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51 Diseases |  |
15 Trials |
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15 Trials |  |
1554 News |  |
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- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Severe SCN8A-developmental and epileptic encephalopathy in a preterm infant presenting with malignant migrating focal seizures and early-onset movement disorder (ePoster) - Apr 9, 2020 - Abstract #EAN2020EAN_474;
This case is the preterm neonate with early and severe clinical phenotypes linked to the SCN8A gene mutation. A high index of suspicion for the genetic etiology of seizures in the preterm neonate must be kept in mind when confronted with intractable seizures and abnormal movements.
- Trileptal (oxcarbazepine) / Novartis
Isolated Hypoparathyroidism: A Rare Initial Manifestation of Hereditary Hemochromatosis (HH) (ENDOExpo, Booth 425) - Apr 1, 2020 - Abstract #ENDO2020ENDO_3726;
Case: A 27 year old male with history of seizure disorder, well controlled on Oxcarbazepine, referred for evaluation of chronic hypocalcemia...As HH is not uncommon in Caucasians, the work up for hemochromatosis as a possible cause of endocrinopathies should be kept in the differential diagnosis. It will help in early diagnosis & treatment which can reverse the effects of the disease leading to better outcomes.
- || carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Review, Journal: Long-Term Efficacy and Complications of Radiofrequency Thermocoagulation at Different Temperatures for the Treatment of Trigeminal Neuralgia. (Pubmed Central) - Mar 28, 2020
The therapeutic effects of pulsed radiofrequency (PRF) are controversial, whereas PRF (≤75°C) combined with RFT can improve long-term effects and decrease the incidence of complications. However, large-scale clinical trials are needed to verify the efficacy of the combination of PRF and RFT.
- | Phase classification, Adverse events: BEEP2b: Characterization of Epilepsy Patients BEEP 2b (clinicaltrials.gov) - Mar 27, 2020
P1, N=21, Completed, Sponsor: Food and Drug Administration (FDA)
However, large-scale clinical trials are needed to verify the efficacy of the combination of PRF and RFT. Phase classification: P4 --> P1
- Trileptal (oxcarbazepine) / Novartis
First case report of Levetiracetam Induced MCD: Unicorn in the the barn () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_362;
He was given IV methylprednisolone and started on PO prednisone daily...Steroids were stopped and patient was gradually tapered off from levetiracetam and started on oxcarbazepine... In patients with significant proteinuria, medications should be reviewed to exclude secondary MCD.
- || Clinical, Journal: Antiepileptic drugs associated with fractures in the elderly: A preliminary population-based study. (Pubmed Central) - Mar 26, 2020
CBZ, GBP, and OXC users have a significantly higher risk of fracture. Most recently-developed antiepileptic drugs are not associated with an increased risk of fracture in individuals aged ≥50 years.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, PK/PD data, Journal: Glomerular filtration rate is a major predictor of clearance of oxcarbazepine active metabolite in adult Chinese epileptic patients: A population pharmacokinetic analysis. (Pubmed Central) - Mar 24, 2020
GFR was first found an important covariate influencing MHD CL. A PPK model was established to estimate the individual MHD CL for adult patients taking OXC and may be applied for individualizing doses in the target population.
- || Trileptal (oxcarbazepine) / Novartis
@Novartis estoy solicitando en calidad de donación , trileptal de 300 mg ( compuesto oxcarbazepina) Se me hace imposible costear mi tratamiento . (Twitter) - Mar 23, 2020
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Catatonia Following Abrupt Cessation of Oxcarbazepine in a Patient With Prader-Willi Syndrome. (Pubmed Central) - Mar 20, 2020
A PPK model was established to estimate the individual MHD CL for adult patients taking OXC and may be applied for individualizing doses in the target population. No abstract available
- ||| carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Journal, Adverse events: Adverse Skin Reactions with Antiepileptic Drugs Using Korea Adverse Event Reporting System Database, 2008-2017. (Pubmed Central) - Mar 17, 2020
When hypersensitivity skin reactions occurred, aromatic AEDs were associated with 4 fold the risk of SJS/TEN/DRESS compared with non-aromatic AEDs. Our findings further emphasize that high risk AEDs should be prescribed under careful monitoring, and early detection and prompt interventions are needed to prevent severe complications.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Treatment of epilepsy in adults: Expert opinion in South Korea. (Pubmed Central) - Mar 13, 2020
Most of the survey results were in accordance with the US expert opinion survey published in 2016. This survey can assist clinicians in making clinical decisions when treating individual adult patients with epilepsy.
