oxcarbazepine News - LARVOL Sigma

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|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, PK/PD data, Review, Journal: Pharmacokinetic Considerations with the Use of Antiepileptic Drugs in Patients with HIV and Organ Transplants. (Pubmed Central) - Sep 28, 2019
Antiepileptic drugs with no or minimal enzyme-inducing properties include brivaracetam, gabapentin, lacosamide, lamotrigine, levetiracetam, perampanel, pregabalin, and vigabatrin. The newer generations of antiepileptic drugs have expanded the therapeutic options in patients with HIV infection or organ transplants.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Journal: The role of reactive oxygen species and carbonate radical in oxcarbazepine degradation via UV, UV/HO: Kinetics, mechanisms and toxicity evaluation. (Pubmed Central) - Sep 28, 2019
Compared with non-selective OH, the reactions involving CO are mainly electron transfer and hydrogen abstraction. And the acute toxicity of OXC was lower after UV/HO and UV/HO/HCO treatments, which was confirmed by luminescent bacterial assay (Vibrio fischeri bacterium).

|||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Review, Journal: Antiepileptic drugs as analgesics/adjuvants in inflammatory pain: current preclinical evidence. (Pubmed Central) - Sep 26, 2019
When co-administered with classic/other alternative analgesics, AEDs exerted synergistic/additive interactions. Reviewed data could serve as a basis for clinical studies on the efficacy/safety of AEDs as analgesics/adjuvants in patients with inflammatory pain, and contribute to the improvement of the treatment of various inflammatory pain states.

|||||||||| Botox (onabotulinumtoxin A) / GSK, Allergan, carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Medical management of primary hemifacial spasm (Agora 3 West, Level 3) - Sep 24, 2019 - Abstract #MDSCongress2019MDS_114;
Clonazepam and Oxcarbazepine alone were not beneficial and Lamotrigine was an alternative for patients not tolerating Carbazepine. Controlled trials are needed in a larger number to establish the findings of this study.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Could Oxcarbazepine be a neuroprotective agent in MS? It doesn’t reduce levels of neurofilaments light (NfL) but had a positive effect on EDSS and MSWS12 #ECTRIMS2019 (Twitter) - Sep 13, 2019

|||||||||| Trileptal (oxcarbazepine) / Novartis
Our @monicacmarta reporting on oxcarbazepine PROXIMUS trial #ECTRIMS2019 (Twitter) - Sep 12, 2019

|||||||||| Trileptal (oxcarbazepine) / Novartis
Retrospective data, Review, Journal, Adverse drug reaction: Association Between HLA genotypes and Oxcarbazepine-induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-Analysis. (Pubmed Central) - Sep 11, 2019
Further studies need to better define other ethnicities at risk and a wider range of MHC gene subtypes. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

|||||||||| risperidone / Generic Mfg., Egis, Trileptal (oxcarbazepine) / Novartis
Retrospective data, Review, Journal: Pharmacological treatments for alleviating agitation in dementia: A systematic review and network meta-analysis. (Pubmed Central) - Sep 11, 2019
Our findings do not support prescribing haloperidol due to lack of efficacy, or oxcarbazepine due to lack of acceptability. The decision to prescribe should be based on comprehensive consideration of the benefits and risks, including those not evaluated in this meta-analysis.

|||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal, Adverse drug reaction: Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015. (Pubmed Central) - Sep 11, 2019
Our findings suggest that clinicians should pay attention to psychiatric ADRs and be alert for SARs, especially when three or more AEDs are used together. Moreover, active surveillance might provide another method of pharmacovigilance in China.

|||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: The phenotype of SCN8A developmental and epileptic encephalopathy. (Pubmed Central) - Sep 1, 2019
SCN8A developmental and epileptic encephalopathy has strikingly consistent electroclinical features, suggesting a global progressive brain dysfunction primarily affecting the temporo-occipital regions. Both uncontrolled epilepsy and developmental compromise contribute to the profound impairment (increasing risk of death) during early childhood, but stabilization occurs in late childhood.

