Triglide (fenofibrate) / Vectura, Shionogi 
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 25 Diseases   1 Trial   1 Trial   1402 News 


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  • ||||||||||  micronized fenofibrate / Generic mfg., fenofibrate / Generic mfg.
    Biomarker, Trial completion date, Trial primary completion date:  Fenofibrate in Type 2 Diabetes (clinicaltrials.gov) -  Nov 8, 2019   
    P4,  N=40, Recruiting, 
    Generic market competition and price negotiation by the UCS led to price reduction. Trial completion date: Dec 2019 --> Jun 2020 | Trial primary completion date: Oct 2019 --> Feb 2020
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi, allopurinol / Generic Mfg.
    Clinical, Journal:  Effect of fenofibrate on uric acid level in patients with gout. (Pubmed Central) -  Nov 4, 2019   
    There was no difference in the levels of creatinine, blood urea nitrogen, and aminotransferases between patients treated with and without fenofibrate. Fenofibrate additionally reduced uric acid levels without showing any change in the results of renal or liver function tests, suggesting that the addition of fenofibrate is a reasonable option for treating gout in patients having high triglyceride levels.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    Retrospective data, Review, Journal:  Impact of fibrates on circulating cystatin C levels: a systematic review and meta-analysis of clinical trials. (Pubmed Central) -  Oct 31, 2019   
    Its downregulation and the pathomorphologic features of steatohepatitis are prevented by co-administration of fenofibrate. The results suggest that fenofibrate treatment adversely affects cystatin C levels and might partially explain the limited efficacy of fenofibrate in reducing cardiovascular events.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    Biomarker, Journal:  Neuroprotective effects of PPARα in retinopathy of type 1 diabetes. (Pubmed Central) -  Oct 31, 2019   
    Two independent prospective clinical trials unexpectedly identified that the PPARα agonist fenofibrate had unprecedented therapeutic effects in DR, but gave little insight into the physiological and molecular mechanisms of action...Mitochondrially mediated apoptosis and oxidative stress secondary to mitochondrial dysfunction contribute to neurodegeneration in DR. Taken together, these findings identify a robust neuroprotective effect for PPARα in DR, which may be due to improved mitochondrial function and subsequent alleviation of energetic deficits, oxidative stress and mitochondrially mediated apoptosis.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    Journal:  Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis. (Pubmed Central) -  Oct 29, 2019   
    Hippocampal PPARα is a potential novel antidepressant target which mediates the antidepressant actions of fluoxetine in mice. Taken together, these findings strongly support a critical role of the AR-stimulated inflammatory response in the hepatic SAA production under stressful conditions, highlighting distinct AR type-specific mechanisms that regulate the hepatic synthesis of SAA1/2 and SAA3.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    Journal:  Fenofibrate and telmisartan in the management of abdominal aortic aneurysm. (Pubmed Central) -  Oct 29, 2019   
    Methods / Results Data from preclinical and human studies investigating the efficacy of fenofibrate and telmisartan to limit AAA growth is presented and provides the rationale for three current randomized controlled trials assessing these medications as potential interventions to limit aneurysm growth in AAA patients. Conclusions Fenofibrate and telmisartan have potential as repurposed medications to limit AAA growth and randomized trials for further assessment in AAA patients are ongoing.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    Journal:  Residual cardiovascular risk of lipid origin. Components and pathophysiological aspects. (Pubmed Central) -  Oct 27, 2019   
    The treatment of atherogenic dyslipidemia is based on weight loss and physical exercise. Regarding pharmacological treatment, we have no evidence of cardiovascular benefit with drugs aimed at lowering triglycerides and HDL-c, fenofibrate seems to be effective in situations of atherogenic dyslipidemia.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    Journal:  Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision. (Pubmed Central) -  Oct 24, 2019   
    Neurotrophic signaling was restored by exogenous cholesterol delivery. These findings implicate de novo lipogenesis in neurotrophin-dependent cell survival by maintaining retinal membrane configuration and lipid composition, and they suggest that ongoing lipogenesis may be required to prevent cell death in many forms of retinopathy.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    Preclinical, Journal:  Fenofibrate Ameliorates Oxidative Stress-Induced Retinal Microvascular Dysfunction in Diabetic Rats. (Pubmed Central) -  Oct 24, 2019   
