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7 Diseases |  |
124 Trials |
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124 Trials |  |
723 News |  |
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- ||| lignocaine / Generic mfg.
Because these ampoules r also meant for IM PCM injections and im pcm is painful. I think that could b the reason they might mix lignocaine with that. (Twitter) - Nov 2, 2022
- |||| paracetamol / Generic mfg., lignocaine / Generic mfg.
Clinical: Found paracetamol ampoules in our hospital supply. Just curious to know why does it contain Lignocaine while we have never seen lignocaine being mixed with PCM in the 100/50 ml bottles. Anyone in Med-twitter? #MedTwitter @AaronGoodman33 @BrownHospMed @Sthanu5 (Twitter) - Nov 2, 2022
- | digoxin / Generic mfg., furosemide / Generic mfg.
New trial: Intralesional Injection of Combined Digoxin and Furosemide Versus 5-Flurouracil in Plantar Warts (clinicaltrials.gov) - Oct 31, 2022
P=N/A, N=45, Not yet recruiting, Sponsor: Zagazig University
- || lignocaine / Generic mfg.
Clinical, Journal: A Prospective, Randomized, Double-Blind Study on the Efficacy of Different Modes of Topical Application of Nasal Anesthetics in the Diagnostic Nasal Endoscopy Procedure. (Pubmed Central) - Oct 28, 2022
Still, the packing of the nasal cavity with cotton pledgets is better when compared to spraying with 4% lignocaine-oxymetazoline. However, 4% lignocaine-oxymetazoline spray can be used during an emergency situation and with sensitive patients.
- | lignocaine / Generic mfg.
Journal: Evaluation of pulpal anesthesia and injection pain using IANB with pre-heated, buffered and conventional 2% lignocaine in teeth with symptomatic irreversible pulpitis-a randomized clinical study. (Pubmed Central) - Oct 26, 2022
Warm and buffered local anaesthetic (LA) were effective in reducing intraoperative discomfort than conventional LA. Preheated local anesthetics caused the least pain, followed by buffered local anesthetics, while conventional local anesthetics caused the most pain.
- | fentanyl citrate / Generic mfg., lignocaine / Generic mfg., dexmedetomidine / Generic mfg.
Journal: Awake videolaryngoscopic orotracheal intubation in patients with laryngeal tumour using the C-MAC D-Blade. (Pubmed Central) - Oct 25, 2022
Topicalisation of the oropharynx, tonsillar pillars and base of the tongue was done with lignocaine 10% spray...The VAS score for anaesthesiologist's ease and for patient's experience was 85.83 ± 7.20 and 86.66 ± 14.46, respectively. C-MAC VL D-blade-assisted awake intubation is an effective and safe method to manage the airway of patients with laryngeal tumour once adequate topicalisation is ensured before the procedure.
- | lignocaine / Generic mfg.
Journal: A randomized controlled trial to study the effect of intratracheal and intravenous lignocaine on airway and hemodynamic response during emergence and extubation following general anesthesia. (Pubmed Central) - Oct 25, 2022
IT lignocaine administered before extubation significantly attenuates post-extubation cough reflex than IV lignocaine. Both IT and IV lignocaine can effectively attenuate the airway and hemodynamic response to extubation.
- | Exparel (bupivacaine liposome injectable suspension) / Pacira
Trial completion date, Trial primary completion date, Biopsy: EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement (clinicaltrials.gov) - Oct 24, 2022
P2, N=80, Recruiting, Sponsor: M.D. Anderson Cancer Center
Both IT and IV lignocaine can effectively attenuate the airway and hemodynamic response to extubation. Trial completion date: Apr 2023 --> Jan 2026 | Trial primary completion date: Apr 2023 --> Jan 2026
- | dexamethasone / Generic mfg., lignocaine / Generic mfg.
