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51 Diseases |  |
15 Trials |
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- Trileptal (oxcarbazepine) / Novartis
Awareness of Seizures: Patient Report and RNS Record (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1515;
It can also be challenging to differentiate focal seizures without awareness from non-epileptic hypervigilant behaviors by patients’ descriptions. RNS ECog recordings provide further objective electrophysiological evidence, and therefore could be helpful in the diagnosis and treatment.
- Trends in the Use of Antiepileptic Drugs During Pregnancy Across Two Decades – a Danish Population-Based Study (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1505;
The use of Valproate in Danish pregnant women has decreased in recent years following reports of adverse birth outcomes after Valproate exposure in pregnancy. Lamotrigine is now the main AED used in pregnant women in Denmark.
- Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
Safety and Tolerability of Eslicarbazepine Acetate as First Adjunctive Therapy with Levetiracetam or Lamotrigine, or as Later Adjunctive Therapy in Patients with Focal Seizures (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1402;
P4
Whereas, TEAE frequency was comparable between patients taking ESL with LEV or LTG as a later therapy. The overall types and frequencies of TEAEs were comparable to those reported in previous trials.
- Trileptal (oxcarbazepine) / Novartis
Ictal Forced Mouth Opening in a Patient with Refractory Focal Epilepsy (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1373;
In 2017 the seizures recurred and oxcarbazepine was added but she continued to have nightly seizures...Conclustions Ictal forced mouth opening be considered as a rare automatism seen in epileptic seizures and can be a semiologic sign of a right frontal convexity epilepsy. This rare ictal manifestation should be recognized as epileptic to avoid misdiagnosis and treatment failure.
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
The Phenotype of KCNQ2 Epileptic Encephalopathy (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1353;
Ohtahara syndrome with burst-suppression patterns on EEGs are characteristic. Seizures are well controlled with sodium channel blockers, regardless of type of mutations.
- Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
Efficacy of Eslicarbazepine Acetate as First Adjunctive Therapy with Levetiracetam or Lamotrigine, or as Later Adjunctive Therapy in Patients with Focal Seizures (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1254;
P4
Conclustions In this real-world open-label study, ESL was effective for treatment of focal seizures. Seizure improvements were greater when ESL was taken as a first adjunctive therapy with LEV or LTG monotherapy, compared with when taken as a later adjunctive therapy.
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Antiepileptic Drug Use and Pregnancy Outcomes in African American Women with Epilepsy (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1164;
The other AEDs used were oxcarbazepine (OXC) and phenytoin (PHT)...The only major congenital malformation (carbamazepine) in the cohort also occurred in an AA woman taking carbamazepine...Despite the overall safety profile of newer AEDs reported in national registries, our cohort of mostly AA WWE showed slightly more adverse pregnancy and fetal outcomes which could be due to the low use of pre-conception folic acid use and higher incidence of unplanned pregnancies. Medical provider and patient education is essential in planning pregnancies and prescribing folic acid as AA WWE may be exposed to slightly higher risks of complications in pregnancy than reported in existing national registries.
- pregabalin / Generic mfg., carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Levetiracetam Versus Sodium Channel Blockers as First Prescribed Antiepileptic Drug: Data from the Human Epilepsy Project (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1095;
Results 157 (59.5%) initiated levetiracetam (LEV), 49 (18.6%) lamotrigine (LTG), 21 (8%) oxcarbazepine (OXC), 11 (4.2%) phenytoin, 5 (1.9%) topiramate, 12 (4.5%) carbamazepine, (CBZ) 2 (0.8%) lacosamide, 5 (1.9%) valproic acid, 1 (0.4%) pregabalin, and 1 (0.4%) zonisamide.Of the 157 started on LEV, 63 (31.6%) remained on the drug in monotherapy, 76 (48%) switched to another AED, 12 (7.6%) added an AED in conjunction, and 6 (3.8%) ceased AED usage...By the end of the study, pts were receiving the following AEDs alone or in combination: LEV 36.0%, LTG 37.5%, CBZ 6.8%, OXC 17.0%, PHT 0.8%, topiramate 2.3%, lacosamide 7.2%, valproic acid 1.9%, zonisamide 4.9%, lorazepam 0.8%, clobazam 0.4%, clonazepam 0.4%...The likelihood of remaining on initial monotherapy was twice as high for a sodium channel blocker as for LEV in the first 2 years of treatment. (P=.001)
- Fycompa (perampanel) / Eisai, carbamazepine / Generic mfg.
