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- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] A Case Report of an Epilepsy Patient in Bangladesh () - May 2, 2021 - Abstract #APA2021APA_1019;
After 2 two years he came to me & was happy to say that he had no convulsion till now. In conclusion, it is observed that oxcarbazepine is also effective in Generalized Tonic- Clonic Seizure as well as Partial Seizure.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Pedophilia in a Female Adolescent: A Diagnostic Dilemma () - May 2, 2021 - Abstract #APA2021APA_981;
This case contributes to the limited literature currently available on pedophilia in female adolescents. Clinicians should be aware that pedophilic behavior in this population may be related to co-occurring personality disorders or other conditions.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Jane Against the World: A Case of Bipolar I Disorder With Persecutory Delusions () - May 2, 2021 - Abstract #APA2021APA_619;
The achievement of emotion regulation with appropriate coping skills could potentially eliminate the need to pursue repetitive legal action and re-enact situations reminiscent of the past. The hypnotherapy can allow the safe remembrance of traumatic events and the integration of the events in a new context with the aim to reduce or eliminate projections onto situationally irrelevant individuals, and to provide emotional and psychological resolution.
- | Trileptal (oxcarbazepine) / Novartis
Journal: Electrophysiological features: The next precise step for SCN2A developmental epileptic encephalopathy. (Pubmed Central) - May 1, 2021
These findings provided the insights into the phenotype-genotype-funotype relationships of SCN2A-related DEE. The preliminary evaluation using the distinct hints of GOF and LOF helped plan the treatment, and the next precise step should be electrophysiological study.
- | Trileptal (oxcarbazepine) / Novartis
Journal: Hip Fracture Risk in Antiepileptic Drug Initiators and Non-Initiators with Alzheimer's Disease. (Pubmed Central) - Apr 30, 2021
These findings prompt careful consideration before prescribing AEDs to persons with AD. Persons with AD treated with antiepileptics should be carefully monitored due to their increased risk of falling and fractures.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal, Real-world evidence: Real-world effectiveness and tolerability of carbamazepine and oxcarbazepine in 354 patients with trigeminal neuralgia. (Pubmed Central) - Apr 28, 2021
Persons with AD treated with antiepileptics should be carefully monitored due to their increased risk of falling and fractures. Our real-world study show that carbamazepine and oxcarbazepine are effective in most patients with trigeminal neuralgia; nevertheless, side effects are still a major issue, particularly in patients with secondary and idiopathic trigeminal neuralgia.
- | Trileptal (oxcarbazepine) / Novartis
Journal: Accurate and simple determination of oxcarbazepine in human plasma and urine samples using switchable-hydrophilicity solvent in GC-MS. (Pubmed Central) - Apr 27, 2021
The percent relative standard deviation was calculated as 6.9% for six replicates measurements of the lowest concentration of the calibration plot. Satisfactory recovery results were calculated in the range of 97 - 100% for human plasma and urine samples spiked at five different concentrations.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Oxcarbazepine-Induced Hyponatremia: a case report (e-Poster Gallery) - Apr 26, 2021 - Abstract #EPA2021EPA_1848;
Periodic evaluations of serum sodium levels should be carried out. Cases of severe and/or symptomatic hyponatremia should be rapidly identified and treated in order to reduce the risk of developing brain injury and death.
- || Trileptal (oxcarbazepine) / Novartis
Review, Journal: Epileptogenesis and oncogenesis: An antineoplastic role for antiepileptic drugs in brain tumours? (Pubmed Central) - Apr 23, 2021
Therefore, a special focus will be provided on the anticancer effects of commonly prescribed AEDs (including levetiracetam, valproic acid, oxcarbazepine and others), with an overview of both preclinical and clinical data. Potential clinical applications of this finding are discussed.
- ||| oxcarbazepine / Generic mfg.
Journal, Adverse events: Drug-induced liver injury associated with antiseizure medications from the FDA Adverse Event Reporting System (FAERS). (Pubmed Central) - Apr 21, 2021
The majority of newer generation ASMs were not significantly associated with DILI. Future studies utilizing FAERS in conjunction with other data sources will be critical for the ongoing surveillance of DILI, particularly as newly marketed ASMs continue to enter into widespread clinical use.