- | Trileptal (oxcarbazepine) / Novartis
Journal: Slow graded reintroduction of oxcarbazepine for delayed maculopapular eruption. (Pubmed Central) - Mar 12, 2020
This survey can assist clinicians in making clinical decisions when treating individual adult patients with epilepsy. No abstract available
- | carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Fast liquid chromatography-tandem mass spectrometry method for simultaneous determination of eight antiepileptic drugs and an active metabolite in human plasma using polarity switching and timed selected reaction monitoring. (Pubmed Central) - Mar 12, 2020
The method is accurate and precise, with intra-day and inter-day accuracy ranging from 93.7 to 104.7% and 94.1 to 107.1%, respectively, and intra-day and inter-day coefficient of variation (CV) ranging of 0.8-4.4% and 1.5-7.1%, respectively. Simple two-step protein precipitation and dilution sample preparation, high sensitivity, and high throughput make this method suitable for multi-drug monitoring for epileptic patients.
- | Trileptal (oxcarbazepine) / Novartis
Journal: Practice variation in anti-epileptic drug use for neonatal hypoxic-ischemic encephalopathy among regional NICUs. (Pubmed Central) - Mar 5, 2020
Amongst Children's Hospitals, there is marked ICV in AED utilization for neonatal HIE. Variation was particularly notable for HIE patients without electrographic seizures, indicating that this population may be an appropriate target for QI processes to harmonize neuromonitoring and AED practices across centers.
- || carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Effectiveness and safety of CyberKnife radiosurgery in treatment of trigeminalgia - experiences of Polish neurological and oncological centres. (Pubmed Central) - Mar 5, 2020
Radioablation of nerve V root in patients with neuralgia allows us to entirely stop antiepileptic therapy or reduce its doses, which in turn reduces the risk of potential side effects. CyberKnife can be a therapeutic option in those patients who have been offered ineffective therapies, or treatments with limited efficacy, and/or in older patients with comorbidities.
- | carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Preclinical, Journal: Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. (Pubmed Central) - Mar 4, 2020
In the chimney test, AND given at a dose enhancing the protective activity of carbamazepine, gabapentin, and phenobarbital (which alone was without effect on motor performance of mice) did not affect impairment of motor coordination produced by the antiepileptics. Our findings recommend further preclinical and clinical research on AND in respect of its use as adjuvant therapy in the management of epilepsy in men with deficiency of androgens.
- | Trileptal (oxcarbazepine) / Novartis
Preclinical, Journal, Combination therapy: Effect of gamma radiation on combination therapy of certain antiepileptic drugs in rats. (Pubmed Central) - Feb 25, 2020
The Results of the histopathological examination of liver, kidney, heart and brain tissues indicated coincidence with those recorded by the biochemical analysis. It seems promising to conclude that the exposure to υ-radiation intensified the deleterious and detrimental effect of dual treatment of LEV and OXC in rats.
- || carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Retrospective data, Journal: Patterns of opioid use in patients with trigeminal neuralgia undergoing neurosurgery. (Pubmed Central) - Feb 22, 2020
In spite of its high potential for abuse, opioid use, mostly as an adjunct to AEDs, is prevalent in patients with facial pain. Opportunities to curb opioid use in TN1 include earlier neurosurgical intervention.
- || olanzapine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Journal, Combination therapy: The unmasking of hidden severe hyponatremia after long-term combination therapy in exacerbated bipolar patients: a case series. (Pubmed Central) - Feb 22, 2020
Psychiatrists should consider that bipolar patients on long-term polypharmacotherapy may present a higher risk of severe hyponatremia not clinically detectable. Consequently, routine laboratory tests should be periodically repeated as they represent the only available tool to unmask such electrolyte imbalances.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Mood stabilizer prescription in patients affected by pathological addictions (All Screens in Poster Area) - Feb 20, 2020 - Abstract #EPA2020EPA_1015;
These type of drugs, according to recent scientific literature, are useful to treat patients affected by pathological addictions and personality disorders, in particular Cluster B personality disorders (sudden mood changes, behavioural and relational instability, impulsivity) A diagnosis of Cluster B Personality disorder or Bipolar disorder in mania phase will justify the prescription of a mood stabilizer (Valproic Acid 500-1500 mg/die), Oxcarbazepine 300-1800 mg/die, Topiramate 25-300 mg/die, Gabapentin 30-1800 mg/die). Further research is needed to reach new pharmachological strategies to overcome dual diagnosis.