Efficacy and Safety of Perampanel as First Adjunctive Therapy in Patients with Partial-Onset Seizures: Post Hoc Analysis of the FAME Study by First-Line Antiepileptic Drug Use (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1085;
P4
Eight pts reported a serious adverse event (SAE); one SAE of suicidal ideation with perampanel and levetiracetam was considered possibly related to treatment; all other SAEs were considered unrelated to treatment. Conclustions Despite the small pt numbers for some of the concomitant AED groups, these results suggest perampanel is effective in achieving seizure control and response with a favorable tolerability outcome in patients with POS, with or without SGS, regardless of the first-line concomitant AED used during Baseline.
- Trileptal (oxcarbazepine) / Novartis
New Pathogenic Variant in SCN8A Causing SCN8A-Epilepsy in Identical Twins (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1075;
Future steps including genetic testing on parents and identical twin brother. We propose that our patient (Twin1) demonstrates a new pathogenic variant of SCN8A (c.796G>A (p.Ala266Thr) not previously described in the literature based on clinical phenotype and ancillary studies.
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Effect of Antiepileptic Drug Monotherapy on the Risk of Death in Patients with Poststroke Epilepsy (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_941;
The opposite applies for patients treated with VPA, who seem to have a higher risk of both cardiovascular and all-cause death compared to CBZ and LTG. The analyses are adjusted for several confounders, but further studies are needed to establish a causal relationship.
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Risk of Epileptic Spasms Induction by Voltage-Gated Sodium Channel Blockade (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_858;
Several case reports have suggested that voltage-gated sodium channel blockade by carbamazepine (CBZ) or oxcarbazepine (OXC) may induce epileptic spasms (Mutoh 1993; Veerapandiyan 2012)...Cox proportional hazards regression, with time-varying covariates to account for dynamic exposure to specific anti-seizure drugs, was used to determine whether time to onset of ES was associated with exposure to any voltage-gated sodium channel blocker, namely CBZ, OXC, lacosamide (LAC), and phenytoin (PHT)...However, these results should be interpreted in the context of the limitations of the study design-especially the lack of randomization. Further study is warranted.
- Trileptal (oxcarbazepine) / Novartis
Investigating Predictors for Developing Refractory Epilepsy in Patients with Tumor-Related Epilepsy (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_708;
Conclustions The only significant factor predicting the development of refractory epilepsy in this study was the length of seizure freedom period after initiation of first line AED, with seizure free intervals less than 1 month having a much higher risk for refractory epilepsy. Additionally, there was also no statistical difference in efficacy between the 1st and 2nd line anti-epileptic medications in tumor-related epilepsy.
- Fycompa (perampanel) / Eisai, carbamazepine / Generic mfg.
Long-Term Effect of Concomitant Enzyme-Inducing Anti-Seizure Drugs on the Safety and Efficacy of Adjunctive Perampanel in Patients (Aged 4 to <12 Years) with Partial-Onset Seizures in Study 311 (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_702;
P3
Seizure-freedom rates for POS and SGS at Weeks 40–52 were: 7/32 (21.9%) and 2/6 (33.3%) with EIASDs; and 7/76 (9.2%) and 8/35 (22.9%) without EIASDs, respectively. Conclustions These data suggest long-term (≤52 weeks) adjunctive perampanel is generally well tolerated and efficacious in pts aged 4 to <12 years with POS with/without SGS, regardless of EIASD status.
- Briviact (brivaracetam) / UCB, carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Real-World Study of Brivaracetam in the US: An Interim Analysis (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_653;
Three patients died during the study, but none were judged to be drug-related. Conclustions This interim analysis indicates that retention on BRV (a measure of effectiveness) at 3 and 6 months is similar between patients that had previously failed LEV, LTG, OXC, and CBZ.