Journal: Muscle Activity in Pre-Treatment and Post-Treatment Oral Submucous Fibrosis Patients: Electromyography Study. (Pubmed Central) - Oct 21, 2022
In OSMF patients, EMG may help in determining the involvement of the mastication and facial expression muscles. It can also be used as a diagnostic tool to assess the treatment outcome of muscle activity in OSMF patients.
- | fentanyl citrate / Generic mfg., lignocaine / Generic mfg.
Journal: A survey of Pediatric Flexible bronchoscopy in India. (Pubmed Central) - Oct 19, 2022
It can also be used as a diagnostic tool to assess the treatment outcome of muscle activity in OSMF patients. There is a considerable variation in pediatric flexible bronchoscopy practices across the country, highlighting the need to develop a uniform guideline.
- | ropivacaine / Generic mfg., lignocaine / Generic mfg.
Observational data, Journal: A Prospective Observational Study of the Efficacy of Combined Interscalene Block and Superficial Cervical Plexus Block using Peripheral Nerve Stimulator and Landmark-Based Technique, as a Sole Anesthetic for Surgeries on the Clavicle in the COVID-19 Pandemic. (Pubmed Central) - Oct 18, 2022
Pain relief lasted postoperatively for 5 ± 0.92 h. ISB combined with SCPB is safe and effective as a sole anesthetic for clavicular surgery. We successfully avoided the use of a general anesthetic in these patients during the COVID-19 pandemic and gave them a safe and effective alternative.
- || lignocaine / Generic mfg.
Clinical, Journal: A Comparative Study of Sodium Bicarbonate and Hyaluronidase on Pain Perception, Anesthesia, and Akinesia during Peribulbar Anesthesia for Cataract Surgery. (Pubmed Central) - Oct 18, 2022
An independent observer labeled two injections as A (hyaluronidase 1500 IU in 30 mL of lignocaine) and B (7.5% sodium bicarbonate 1 mL in 30 mL of lignocaine)...Grading of akinesia was better in Group 1. Sodium bicarbonate reduces pain on injection in peribulbar anesthesia and also results in a quicker onset of anesthesia.
- | lignocaine / Generic mfg.
Trial completion date, Trial primary completion date: Bilateral Sphenopalatine Ganglion Block With or Without Bilateral Greater Occipital Nerve Block for Treatment of Obstetric Post-Dural Puncture Headache (clinicaltrials.gov) - Oct 18, 2022
P=N/A, N=42, Completed, Sponsor: Zagazig University
Sodium bicarbonate reduces pain on injection in peribulbar anesthesia and also results in a quicker onset of anesthesia. Trial completion date: Jun 2021 --> Jun 2022 | Trial primary completion date: Jun 2021 --> May 2022
- | lignocaine / Generic mfg., dexmedetomidine / Generic mfg.
Journal: Comparative Analysis of Anaesthetic Efficacy of 2% Lignocaine With Dexmedetomidine as an Adjunct in Nerve Blocks for Dental Extractions: A Randomised Controlled Study. (Pubmed Central) - Oct 14, 2022
The hemodynamic parameters displayed no statistically significant difference from their baseline values in the two groups. Conclusion The study concluded that dexmedetomidine when administered with lignocaine in nerve blocks provides greater hemodynamic stability and increases its anesthetic and analgesic potency making it a suitable addition to the existing list of additives for local anesthetic agents.
- || lignocaine / Generic mfg.
Scorpion bites cause failure of central neuraxial blockade with lignocaine and bupivacaine . Na + receptor modifications, or something else contributing to it . Potential anticonvulsant lying somewhere there ? (Twitter) - Oct 14, 2022
- | tazarotene topical / Generic mfg.
New P1 trial, New P2/3 trial: Comparing the Efficacy of Topical Tazarotene Gel 0.1% v/s Microneedling in Atrophic Post Acne Scars (clinicaltrials.gov) - Oct 10, 2022
P1, N=202, Completed, Sponsor: Jinnah Postgraduate Medical Centre
- | fentanyl citrate / Generic mfg., lignocaine / Generic mfg.
