- |||||||||| psilocybin (COMP360) / Compass Pathways
[VIRTUAL] The Effects of Psilocybin on Binge-Like Feeding Behaviour in Rats () - Sep 30, 2020 - Abstract #ACNP2020ACNP_64;
These results suggest that psilocybin treatment is able to modulate hyperphagia associated with access to a highly palatable food in rats. Future work should consider the involvement of different serotonin receptor subtypes in the expression of this response.
- |||||||||| NN1213 / Novo Nordisk, Intuniv (guanfacine XR) / Shionogi, Takeda
Trial primary completion date: ADAPT: ADHD Medication and Predictors of Treatment Outcome (clinicaltrials.gov) - Sep 7, 2020
P=N/A, N=2000, Enrolling by invitation,
Future work should consider the involvement of different serotonin receptor subtypes in the expression of this response. Trial primary completion date: Dec 2020 --> Apr 2021
- |||||||||| Vyvanse (lisdexamfetamine) / Shionogi, Takeda
Journal: Takotsubo Cardiomyopathy Due to Combined Use of Phentermine and Lisdexamfetamine. (Pubmed Central) - Aug 14, 2020
Caution with the use of sympathomimetic medications in post-menopausal women appears warranted. This is the first case report in the published English literature of medication-induced Takotsubo cardiomyopathy due to combination use of lisdexamfetamine and phentermine.This provides new information about iatrogenic causes of Takotsubo cardiomyopathy.Caution is indicated in the use of such medications, particularly in post-menopausal women, who are at higher risk.
- |||||||||| Vyvanse (lisdexamfetamine) / Shionogi, Takeda, dasotraline (SEP-225289) / Sumitomo Dainippon
Journal: Binge eating disorder revisited: what's new, what's different, what's next. (Pubmed Central) - Aug 4, 2020
Psychological treatments such as cognitive behavioral interventions have been recommended as first line and are supported by meta-analytic reviews; however, access to such treatments may be limited because of local availability and/or cost, and these treatments generally lead to little to no weight loss, although successfully eliminating binge eating can protect against future weight gain. Routine medication treatments for anxiety and depression do not necessarily ameliorate the symptoms of BED, but there are approved and emerging medication options, lisdexamfetamine and dasotraline, respectively, that specifically address the core drivers behind binge eating, namely obsessive thoughts and compulsive behaviors regarding food, resulting in marked decreases in binge eating behaviors as well as weight loss.
- |||||||||| NN1213 / Novo Nordisk, Intuniv (guanfacine XR) / Shionogi, Takeda
Trial completion date, Trial primary completion date: An fMRI Study of Stimulant vs. Non-Stimulant Treatment of ADHD (clinicaltrials.gov) - Jul 21, 2020
P=N/A, N=160, Recruiting,
Routine medication treatments for anxiety and depression do not necessarily ameliorate the symptoms of BED, but there are approved and emerging medication options, lisdexamfetamine and dasotraline, respectively, that specifically address the core drivers behind binge eating, namely obsessive thoughts and compulsive behaviors regarding food, resulting in marked decreases in binge eating behaviors as well as weight loss. Trial completion date: Jul 2020 --> Sep 2022 | Trial primary completion date: Jul 2020 --> Sep 2021
- |||||||||| methylphenidate tablet / Generic mfg.
[VIRTUAL] A Case of Spontaneous Coronary Artery Dissection Associated with the Use of Methylphenidate (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_4277;
Multiple injections of IV nitroglycerine, nitroprusside and adenosine were injected, however it did not show any improvement of the vessel...The second case was of a 22 year old male patient with ADHD being treated with lisdexamfetamine who developed SCAD...Cardiovascular safety of these agents has been a matter of concern over the last few years, following reports of sudden cardiac death in patients with ADHD. With the increased use of drugs for ADHD globally, the benefits of methylphenidate must be carefully weighed against the potential cardiovascular risks of this drug.
- |||||||||| lisdexamfetamine / Generic mfg.
Trial primary completion date: Lisdexamfetamine for Adults With Bulimia Nervosa (clinicaltrials.gov) - Jun 11, 2020
P2, N=30, Recruiting,
Lisdexamfetamine appears promising for the treatment of two of the most common symptoms of narcolepsy: excessive daytime sleepiness and weight gain. Trial primary completion date: Dec 2019 --> Dec 2020
- |||||||||| Vyvanse (lisdexamfetamine) / Shionogi, Takeda
Neurobiological Basis of Reinforcement-Based Decision Making in Adults With ADHD Treated With Lisdexamfetamine Dimesylate (Americas Hall I & II) - Apr 17, 2020 - Abstract #SOBP2020SOBP_1490;
The current study extends early reports on the brain effects of LDX by showing that LDX related increase of the responsiveness of the brain reward system is also positively related to symptom improvement. As such, these results support the hypothesis that stimulant treatment of ADHD can restore balance to dysfunction (e.g. hypoactivation) within motivation-reward related brain circuitry.
- |||||||||| methylphenidate tablet / Generic mfg., modafinil / Generic mfg.
[VIRTUAL] Emerging Stimulant Mortality Trends by Active Ingredient () - Apr 17, 2020 - Abstract #CPDD2020CPDD_267;
Misclassification of amphetamine and other stimulants could be present. While there has been a large push to increase regulations on opioids, there is a need to monitor the deaths resulting from stimulant overdose and improve reporting accuracy for stimulants.
