- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg., oxcarbazepine / Generic mfg.
Clinical, Journal, Real-world evidence: Outcome analysis of children with rolandic discharges on EEG: A real-world study. (Pubmed Central) - Jul 2, 2021
Those with multiple seizures can be treated with OXC, LEV, and VPA. OXC serves as the initial antiepileptic drug with a lower failure rate and significant efficacy.
- |||||||||| desloratadine / Generic mfg.
Clinical, Journal: Epileptic convulsions probably induced by desloratadine: a case report. (Pubmed Central) - Jun 30, 2021
At the follow-up, his father reported that the boy's memory was not as good as it had been previously. The convulsions continued after the withdrawal of desloratadine; therefore, the pathological mechanism of convulsion and the treatment plan need further research.
- |||||||||| oxcarbazepine / Generic mfg.
Clinical, Journal: EEG source estimation in a rare patient with cold-induced reflex epilepsy. (Pubmed Central) - Jun 30, 2021
Four antiepileptic drugs were taken during the drug treatment, and oxcarbazepine was the most effective at stopping the seizures...This study provides a valuable reference for clinical drug therapy and provides insights into the characteristics of the brain activities involved in cold-induced reflex epilepsy. [Published with video sequences].
- |||||||||| carbamazepine / Generic mfg.
Clinical, Retrospective data, Journal, Monotherapy: Effects of antiseizure monotherapy on visuospatial memory in pediatric age. (Pubmed Central) - Jun 30, 2021
Children with epilepsy may exhibit visuospatial memory impairment compared to their peer, that may be correlated to some features of the epilepsy itself and to the impairment of executive functions. Different antiseizure medications can affect visuospatial memory differently, so it is important monitoring this aspect in pediatric patients.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
Preclinical, Journal: Interactions among Lacosamide and Second-Generation Antiepileptic Drugs in the Tonic-Clonic Seizure Model in Mice. (Pubmed Central) - Jun 26, 2021
No adverse effects associated with triple ASM combinations, containing LCM and second-generation ASMs were observed in mice; (4) The combination of LCM + TPM + PGB was the most beneficial combination among the tested in this study, offering synergistic suppression of tonic-clonic seizures in mice subjected to the MES model. Both the isobolographic analysis and polygonogram method can be recommended for experimental epileptology when classifying interactions among the ASMs.
- |||||||||| phenytoin / Generic mfg., oxcarbazepine / Generic mfg.
Review, Journal: Personalized medicine in genetic epilepsies - possibilities, challenges, and new frontiers. (Pubmed Central) - Jun 22, 2021
Moving forward, the development of standardized outcome measures will be critical to successful precision medicine trials in complex and heterogeneous disorders like the epilepsies. Finally, we address new frontiers in epilepsy precision medicine, including the need to match the growing volume of genetic data with high-throughput functional assays to assess the functional consequences of genetic variants and the ability to extract clinical data at large scale from electronic medical records and apply quantitative methods based on standardized phenotyping language.
- |||||||||| lithium carbonate ER / Generic mfg., risperidone / Generic mfg., carbamazepine / Generic mfg.
Clinical, Review, Journal: Pharmacological prevention of mood episodes in women with bipolar disorder during the perinatal period: A systematic review of current literature. (Pubmed Central) - Jun 22, 2021
Finally, we address new frontiers in epilepsy precision medicine, including the need to match the growing volume of genetic data with high-throughput functional assays to assess the functional consequences of genetic variants and the ability to extract clinical data at large scale from electronic medical records and apply quantitative methods based on standardized phenotyping language. This review suggests that lithium, lamotrigine and olanzapine seem to be effective in preventing new mood episodes in patients with bipolar disorder during the perinatal period.
- |||||||||| carbamazepine / Generic mfg.
Journal, Video: Seizures in self-limited epilepsy with centrotemporal spikes: video-EEG documentation. (Pubmed Central) - Jun 22, 2021
This review suggests that lithium, lamotrigine and olanzapine seem to be effective in preventing new mood episodes in patients with bipolar disorder during the perinatal period. Although self-limited epilepsy with centrotemporal spikes is a very common epileptic syndrome, seizure visualization is very difficult, and these videos may bring didactical information for recognition of this usual presentation of benign childhood focal epilepsy.