Journal: Intravenous fentanyl vs. topical lignocaine for ProSeal™ laryngeal mask airway insertion with propofol induction. (Pubmed Central) - Oct 8, 2022
Success rate and optimal insertion condition at the first attempt, propofol requirement, blood pressure, adverse events and airway complications were comparable. Heart rate obtundation was less with topical lignocaine spray but remained within clinically acceptable values.
- ||| lignocaine / Generic mfg.
IVRA-Nostalgic to me. Last performed 5yrs ago. Have used only in UL. My technique- 1. Inflate the proximal tourniquet first. inject the Lidocaine. Inflate the distal tourniquet and deflate the proximal. I dont wait for tourniquet pain. 2. Always preservative free Lignocaine. (Twitter) - Oct 5, 2022
- | lignocaine / Generic mfg.
Journal: Effect of perioperative lignocaine infusion on postoperative pain relief for laparoscopic intraperitoneal onlay mesh repair: A randomized controlled study. (Pubmed Central) - Oct 5, 2022
Perioperative IV lignocaine infusion provided good pain relief, hemodynamic stability and decreased perioperative analgesic consumption. PONV incidence decreased along with an early return of bowel function, reduced LOS and improved patient satisfaction in patients undergoing laparoscopic IPOM surgery.
- | pentoxifylline / Generic mfg.
Journal: Pentoxifylline - A Novel Adjunct in the Management of Patients with Oral Submucous Fibrosis in Terai Population of Nepal: A Prospective Case Control Study. (Pubmed Central) - Oct 4, 2022
As far as improvement in tongue protrusion and cheek flexibility were concerned, the results were appreciating but statistically not significant (p=0.231) and (p=0.251) respectively. This study showed the effectiveness of pentoxifylline as an adjunct in the routine management of oral submucous fibrosis.
- | gabapentin / Generic mfg.
Journal: Effect of add-on Gabapentin premedication on hemodynamic response to skull pin insertion. (Pubmed Central) - Oct 1, 2022
The mean emergence time and sedation scores in both the groups were statistically similar (P = 0.060).The incidence of adverse effects like hypotension, bradycardia, nausea/vomiting, sedation or dry mouth were similar in both the groups. Add-on oral gabapentin premedication potentiates the effect of s.c. lignocaine Inj for suppression of skull pin insertion response.
- | lignocaine / Generic mfg.
Journal: Superior laryngeal nerve block with in-line lignocaine nebulization for awake extubation response. (Pubmed Central) - Oct 1, 2022
No cough was observed postextubation in 80% patients while 20% had mild Grade 1 cough. Superior laryngeal nerve block with in-line lignocaine nebulization for awake extubation is effective in curbing the haemodynamic and respiratory responses of extubation.
- | lignocaine / Generic mfg., levamisole / Generic mfg.
Journal: Rates, characteristics and toxicology of cocaine-related deaths in Australia, 2000-2021. (Pubmed Central) - Sep 29, 2022
There was a large increase in cocaine-related deaths across Australia from 2000 to 2021. This was accompanied by changes in case profiles, with histories of injecting drug use and substance use problems, as well as recent opioid use, becoming less prominent.
- | lignocaine / Generic mfg.
Journal: Tonsillectomy: Post-Operative Hemorrhage Reduction Strategy in Jos, North Central Nigeria. (Pubmed Central) - Sep 29, 2022
We established that blood loss was directly proportional to the tonsil size which brings new insights in PTH prevention. Our use of specific agents for GA, technique/ expertise, pillar infiltration with Lignocaine, 'awake extubation, liberal post-operative analgesia with systemic antibiotics may be responsible for the low incidence of PTH in this series.
- | lignocaine / Generic mfg.