- Trileptal (oxcarbazepine) / Novartis
Feasibility and Utility of Applications of the Common Data Model for Antiepileptic Drug Related Adverse Reactions (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_607;
Conclustions Our observational study from a single institution demonstrates that ADRs of antiepileptic drugs using the OHDSI CDM are feasible. Standardized OHDSI CDM platform can be used as a valuable tool for monitoring nationwide antiepileptic drug safety surveillance.
- Use of Perampanel in Two Patients with Epilepsy and Severe Mental Health or Behavioral Disorders (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_567;
She was unable to work or maintain custody of her child due to bipolar disorder (treated with 1 mg risperidone twice daily)...He was transitioned to 1600 mg/day eslicarbazepine acetate (replacing oxcarbazepine) and 200 mg lacosamide twice daily; phenobarbital was slowly tapered off over 6 months...The patient has continued to receive quetiapine 200 mg twice daily...During titration and at higher doses of perampanel, patients must be monitored for atypical behavior. Further research is required.
- Trileptal (oxcarbazepine) / Novartis
Mortality in Children with Sturge Weber Syndrome (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_558;
Seizures were not controlled despite adding levetiracetam and lorazepam, and she underwent right functional hemispherectomy at 6 months; however, resection was limited by blood loss...At 4 months, he developed left-sided focal seizures treated with phenobarbital, levetiracetam, and phenytoin, later responding to oxcarbazepine...No death directly related to prolonged seizures or SUDEP was seen in this cohort. Further studies will be necessary to identify the risk factors for mortality in children with SWS.
- Trileptal (oxcarbazepine) / Novartis
Hippocampal DBS As an Option for Treatment of Refractory Seizures in a Patient with Bilateral Periventricular Nodular Heterotopia: Long-Term Follow Up (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_492;
Hip-DBS might prove to be a good treatment option in this patient population. BiPNH is a rare disease; larger series and longer follow-up would be needed to further evaluate Hip-DBS efficacy in this setting.
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Suspected Insular Autonomic Seizures in Infants with Apneic Seizures; Normal Routine EEG Cannot Exclude Apneic Seizure in Infants (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_456;
We found apneic events with preceding ictal EEG findings on the prolonged video-EEG. The normal EEG findings without epileptiform discharges, apneic seizures and bradycardia of autonomic symptoms might indicate deep seated focal onset autonomic seizures from insula in a subset of infants with apneic seizures.
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Anti-Epileptic Drug Use in Esmeraldas, Ecuador Identified During US Humanitarian Assistance in Response to Venezuelan and Central American Migration (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_373;
It is unclear whether this represents a difficulty accessing specialty care versus difficulty obtaining the medication itself, as it has been reported that large proportions of patients with epilepsy in rural Ecuador were AED naïve5. Addressing state-run formularies may be helpful in providing access to a wider variety of anti-epileptic medications.
- lamotrigine liquid oral suspension / OWP Pharma, carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Prevalence of Concurrent Prescriptions for Oral Anticoagulants and Antiepileptic Drugs Among People with Epilepsy Between 2010-2016 (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_341;
The OACs included warfarin, as well as those DOACs that received regulatory approval during the study time frame (dabigatran, rivaroxaban, apixaban, and edoxaban)...These findings highlight the clinical significance of advancing understanding of interactions between EI-AEDs and OACs, given their potential impact on as much as 7.17% of PWE. In particular, further research into proposed interactions with DOACs appears warranted in light of rapid uptake of this form of anticoagulation within the population with epilepsy.
- zonisamide / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Pregnancy-Related Changes in Zonisamide and Oxcarbazepine Clearance (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_338;
Without compensatory dose adjustments, WWE on ZNS or OXC during their pregnancy will likely have lower serum concentrations and a higher risk for seizure worsening.Future directions:Several pregnant women on ZNS and OXC will complete pregnancies in the near future. We will expand our pharmacokinetic analyses to include those women and to assess if there is a correlation between the pregnancy ASM concentrations and seizure control.
- Fycompa (perampanel) / Eisai, carbamazepine / Generic mfg.