- |||||||||| Vyvanse (lisdexamfetamine) / Shionogi, Takeda
Journal: Lisdexamfetamine Overdose. (Pubmed Central) - Apr 10, 2020
Learning Objectives: 1. No abstract available
- |||||||||| Vyvanse (lisdexamfetamine) / Shionogi, Takeda
Retrospective data, Journal: Lisdexamfetamine in Pediatric Binge Eating Disorder: A Retrospective Chart Review. (Pubmed Central) - Apr 10, 2020
No abstract available Lisdexamfetamine dimesylate may have clinical utility for BED in adolescents, but randomized, placebo-controlled studies of its efficacy, tolerability, and safety in this population are needed.
- |||||||||| Vyvanse (lisdexamfetamine) / Shionogi, Takeda
Preclinical, Journal: The effects of the prodrug Vyvanse on spatial working memory and adiposity in rats. (Pubmed Central) - Apr 3, 2020
When compared to placebo treatment, Vyvanse treatment produced no significant influence on food and water intake. It was concluded that Vyvanse treatment in rats can enhance spatial working memory, and decrease adiposity without suppressing normal appetite.
- |||||||||| methylphenidate tablet / Generic mfg.
A Case of Spontaneous Coronary Artery Dissection Associated with the Use of Methylphenidate (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area K) - Mar 15, 2020 - Abstract #ATS2020ATS_6731;
Multiple injections of IV nitroglycerine, nitroprusside and adenosine were injected, however it did not show any improvement of the vessel...The second case was of a 22 year old male patient with ADHD being treated with lisdexamfetamine who developed SCAD...Cardiovascular safety of these agents has been a matter of concern over the last few years, following reports of sudden cardiac death in patients with ADHD. With the increased use of drugs for ADHD globally, the benefits of methylphenidate must be carefully weighed against the potential cardiovascular risks of this drug.
- |||||||||| fluoxetine / Generic mfg.
Review, Journal: Progress in Developing Pharmacologic Agents to Treat Bulimia Nervosa. (Pubmed Central) - Mar 12, 2020
Preclinical models suggest that nociceptin receptor antagonists, the selective serotonin 5-HT2C receptor agonist lorcaserin, monoamine stabilizers, and selective orexin-1 receptor antagonists might be helpful...Future areas for research in the pharmacotherapy of BN are suggested. Importantly, until drugs are developed specifically for eating disorders, drugs developed for other conditions that are centrally acting and associated with beneficial psychotropic effects and/or reduced appetite or weight loss might be considered for repurposing in BN.
- |||||||||| methylphenidate tablet / Generic mfg.
[VIRTUAL] PRESCRIPTION DRUG MONITORING PROGRAM QUERYING RATES FOR PRESCRIPTION STIMULANTS () - Mar 8, 2020 - Abstract #ISPOR2020ISPOR_1422;
This cross-sectional study of prescription stimulants included patients of all ages who received at least one prescription for any of the following drug ingredients between October 1st, 2016 and December 31st, 2018: mixed amphetamine salts, amphetamine, methylphenidate, dextroamphetamine, dexmethylphenidate, or lisdexamfetamine. Despite the increased prevalence of stimulant misuse and diversion, healthcare providers in Texas still squander the potential of the PMP by not querying these medications in a consistent manner prior to prescribing or dispensing.
- |||||||||| methylphenidate tablet / Generic mfg.
[VIRTUAL] Review of psychotropic drugs approved for ADHD in Spain (All Screens in Poster Area) - Feb 20, 2020 - Abstract #EPA2020EPA_2207;
In Spain: - Within the group of psychostimulants the short-acting dextroamphetamine is not approved. -In the group of non-psychostimulants, long-acting clonidine is not approved.I Both drugs do not have an official data sheet and there is no evidence that they are pending approval by the Spanish agency of the drug for use in the treatment of ADHD.
- |||||||||| methylphenidate tablet / Generic mfg.
[VIRTUAL] Should we Stimulate Prescribing Stimulants? (Paris) - Feb 20, 2020 - Abstract #EPA2020EPA_120;
The treatment with stimulants are quite well tolerated in adults, but it is necessary to carry out a clinical examination prebious to prescription (blood tension, family history of sudden dead). Treatment with stimulants in adults with ADHD is associated with reductions in criminality, car accidents, suicide, depression and substance use disorder.
- |||||||||| methylphenidate tablet / Generic mfg., amphetamine/dextroamphetamine immediate release tablet / Generic mfg.
Review, Journal: Drugs for ADHD. (Pubmed Central) - Feb 15, 2020
Treatment with stimulants in adults with ADHD is associated with reductions in criminality, car accidents, suicide, depression and substance use disorder. No abstract available
- |||||||||| methylphenidate tablet / Generic mfg., Vyvanse (lisdexamfetamine) / Shionogi, Takeda, modafinil / Generic mfg.
Retrospective data, Review, Journal: Efficacy, Acceptability, and Tolerability of Lisdexamfetamine, Mixed Amphetamine Salts, Methylphenidate, and Modafinil in the Treatment of Attention-Deficit Hyperactivity Disorder in Adults: A Systematic Review and Meta-analysis. (Pubmed Central) - Feb 7, 2020
Moreover, VPFC-subcortical activation at baseline is a potential biomarker of LDX response. The results suggest that LDX has the largest effect size and has a promising potential for treating adults with ADHD.
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