New trial: PET/CT Guided Robotic Arm-assisted Pain Palliation in Chronic Nociceptive Low Backache (clinicaltrials.gov) - Sep 29, 2022
P=N/A, N=30, Recruiting, Sponsor: Postgraduate Institute of Medical Education and Research
- | lignocaine / Generic mfg.
New P2 trial, Intubation: Lignocaine Nebulization Versus Airway Block for Awake Nasal Fiberoptic Intubation in Patients With Head and Neck Burns. (clinicaltrials.gov) - Sep 22, 2022
P2, N=50, Recruiting, Sponsor: Ain Shams University
- pregabalin / Generic mfg., lignocaine / Generic mfg.
NEUROPATHIC PAIN POST NECK SURGERY - T2-T3 SYMPATHETIC BLOCK, A VALUABLE OPTION! (STATION 3) - Sep 21, 2022 - Abstract #WIP2022WIP_240;
Post laminectomy syndrome can have a varied presentation often leading to diagnostic dilemma. Neuropathic component of pain is often central and it's management requires multimodal approach.
- Qutenza (capsaicin) / Grunenthal, LTS Lohmann Therapy Systems
POCKET PAIN IN NEUROMODULATION, A THOUGH NUT TO CRACK (STATION 5) - Sep 21, 2022 - Abstract #WIP2022WIP_234;
The success rate for full recovery after surgical intervention was 47%. Conventional treatment of this pain remains challenging in neuromodulation patients.
- | lignocaine / Generic mfg.
Journal: Preoperative amylmetacresol and dichlorobenzyl alcohol with lignocaine lozenge reduces postoperative sore throat following general anaesthesia using supraglottic airway devices: A double-blinded, randomised, placebo-controlled trial. (Pubmed Central) - Sep 20, 2022
AMC/DCBA with lignocaine lozenges showed a relative risk reduction of 50% and a number needed to treat of 4 in reducing POST. AMC/DCBA with lignocaine lozenges administered before GA using SAD is a simple and safe method to reduce the incidence and severity of POST.
- || lignocaine / Generic mfg., dexmedetomidine / Generic mfg.
Clinical, Journal: Evaluation of lignocaine, dexmedetomidine, lignocaine-dexmedetomidine infusion on pain and quality of recovery for robotic abdominal hysterectomy: a prospective randomized controlled trial. (Pubmed Central) - Sep 14, 2022
AMC/DCBA with lignocaine lozenges administered before GA using SAD is a simple and safe method to reduce the incidence and severity of POST. Combined infusion of lignocaine and dexmedetomidine significantly decreased postoperative pain, fentanyl consumption, and improved quality of recovery score after surgery in patients undergoing Robotic abdominal hysterectomy.
- | lignocaine / Generic mfg.
Journal: Role of lignocaine in aerosol prevention during COVID-19: A new perspective. (Pubmed Central) - Sep 7, 2022
Combined infusion of lignocaine and dexmedetomidine significantly decreased postoperative pain, fentanyl consumption, and improved quality of recovery score after surgery in patients undergoing Robotic abdominal hysterectomy. No abstract available
- | 5-fluorouracil / Generic mfg., digoxin / Generic mfg., furosemide / Generic mfg.
New trial: Evaluation of the Efficacy of Intralesional Injection of Combined Digoxin and Furosemide Versus 5 - Fluorouracil in Treatment of Plantar Warts (clinicaltrials.gov) - Aug 30, 2022
P=N/A, N=60, Recruiting, Sponsor: Sohag University
- | lignocaine / Generic mfg.
Trial completion, Metastases: The Laterally Closed Tunnel Versus Modified Coronally Advanced Tunnel for Mandibular Anterior Gingival Recession Defects (clinicaltrials.gov) - Aug 30, 2022
P=N/A, N=26, Completed, Sponsor: Krishnadevaraya College of Dental Sciences & Hospital
No abstract available Enrolling by invitation --> Completed
- | lignocaine / Generic mfg.