- | Trileptal (oxcarbazepine) / Novartis
Journal, HEOR: Incidence rates of severe cutaneous adverse reactions due to antiseizure medication: A nationwide study using health claims data in Korea. (Pubmed Central) - Apr 20, 2021
This is the first study in Asia to determine the IRs of SCARs for various ASMs and compare the rates across drugs using a large dataset. The results from this study should help clinicians select safer ASMs in practice.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Association between antiseizure medication use and risk of urinary tract infection: A case-control study. (Pubmed Central) - Apr 20, 2021
Oxcarbazepine, topiramate, and gabapentin are also associated with increased risk of UTI, albeit to a less significant extent. In general, the immunological and hematological side effects of these molecules may play an important role in the development of UTI under anticonvulsant therapy.
- | Trileptal (oxcarbazepine) / Novartis
Journal: Potential induction of epileptic spasms by nonselective voltage-gated sodium channel blockade: Interaction with etiology. (Pubmed Central) - Apr 20, 2021
This study suggests that voltage-gated sodium channel blockade may induce epileptic spasms among children at risk on the basis of etiology. Further study is warranted to replicate these findings, ascertain possible drug- and dose-specific risks, and identify potential mechanisms of harm.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Retrospective data, Journal, Monotherapy: A meta-analysis: efficacy and safety of anti-epileptic drugs prescribed in Korea as monotherapy and adjunctive treatment for patients with focal epilepsy. (Pubmed Central) - Apr 17, 2021
In general, the 50% responder rate and treatment withdrawal rate tended to increase as the dose of the AEDs increased. The results from the current meta-analysis of the efficacy and safety data of various AEDs may provide insight into optimal pharmacotherapy for the treatment of focal epilepsy.
- || Trileptal (oxcarbazepine) / Novartis
Review, Journal: Expert consensus of the Chinese Association for the Study of Pain on ion channel drugs for neuropathic pain. (Pubmed Central) - Apr 15, 2021
Here, we reviewed the mechanism and characteristics of sodium and calcium channel drugs, and developed recommendations for the therapeutic principles and clinical practice for carbamazepine, oxcarbazepine, lidocaine, bulleyaconitine A, pregabalin, and gabapentin. We hope this guideline provides guidance to clinicians and patients on the use of ion channel drugs for the management of NPP.
- || Trileptal (oxcarbazepine) / Novartis, Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
Review, Journal: Carbamazepine-, Oxcarbazepine-, Eslicarbazepine-Associated Movement Disorder: A Literature Review. (Pubmed Central) - Apr 13, 2021
We believe that the study of CBZ contributes not only to the improvement of this drug but also to the knowledge about the drug-induced MD of OXC and ESL. In the literature, the description of the MD onset and recovery has been poorly reported.
- carbamazepine / Generic mfg.
[VIRTUAL] IMPACT of LONG-TERM Drug Monotherapy of Enzyme Inducing Drugs on SERUM Lipid Concentrations in Patients with Epilepsy- Implications to Ischemic Heart Disease () - Apr 12, 2021 - Abstract #ISPOR2021ISPOR_884;
The increase in the TC, TG, LDL-C, VLDL-C levels maybe associated with the liver enzyme induction. Carbamazepine & Oxcarbazepine exclusively increases the parameters to highly significant values whereas the non inducers did not show any increase.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal, Monotherapy: The effect of levetiracetam and oxcarbazepine monotherapy on thyroid hormones and bone metabolism in children with epilepsy: A prospective study. (Pubmed Central) - Apr 10, 2021
Our data show that levetiracetam treatment has no significant effect on thyroid function and bone metabolism in children with epilepsy. Long-term use of oxcarbazepine may reduce serum free thyroxine levels, resulting in impaired thyroid function, and may reduce serum calcium and increase parathyroid hormone levels, leading to bone metabolism disorders.
