lignocaine / Generic mfg. 
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  • ||||||||||  lignocaine / Generic mfg.
    Enrollment closed, Trial primary completion date, Surgery:  Systemic and Local Levels of Lidocaine During Surgery for the Removal of Glioblastoma (clinicaltrials.gov) -  Jan 25, 2022   
    P1,  N=12, Active, not recruiting, 
    Modified Jaipur block is an effective and safe treatment for PHN. Recruiting --> Active, not recruiting | Trial primary completion date: Jul 2022 --> Dec 2021
  • ||||||||||  lignocaine / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date, Intubation:  Lignocaine Nebulization for Attenuation of Intubation Stress Response (clinicaltrials.gov) -  Jan 19, 2022   
    P4,  N=100, Recruiting, 
    Recruiting --> Active, not recruiting | Trial primary completion date: Jul 2022 --> Dec 2021 Not yet recruiting --> Recruiting | Trial completion date: Jul 2021 --> Feb 2022 | Trial primary completion date: Jun 2021 --> Feb 2022
  • ||||||||||  lignocaine / Generic mfg.
    Preclinical, Journal:  Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models. (Pubmed Central) -  Dec 16, 2021   
    Separate groups of experiments were conducted to demonstrate the involvement of somatic nerves in mediating histamine-induced responses after ipsilateral femoral and sciatic nerve sectioning (+NX) and lignocaine pre-treatment (+Ligno)...Paw edema was absent in both hind limbs indicating that the histamine did not reach the paws and did not spill out into the systemic circulation. +NX, +VagX, +Ligno attenuated histamine-induced cardiorespiratory responses significantly. These observations conclude that instillation of 10 mM of histamine produces optimal vasosensory reflex responses originating from the local vascular bed; afferents and efferents of which are mostly located in ipsilateral somatic and vagus nerves respectively.
  • ||||||||||  fentanyl citrate / Generic mfg., lignocaine / Generic mfg., methadone / Generic mfg.
    Analgesia Nociception Index to verify an epidural block in a patient addicted to opioids. Case Report ([VIRTUAL]) -  Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1148;    
    Case Report: A 42-year-old male, treated with methadone for addition to opioids...After the incision, a high hemodynamic response appeared without response to repeated doses of fentanyl, urapidil and epidural lignocaine boluses...ANI could predict hemodynamic reactivity, works better than hemodynamic variations to predict pain, can be useful to adjust opioid titration, to predict the origin of a hemodynamic event, and in the verification of peripheral regional blocks in patients undergoing general anesthesia.Learning points: ANI allows continuous pain measurement and can be useful in pain monitoring in complex patients with central or peripheral blocks, undergoing general anesthesia.-ANI can optimize and individualize analgesia, facilitating the use of closed loop systems. Postoperative subjetive pain shows a good correlation with the ANI value.-The ANI limitations are the pathologies and medications that interfere with the parasympathetic tone.
  • ||||||||||  Chirocaine (levobupivacaine) / Purdue, AbbVie
    COVID era : Regional anesthesia expertise, a boon or a necessity? ([VIRTUAL]) -  Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1057;    
    PEC-I and II and SA blocks purportedly block the medial and lateral pectoral nerves, T2–T6 intercostal nerves, and intercostobrachial and long thoracic nerves providing effective analgesia to the anterior chest wall and axilla.[1] They reduce postoperative opioid consumption and pain scores in comparison with paravertebral blockade following mastectomy.[2] Obesity is associated with higher block failure rate but effective analgesia and overall patient satisfaction is high, encouraging regional blocks[3].Learning points: Regional block is an indispensable tool for an anesthesiologist in COVID era. PEC1,2 and serratus anterior block solely provide good anesthesia and post op analgesia for breast surgeries
  • ||||||||||  epinephrine / Generic mfg., lignocaine / Generic mfg.
    Clinical, Review, Journal:  Case reports and narrative fallacies: the enigma of black swans in dermatology. (Pubmed Central) -  Nov 17, 2021   
    Awareness of the biases in case reports and the employment of metacognition may help us to avoid falling victim to narrative fallacies. Given the potential problems with this heuristic, Clinical and Experimental Dermatology (CED) utilizes case reports to further medical education and offer different clinical perspectives, rather than as a driver of medical knowledge.
  • ||||||||||  lignocaine / Generic mfg., dexmedetomidine / Generic mfg.
    New P4 trial, Surgery:  Dexmedetomidine in IVRA (clinicaltrials.gov) -  Nov 16, 2021   
    P4,  N=90, Completed, 
  • ||||||||||  lignocaine / Generic mfg.
    Trial completion, Enrollment change:  A Novel Approach in Reducing Dental Pain and Anxiety of Pediatric Patient During Local Anesthesia. (clinicaltrials.gov) -  Nov 11, 2021   
    P=N/A,  N=31, Completed, 
    However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline. Not yet recruiting --> Completed | N=60 --> 31
  • ||||||||||  ondansetron / Generic mfg.
    Preclinical, Journal:  Intra-arterial instillation of a nociceptive agent modulate cardiorespiratory parameters involving 5-HT3 and TRPV1 receptors in anesthetized rats. (Pubmed Central) -  Oct 28, 2021   
    Ropivacaine (0.75%) is a safe and an adrenaline-free local anesthetic option for posterior superior alveolar nerve block, which provides adequate intraoperative anesthesia and a stable hemodynamic profile for the removal of the maxillary third molar. In conclusion, presence of a nociceptive agent in the local segment of an artery evokes vasosensory reflex responses modulating CVR parameters involving TRPV1 and 5-HT3 receptors present on the perivascular sensory nerve terminals in anesthetized rats.
  • ||||||||||  ticagrelor / Generic mfg., lignocaine / Generic mfg.
    Journal:  Effects of lignocaine vs. opioids on antiplatelet activity of ticagrelor: the LOCAL trial. (Pubmed Central) -  Oct 28, 2021   
    Both drugs were well tolerated and effective with a high level of patient satisfaction for procedural analgesia. Routine procedural analgesia during percutaneous coronary intervention should be reconsidered and if performed, lignocaine is a beneficial alternative to fentanyl.