- |||||||||| Clinical, Review, Journal: Prescription patterns of antiseizure drugs in Tuberous sclerosis complex (TSC)-associated epilepsy: a multicenter cohort study from Germany and review of the literature. (Pubmed Central) - Jun 22, 2021
We evaluated the pattern of routine ASD use and everolimus prescriptions based on a 2019 multicenter survey of 268 individuals with TSC-associated epilepsy...In this German sample, the majority of patients were treated with polytherapy, and lamotrigine (34.7%), valproate (32.8%), oxcarbazepine (28.7%), vigabatrin (19.0%), and levetiracetam (17.9%) were identified as the most-commonly used ASDs...The selection of ASDs for patients with TSC-associated epilepsy follows well-evaluated recommendations, including the guidelines regarding vigabatrin use in children. Several characteristics, such as the comparatively high frequency of valproate use and polytherapy, reflect the severity of TSC-associated epilepsy.
- |||||||||| pregabalin / Generic mfg., gabapentin / Generic mfg., carbamazepine / Generic mfg.
Review, Journal: Medical Management of Trigeminal Neuralgia. (Pubmed Central) - Jun 22, 2021
The first-line drugs for the treatment of TN are CBZ and oxcarbazepine (OXC)...The second-line drugs comprise lamotrigine, baclofen, gabapentin, and pregabalin used as monotherapy or in combination with CBZ/OXC...Newer drug like vixotrigine has shown good results in phase two randomized control trials...Combination therapy with second-line or other drugs may become necessary with poor response to CBZ/OXC, or if adverse events occur. Patients should be offered surgical options if there is poor response or tolerance to the medical therapy.
- |||||||||| carbamazepine / Generic mfg.
Clinical, Journal: The Efficacy and Safety of the Application of Pulsed Radiofrequency, Combined With Low-Temperature Continuous Radiofrequency, to the Gasserian Ganglion for the Treatment of Primary Trigeminal Neuralgia: Study Protocol for a Prospective, Open-Label, Parall. (Pubmed Central) - Jun 16, 2021
P=N/A
To our knowledge, this will be the first prospective, open-label, parallel, randomized controlled trial to compare the efficacy and safety of the application of high-voltage PRF, combined with and without low-temperature (60°C) CRF, for the patients who have failed to respond to pharmacologic treatments for primary trigeminal neuralgia. If proven effective, this will be an important, safe, minimally destructive alternative treatment modality for primary trigeminal neuralgia following an ineffective conservative treatment.
- |||||||||| carbamazepine / Generic mfg.
Journal: HLA Risk Alleles in Aromatic Antiepileptic Drug-Induced Maculopapular Exanthema. (Pubmed Central) - Jun 16, 2021
The multiplicative risk potential between HLA-A*24:02 and HLA-B*38:02 suggests that patients with two risk alleles are at greater risk than those with one risk allele. Inclusion of these HLA alleles in pre-treatment screening would help estimating the risk of AED-MPE.
- |||||||||| levetiracetam / Generic mfg., oxcarbazepine / Generic mfg.
Journal: Different experiences of two PRRT2-associated self-limited familial infantile epilepsy. (Pubmed Central) - Jun 9, 2021
Oxcarbazepine, which plays the mechanism of the sodium channel blockers, has a more significant effect than levetiracetam, which has no mechanism of the sodium channel blockers in self-limited familial infantile epilepsy. The PRRT2 gene of infantile epileptic patients with a family history of infantile convulsions or paroxysmal kinesigenic dyskinesia(PKD) could be detected by sanger sequencing and a biomarker to select antiepileptic drugs which play the mechanism of the sodium channel blockers could be utilized.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg., oxcarbazepine / Generic mfg.
[VIRTUAL] Differential diagnosis of seizures in Klinefelter’s syndrome (Room Seville) - May 30, 2021 - Abstract #EAN2021EAN_1541;
In our case, Kariotype and VEEG allowed successful diagnosis and treatment. We should be aware that focal signs of onset as well as MRI images, could induce misdiagnose and pharmacoresistance in GE.