Journal: Percutaneous distal clavicle excision for acromioclavicular joint arthritis: our experience and early results of a novel surgical technique. (Pubmed Central) - Aug 24, 2022
Enrolling by invitation --> Completed Our novel technique of percutaneous distal clavicle excision yields a 93.3% good-to-excellent results based on the Constant shoulder score and durable pain relief based on VAS at two years.
- || dexamethasone / Generic mfg., lignocaine / Generic mfg.
Awesome talk Sir! Would lignocaine with an additive like dexamethasone provide the same duration as bupivacaine in a block? I was thinking in terms of making it safer… (Twitter) - Aug 17, 2022
- | lignocaine / Generic mfg.
Trial completion date: Fluoroscopic Anterior Approach Versus Ultrasound Guided Superior Hypogastric Plexus Neurolysis in Cancer Pelvic Pain (clinicaltrials.gov) - Aug 16, 2022
P2, N=96, Recruiting, Sponsor: Mansoura University
Our novel technique of percutaneous distal clavicle excision yields a 93.3% good-to-excellent results based on the Constant shoulder score and durable pain relief based on VAS at two years. Trial completion date: May 2022 --> Sep 2022
- lignocaine / Generic mfg.
An Analysis Of Systemic Absorption Of Lidocaine From Continuous Fascial Plane Catheters (Virtual - Mobile App) - Aug 15, 2022 - Abstract #ASA2022ASA_698;
Pharmacokinetics and pharmacodynamics of lignocaine. World J Anes 2015;4(2):17-29.
- | lignocaine / Generic mfg.
Journal: The application of xylocaine 10% pump-spray to improve immediate post-adenotonsillectomy pain in children: A randomized controlled trial. (Pubmed Central) - Aug 14, 2022
Xylocaine also offers improved comfort with oral intake and decreases emergence delirium and need for rescue analgesia without any increase in post-operative complications. Local anesthesia may decrease costs and help to solve the conundrum of a painless adenotonsillectomy especially in resource-limited settings.
- | lignocaine / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Treatment of Renal Colic in the Emergency Departement (ED). (clinicaltrials.gov) - Aug 10, 2022
P2, N=600, Completed, Sponsor: University of Monastir
Local anesthesia may decrease costs and help to solve the conundrum of a painless adenotonsillectomy especially in resource-limited settings. Recruiting --> Completed | Trial completion date: Dec 2040 --> Jul 2022 | Trial primary completion date: Jan 2040 --> Jan 2022
- | lignocaine / Generic mfg.
New P1 trial: Lignocaine Versus Sodium Bicarbonate on Reducing Pain During Propofol Injection (clinicaltrials.gov) - Aug 4, 2022
P1, N=180, Recruiting, Sponsor: Cairo University
- | lignocaine / Generic mfg.
Journal: Effectiveness of Peripheral Median, Radial, and Ulnar Nerve Block at Wrist along with Intra-Articular Steroid Injection in Shoulder Joint in Management of Complex Regional Pain Syndrome of Upper Limb: 1-Week Follow-Up Study. (Pubmed Central) - Jul 30, 2022
Single-dose of the intra-articular shoulder joint injection and peripheral nerve blocks at the wrist with steroid, 2% lignocaine, and sterile water was given...The decrease in pain scores on VAS [mean difference -5.1 (CI -5.7, -4.5)] and reduction in hand swelling [mean difference -0.9 (CI -1.1, -0.7)] was also significant. Peripheral median, radial, and ulnar nerve block at wrist along with intra-articular steroid injection in the shoulder joint is an effective method of management of CRPS of the upper limb.
- | lignocaine / Generic mfg.
Preclinical, Journal: Effects of camphor and related compounds on slowly adapting mechanoreceptors in the rat sinus hair follicle. (Pubmed Central) - Jul 29, 2022
The depressant effects of the compounds appeared similar to those obtained using the local anaesthetic lignocaine...The results question whether the depressant effects of camphor and related compounds act through TRP channels. Perhaps the use of more selective blockers may reveal the molecular mechanisms through which these compounds act.
