- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, TriptoSar (triptolide) / Pierre Fabre
Biomarker, Journal: The Protective Roles of PPARα Activation in Triptolide-induced Liver Injury. (Pubmed Central) - Jun 27, 2019
In agreement with these observations in mice, the increase of long-chain acylcarnitines was observed in the serum of patients with cholestatic liver injury compared to heathy volunteers. These data demonstrated the role of PPARα and long-chain acylcarnitines in TP-induced hepatotoxicity, and suggest that modulation of PPARα may protect against drug-induced liver injury.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Clinical, Journal, Combination therapy: Efficacy and Safety of Policosanol Plus Fenofibrate Combination Therapy in Elderly Patients with Mixed Dyslipidemia: A Randomized, Controlled Clinical Study. (Pubmed Central) - Jun 26, 2019
Finally, all films achieved adequate mechanical properties, notwithstanding minor negative impact of SDIs. Policosanol + fenofibrate combination therapy significantly improved lipid parameters, arterial stiffness, and quality of life, with good tolerability.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Shortening of telomere length by metabolic factors in diabetes: protective effects of fenofibrate. (Pubmed Central) - Jun 17, 2019
However knockdown of Trf1 and Trf2 expression using specific siRNA did not prevent HO effects to lower RTL, thus implicating factors other than these Trfs alone in the fenofibrate protection against the HO induction of RTL lowering. These in vitro findings demonstrate that diabetic conditions can induce telomere shortening and that fenofibrate has protective effects on telomere attrition, through as yet undefined mechanisms.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Review, Journal: Management of diabetic dyslipidemia: An update. (Pubmed Central) - May 30, 2019
Attractive adjunctive therapies include Ezetimibe which is more cost effective and PCSK9 inhibitors which display potent LDL-cholesterol lowering and ASCVD event reduction. For severe hypertriglyceridemia, to avert the risk of pancreatitis, both fish oil and fenofibrate in concert with diet is the best strategy.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. (Pubmed Central) - May 29, 2019
Conversely, fatty acid transport protein Slc27a2 deficiency or co-administration of PPARA agonist fenofibrate (20 mg/kg) prevented zoledronate-induced lipid accumulation and kidney fibrosis in mice, indicating that over-expression of fatty acid transporter SLC27A2 and defective fatty acid β-oxidation following zoledronate treatments were significant factors contributing to its nephrotoxicity. These pharmacological and genetic studies provide an important mechanistic insight into zoledronate-associated kidney toxicity that will aid in development of therapeutic prevention and treatment options for this nephropathy.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Retrospective data, Journal: Metabolic Syndrome as a Predictor of Adrenal Functional Status: A Discriminant Multivariate Analysis Versus Logistic Regression Analysis. (Pubmed Central) - May 26, 2019
...Diabetes, impaired glucose tolerance, impaired fasting glucose, hypertension, body mass index, HDL-cholesterol levels, triglyceride levels, drug treatment for lipid disorder (statins, fenofibrate, and fish oils, alone or in combination), and maximal adrenal lesion diameter were used as discriminating covariates...MetS components exhibit a good predictive feature of hormonal hypersecretion in patients with adrenal tumors. Predictive functions may help in the search for an easy and generally available algorithm to validly predict the functional activity of adrenal masses.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential. (Pubmed Central) - May 13, 2019
In addition, one of the lead compounds, PP1, has improved water solubility and is significantly more stable when exposed to human blood in comparison to fenofibrate. Importantly, mice bearing large intracranial glioblastoma tumors demonstrated extensive areas of tumor cell death within the tumor mass following oral administration of PP1, and the treated mice did not show any major signs of distress, and accumulated PP1 at therapeutically relevant concentrations in several tissues, including brain and intracranial tumors.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Sleep Deprivation Induces Dry Eye Through Inhibition of PPARα Expression in Corneal Epithelium. (Pubmed Central) - May 13, 2019
In cultured corneal epithelial sheets, fenofibrate increased PPARα and TRPV6 gene and protein expression levels and restored microvilli morphology, whereas MK886 attenuated these changes. Sleep deprivation induces dry eye through abnormal SCEC microvilli morphology, which is caused by sequential downregulation of PPARα, TRPV6 expression, and Ezrin phosphorylation status in mice.
- |||||||||| micronized fenofibrate / Generic mfg., fenofibrate / Generic mfg.
