for the decline in serum levels; exceptions are valproate and carbamazepine...Many ASMs in monotherapy are (moderately) safe for breastfeeding and women should be encouraged to do so. This review provides a practically oriented overview of the complex management of WWE before, during, and after pregnancy.
  • ||||||||||  oxcarbazepine / Generic mfg.
    Retrospective data, Journal:  Oxcarbazepine and Hyponatremia. (Pubmed Central) -  Jun 5, 2022   
    Other factors (gender, age, polypharmacy, OXC dosage, and serum concentration) did not show a significant association with the development of hyponatremia. Longer duration of treatment with OXC is an important factor in the development and severity of hyponatremia.
  • ||||||||||  lacosamide / Generic mfg., carbamazepine / Generic mfg., oxcarbazepine / Generic mfg.
    Journal:  Clinical Reasoning: A 73-Year-Old Woman With Episodic Dysarthria and Horizontal Binocular Diplopia. (Pubmed Central) -  May 6, 2022   
    Our patient was started on lacosamide 50 mg twice a day with a notable decrease in symptom frequency. This case illustrates the importance of detailed clinical and electrodiagnostic studies in making the diagnosis of delayed radiation induced myokymia with episodic dysarthria and provides guidance on potential therapeutics.
  • ||||||||||  oxcarbazepine / Generic mfg.
    Urticariform exanthema in pediatric age:it is not always infectious () -  Apr 30, 2022 - Abstract #EAACI2022EAACI_1838;    
    Method A 7-year-old boy was diagnosed in June 2018 with symptomatic focal epilepsy and therefor he started treatment with oxcarbazepine...Conclusion DRESS syndrome is an uncommon disease in pediatric population which requires a high degree of clinical suspicion in cases of rash after starting taking a new drug. It is important to highlight the importance of an early diagnosis to withdraw the suspected drug and thus avoid possible complications.
  • ||||||||||  hydroxychloroquine / Generic mfg., oxcarbazepine / Generic mfg.
    Multiple drug hypersensitivity: a series of cases () -  Apr 30, 2022 - Abstract #EAACI2022EAACI_1300;    
    Results The first DRESS syndrome, sensitization to Ceftriaxone and Carbamazepine was confirmed by PT, been positive to Carbamazepine 10% in dimetilsulfoxide (DMSO) (+++), Oxcarbazepine 10% DMSO(+) and Ceftriaxone 20% petrolatum (pet)(++) with delayed readings at day 2 (D2) and day 4 (D4)...In the second DRESS syndrome four different structurally drugs as Ceftriaxone, Ritonavir, Enoxaparin, and Hydroxychloroquine were implicated, being positive at PT to Ceftriaxone 20% pet (++), Hydroxychloroquine 5% DMSO (++), Lopinavir 10% DMSO (++), and Ritonavir 10% DMSO (++) at D2 and D4...All PT had negative control DMSO. Conclusion In all the cases, MDH appears simultaneously in a severe cutaneous reaction to almost two structurally different drugs. In one case, we found sensitization to four unrelated structurally pharmacological group of drugs. In our cases, PT and IDT were diagnosis, suspecting non-immediate type IV hypersensitivity reactions.
  • ||||||||||  lacosamide / Generic mfg., oxcarbazepine / Generic mfg.
    Journal:  Comparative Efficacy and Safety of Lacosamide and Oxcarbazepine for Seizure Control in Children with Newly Diagnosed Solitary Neurocysticercosis. (Pubmed Central) -  Apr 30, 2022   
    Conclusion In all the cases, MDH appears simultaneously in a severe cutaneous reaction to almost two structurally different drugs. In one case, we found sensitization to four unrelated structurally pharmacological group of drugs. In our cases, PT and IDT were diagnosis, suspecting non-immediate type IV hypersensitivity reactions. Lacosamide appears to be efficacious and safe for achieving seizure freedom in patients with solitary viable parenchymal neurocysticercosis.
  • ||||||||||  Clopixol (zuclopenthixol) / Lundbeck
    Pharmacogenetics: Clinical Applications and Cases Across the Lifespan (Rooms 283-285 , Ernest N. Morial Convention Center) -  Apr 26, 2022 - Abstract #APA2022APA_286;    
    Helen Lavretsky will focus on late-life mental health. She will present a published case highlighting the potential utility of pharmacogenetic testing in late-life depression and will also share results of a recent survey that assessed the perspectives on pharmacogenetic testing among members of the American Association of Geriatric Psychiatry.
  • ||||||||||  carbamazepine / Generic mfg., oxcarbazepine / Generic mfg.
    Retrospective data, Journal:  A woman in her sixties with epilepsy and syncope. (Pubmed Central) -  Apr 26, 2022   
    The diagnosis of epilepsy was convincing, but was the heart condition linked to her epilepsy, her medication or was it a separate entity? When seizures become more frequent or change character in a previously stabilised patient with epilepsy, it is important to look for non-epileptic causes, and cardiac arrhythmias should be high on the list.
  • ||||||||||  naltrexone / Generic mfg., fluoxetine / Generic mfg., oxcarbazepine / Generic mfg.