|||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Pharmacotherapy of Vestibular Disorders, Nystagmus and Cerebellar Disorders (Pubmed Central) - Aug 30, 2019
...In vestibular paroxysmia, oxcarbazepine was effective (one randomized controlled trial (RCT))...There has been no RCT on the efficacy of beta-blockers or topiramate but one RCT on flunarizine in vestibular migraine...Acetyl-DL-leucine improved cerebellar ataxia (two observational studies); it also accelerated central compensation in an animal model of acute unilateral lesion, but RCTs were negative. There are ongoing RCTs on treatment of vestibular paroxysmia with carbamazepine (VESPA), acute unilateral vestibulopathy with betahistine (BETAVEST), vestibular migraine with metoprolol (PROVEMIG), benign paroxysmal positional vertigo with vitamin D (VitD@BPPV), EA2 with 4-aminopyridine versus acetazolamide (EAT-2-TREAT), and cerebellar ataxias with acetyl-DL-leucine (ALCAT).

|||||||||| Trileptal (oxcarbazepine) / Novartis
Oxcarbazepine as a neuroprotective agent in MS: a phase IIa trial (PROXIMUS) (Hall A) - Aug 28, 2019 - Abstract #ECTRIMS2019ECTRIMS_1405;
Whilst oxcbz had no significant effect on CSF NFL levels, there was a significant clinical treatment effect as measured by EDSS and MSWS scores. This suggests the need for combined clinical and biomarkers outcomes and a combination of anti-inflammatory and neuroprotective drugs in future trials of PwMS with progressive deterioration.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Seamless phase II-III adaptive trial design elements for progressive MS: Neurofilament light chain (phase II/interim endpoint), phase III endpoints and patient populations (Poster Exhibition) - Aug 28, 2019 - Abstract #ECTRIMS2019ECTRIMS_1262;
P2, P2a
For example, low s-NfL values (75th percentile) could be a stratification covariate for highly active patients. S-NfL can be considered a candidate interim endpoint in a MAMS design.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Antiepileptic drug clearances during pregnancy and clinical implications for women with epilepsy. (Pubmed Central) - Aug 28, 2019
Lower RTC was associated with seizure worsening. Early therapeutic drug monitoring and dose adjustment may be helpful to avoid increased seizure frequency.

|||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Anticonvulsants and the risk of perinatal bleeding complications: A pregnancy cohort study. (Pubmed Central) - Aug 23, 2019
Evidence from this large observational study suggests that use of ACDi near delivery does not increase the risk of bleeding complications compared to other ACDs in clinical settings where neonatal intramuscular or oral vitamin K administration is considered standard of care. These findings provide reassurance for clinicians and pregnant women successfully treated with ACDi.

||||||||||  oxcarbazepine / Generic mfg.
Trial completion date, Trial primary completion date:  Long-term Safety and Tolerability of TRI476 (Oxcarbazepine) in Children With Inadequately Controlled Partial Onset Seizures (clinicaltrials.gov) -  Aug 22, 2019
P2/3, N=88, Active, not recruiting,  Sponsor: Nobelpharma
These findings provide reassurance for clinicians and pregnant women successfully treated with ACDi. Trial completion date: Mar 2019 --> Sep 2019 | Trial primary completion date: Mar 2019 --> Sep 2019

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society. (Pubmed Central) - Aug 17, 2019
No high-quality studies suggest clobazam, eslicarbazepine, ezogabine, felbamate, GBP, lacosamide, LEV, LTG, oxcarbazepine, perampanel, pregabalin, rufinamide, tiagabine, topiramate, vigabatrin, or ZNS is effective in treating new-onset epilepsy because no high-quality studies exist in adults of various ages. A recent Food and Drug Administration (FDA) strategy allows extrapolation of efficacy across populations; therefore, for focal epilepsy, eslicarbazepine and lacosamide (oral only for pediatric use) as add-on or monotherapy in persons ≥4 years old and perampanel as monotherapy received FDA approval.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society. (Pubmed Central) - Aug 17, 2019
This evidence-based assessment informs AED prescription guidelines for TR epilepsy and indicates seizure types and syndromes needing more evidence. A recent Food and Drug Administration (FDA) strategy allows extrapolation of efficacy across populations; therefore, for focal epilepsy, eslicarbazepine and lacosamide (oral only for pediatric use) as add-on or monotherapy in persons ≥4 years of age and perampanel as monotherapy received FDA approval.

|||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Use of antiepileptic drugs during breastfeeding : What do we tell the mother? (Pubmed Central) - Aug 15, 2019
Since data on the use of mesuximide, clobazam, rufinamide, felbamate, lacosamide, sultiame, perampanel and retigabine are insufficient to adequately assess the risk for breastfed infants, use in breastfeeding women is in principle not recommended and should be carefully evaluated on a case by case basis. In practice, a risk-benefit analysis should be performed for each mother under antiepileptic treatment wishing to breastfeed her child, so that individual risk factors can adequately be taken into account when counseling the patient.