- | lignocaine / Generic mfg.
New P2 trial, Surgery: Comparison of Erector Spinae Block and Pecto-Intercostal Facial Block For Enhanced Recovery in Adult Cardiac Surgery (clinicaltrials.gov) - Jul 27, 2022
P2, N=60, Completed, Sponsor: Alexandria University
- || lignocaine / Generic mfg.
Could always do a proximal block with lignocaine and distal blocks with long acting LA https://t.co/yjQHRJzOhS (Twitter) - Jul 16, 2022
- ||| lignocaine / Generic mfg.
Study that @MKwesiKwofie posted makes me cautious (more than usual). If it was my arm, I'd always said I'd hope an anaesthetist would wait 3 more minutes to reduce potential risk of nerve injury, guess now it's wait 30 more? Or more lignocaine? (Twitter) - Jul 13, 2022
- | fentanyl citrate / Generic mfg., lignocaine / Generic mfg.
Journal: Randomized Comparative Study Between Bilateral Erector Spinae Plane Block and Transversus Abdominis Plane Block Under Ultrasound Guidance for Postoperative Analgesia After Total Abdominal Hysterectomy. (Pubmed Central) - Jun 25, 2022
Perhaps the use of more selective blockers may reveal the molecular mechanisms through which these compounds act. We conclude that ultrasound-guided ESP block provide better postoperative pain control and prolonged duration of analgesia with less tramadol consumption compared to ultrasound-guided TAP block in patients after total abdominal hysterectomy.
- || paracetamol / Generic mfg., lignocaine / Generic mfg.
Review, Journal: Opioid sparing strategies for perioperative pain management other than regional anaesthesia: A narrative review. (Pubmed Central) - Jun 22, 2022
On the other hand, non-pharmacological methods include techniques such as cognitive behavioral therapy, transcutaneous electrical nerve stimulation (TENS), electroanalgesia, acupuncture and hypnosis. However, research regarding the effect of these non-pharmacological techniques on pain management is still needed.
- | lignocaine/adrenaline / Generic mfg., lignocaine / Generic mfg., dexmedetomidine / Generic mfg.
Journal: A Comparative Study Evaluating the Efficacy of Lignocaine and Dexmedetomidine with Lignocaine and Adrenaline in Third Molar Surgery. (Pubmed Central) - Jun 22, 2022
There were no significant changes in the systolic blood pressure, diastolic blood pressure, and heart rate from the baseline following the injection of dexmedetomidine. The study demonstrated that the combination of dexmedetomidine with lignocaine enhances the local anesthetic potency of lignocaine without significant systemic effects when locally injected into oral mucosa.
- epinephrine / Generic mfg., lignocaine / Generic mfg.
Impact of an interdisciplinary process to increase utilization of neuraxial anesthesia for cesarean delivery: a retrospective database analysis (Poster eBoard 4) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1157;
It highlights the importance of proactive interdisciplinary labor management. Future investigations will investigate use of supplementary intravenous medications during CD.
- lignocaine / Generic mfg.
A comparative study of peripheral nerve stimulator guided supraclavicular brachial plexus block using bupivacaine- lignocaine v/s bupivacaine – lignocaine with buprenorphine (Virtual Platform - Poster section) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_489;
Mean time for rescue analgesia was also longer in group B as the duration of post operative analgesia was significantly prolonged in group B (p<0.01).Conclusion(s): Buprenorphine (0.3mg) when added to 0.5% Bupivacaine and 2% Lignocaine in Supraclavicular Brachial Plexus block prolongs the duration of sensory and motor block and thereby the duration of post- operative analgesia. Buprenorphine also improves the quality of blockade with no significant hemodynamic alterations and systemic side effects or complications.