Post-Marketing Observational Study to Evaluate Safety and Tolerability of Perampanel as Add-On Therapy in Patients with Epilepsy: Post Hoc Analysis by Dose and Enzyme-Inducing Anti-Seizure Drugs (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_319;
P=N/A
Conclustions Between 23.8% and 28.6% of patients in Study 402 experienced a TEAE; results were comparable across all dose groups. As Study 402 was not randomized, it should be noted that only patients who tolerated lower doses will have subsequently received the higher doses of perampanel.
- | Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: EXPRESS: Rapid and Quantitative Determination for Oxcarbazepine Clinically in Plasma Using Surface-Enhanced Raman Spectroscopy (SERS) Coupled with Chemometrics. (Pubmed Central) - Nov 27, 2019
As Study 402 was not randomized, it should be noted that only patients who tolerated lower doses will have subsequently received the higher doses of perampanel. No abstract available
- ||| oxcarbazepine / Generic mfg.
Trial completion: Pharmacokinetics of Anti-epileptic Drugs in Obese Children (clinicaltrials.gov) - Nov 27, 2019
P=N/A, N=106, Completed, Sponsor: Christoph P Hornik, MD MPH
No abstract available Recruiting --> Completed
- ||| Trileptal (oxcarbazepine) / Novartis
Increased risk of glaucoma, liver injury, serious (even fatal) skin reactions, serious blood disorders, reduced sodium levels (oxcarbazepine), potentially irreversible eye damage, potentially irreversible skin discoloration, fatal liver failure,.. https://t.co/PvLZsoZ0E2 (Twitter) - Nov 25, 2019
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Focal Electrographic Seizures in a Patient With Autism Spectrum Disorder and Speech Delay. (Pubmed Central) - Nov 22, 2019
EEG unexpectedly showed extremely frequent, almost constant focal electrographic seizures arising from the T3/T5 electrodes in the speech area of the left temporal lobe, prompting the initiation of oxcarbazepine maintenance therapy...Hindsight is always 20/20. As a clinician evaluating the patient initially, would you have pursued further workup sooner?
- || carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: The influence of concomitant antiepileptic drugs on lamotrigine serum concentrations in Northwest Chinese Han population with epilepsy. (Pubmed Central) - Nov 21, 2019
Combination with enzyme-inducer AEDs, especially CBZ could significantly decrease LTG serum concentrations, VPA could significantly increase LTG serum concentrations, and the inducer only partially compensated for the inhibitory effect of VPA in triple combination. In the clinical setting, these findings can help to estimate LTG concentrations and adjust dosage and evaluate adverse drug reactions.
- || Trileptal (oxcarbazepine) / Novartis
La bipolaridad que está manejando el clima. Ni un trileptal lo salva. (Twitter) - Nov 18, 2019
- ||||| oxcarbazepine / Generic mfg.
Trial completion: Long-term Safety and Tolerability of TRI476 (Oxcarbazepine) in Children With Inadequately Controlled Partial Onset Seizures (clinicaltrials.gov) - Nov 15, 2019
P2/3, N=88, Completed, Sponsor: Nobelpharma
In the clinical setting, these findings can help to estimate LTG concentrations and adjust dosage and evaluate adverse drug reactions. Active, not recruiting --> Completed
- Drug-drug interactions between antiretrovirals and carbamazepine or oxcarbazepine: a real-life investigation (Exhibition hall) - Nov 15, 2019 - Abstract #EACS2019EACS_1714;
Coadministration of carbamazepine or oxcarbazepine with atazanavir or dolutegravir should be avoided; for these two drugs, the adoption of TDM is strongly advisable, eventually combined with increased antiretroviral doses. [FIgure 1]
- Drug-drug interactions between antiretrovirals and carbamazepine or oxcarbazepine: a real-life investigation (Exhibition hall) - Nov 15, 2019 - Abstract #EACS2019EACS_904;
Coadministration of carbamazepine or oxcarbazepine with atazanavir or dolutegravir should be avoided; for these two drugs, the adoption of TDM is strongly advisable, eventually combined with increased antiretroviral doses. [FIgure 1]
- Drug-drug interactions between antiretrovirals and carbamazepine or oxcarbazepine: a real-life investigation (Exhibition hall) - Nov 15, 2019 - Abstract #EACS2019EACS_481;
Coadministration of carbamazepine or oxcarbazepine with atazanavir or dolutegravir should be avoided; for these two drugs, the adoption of TDM is strongly advisable, eventually combined with increased antiretroviral doses. [FIgure 1]
- | Botox (onabotulinumtoxin A) / GSK, Allergan, carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Review, Journal: Botulinum toxin type A as an alternative way to treat trigeminal neuralgia: a systematic review. (Pubmed Central) - Nov 14, 2019
[FIgure 1] BoNT-A therapy is a safe and effective method of treating trigeminal neuralgia.
- | carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Migraine Headache Prophylaxis. (Pubmed Central) - Nov 10, 2019
Acebutolol, oxcarbazepine, lamotrigine, and telmisartan are ineffective...The complementary treatments petasites, feverfew, magnesium, and riboflavin are probably effective. Nonpharmacologic therapies such as relaxation training, thermal biofeedback combined with relaxation training, electromyographic feedback, and cognitive behavior therapy also have good evidence to support their use in migraine prevention.
- | Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Clinical and genetic characteristics of focal epilepsy in children caused by GATOR1 complex gene variation (Pubmed Central) - Oct 30, 2019
During the follow-up period from 6 months to 2 years and 6 months, 6 cases had seizure control, 3 of them were controlled by oxcarbazepine...Most of the patients have hereditary loss-of-function variations. Approximately half of cases are drug-resistant epilepsy.
- | Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Pre- and Post-Treatment with Novel Antiepileptic Drug Oxcarbazepine Exerts Neuroprotective Effect in the Hippocampus in a Gerbil Model of Transient Global Cerebral Ischemia. (Pubmed Central) - Oct 20, 2019
In addition, pre- and post-treatment with oxcarbazepine (200 mg/kg) significantly ameliorated astrocytes and microglia activation in the ischemic cornu ammonis 1 subfield. In brief, our current results indicate that post-treatment as well as pre-treatment with 200 mg/kg of oxcarbazepine can protect neurons from ischemic insults via attenuation of the glia reaction.
- | carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Old Friends with New Faces: are Sodium Channel Blockers the Future of Adjunct Pain Medication Management? (Pubmed Central) - Oct 18, 2019
There is a disparity in evidence using sodium channel blockers for pain and this article highlights the potential that is currently underutilized. The authors believe this will catalyze interest for further studies.
- | carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Preclinical, Journal: Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs. (Pubmed Central) - Oct 18, 2019
Thus, the co-administration of AEDs with baicalein, (-)-epigallocatechin gallate, kaempferol, quercetin and silymarin should continue to be explored as adjuvant therapy for refractory epilepsy. List of chemical compounds studied in this article: Baicalein (PubChem CID: 5,281,605); Carbamazepine (PubChem CID: 2554); Carbamazepine 10,11-epoxide (PubChem CID: 2555); (-)-Epigallocatechin gallate (PubChem CID: 65064); Kaempferol (PubChem CID: 5280863); Lamotrigine (PubChem CID: 3878); Licarbazepine (PubChem CID: 114709); Oxcarbazepine (PubChem CID: 34312); Phenytoin (PubChem CID: 1775); Silymarin (PubChem CID: 7073228); Quercetin (PubChem CID: 5280343); Verapamil (PubChem CID: 2520).
- | Sebifin (terbinafine HCL) / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison to the USA FDA Label. (Pubmed Central) - Oct 18, 2019
In addition to sulfa drugs and beta-lactam antibiotics, quinolones was also a common cause. Only one acetaminophen-induced SJS was identified, while several medications (e.g., oseltamivir, terbinafine, isotretinoin, and sorafenib) labeled as carrying a risk of SJS/TEN by USFDA were not found to have caused any of the cases in the Asian countries investigated in this study.