    Review, Journal:  Pharmacotherapy of impulse control disorders: A systematic review. (Pubmed Central) -  Apr 20, 2022   
    For the treatment of IED, oxcarbazepine and fluoxetine were the most efficacious...In the treatment of kleptomania, only naltrexone was effective...Much of the current research on impulse control disorders focuses on management with anticonvulsants and antidepressants. Further studies conducted on these interventions in this population may yield promising results.
  • ||||||||||  oxcarbazepine / Generic mfg.
    Journal:  SCN2A-Related Epilepsy: The Phenotypic Spectrum, Treatment and Prognosis. (Pubmed Central) -  Apr 19, 2022   
    Oxcarbazepine has been used by 38 patients, and seizure-free was observed in 11 of them (11/38, 28.9%), while 6 patients had seizure worsening by oxcarbazepine...Abnormal brain MRI findings and de novo variations were often related to poor prognosis. Most SCN2A variants located in transmembrane regions were related to patients with developmental delay.
  • ||||||||||  Review, Journal:  Antiseizure Medications for Adults With Epilepsy: A Review. (Pubmed Central) -  Apr 15, 2022   
    For focal epilepsy, oxcarbazepine and lamotrigine are first-line therapy, while levetiracetam can be also considered if there is no history of psychiatric disorder...ASDs with cytochrome P450 enzyme-inducing properties (eg, carbamazepine, phenytoin) may worsen comorbid coronary and cerebrovascular disease by causing hyperlipidemia and accelerating the metabolism of concomitant drugs used for their treatment...Epilepsy affects approximately 65 million people worldwide and is associated with increased rates of bodily injuries and mortality when not optimally treated. For focal and generalized epilepsy, selection of ASDs should consider the seizure and epilepsy types and epilepsy syndrome, as well as the patient's age and sex, comorbidities, and potential drug interactions.
  • ||||||||||  Vimpat (lacosamide) / UCB, Daiichi Sankyo
    Journal:  Antiseizure Medication Concentrations During Pregnancy: Results From the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) Study. (Pubmed Central) -  Apr 14, 2022   
    Additionally, compared with dose-normalized concentrations from control participants, pregnancy dose-normalized median (SE) concentrations decreased significantly by week of gestational age: carbamazepine, -0.14 (0.06) μg/L/mg (P = .02); carbamazepine unbound, -0.04 (0.01) μg/L/mg (P = .01); lacosamide, -0.23 (0.07) μg/L/mg (P < .001); lamotrigine, -0.20 (0.02) μg/L/mg (P < .001); levetiracetam, -0.06 (0.03) μg/L/mg (P = .01); oxcarbazepine, -0.14 (0.04) μg/L/mg (P < .001); oxcarbazepine unbound, -0.11 (0.03) μg/L/mg (P < .001); and zonisamide, -0.53 (0.14) μg/L/mg (P < .001) except for topiramate (-0.35 [0.20] μg/L/mg per week) and carbamazepine-10,11-epoxide (0.02 [0.01] μg/L/mg). Study results suggest that therapeutic drug monitoring should begin early in pregnancy and that increasing doses of these anticonvulsants may be needed throughout the course of pregnancy.
  • ||||||||||  oxcarbazepine / Generic mfg.
    PK/PD data, Journal:  Pharmacokinetic changes for newer antiepileptic drugs and seizure control during pregnancy. (Pubmed Central) -  Apr 8, 2022   
    We would encourage at least one monitoring every trimester and probably more frequently for women with poorly seizure control before pregnancy, and AEDs dose adjustment should keep up with clearance changes. In addition, a well-controlled seizure nine months before pregnancy could lower the risks of seizure during pregnancy, highlighting the importance of pre-pregnancy counseling and seizure management before pregnancy.
  • ||||||||||  Vimpat (lacosamide) / UCB, Daiichi Sankyo, Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
    Retrospective data, Review, Journal, Monotherapy:  Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. (Pubmed Central) -  Apr 8, 2022   
    For people with generalised tonic-clonic seizures (with or without other seizure types), current first-line treatment sodium valproate has the best profile compared to all other treatments, but lamotrigine and eventrate would be the most suitable alternative first-line treatments, particularly for those for whom sodium valproate may not be an appropriate treatment option. Further evidence from randomised controlled trials recruiting individuals with generalised tonic-clonic seizures (with or without other seizure types) is needed.
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Change in intestinal flora after treatment in children with focal epilepsy. (Pubmed Central) -  Apr 6, 2022   
    There is a significant difference in intestinal flora between children with focal epilepsy and healthy children. Oxcarbazepine can significantly improve the symptoms and intestinal flora in children with epilepsy.
  • ||||||||||  carbamazepine / Generic mfg.
    Clinical, Review, Journal:  Effects of anti-seizure medications on sleep architecture and daytime sleepiness in patients with epilepsy: A literature review. (Pubmed Central) -  Mar 31, 2022   
    Eslicarbazepine acetate, lacosamide, and perampanel improved or had no effect on sleep...Clonazepam, felbamate, lamotrigine, oxcarbazepine, and phenobarbital worsened or had no effect on sleep...Overall, cannabidiol, carbamazepine, and levetiracetam had no effect on sleep...Nonetheless, other ASMs may worsen sleep in some settings. Clinicians should consider such observations when making treatment decisions, particularly for patients with comorbid sleep disorders.