- |||| Trileptal (oxcarbazepine) / Novartis
Clinical, Adverse events: Mexiletine in the past, mainly for PHN in AIDS patients. Lots of side effects, don't use it. Have used IV ketamine in hospital, and occasionally po ketamine at home, but would try trileptal, lamictal prior to this. Have they tried lidoderm patches at night to most painful area? (Twitter) - Apr 7, 2021
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: An evaluation of medication appropriateness in pregnant women with coexisting illness in a tertiary care hospital. (Pubmed Central) - Apr 7, 2021
The study has also highlighted areas in drug prescribing where scope for improvement exists. Further, it can act as a benchmark for comparison of future studies to evaluate medication appropriateness in pregnant women.
- | Trileptal (oxcarbazepine) / Novartis
Journal: Molecular Recognition of the HPLC Whelk-O1 Selector towards the Conformational Enantiomers of Nevirapine and Oxcarbazepine. (Pubmed Central) - Apr 2, 2021
The values of the energetic barriers of interconversion indicate, for the single enantiomers of both compounds, half-lives sufficiently long enough to allow their separation only at critically sub-ambient temperatures. The chiral selector Whelk-O1 performed as a strongly selective discriminating agent both when applied as a chiral stationary phase (CSP) in HPLC and as CSA in NMR spectroscopy.
- ||| Trileptal (oxcarbazepine) / Novartis
My hyponatremia was due to being on a high dose of oxcarbazepine for seizures. (Twitter) - Mar 26, 2021
- | Trileptal (oxcarbazepine) / Novartis
Preclinical, Journal: Prenatal Exposure to Oxcarbazepine Increases Hippocampal Apoptosis in Rat Offspring. (Pubmed Central) - Mar 24, 2021
The results demonstrate that OXC administered during gestation is pro-apoptotic, alters the cytoarchitecture of the hippocampus, reduces litter size, and probably influences postnatal weight. We provide evidence of the proapoptotic effect of CBZ when administered early in gestation.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Trends in prescribing patterns of antiepileptic drugs among older adult inpatients in a Brazilian tertiary center. (Pubmed Central) - Mar 23, 2021
Phenytoin was the main suboptimal AED prescribed in our population, and convulsive SE and acute symptomatic seizures associated with some etiologies were independent risk factors for phenytoin prescription. These results suggest ongoing commitment to reducing the prescription of suboptimal AEDs, particularly phenytoin in Brazilian emergence rooms.
- ||| Tavegil (clemastine) / GSK, Trileptal (oxcarbazepine) / Novartis
Results: from short list of 55 treatments, recommended 4 treatments for testing in progressive MS: R-α-lipoic acid, metformin, combination treatment of R-α-lipoic acid and metformin, and niacin. Also Prioritised clemastine, lamotrigine, oxcarbazepine, nimodipine and flunarizine (Twitter) - Mar 22, 2021
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal, Monotherapy: Metabolic syndrome and obstructive sleep apnea syndrome among patients with epilepsy on monotherapy. (Pubmed Central) - Mar 18, 2021
These results suggest ongoing commitment to reducing the prescription of suboptimal AEDs, particularly phenytoin in Brazilian emergence rooms. Higher frequency of MetS and OSAS risk should be kept in mind on clinical follow-up of patients with epilepsy receiving monotherapy.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Neurogenic Pain in Multiple Sclerosis: A Single Center Comprehensive Pain Assessment () - Mar 18, 2021 - Abstract #AAN2021AAN_1658;
It also highlights the high levels of pain, use of AEDs, and that pain control is often suboptimal. Utilization of this form in follow up visits and tracking the data longitudinally creates a potential to optimize therapies for individuals.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Alternative Medications for Paroxysmal Kinesigenic Dyskinesia () - Mar 18, 2021 - Abstract #AAN2021AAN_1317;
In addition to carbamazepine, low doses of lamotrigine, oxcarbazepine, and phenytoin appear to be effective in PKD. However, levetiracetam and valproate may be ineffective options for PKD.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Bone density screening in epilepsy patients () - Mar 18, 2021 - Abstract #AAN2021AAN_882;
There is room for improvement for neurologists to screen high risk patients for osteoporosis and osteopenia as well as supplementing those high risk patients with calcium and Vitamin D. Education in identifying high risk patients will improve quality care in outpatient offices. A future project will investigate if there was better screening after educational intervention.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Women with Epilepsy and Postpartum Toxicity: A Retrospective Analysis () - Mar 18, 2021 - Abstract #AAN2021AAN_840;
Pregnant WWE on LTG may benefit from careful postpartum clinical management, LTG dose reduction, and education. Further research is needed to define the best clinical practices for ASD modifications during postpartum care.