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Atypical Trigeminal Neuralgia in The Setting of Recurrent Tongue Squamous Cell Cancer: A Case Report. () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_520;
Case Diagnosis : The patient had minimal pain relief with a regimen of hydromorphone and gabapentin...First line therapy is carbamazepine or oxcarbazepine...The mechanism of analgesia is unknown.Conclusions : Constant burning pain in multiple dermatomes can raise suspicion for atypical TN. Oropharyngeal tumors can be a possible cause of atypical TN.
- ||| Trileptal (oxcarbazepine) / Novartis
Clinical: Thanks! Oxcarbazepine. I know there's a small case series where they were accidentally co-prescribed and the pts did OK, but given the warning on the DTG label and big "Contraindicated" in Micromedex, thought not wise in this pt (now very stable) but w/hx dissem cocci, PML, etc. (Twitter) - Feb 9, 2020
- Trileptal (oxcarbazepine) / Novartis
Isolated Hypoparathyroidism: A Rare Initial Manifestation of Hereditary Hemochromatosis (HH) (ENDOExpo) - Feb 7, 2020 - Abstract #ENDO2020ENDO_1426;
Case: A 27 year old male with history of seizure disorder, well controlled on Oxcarbazepine, referred for evaluation of chronic hypocalcemia...As HH is not uncommon in Caucasians, the work up for hemochromatosis as a possible cause of endocrinopathies should be kept in the differential diagnosis. It will help in early diagnosis & treatment which can reverse the effects of the disease leading to better outcomes.
- | Fycompa (perampanel) / Eisai, Catalyst Pharma, Ospolot (sultiam) / AOP Orphan Pharma, Diacomit (stiripentol) / Biocodex, Meiji Seika
Trial completion date, Trial primary completion date: EPIPOP: Population Pharmacokinetics of Antiepileptic in Pediatrics (clinicaltrials.gov) - Feb 5, 2020
P=N/A, N=1000, Recruiting, Sponsor: Assistance Publique - H
It will help in early diagnosis & treatment which can reverse the effects of the disease leading to better outcomes. Trial completion date: Jun 2019 --> Jun 2022 | Trial primary completion date: Jun 2019 --> Jun 2022
- Treatment and Comorbidities of Trigeminal Neuralgia in Patients Diagnosed with Multiple Sclerosis at a Large Tertiary Medical Center () - Feb 3, 2020 - Abstract #AAN2020AAN_5242;
The prevalence of TN in this sample is consistent with prior large study that included participants from multiple centers and reported a low prevalence of TN in only 2% in MS patients. Our analysis shows high rates of comorbid fatigue, opioid prescribing and disability.
- | Journal: Eslicarbazepine acetate for neuropathic pain, headache, and cranial neuralgia: Evidence and experience. (Pubmed Central) - Jan 30, 2020
Evidence is insufficient to recommend ESL for neuropathic pain, headache, and cranial neuralgia. Most of the available evidence comes from open and observational studies with small sample sizes and no control group; however, their favourable results call for further studies on the usefulness of ESL for neuropathic pain, headache, and cranial neuralgia.
- ||| carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Review, Journal, Adverse events: Adverse outcomes during pregnancy and major congenital malformations in infants of patients with bipolar and schizoaffective disorders treated with antiepileptic drugs: A systematic review. (Pubmed Central) - Jan 21, 2020
LTG could be considered in this type of patients, given the low rate of adverse events. VPA and CBZ use should be avoided during pregnancy.
- Trileptal (oxcarbazepine) / Novartis
Reversible splenial lesion from abrupt withdrawal of Oxcarbazepine () - Jan 21, 2020 - Abstract #AAN2020AAN_3096;
It is important for the clinicians to be aware of this self-limiting condition to avoid further workup in the appropriate clinical context. To our knowledge this is the second case of RESLES associated with Oxcarbazepine in the literature.
- Fycompa (perampanel) / Eisai, carbamazepine / Generic mfg.
Effect of Concomitant Enzyme-Inducing Antiepileptic Drugs (EIAEDs) on the Efficacy and Safety of Adjunctive Perampanel 4 mg/day in Patients Aged ≥12 Years with Partial-Onset Seizures in Asia-Pacific Study 335 () - Jan 21, 2020 - Abstract #AAN2020AAN_3089;
P3
Based on this analysis, adjunctive perampanel 4 mg/day is effective in patients aged ≥12 years with refractory POS (with/without SGS), from the Asia-Pacific region, however, a higher dose may need to be considered in patients taking EIAEDs. Funding: Eisai Inc.