- |||||||||| gabapentin / Generic mfg., carbamazepine / Generic mfg.
[VIRTUAL] Prenatal exposure to antiseizure medication and the full spectrum of diagnosed psychiatric disorders: A SCAN- AED study (Raum2) - May 30, 2021 - Abstract #EAN2021EAN_1023;
Compared with children of mothers with epilepsy who did not use ASM during pregnancy, we found an increased risk of psychiatric disorders with prenatal exposure to valproate (aHR=1.85, 95% CI: 1.62–2.13) and topiramate (aHR= 1.43, 1.00–2.05), but not with lamotrigine, levetiracetam, carbamazepine, oxcarbazepine, clonazepam, and gabapentin. In pregnant women with epilepsy, treatment with valproate and topiramate was associated with an increased risk of early-onset psychiatric disorders in the child.
- |||||||||| pregabalin / Generic mfg., gabapentin / Generic mfg., carbamazepine / Generic mfg.
Clinical, Review, Journal: Neurocognitive Effects of Antiseizure Medications in Children and Adolescents with Epilepsy. (Pubmed Central) - May 29, 2021
There is limited data for cannabidiol, clobazam, eslicarbazepine acetate, ethosuximide, rufinamide, vigabatrin and zonisamide, although the available evidence suggests these drugs are not associated with severe cognitive impairment. There was too little information to reach conclusions about the effects of brivaracetam, felbamate, gabapentin, pregabalin, retigabine, stiripentol or tiagabine.
- |||||||||| gabapentin / Generic mfg., carbamazepine / Generic mfg.
Clinical, Review, Journal: Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy. (Pubmed Central) - May 25, 2021
Carbamazepine clearance remains unchanged during pregnancy...Monitoring of clobazam, N-desmethylclobazam, gabapentin, lacosamide, perampanel, and zonisamide during and after pregnancy should be considered...If that is impossible, monitoring of both total and unbound valproate is recommended. More research is needed on the large number of unclear pregnancy-related effects on the pharmacokinetics of antiepileptic drugs.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Clinical, Journal: Treatment for the Benign Childhood Epilepsy With Centrotemporal Spikes: A Monocentric Study. (Pubmed Central) - May 25, 2021
Monotherapy, particularly levetiracetam seems to be a good first-line therapy which can help in normalizing the electroencephalograph and preventing cognitive decline. Polytherapy, mostly the administration of sodium valproate seems to relate with poor cognition, therefore, it is recommended to avoid it.
- |||||||||| oxcarbazepine / Generic mfg.
[VIRTUAL] Patient Stratification by Symptom and Sensory Profiling () - May 22, 2021 - Abstract #IASP2021IASP_36;
A recent phenotype-stratified study, e.g., found a better effect of oxcarbazepine in patients with peripheral neuropathic pain and the so-called irritable nociceptor phenotype with evoked pain and preserved small nerve fiber function, as determined by detailed quantitative sensory testing. Pain descriptors, individual pain processing characteristics, ability to engage pain inhibitory pathways and pain catastrophizing may also predict response to some treatments.
- |||||||||| sirolimus / Generic mfg.
Clinical, PK/PD data, Journal: Population Pharmacokinetics and Initial Dose Optimization of Sirolimus Improving Drug Blood Level for Seizure Control in Pediatric Patients With Tuberous Sclerosis Complex. (Pubmed Central) - May 20, 2021
With oxcarbazepine, for once-daily sirolimus regimen, the doses of 0.09, 0.08, 0.07, 0.06, 0.05, and 0.04 mg/kg/day were recommended for weights of 5-7.5, 7.5-10, 10-13.5, 13.5-20, 20-35, and 35-70 kg, respectively; for twice-daily sirolimus regimen, the doses of 0.06, 0.05, 0.04, and 0.03 were recommended for weights of 5-7, 7-14.5, 14.5-38, and 38-70 kg, respectively. The present study was the first to establish a population pharmacokinetic model of sirolimus improving drug blood level for seizure control in pediatric patients with TSC and recommend the initial dosage regimen.