|||||||||| citalopram / Generic Mfg., Ritalin (methylphenidate tablet) / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Dose-related concentrations of neuro-/psychoactive drugs expected in blood of children and adolescents. (Pubmed Central) - Aug 9, 2019
In practice, a risk-benefit analysis should be performed for each mother under antiepileptic treatment wishing to breastfeed her child, so that individual risk factors can adequately be taken into account when counseling the patient. It was concluded that concentrations of neuro-/psychoactive drugs to be expected in blood for a given dose may differ between adults and children or adolescents, most probably owing to age-dependent differences in the elimination of these drugs.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Treating Acute Hepatitis C Virus Infections: Is It Cost Effective? (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2125;
Though the presence of the eosinophils and granulomas suggest Oxcarbazepine induced liver injury, the marked hepatocyte injury coincides with acute HCV...In high risk patients the QALY increased by 0.03 and decreased costs up to $3,655, substantiating this as a cost saving outcome. Although more studies are needed to demonstrate the effectiveness of DAAS,this particular study seemed to be promising.

|||||||||| Trileptal (oxcarbazepine) / Novartis
High SVR Rates in HCV-Infected Patients With Multiple Co-Morbid Medical Conditions Treated With HCV DAAs in Community Practice Using a Specialized Pharmacy Team (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1998;
This cohort included many patients with complicated medical histories including HCC (4.4%), ESRD (2.7%), liver transplant (2.1%) and seizure disorders (4.5%). Liver staging was done via Fibrotest (71%), Fibroscan (22%), Fibrosure (13%) and liver biopsy (0.6%).

|||||||||| Trileptal (oxcarbazepine) / Novartis
Review, Journal: Update on Trigeminal Neuralgia. (Pubmed Central) - Aug 2, 2019
A patient with classic trigeminal neuralgia would benefit from neurosurgical consultation. The advent of high-resolution MRI and MRA sequences now allows a neurosurgeon to detect when neurovascular compression is likely, and select the optimal procedure for treatment.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Retrospective data, Journal: Levetiracetam administration is correlated with lower mortality in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes: a retrospective study. (Pubmed Central) - Jul 24, 2019
The LEV administration is associated with lower mortality in patients with MELAS in this retrospective study. Further laboratory research and prospective cohort studies are needed to confirm whether LEV has neuroprotective effects on patients with mitochondrial diseases.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Journal, Adverse drug reaction: Why we should be monitored the hematologic adverse drug reaction of oxcarbazepine? (Pubmed Central) - Jul 20, 2019
Further laboratory research and prospective cohort studies are needed to confirm whether LEV has neuroprotective effects on patients with mitochondrial diseases. No abstract available