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Anti-Epileptic Drug Psychiatric Adverse Events in Focal Epilepsy-A Cohort Study () - Jan 21, 2020 - Abstract #AAN2020AAN_2073;
CBZ and LTG are more tolerable, psychiatrically. Several limitations of this study include: missing data and many confounding variables could affect depressive scores during the study period.
- lamotrigine liquid oral suspension / OWP Pharma, carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Prescribing Practices and Antiepileptic Drug Choice in Benign Epilepsy with Centrotemporal Spikes () - Jan 21, 2020 - Abstract #AAN2020AAN_2010;
Oxcarbazepine was the most commonly prescribed AED. Side effects were commonly reported in this cohort to all AEDs.
- Trileptal (oxcarbazepine) / Novartis
An Online Survey of Caregivers of Patients with SCN8A-related epilepsy () - Jan 21, 2020 - Abstract #AAN2020AAN_2006;
SCN8A-related epilepsy is a highly variable disorder. There is no current standard of care and existing therapies appear to have a high failure rate with the majority of patients experiencing continuing intractable seizures.
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Incidence of Anti-Epileptic Drug Related Falls () - Jan 21, 2020 - Abstract #AAN2020AAN_1745;
On univariate analysis, people with epilepsy treated with sodium channel blocking AEDs have a higher rate of falls in comparison to those treated with other treatments. We are currently in the process of extracting data to evaluate for confounders, perform multivariate analysis, review the cause of falls, and compare rates of injuries from falls including fractures
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Reducing Axonal Firing Induces Sustained Pain Remission and Axonal Regrowth in SCN9A Variant Small-fiber Neuropathy () - Jan 21, 2020 - Abstract #AAN2020AAN_1628;
In 2/2, blocking excitotoxic firing resolved pain, then permitted off-medication remissions. In 3/3, treatment delayed or reversed axonopathy, aiding remissions.
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Treatment of Paroxysmal Kinesigenic Dyskinesia With Use of Low Dose Oxcarbazepine: Experience at a Pediatric Tertiary Care Center. () - Jan 21, 2020 - Abstract #AAN2020AAN_1391;
In our cohort, oxcarbazepine was found to be effective and in doses much lower than those used in epilepsy without adverse effects. We propose a trial of oxcarbazepine for first line treatment of PKD.
- Briviact (brivaracetam) / UCB, carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Real-world Study of Brivaracetam in the US: an Interim Analysis () - Jan 21, 2020 - Abstract #AAN2020AAN_1230;
Determine whether BRV retention is associated with lifetime levetiracetam (LEV), lamotrigine (LTG), oxcarbazepine (OXC), or carbamazepine (CBZ) failure. This interim analysis indicates that BRV retention (a measure of effectiveness) at 3 and 6 months is similar between patients that previously failed LEV, LTG, OXC, and CBZ.
- pregabalin / Generic mfg., clobazam / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Efficacy of clobazam as an add-on therapy in brain tumor-related epilepsy. () - Jan 21, 2020 - Abstract #AAN2020AAN_889;
Our analysis shows clobazam to be an effective agent in BTRE. A comparative study between clobazam and other anti-epileptics in BTRE could be considered in the future.
- pregabalin / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Neurogenic Pain in Multiple Sclerosis: A Single Center Comprehensive Pain Assessment () - Jan 21, 2020 - Abstract #AAN2020AAN_541;
In addition, it has highlighted the high levels of pain, the use of AEDs, and that pain control is often suboptimal. Utilization of this form in follow up visits and tracking the data longitudinally creates a significant potential to optimize therapies for individual patients.
- carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
An Online Survey of Caregivers of Patients with KCNQ2 Developmental & Epileptic Encephalopathy (KCNQ2-DEE) () - Jan 21, 2020 - Abstract #AAN2020AAN_199;
There is a significant unmet medical need that requires better treatment options. Parents/caregivers are confident in recognizing seizures and most have been trained by medical personnel using video electroencephalography-documented seizures.
