- |||||||||| NN1213 / Novo Nordisk
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: ultradian: Dynamic Hormone Diagnostics in Endocrine Disease (clinicaltrials.gov) - Nov 15, 2023 P=N/A, N=528, Completed, Recruiting --> Completed Unknown status --> Completed | N=350 --> 528 | Trial completion date: Sep 2020 --> Nov 2023 | Trial primary completion date: Sep 2020 --> Nov 2023
- |||||||||| lignocaine / Generic mfg.
Journal: Topical anaesthesia and decongestion in rhinology. (Pubmed Central) - Nov 9, 2023 Topical agents used for sinonasal anaesthesia include lignocaine, tetracaine and cocaine...Indeed, some authors have argued that no anaesthetic is required at all for flexible nasendoscopy despite the apparent consensus that nasal instrumentation is generally uncomfortable, inferred by the persistence of ongoing research in this area. This review provides a practical summary of local anaesthetic and decongestant pharmacology as it relates to rhinologic practice and summarises the literature to date, with the goal of identifying current gaps in the literature and guiding future research efforts.
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Trial completion, Trial completion date: LAMA: Laser Ablation Versus Mechanochemical Ablation Trial (clinicaltrials.gov) - Sep 21, 2023 P4, N=150, Completed, In this study with a unique paired design to obviate individual differences in pain, local anaesthesia of the overlying skin led to a definite but modest reduction (approximately 15%) in pain felt by the patient during intraarticular injection. Active, not recruiting --> Completed | Trial completion date: Aug 2025 --> Sep 2023
- |||||||||| lignocaine / Generic mfg.
Enrollment open, Trial initiation date: The role of pressure on fluid irrigation on pain during flexible cystoscopy (EUDRACT) - Sep 1, 2023 P=N/A, N=190, Recruiting, Dexmedetomidine and lignocaine IV infusion demonstrated stable intraoperative haemodynamic stability, lower anaesthetic requirement, and better recovery profile than morphine without significant complications. Not yet recruiting --> Recruiting
- |||||||||| lignocaine / Generic mfg.
Trial completion date, Trial primary completion date: Hematoma Block Versus Bier Block for Closed Fracture Reduction (clinicaltrials.gov) - Aug 8, 2023 P1, N=500, Enrolling by invitation, Preoperative, SPGB administered by mucosal application of local anesthetic significantly reduced sevoflurane and fentanyl requirements, with stable hemodynamics, quicker recovery, and less emergence delirium in children undergoing palatoplasty. Trial completion date: Jul 2023 --> Jul 2025 | Trial primary completion date: Jul 2023 --> Jul 2025
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Intravenous Lignocaine Is Cost-effective To Prevent Emergence Delirium In Children After Ambulatory Procedures- A Randomized Controlled Study. (Exhibit Hall) - Jul 20, 2023 - Abstract #ASA2023ASA_485; We hypothesized that the neuronal inhibition of the subcortical centres by IV lignocaine can potentially counter the hyperexcitability and increased motor activity during waking up from sevoflurane, and thus, may offer promise to prevent ED in children.Aim: To study the efficacy of intravenous lignocaine to prevent emergence delirium in children who received sevoflurane anaesthesia for ambulatory procedures.After approval of Institute Ethics Committee, a prospective randomized, double-blind, placebo-controlled study was conducted in children aged 2-6 years of ASA physical status 1 and 2, scheduled for ambulatory ophthalmic procedures...The secondary outcome measures were initial PAED score in PACU, emergence and extubation times, and number of children who required fentanyl postop... End-operative administration of IV lignocaine is a cheap and efficacious medication to reduce emergence delirium significantly without excessive sedation in children who undergo ambulatory procedures.
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Journal: A Split-Mouth Clinical Comparative Evaluation of the Anesthetic Efficacy of Articaine and Lignocaine for Maxillary Bicuspids Extraction. (Pubmed Central) - Jul 11, 2023 The average onset time of anesthesia in Group A was 1.2 minutes and 2.55 minutes in Group B. In Group A, the average duration of anesthesia was 70 minutes, and 46.5 minutes in Group B. These parameters were statistically significant with a p-value of <0.05. Conclusion The study concluded that as an alternative to lignocaine, articaine could be used effectively for maxillary premolar extractions for orthodontic reasons obviating palatal injection which is very painful to the patient.
- |||||||||| clobetasol propionate topical / Generic mfg., methotrexate / Generic mfg., lignocaine / Generic mfg.
The use of intralesional hyaluronidase for scleroderma of the hands () - Jul 3, 2023 - Abstract #WCD2023WCD_6231; Dogs receiving retrobulbar BLD had a significantly lower intraoperative RR and isoflurane requirement and an increased incidence of intraoperative bradycardia and hypertension. OBSERVATIONS: A 76-year-old female with a 12-month history of limited scleroderma involving hands, legs, face, lungs and gastrointestinal tract, had treatments including topical clobetasol, topical betamethasone diproprionate and oral methotrexate, which improved the inflammation, but failed to improve her hand and finger function...Lignocaine 1% was injected locally or as a nerve block...This demonstrated objective and subjective improvements in our patient
- |||||||||| minoxidil / Generic mfg., lignocaine / Generic mfg.
Umbilical Cord Lining Mesenchymal Exosomes with Microneedling for Scalp Rejuvenation () - Jul 3, 2023 - Abstract #WCD2023WCD_5892; OBSERVATIONS: A 76-year-old female with a 12-month history of limited scleroderma involving hands, legs, face, lungs and gastrointestinal tract, had treatments including topical clobetasol, topical betamethasone diproprionate and oral methotrexate, which improved the inflammation, but failed to improve her hand and finger function...Lignocaine 1% was injected locally or as a nerve block...This demonstrated objective and subjective improvements in our patient Moreover, in-Vitro Trials of PTT-6
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Dermatitis and the Dangers of Fashion () - Jul 3, 2023 - Abstract #WCD2023WCD_5123; She was treated for erythrasma, folliculitis and fungal infections: clobetasone butyrate, fusidic acid & betamethasone valerate, topical erythromycin, emollients, topical terbinafine, oral lymecycline and oral erythromycin...Topical lignocaine was used to alleviate ongoing dysesthesia...The presentation is highly variable, and one must exercise a high index of suspicion. In the context of today
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Journal, Surgery: The Effects of Prophylactic Intravenous Lignocaine vs Vecuronium on Succinylcholine-Induced Fasciculation and Postoperative Myalgia in Patients Undergoing Elective Surgery at Debre Markos Comprehensive Specialized Hospital, Ethiopia, 2022: Prospective Cohort Study. (Pubmed Central) - Jun 30, 2023 The rate of mild-to-moderate postoperative myalgia in the vecuronium bromide group was 23.7%, 30.9%, and 16.4% in the first, 24th, and 48th hours, respectively (p-value 0.001), as opposed to 0%, 37.3%, and 9.1%, respectively (p-value 0.008) in the group receiving preservative-free 2% plain lignocaine hydrochloride. Pretreatment with 2% plain lignocaine that is preservative-free is more efficient than vecuronium bromide at reducing the frequency and intensity of postoperative succinylcholine-induced myalgia, whereas defasciculation dose of vecuronium was more effective prevention of succinylcholine-induced fasciculation.
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