|||||||||| Trileptal (oxcarbazepine) / Novartis, Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
Clinical, Journal: Levels of anger in epilepsy patients treated with eslicarbazepine acetate. (Pubmed Central) - Jul 19, 2019
Therefore, ESL seems to exert a favorable influence on the anger levels of otherwise healthy patients with epilepsy, including those unresponsive to seizure control. The potential ESL anti-aggressive effect should be studied in patients with epilepsy and active psychiatric disorders.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Observational data, Journal: Brand-to-generic oxcarbazepine switch - A prospective observational study. (Pubmed Central) - Jul 13, 2019
The potential ESL anti-aggressive effect should be studied in patients with epilepsy and active psychiatric disorders. The switching from brand-name to generic OXC seems to be safe, however, larger prospective studies are required in order to confirm our findings.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Review, Journal: Current and Innovative Pharmacological Options to Treat Typical and Atypical Trigeminal Neuralgia. (Pubmed Central) - Jul 13, 2019
A new, better tolerated, Nav1.7 selective state-dependent, sodium channel blocker (vixotrigine) is under development. Future trials testing the effect of combination therapy in patients with TN are needed, especially in patients with concomitant continuous pain and in TN secondary to multiple sclerosis.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Propofol-induced refractory status epilepticus at remission age in benign epilepsy with centrotemporal spikes: A case report and literature review. (Pubmed Central) - Jul 12, 2019
This was the first report of an SE in BECTS patient past the remission age. This report implied that interventions of sedation or analgesia in a patient after remission age of BECTS might still be at risk of refractory SE and therefore, should be carefully evaluated and monitored during such procedures, especially when an AED medication has been withdrawn or altered.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Specific Patient Features Affect Antiepileptic Drug Therapy Decisions. Focus on Gender, Age, and Psychiatric Comorbidities. (Pubmed Central) - Jul 11, 2019
This report implied that interventions of sedation or analgesia in a patient after remission age of BECTS might still be at risk of refractory SE and therefore, should be carefully evaluated and monitored during such procedures, especially when an AED medication has been withdrawn or altered. A careful evaluation of the patient variables analysed in the present review is useful to personalize and optimize AED therapy.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Journal: Sexual Dysfunction In Epilepsy And The Role Of Anti-Epileptic Drugs. (Pubmed Central) - Jul 11, 2019
A careful evaluation of the patient variables analysed in the present review is useful to personalize and optimize AED therapy. Management of sexual dysfunction thought to be caused by anti-convulsants should include the cessation of the offending drug, and consideration of switching to alternative anti-convulsants that have been reported to improve sexual function such as oxcarbazepine, and lamotrigine.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Journal: Lesson of the month 1: To stop a fit, but swinging low. (Pubmed Central) - Jun 30, 2019
In few cases, immunoglobulin infusion is required. Antiepileptic drug-associated thrombocytopenia is difficult to predict and so it is imperative to monitor the platelet level when antiepileptic drugs are started and even after the medication is switched to a different one.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Review, Journal: A descriptive systematic review of salivary TDM in neonates and infants. (Pubmed Central) - Jun 26, 2019
Of the properties investigated, pKa was the most influential with both logP and protein binding having little effect on this correlation. To conclude any compound with a pKa within physiological range (pH 6 - 8) should be considered with extra care, with the extraction and analysis method examined and optimized on a case-by-case basis.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Journal: Analysis and fate of 14 relevant wastewater-derived organic pollutants in long-term exposed soil. (Pubmed Central) - Jun 26, 2019
Only trace levels of ten drugs were measured in soil irrigated with regenerated water (average concentrations between 1.6 and 4.7 ng g d.w.). Graphical abstract.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Journal, Adverse events: Cognitive, behavioural and sleep-related adverse effects on introduction of levetiracetam versus oxcarbazepine for epilepsy. (Pubmed Central) - Jun 22, 2019
On cross-sectional as well as on longitudinal assessment, nearly one-fifth of patients on levetiracetam have behaviour related adverse effects, with dose modification required for half among these. Nearly 11% of patients on oxcarbazepine reported sleep-related adverse effects (higher total sleep duration per 24 h).

|||||||||| Trileptal (oxcarbazepine) / Novartis
Journal: Detection of potential look-alike/sound-alike medication errors using Veterans Affairs administrative databases. (Pubmed Central) - Jun 19, 2019
Through the use of administrative databases, potential LASA errors that could be reviewed for an actual error via chart review were identified. While a high rate of potential LASA errors was detected, the number of actual errors identified was low.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Journal: Rasmussen syndrome: absence seizures may be induced by oxcarbazepine. (Pubmed Central) - Jun 19, 2019
Our patient who met the diagnostic criteria for Rasmussen syndrome presented with absence seizures that may have been induced by OXC. The absence seizures disappeared after OXC was discontinued.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Journal: Modern aspects of antiepileptic therapy during pregnancy (Pubmed Central) - Jun 15, 2019
In addition to classic AEDs, new AEDs (vigabatrin, gabapentin, topiramate, tiagabine, oxcarbazepine, levetiracetam, pregabalin) were investigated...It has been found that the risk of birth defects in children is associated with high doses of drugs and polytherapy compared to monotherapy. New data of recent studies showed the effect of psychotropic drugs on the fetus allowing to assess the 'risk/benefit' ratio and develop recommendations on rational pharmacotherapy of epilepsy in pregnancy.

||||||||||  padsevonil (UCB0942) / UCB
Trial completion:  A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil (clinicaltrials.gov) -  Jun 13, 2019
P1, N=28, Completed,  Sponsor: UCB Biopharma S.P.R.L.
New data of recent studies showed the effect of psychotropic drugs on the fetus allowing to assess the 'risk/benefit' ratio and develop recommendations on rational pharmacotherapy of epilepsy in pregnancy. Recruiting --> Completed