- |||||||||| lithium carbonate ER / Generic mfg., lurasidone / Generic mfg.
[VIRTUAL] A Case of Parasomnia Overlap Disorder in a Patient on Lithium () - May 17, 2021 - Abstract #SLEEP2021SLEEP_1074;
His other medications included propranolol 40mg BID, lithium 900mg/1200mg, oxcarbazepine 600mg bid, lamictal 225mg bid, lurasidone 80mg qday, and benztropine 2mg bid...His workup and treatment is still ongoing, but he has continued on clonazepam 2mg but taken 2 hours earlier, and has started a new APAP. Because of the severity of his bipolar disorder (including severe suicidal ideation), he is not a candidate to tapering the lithium or to taking serotonergic antidepressants.
- |||||||||| Clinical, Journal: Roux-en-Y Gastric Bypass and Antipsychotic Therapeutic Drug Monitoring: Two Cases. (Pubmed Central) - May 15, 2021
Her medications prior and following the procedure include bupropion, fluvoxamine, lurasidone, methylphenidate, oxcarbazepine, and verapamil...Medications on admission included phenytoin, oxcarbazepine, risperidone, and venlafaxine...We describe the contributions of drug-drug interactions, medication release mechanisms, and food coadministration that may have affected our therapeutic drug monitoring. Our therapeutic drug monitoring results need to be replicated prior to use in the general population but suggest that oral extended-release drug formulations are particularly poor choices and that nonoral antipsychotic formulations may be preferred in some patients who have undergone RYBG.
- |||||||||| carbamazepine / Generic mfg., oxcarbazepine / Generic mfg.
Clinical, Retrospective data, Journal: A multicenter survey on access to care in Multiple Sclerosis-related trigeminal neuralgia. (Pubmed Central) - May 15, 2021
The most commonly available surgical procedure was microvascular decompression, but the frequency and types of surgical procedures available locally differed considerably throughout MS centers, and were unavailable in one quarter of them. This survey reveals some of the issues that could hamper an optimal patient management and underlines the need for a consensus on MS-related TN to support health-care professionals in their approach to this challenging condition and to facilitate the development of local guidelines aimed at ensuring equity in access to care and treatment optimization.
- |||||||||| carbamazepine / Generic mfg., oxcarbazepine / Generic mfg.
Clinical, Review, Journal: Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder. (Pubmed Central) - May 15, 2021
Especially with carbamazepine, tolerability issues and drug-drug interactions need to be kept in mind. Two of the medications discussed in this review, carbamazepine and oxcarbazepine, match Class A criteria according to the criteria proposed by Ketter and Calabrese, meaning acute antimanic efficacy, prevention of manic relapses, and not causing or worsening depression.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Drug-Drug Interactions Between Antiretrovirals and Carbamazepine/Oxcarbazepine: A Real-Life Investigation. (Pubmed Central) - May 6, 2021
Two of the medications discussed in this review, carbamazepine and oxcarbazepine, match Class A criteria according to the criteria proposed by Ketter and Calabrese, meaning acute antimanic efficacy, prevention of manic relapses, and not causing or worsening depression. Co-administration of carbamazepine or oxcarbazepine with atazanavir or dolutegravir should be avoided owing to the potential risk of virological failure; in case of these two drugs, the adoption of TDM is strongly advisable, eventually combining with increased antiretroviral doses.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Dose-Related Concentrations of Neuroactive/Psychoactive Drugs Expected in Blood of Children and Adolescents. (Pubmed Central) - May 6, 2021
Co-administration of carbamazepine or oxcarbazepine with atazanavir or dolutegravir should be avoided owing to the potential risk of virological failure; in case of these two drugs, the adoption of TDM is strongly advisable, eventually combining with increased antiretroviral doses. It was concluded that concentrations of neuroactive/psychoactive drugs to be expected in blood for a given dose may differ between adults and children or adolescents, most probably owing to age-dependent differences in the elimination of these drugs.
|