- | Trileptal (oxcarbazepine) / Novartis
Preclinical, Journal, IO Biomarker: Oxcarbazepine causes neurocyte apoptosis and developing brain damage by triggering Bax/Bcl-2 signaling pathway mediated caspase 3 activation in neonatal rats. (Pubmed Central) - Oct 12, 2019
Only one acetaminophen-induced SJS was identified, while several medications (e.g., oseltamivir, terbinafine, isotretinoin, and sorafenib) labeled as carrying a risk of SJS/TEN by USFDA were not found to have caused any of the cases in the Asian countries investigated in this study. Oxcarbazepine at a concentration of 281.25 mg/kg or more causes neurocyte apoptosis and developing brain damage by triggering Bax/Bcl-2 signaling pathway mediated caspase 3 activation in neonatal rats.
- | carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Characterizing Treatment Utilization Patterns for Trigeminal Neuralgia in the United States. (Pubmed Central) - Oct 12, 2019
A high proportion of pharmacologically treated patients receive multiple treatment episodes, suggesting frequent therapy switching, perhaps due to suboptimal efficacy/tolerability. Our data suggest a high burden of illness associated with TN.
- | carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Review, Journal, Benefit-risk assessment: Refining the Benefit/Risk Profile of Anti-Epileptic Drugs in Headache Disorders. (Pubmed Central) - Oct 11, 2019
In particular, valproate, topiramate, carbamazepine, and phenytoin may lead to adverse outcomes for infants of exposed mothers. Valproate should not be given to women of childbearing potential for migraine prevention.
- | Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Bilateral adrenal hemorrhage revealed antiphospholipid syndrome in a male patient: benefit from comprehensive treatment. (Pubmed Central) - Oct 9, 2019
He remains well with adrenal lesions shrunken under the treatment of steroid, cyclophosphamide, hydroxychloroquine, warfarin, oxcarbazepine and entecavir. We present such a case to warning that the correct diagnosis of adrenal hemorrhage and appropriate treatment is needed, especially when complications set in.
- Trileptal (oxcarbazepine) / Novartis
Changes in background electroencephalographic activity in benign childhood Epilepsy with centrotemporal spikes after Oxcarbazepine treatment: a Standardized Low-Resolution Brain Electromagnetic Tomography (sLORETA) Study () - Oct 4, 2019 - Abstract #EPNS2019EPNS_4;
Our results indicate the involvement of the fronto-temporal and limbic cortices in BCECTS, and limbic lobe involvement, including the parahippocampal gyrus, was noted. In addition to evidence of the involvement of the fronto-temporal and limbic cortices in BCECTS, this study also found that an antiepileptic drug could reduce the delta frequency activity of the background EEG in these regions.
- | carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal, Adverse events: Adverse Pregnancy Outcomes Associated With Gestational Exposure to Antiepileptic Drugs. (Pubmed Central) - Oct 2, 2019
These caveats notwithstanding, guidance should err on the side of caution. Therefore, a conservative conclusion is that whereas analyses based on exposures in 2,000-4,000 pregnancies suggest that lamotrigine and carbamazepine are not associated with an increased risk of fetal loss, IUGR, and preterm birth, there is insufficient evidence to either firmly indict or firmly exonerate the other AEDs with regard to these outcomes.
- | carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Major Congenital Malformations Associated With Exposure to Antiepileptic Drugs During Pregnancy. (Pubmed Central) - Oct 2, 2019
In the AEDs associated with elevated risks, the extent to which the risks are due to confounding by indication is unknown. Importantly, confounding by indication notwithstanding, at conventional doses lamotrigine, levetiracetam, and oxcarbazepine, and possibly zonisamide and gabapentin, as well, are associated with absolute MCM risks that are no greater than the 2%-3% MCM risk in the general population.
- | Trileptal (oxcarbazepine) / Novartis
Le trileptal me causent un ventre gonflé alors que je n’ai pas de graisse de la fatigue aux muscles (Twitter) - Oct 1, 2019
- | carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Association Between Prenatal Valproate Exposure and Performance on Standardized Language and Mathematics Tests in School-aged Children. (Pubmed Central) - Sep 28, 2019
Maternal use of valproate was associated with a significant decrease in school performance in offspring compared with children unexposed to AEDs and children exposed to lamotrigine. Findings of this study further caution against the use of valproate among women of childbearing potential.