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, PK/PD data, Journal: Population pharmacokinetics of oxcarbazepine active metabolite in Chinese paediatric epilepsy patients and its application in individualised dosage regimens. (Pubmed Central) - Jun 7, 2019
Recruiting --> Completed A PPK model was established to estimate individual MHD clearance in paediatric patients taking OXC to develop individualised OXC dosing regimens for Chinese paediatric epilepsy patients.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Biomarker, Clinical, Journal: Persistent cholestasis resulting from duodenal papillary carcinoma in an adolescent male: A case report. (Pubmed Central) - Jun 7, 2019
A PPK model was established to estimate individual MHD clearance in paediatric patients taking OXC to develop individualised OXC dosing regimens for Chinese paediatric epilepsy patients. Cholestasis resulting from primary duodenal papillary carcinoma is rare in pediatric patients but should be considered in the differential diagnosis.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, PK/PD data, Review, Journal: Possible Pharmacodynamic and Pharmacokinetic Drug-Drug Interactions That Are Likely to Be Clinically Relevant and/or Frequent in Bipolar Disorder. (Pubmed Central) - May 30, 2019
The purpose is to be practical, helping clinicians pay attention to and manage polypharmacy, avoiding adverse drug reactions (ADRs) in patients with bipolar disorder, including both the frequent ADRs and those rare but potentially lethal ADRs. Future articles should improve these tables.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Biomarker, Clinical, Journal: Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update. (Pubmed Central) - May 15, 2019
The variant allele HLA-A*31:01 is associated with greater risk of maculopapular exanthema, drug reaction with eosinophilia and systemic symptoms, and SJS/TEN in patients treated with carbamazepine. We summarize evidence from the published literature supporting these associations and provide recommendations for carbamazepine and oxcarbazepine use based on HLA genotypes.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Journal: Reliability of information about the use of antiepileptic drugs during pregnancy from three major web search engines in China. (Pubmed Central) - May 14, 2019
We summarize evidence from the published literature supporting these associations and provide recommendations for carbamazepine and oxcarbazepine use based on HLA genotypes. Accurate and professional online information for female patients with epilepsy should be provided through major efforts by the government, search engine companies, professional websites and epilepsy physicians.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: and Oxcarbazepine-Induced DRESS in a Patient With Seizures and CompleteDeletion. (Pubmed Central) - May 7, 2019
In addition, we review the population-wide prevalence of various hypersensitivity reactions to AEDs and associated HLA antigen alleles. Finally, we discuss the potential utility of preemptive pharmacogenomic screening of patients before pharmacological treatment of epilepsy to assess the risk of developing hypersensitivity reactions.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Of course. But maybe somebody on the panel is on Oxcarbazepine 😏 (Twitter) - May 2, 2019

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Reimbursement, Journal: Epidemiology of traumatic brain injury-associated epilepsy and early use of anti-epilepsy drugs: An analysis of insurance claims data, 2004-2014. (Pubmed Central) - May 1, 2019
There was no evidence suggesting AEDs helped to prevent PTE with the possible exception of acetazolamide. However, further studies may be needed to test the efficacy of acetazolamide in preventing PTE.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Spontaneous fetal loss in women with epilepsy: prospective data from pregnancy registry in India. (Pubmed Central) - May 1, 2019
However, further studies may be needed to test the efficacy of acetazolamide in preventing PTE. SPFL risk is increased in pregnancies with AED exposure, being least with levetiracetam and highest with topiramate.

|||||||||| Trileptal (oxcarbazepine) / Novartis
Journal: Therapeutic Drug Monitoring of Antiepileptic Drugs in Epilepsy: A 2018 Update. (Pubmed Central) - Apr 30, 2019
For the older first generation AEDs (carbamazepine, ethosuximide, phenobarbital, phenytoin, primidone and valproic acid), much data has accumulated in this regard. However, this is occurring increasingly for the new AEDs (brivaracetam, eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, perampanel, piracetam, pregabalin, rufinamide, stiripentol, sulthiame, tiagabine, topiramate, vigabatrin and zonisamide).

|||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Influence of Dose and Antiepileptic Comedication on Lacosamide Serum Concentrations in Epilepsy Patients of Different Ages. (Pubmed Central) - Apr 30, 2019
In accordance with previous therapeutic drug monitoring studies, our results confirmed that enzyme inducers reduce the LCM trough serum concentrations by 30% to 40%. In children, the effects of comedication are more pronounced but should be confirmed by further studies.



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