lisdexamfetamine / Generic mfg. 
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 42 Diseases   12 Trials   12 Trials   1286 News 


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  • ||||||||||  Vyvanse (lisdexamfetamine) / Shionogi, Takeda
    Retrospective data, Review, Journal:  Binge Eating Disorder: A 5-Year Retrospective Study on Experimental Drugs. (Pubmed Central) -  Feb 7, 2021   
    However, due to a better understanding of BED psychopathology in the last decade, it is notorious that improvement of eating-related symptoms is not the only desired target. Due to the significant comorbidity percentage (30%), weight loss is highly pursued, as well as the amelioration of clinical parameters which highlights the importance of having new agents combining both objectives.
  • ||||||||||  lisdexamfetamine / Generic mfg.
    Trial completion date, Trial primary completion date:  Evaluation of the Effect and Safety of Lisdexamfetamine in Children Aged 6-12 With ADHD and Autism (clinicaltrials.gov) -  Feb 4, 2021   
    P4,  N=40, Recruiting, 
    Due to the significant comorbidity percentage (30%), weight loss is highly pursued, as well as the amelioration of clinical parameters which highlights the importance of having new agents combining both objectives. Trial completion date: Oct 2020 --> Oct 2021 | Trial primary completion date: Oct 2020 --> Oct 2021
  • ||||||||||  Vyvanse (lisdexamfetamine) / Shionogi, Takeda, Trintellix (vortioxetine) / Lundbeck, Takeda
    [VIRTUAL] Catecholamine-Producing Adrenal Schwannoma: A Rare Pheochromocytoma Imposter (On-Demand) -  Feb 2, 2021 - Abstract #ENDO2021ENDO_775;    
    A summary of published cases suggests that these are typically large tumors with possible female predominance. This case is the first to document levels of catecholamine metabolite concentrations in CPAS.
  • ||||||||||  Vyvanse (lisdexamfetamine) / Shionogi, Takeda
    Clinical, Journal:  Eating Disorders in Primary Care: Diagnosis and Management. (Pubmed Central) -  Feb 2, 2021   
    Remission is suggested by healthy biopsychosocial functioning, cognitive flexibility with eating, resolution of disordered behaviors and decision-making, and if applicable, restoration of weight and menses. Prevention should emphasize a positive focus on body image instead of a focus on weight or dieting.
  • ||||||||||  methylphenidate tablet / Generic mfg., atomoxetine / Generic mfg., amphetamine / Generic mfg.
    Review, Journal:  Cardiovascular Effects of ADHD Therapies: JACC Review Topic of the Week. (Pubmed Central) -  Jan 23, 2021   
    However, such reports did not imply causation, and there was a paucity of randomized trial evidence addressing long-term safety of ADHD medications, particularly among adults. Further studies are essential to clarify the risks and benefits of ADHD stimulant medications and to explore nonpharmacological options, including regular exercise and omega-3 fatty acids, which could be helpful for improving ADHD symptoms.
  • ||||||||||  methylphenidate tablet / Generic mfg.
    Clinical, Journal:  New-onset trichotillomania during treatment with stimulant drugs. About two pediatric clinical cases (Pubmed Central) -  Jan 15, 2021   
    In the literature we found some published cases of trichotillomania in relation to methylphenidate and dextroamphetamine. We present two cases of new-onset trichotillomania in children followed up in our center by attention deficit hyperactivity disorder and treated with psychostimulant drugs (methylphenidate and lisdexamfetamine), as a probable adverse effect of this treatment.
  • ||||||||||  methylphenidate tablet / Generic mfg.
    Retrospective data, Review, Journal:  Pharmacologic treatment of attention deficit hyperactivity disorder in adults: A systematic review and network meta-analysis. (Pubmed Central) -  Dec 15, 2020   
    Furthermore, the certainty of the evidence was very low to low for all outcomes, and there was limited reporting of long-term adverse events. As such, the choice between ADHD pharmacotherapies may depend on individual patient considerations, and future studies should assess the long-term effects of individual pharmacotherapies on patient-important outcomes, including quality of life, in robust blinded RCTs.
  • ||||||||||  lisdexamfetamine / Generic mfg.
    Trial completion date, Trial termination, Trial primary completion date:  Lisdexamfetamine for Adults With Bulimia Nervosa (clinicaltrials.gov) -  Nov 27, 2020   
    P2,  N=23, Terminated, 
    However, sufficient data was collected to fulfill the aims of the trial. Discontinuation is not related to the drug, its use, or adverse events.
  • ||||||||||  Vyvanse (lisdexamfetamine) / Shionogi, Takeda
    Clinical, Journal:  Acute Effects of Parent Stimulant Medication Versus Behavioral Parent Training on Mothers' ADHD, Parenting Behavior, and At-Risk Children. (Pubmed Central) -  Nov 25, 2020   
    P4
    In general, LDX was more effective at treating mothers' core ADHD symptoms, but both LDX and BPT improved mothers' emotion regulation, and BPT resulted in more consistent effects on parenting measures via both maternal report and direct observation. As most children remained significantly impaired after 8 weeks of unimodal treatment, combination treatment and/or longer treatment duration may be necessary to improve functioning of multiplex ADHD families.