- Xcopri (cenobamate) / SK Bio, Arvelle Therap, Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Dose Adjustments to Concomitant Antiseizure Medications: Post-hoc Analysis of a Phase 3, Open-Label Study of Cenobamate for Treatment of Uncontrolled Focal Seizures () - Mar 18, 2021 - Abstract #AAN2021AAN_768;
In this post-hoc analysis, reducing doses of concomitant ASMs, across a range of drugs with various mechanisms of action, led to fewer cenobamate discontinuations. Decreasing doses of phenytoin, clobazam, and lacosamide occurred early compared to most other ASMs.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Paraneoplastic Autoimmune Encephalitis Due To Amphiphysin Antibodies Manifesting As Focal Seizures With Convulsive Status Epilepticus In a Patient With Small Cell Lung Carcinoma () - Mar 18, 2021 - Abstract #AAN2021AAN_328;
Patient was started on levetiracetam and oxcarbazepine along with intravenous methylprednisolone 1 gram daily for 5 days with some improvement, however he continued to be encephalopathic and had persistence of seizures. To our knowledge, this is the first case of paraneoplastic autoimmune encephalitis associated with amphiphysin antibodies presenting with status epilepticus
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Anti LGI1 Encephalitis–A Retrospective Analysis of Clinical Features and Treatment Response () - Mar 18, 2021 - Abstract #AAN2021AAN_299;
Anti LGI1 encephalitis has a classic phenotype with FBDS, encephalopathy, episodic memory disturbance, hyponatremia and MRI showing limbic encephalitis. Anti LGI 1 encephalitis responds very well to first line immunotherapy
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Observational data, Journal: Gingival overgrowth induced by anticonvulsant drugs: A cross-sectional study on epileptic patients. (Pubmed Central) - Mar 16, 2021
In addition to phenytoin, also lamotrigine, oxcarbazepine, and phenobarbital were associated with increased prevalence of gingival overgrowth. In the management of epileptic patients, dentists should take into account different drugs as possible causes for gingival overgrowth and warn for possible alternatives.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] DRESS Syndrome with Life-Threatening Pneumonitis () - Mar 14, 2021 - Abstract #ATS2021ATS_3132;
She was previously started on oxcarbazepine as an outpatient for PNES 6-7 weeks prior to presentation...Withdrawal of the offending agent is key and may be adequate in mild cases. Here we describe the successful use of pulse dose steroids for management of severe lung involvement with pneumonitis associated with DRESS syndrome.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Review, Journal: Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention. (Pubmed Central) - Mar 2, 2021
The ASMs that yielded the most data (3 or more studies) were topiramate (TPM), followed by tiagabine (TGB), brivaracetam (BRV), and lamotrigine (LTG)...Promising results, but with data from only one or two studies, were seen with cenobamate (18-59% efficacy above placebo), lacosamide (45.1-78.7%), levetiracetam (40.1-60.3%), oxcarbazepine (58.5-81.5%), and gabapentin (50-53.8%)...This review was our attempt at filling a gap in the literature and calling for universal reporting of data specific to BTC seizure reduction in all future studies, preferably including specific reporting on nocturnal BTCS. This will help enable rational ASM selection to minimize BTC seizures and thereby decrease the risk of SUDEP.
- | Trileptal (oxcarbazepine) / Novartis
İlacım olan trileptal 300 mg-600 mg eczanelerde bulunmamakta zam geleceği için mi aylardır yok merak ediyorum? İlacımı nasıl temin edebilirim @NovartisTurkiye @drfahrettinkoca (Twitter) - Feb 26, 2021
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Nummular Headache responding to Oxcarbazepine: A Rare Case. (Pubmed Central) - Feb 25, 2021
This will help enable rational ASM selection to minimize BTC seizures and thereby decrease the risk of SUDEP. No abstract available
- | Trileptal (oxcarbazepine) / Novartis
Journal: [EXPRESS] Trigeminal Neuralgia: an overview from pathophysiology to pharmacological treatments. (Pubmed Central) - Feb 24, 2021
New pharmacological alternatives are being explored such as the active metabolite of OXC, eslicarbazepine, and the new Nav1.7 blocker vixotrigine. The pharmacological profiles of these drugs are addressed in this review.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study. (Pubmed Central) - Feb 16, 2021
However, this study corroborates the well-known association between maternal use of VPA during pregnancy and the risk of neurodevelopmental disorders in the offspring. Longer follow-up is necessary to confirm these findings.