- || Potiga (retigabine) / Bausch Health, GSK, ezogabine (pediatric formulation of potiga) / Xenon, Trileptal (oxcarbazepine) / Novartis
PK/PD data, Journal: Study of gender-related pharmacokinetics of ezogabine in Egyptian volunteers by a validated LC-MS/MS bioanalytical method. (Pubmed Central) - Jan 21, 2020
These findings highlight the difference of ezogabine pharmacokinetics among populations. Further, gender-based ezogabine dose adjustment may be considered.
- | Trileptal (oxcarbazepine) / Novartis
Journal: LC-MS/MS based quantification of nine antiepileptic drugs from dried sample spots device. (Pubmed Central) - Jan 19, 2020
Moreover, in comparison to other alternative matrices, DPS allows the use of the same therapeutic ranges on which routine TDM is based. DPS on DSSD can thus be considered as a useful and cheap tool for the broader application of TDM.
- || Trileptal (oxcarbazepine) / Novartis
Epilepsi tedavisi için trileptal 600 mg hap bulamıyoruz. Hiçbir eczanede yok ithalatının durdurulduğu söyleniyor. Doktorumuz ise bu ilacı bırakmamız gerektiğini söylüyor @NovartisTurkiye @sagliklicozum (Twitter) - Jan 13, 2020
- | carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Teratogenicity of antiepileptic drugs. (Pubmed Central) - Jan 13, 2020
Although for MCMs the risk is primarily associated with the first trimester of gestation, influences on cognitive and behavioral development could extend throughout pregnancy. Available information now permits a more rational AED selection in women of childbearing potential, and evidence-based counseling on optimization of AED treatment before conception.
- | Journal: Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs. (Pubmed Central) - Jan 8, 2020
These results confirm the teratogenicity of valproic acid and topiramate. Because of the small numbers of cases and possible confounding, the other 3 signals should be interpreted with appropriate caution.
- | Decadron (dexamethasone) / Merck (MSD), Trileptal (oxcarbazepine) / Novartis
Journal: Abdominal epilepsia partialis continua in neurocysticercosis. (Pubmed Central) - Jan 4, 2020
The involvement of the primary motor cortex during ictal propagation may account for this curious phenomenon. This is the first report of abdominal EPC in a patient with inflammatory granuloma as a result of neurocysticercosis.
- | carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Advances and limits of two model species for ecotoxicological assessment of carbamazepine, two by-products and their mixture at environmental level in freshwater. (Pubmed Central) - Jan 2, 2020
Higher damages were detected when experiments were conducted at a temperature 3.5 °C above the optimum for Hydra growth, suggesting the relevance of taking into account possible ecotoxicological consequences of global warming. Our results confirmed the necessity of selecting sensitive organisms at different trophic levels to better assess ecotoxicity of pharmaceuticals and their mixture, especially at environmental levels and facing global changes.
- || carbamazepine / Generic mfg., duloxetine delayed release / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Anticonvulsive activity of duloxetine: A new choice for the epileptic patients with depression. (Pubmed Central) - Dec 26, 2019
Furthermore, pretreatment with thiosemicarbazide (an inhibitor of GABA synthesis enzyme) significantly increased the ED of duloxetine, suggesting the GABAergic system may contribute to the anticonvulsive action of duloxetine. These results support the use of duloxetine in the treatment of coexisting depression and epilepsy.
- | pregabalin / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Update on Antiepileptic Drugs 2019. (Pubmed Central) - Dec 20, 2019
These results support the use of duloxetine in the treatment of coexisting depression and epilepsy. Knowledge of AED pharmacokinetics, efficacy, and tolerability profiles facilitates the choice of appropriate AED therapy for patients with epilepsy.
- | Trileptal (oxcarbazepine) / Novartis
Journal: Development of an online solid-phase extraction-liquid chromatography-mass spectrometric analysis of oxcarbazepine and its active metabolite licarbazepine from plasma with a direct injection step. (Pubmed Central) - Dec 19, 2019
The total time for the one step online procedure was only 8 min. This method provides a direct and accurate measurement for therapeutic drug monitoring of oxcarbazepine and its active metabolite licarbazepine.
- lamotrigine liquid oral suspension / OWP Pharma, Trileptal (oxcarbazepine) / Novartis
Multinodular and Vacuolating Neuronal Tumors of the Temporal Lobe (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_1516;
She has rare breakthrough seizures on zonisamide...Also, it is unclear whether lesionectomy is sufficient, or if these patients require 2-step epilepsy surgery with invasive monitoring to define epileptic zone margins beyond radiographic margins. Larger multi-center case series would help to answer these questions.