  • ||||||||||  Vyvanse (lisdexamfetamine) / Shionogi, Takeda
    Journal:  Harmonized measurement and reporting of chiral amphetamine in the follow-up of ADHD treatment (Pubmed Central) -  Nov 25, 2020   
    Today in Sweden, however, only ADHD medications based on D-amphetamine (lisdexamphetamine lysate and dexamphetamine sulfate) are approved, so no L-amphetamine should be found in the samples provided treatment compliance...Since (supervised) urine sampling is sometimes considered sensitive to ADHD patients without any underlying drug problem, using oral fluid testing is a less invasive alternative and would facilitate sampling for both patients and healthcare professionals. However, an analytical disadvantage is that the amphetamine concentration is generally lower in oral fluid than in urine.
  • ||||||||||  lisdexamfetamine / Generic mfg., Daytrana (methylphenidate transdermal system) / Hisamitsu
    Trial completion date, Trial primary completion date:  Stimulant Effects on Disruptive Behavior (clinicaltrials.gov) -  Nov 20, 2020   
    P4,  N=10, Recruiting, 
    However, an analytical disadvantage is that the amphetamine concentration is generally lower in oral fluid than in urine. Trial completion date: Jan 2021 --> Jan 2025 | Trial primary completion date: Jan 2021 --> Jan 2025
  • ||||||||||  methylphenidate tablet / Generic mfg.
    Clinical, Review, Journal:  Amphetamine Use in the Elderly: A Systematic Review of the Literature. (Pubmed Central) -  Nov 7, 2020   
    Amphetamines and methylphenidate are probably effective strategies for different conditions in the elderly population. However, further studies are needed to provide more robust evidence on efficacy, dosage and safety for this population.
  • ||||||||||  methylphenidate tablet / Generic mfg., modafinil / Generic mfg.
    Retrospective data, Review, Journal:  Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis. (Pubmed Central) -  Nov 6, 2020   
    However, further studies are needed to provide more robust evidence on efficacy, dosage and safety for this population. Prescription psychostimulants, particularly prescription amphetamines given in robust doses, have a clinically significant beneficial effect to promote abstinence in the treatment of individuals with PSUD, specifically the population with cocaine use disorder.
  • ||||||||||  lisdexamfetamine / Generic mfg.
    Enrollment change, Trial termination:  Effects of LDX on Cognitive Processes and Appetite (clinicaltrials.gov) -  Nov 6, 2020   
    P=N/A,  N=22, Terminated, 
    Prescription psychostimulants, particularly prescription amphetamines given in robust doses, have a clinically significant beneficial effect to promote abstinence in the treatment of individuals with PSUD, specifically the population with cocaine use disorder. N=35 --> 22 | Recruiting --> Terminated; COVID-19
  • ||||||||||  Vyvanse (lisdexamfetamine) / Shionogi, Takeda
    Clinical, Journal:  Pharmacological properties and clinical effects of the ADHD drug, Lisdexamfetamine (Vyvanse capsules 20 mg and 30 mg) (Pubmed Central) -  Nov 3, 2020   
    The most of the adverse events with a higher incidence than in the placebo were mild, and long-term administration of the drug was not associated with an increase in the incidence of adverse events or the rate of treatment discontinuation. Lisdexamfetamine, which is designated as raw material for stimulants and therefore requires strict distribution control in Japan, is expected to be effective in the treatment of ADHD patients with inadequate responses to existing therapeutic agents.
  • ||||||||||  Vyvanse (lisdexamfetamine) / Shionogi, Takeda
    @venvanse4me corre aqui (Twitter) -  Nov 2, 2020   
  • ||||||||||  methylphenidate tablet / Generic mfg.
    Clinical, Review, Journal:  Pharmacotherapy of attention deficit hyperactivity disorder in adults (Pubmed Central) -  Nov 2, 2020   
    Importantly, an improvement in everyday functionality and quality of life under medication could also be shown in several studies. In this review the evidence for pharmacotherapy of ADHD and its implementation into treatment of adult patients is presented.
  • ||||||||||  amphetamine/dextroamphetamine immediate release tablet / Generic mfg.
    [VIRTUAL] Medication use evaluation of stimulants in the veteran population () -  Oct 8, 2020 - Abstract #ASHP2020ASHP_471;    
    The high percentage of mental health diagnoses among veterans receiving stimulant prescriptions raises concerns for potential exacerbation of psychiatric issues including PTSD, insomnia, anger/irritability, and anxiety. Polypharmacy with sleep aids and benzodiazepines was not uncommon among veterans receiving multiple daily doses of extended-release formulations, as needed, and before bed dosing of stimulants.