Biomarker, Trial completion date: Fenofibrate in Type 2 Diabetes (clinicaltrials.gov) - May 9, 2019
P4, N=40, Recruiting,
Sleep deprivation induces dry eye through abnormal SCEC microvilli morphology, which is caused by sequential downregulation of PPARα, TRPV6 expression, and Ezrin phosphorylation status in mice. Trial completion date: Jun 2019 --> Nov 2019
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, Lacromid (bezafibrate) / Remedica
Journal: Temperature-Induced Surface Effects on Drug Nanosuspensions. (Pubmed Central) - Apr 30, 2019
The combined usage of analytical surface methods provides the basis for a better understanding of phenomena that take place on drug surfaces. Such understanding is of importance for pharmaceutical development to achieve desirable quality attributes of nanosuspensions.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: PPARα activation protects against cholestatic liver injury. (Pubmed Central) - Apr 26, 2019
In the end, the disrupted bile acid metabolism in the enterohepatic circulation and the enhanced oxidative stress and inflammation cytokines induced by ANIT exposure were significantly recovered with the improvement of β-FAO using fenofibrate treatment. These findings provide the rationale for the use of PPARα agonists as therapeutic alternatives for cholestatic liver damage.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, Parmodia (pemafibrate) / Kowa
Biomarker, Retrospective data, Review, Journal: Efficacy and safety of pemafibrate administration in patients with dyslipidemia: a systematic review and meta-analysis. (Pubmed Central) - Apr 26, 2019
In addition to the pemafibrate group having an improved lipid profile, which was comparable with that of the fenofibrate group, the AEs were significantly lower than in the fenofibrate group and an improvement in hepatobiliary enzyme activity was also recognized. However, we believe that actual clinical data as well as long-term efficacy and safety need to be investigated in the future.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Preclinical, Journal: Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice. (Pubmed Central) - Apr 24, 2019
Importantly, simultaneously reducing free fatty acid plasma levels in MIMIC mice with either the lipolysis inhibitor acipimox or the PPARα agonist fenofibrate partially protects against these metabolic alterations. Overall, our data highlight the central role of obesity-associated exosomal miRNAs in the etiopathogeny of glucose intolerance and dyslipidemia.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Preclinical, Journal, IO Biomarker: Beneficial effects of fenofibrate in pulmonary hypertension in rats. (Pubmed Central) - Apr 17, 2019
To conclude, FF prevented MCT-induced PH in rats by various mechanisms. It might be helpful in preventing PH in patients who are likely to develop PH.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Clinical, Review, Journal: Efficacy of fenofibrate for diabetic retinopathy: A systematic review protocol. (Pubmed Central) - Apr 16, 2019
Thus, fenofibrate may effectively prevent the development of fibrosis in renal allograft and improve the outcome. The findings of this systematic review will provide latest evidence of fenofibrate for patients with DRP.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Variability amongst urine toxicology amphetamine readings with concurrent administration of fenofibrate. (Pubmed Central) - Apr 11, 2019
Despite the relatively high prevalence of substance misuse in the population of psychiatric inpatients, there exists a need for increased vigilance towards the possibility of false-positive amphetamine results owing to likely cross-reactivity of fenofibrate with the test reagents. In cases where there is uncertainty when correlating clinically, or where false positives are suspected, gold-standard urine-sample analysis by mass spectrometry should be considered, particularly when the consequences for patients may include restrictive measures.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Anti-Hypertensive Action of Fenofibrate via UCP2 Upregulation Mediated by PPAR Activation in Baroreflex Afferent Pathway. (Pubmed Central) - Apr 11, 2019
Expression of the downstream signaling molecule of PPAR-α, the mitochondrial uncoupling protein 2 (UCP2), was up-regulated in the baroreflex afferent pathway under similar experimental conditions, along with amelioration of reduced superoxide dismutase activity and increased superoxide in HFD rats. These results suggest that chronic treatment with fenofibrate plays a crucial role in the neural control of blood pressure by improving baroreflex afferent function due at least partially to PPAR-mediated up-regulation of UCP2 expression and reduction of oxidative stress.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway. (Pubmed Central) - Apr 7, 2019
However, expression levels of the above markers were downregulated following fenofibrate intervention, blockage of integrin αVβ3 receptor, or ANGPTL3 siRNA interference. We identified fenofibrate exerts its protective effects by inhibiting ANGPTL3-induced apoptosis and inflammation in diabetic retinopathy, which is a novel mechanism.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Stilbenoids and cannabinoids from the leaves of Cannabis sativa f. sativa with potential reverse cholesterol transport activity. (Pubmed Central) - Apr 5, 2019
...They could improve [3H]-cholesterol efflux from Raw 264.7 macrophages to high density lipoproteins by enhancing the protein expression of ABCG1 and SR-B1, and HM1 and HM2 showed a significant difference compared with fenofibrate at 1.0 mg L-1...In conclusion, HM1 showed lower cytotoxicity and higher activity in improving the RCT-related protein expression. Our study suggests that it may be explored as a novel lipid-lowering drug and as a beneficial ingredient in health functional foods and pharmaceuticals.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Preclinical, Journal: Fenofibrate improves vascular endothelial function and contractility in diabetic mice. (Pubmed Central) - Apr 3, 2019
Finally, incubation with indomethacin in vitro improved aortic contractility in diabetic mice. Overall, our results show that fenofibrate treatment in diabetic mice normalizes endothelial function by balancing vascular reactivity via increasing NO production and suppressing the vasoconstrictor prostaglandin, suggesting mechanism of action of fenofibrate in mediating diabetic vascular complications.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: The effects of proprotein convertase subtilisin/kexin type 9 inhibitors on lipid metabolism and cardiovascular function. (Pubmed Central) - Mar 29, 2019
...Although there are several developed lipid lowering drugs such as statins and fenofibrates, many patients do not achieve an adequate response...This review comprehensively summarizes and discusses the effects of PCSK9 inhibitors on lipid metabolism and cardiovascular function comparatively with current lipid lowering drugs. This review also details essential information regarding the cardiovascular benefits of PCSK9 inhibition which could encourage further clinical studies.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Biomarker, Preclinical, Journal: Mate tea reduces high fat diet-induced liver and metabolic disorders in mice. (Pubmed Central) - Mar 28, 2019
...A separate group of mice was treated with fenofibrate as a positive control (a regular drug for lipid disorders)...Treatment also prevented adiponectin increase. Mate tea may be a good resource to reduce hepatic steatosis in the future since it has anti-diabetic, anti-inflammatory and antioxidant effects, which prevent the accumulation of fat in the liver.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Biomarker, Enrollment change: Lipid Biomarkers for Diabetic Heart Disease (clinicaltrials.gov) - Feb 26, 2019
P=N/A, N=70, Completed,
All these results indicated that the polymer/SLS interaction would affect the performance of SDs; hence, it was necessary to study their properties in the preformulation. N=114 --> 70
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