- | Trileptal (oxcarbazepine) / Novartis, Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
Journal: DRESS with eslicarbazepine: The value of allergological exploration. (Pubmed Central) - Feb 16, 2021
Longer follow-up is necessary to confirm these findings. No abstract available
- || Trileptal (oxcarbazepine) / Novartis
@NovartisTurkiye neden biz epilepsi ilacını eczanelerde bulamıyoruz kesinlikle hiçbir trileptal ilacı ve muadili piyasada yok ne yapmamızı istiyorsunuz epilepsi hastası olanlara kriz geçirirken 3 kulhuvallah 1 elham mı okuyalım. @drfahrettinkoca (Twitter) - Feb 15, 2021
- | Trileptal (oxcarbazepine) / Novartis
Journal, Monotherapy: Evidence-based Anti-seizure Monotherapy in Newly Diagnosed Epilepsy: a New Approach. (Pubmed Central) - Feb 9, 2021
Lamotrigine and levetiracetam can be used as first choice for focal seizures and generalized epilepsy with GTC, suitable in all age-groups and for both men and women. Recommendations for GTC seizures have lower evidence than those for focal seizures.
- | Trileptal (oxcarbazepine) / Novartis
Journal: Complete loss of KCNA1 activity causes neonatal epileptic encephalopathy and dyskinesia. (Pubmed Central) - Feb 3, 2021
This newly identified variant is the first to be reported to act in a recessive mode of inheritance in KCNA1. These findings serve as a cautionary tale for the diagnosis of channelopathies, in which an unreported phenotypic presentation or mode of inheritance for the variant of interest can hinder the identification of causative variants and adequate treatment choice.
- | Trileptal (oxcarbazepine) / Novartis
@NovartisTurkiye trileptal 600 mg olayını nasıl çözeceğiz? (Twitter) - Jan 28, 2021
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones. (Pubmed Central) - Jan 21, 2021
Statistically significant associations were also found for prenatal exposure to other AEDs. These findings suggest that women of childbearing potential may need to be counseled on use of AEDs.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Utility of oxcarbazepine in the treatment of childhood and adolescent psychiatric symptoms. (Pubmed Central) - Jan 20, 2021
Oxcarbazepine may prove to be an appropriate alternative to antipsychotic and antidepressant medications for treating psychiatric symptoms in children and adolescents. In particular, it may be a more metabolically neutral psychotropic medication.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Diabetes mellitus risk for 102 drugs and drug combinations used in patients with bipolar disorder. (Pubmed Central) - Jan 13, 2021
There is an increased risk of diabetes mellitus associated with antipsychotic and psychotropic polypharmacy use in bipolar disorder. The evidence of a lower-than-baseline risk of DM with lamotrigine, oxcarbazepine, lithium, and bupropion monotherapy should be further investigated.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Sensory profiles in women with neuropathic pain after breast cancer surgery. (Pubmed Central) - Jan 13, 2021
Extensive sensory loss is characteristic for chronic post-surgical NP several years after treatment for breast cancer. These patients are unlikely to respond to Na-channel blockers.
- || Botox (onabotulinumtoxin A) / GSK, AbbVie, Trileptal (oxcarbazepine) / Novartis
Review, Journal: Trigeminal neuralgia : Modern diagnostic workup and treatment (Pubmed Central) - Jan 9, 2021
In patients insufficiently responding to medical treatment, there are neurosurgical treatment options giving very good results. The best long-term results have been described for microvascular decompression, but percutaneous and radiosurgical treatments also are good options, especially in patients with an increased surgical risk profile, in secondary trigeminal neuralgia, and in case of recurrence after microvascular decompression.