    These findings implicate de novo lipogenesis in neurotrophin-dependent cell survival by maintaining retinal membrane configuration and lipid composition, and they suggest that ongoing lipogenesis may be required to prevent cell death in many forms of retinopathy. FA prevents the retinal microvascular dysfunction induced by diabetes, likely by restoring VEGF and P-p65 levels, and possibly by reducing oxidative stress and TXNIP expression.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    Journal:  Effect of molecular weight of hypromellose on mucin diffusion and oral absorption behavior of fenofibrate nanocrystal. (Pubmed Central) -  Oct 18, 2019   
    In vivo oral absorption studies showed rapid FFB absorption from FFB nanocrystal formulations using HPMC of low molecular weights. The present study revealed that the molecular weight of the dispersion stabilizer for drug nanocrystal formulation should be taken into consideration to achieve improved absorption of poorly water-soluble drugs after oral administration.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi, Ocaliva (obeticholic acid) / Intercept, Lacromid (bezafibrate) / Remedica
    ADDITIVE BENEFICIAL EFFECTS OF FIBRATES COMBINED WITH OBETICHOLIC ACID IN THE TREATMENT OF PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND INADEQUATE RESPONSE TO SECOND-LINE THERAPY (Hynes Convention Center, Hall B) -  Oct 15, 2019 - Abstract #AASLD2019AASLD_3159;    
    Patients with PBC treated for at least 12 weeks with, and with no intolerance to, a combination of OCA (5-10 mg/d), fibrates (bezafibrate 400 mg/d or fenofibrate 200 mg/d) and UDCA (13-15 mg/kg/d) because of a Paris-2 inadequate response to one second-line option were included in a multicenter retrospective cohort study. Triple therapy with fibrates, OCA, and UDCA improves biochemical liver tests and increases the rate of ALP normalization in patients with PBC and incomplete response to second-line therapy.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    Fibrate Therapy in Hemodialysis Patients: A Prospective 10-Year Study (Exhibit Hall, Walter E. Washington Convention Center) -  Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_3110;    
    Both drugs were well-tolerated and could be useful alternatives to statin in HD patients with hyperlipidemia. Funding Government Support - Non-U.S.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    AKI Associated with Fenofibrate (Exhibit Hall, Walter E. Washington Convention Center) -  Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_2329;    
    Conclusion Diabetes mellitus, hypertension, and concomitant use of RAS blocker have a statistically significant association with acute kidney injury by fenofibrate in our study. And patients with chronic kidney disease have greater risk in acute kidney injury by fenofibrate.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    Clinical, Journal:  Paradoxical fall in proteinuria during pregnancy in an LCAT-deficient patient-A case report. (Pubmed Central) -  Oct 8, 2019   
    Her pregnancy was complicated by rising triglyceride levels from the second trimester requiring treatment with omega-3 fatty acid and fenofibrate...She was diagnosed with pre-eclampsia and had an emergency cesarean section at 39 weeks delivering a healthy baby. This case adds to the knowledge of the pathophysiology of LCAT deficiency during pregnancy and will be useful in future patient management.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    Fibrates as Drugs with Senolytic and Autophagic Activity for Osteoarthritis Treatment (Hall B5) -  Oct 7, 2019 - Abstract #ACRARHP2019ACR_3177;    
    These results demonstrate that FDA-approved fibrate drugs targeting lipid metabolism protect against cartilage degeneration with aging and OA. Thus, these drugs could have immediate clinically utility for the treatment of OA and age-related cartilage degeneration.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi, Lacromid (bezafibrate) / Remedica
    HUMAN-DERIVED HEPATIC IN VITRO MODELS IDENTIFY DISTINCT ANTI-NASH EFFICACIES OF PPAR-AGONISTS (Hynes Convention Center, Hall B) -  Sep 29, 2019 - Abstract #AASLD2019AASLD_2005;    
    Elafibranor, followed by pioglitazone, showed the strongest anti-‘NASH’ activity in all in vitro systems tested. The effects were most firmly unveiled by PHH and stem cells and correspond to current clinical guidelines and patient trial results.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    IS THAT A HIGH OR LOW BLOOD SUGAR I AM FEELING? HYPOGLYCEMIC DIABETIC KETOACIDOSIS (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 5) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_3338;    
    Agents that activate PPARα might be developed for chemoprevention or treatment of colon cancer. He was discharged in stable condition with insulin and fenofibrate prescriptions the day after the presentation.DKA results from dehydration during a state of relative insulin deficiency, usually associated with high blood glucose and organic acid levels.The likely cause of hypoglycemia in this DKA patient may be starvation and home administration of a high dose of insulin...Hypoglycemic DKA, a paradoxical condition that requires prompt recognition and treatment.
  • ||||||||||  Triglide (fenofibrate) / Vectura, Shionogi
    EARLY THERAPEUTIC PLASMA EXCHANGE FOR TREATMENT OF RECURRENT TRIGLYCERIDE-INDUCED PANCREATITIS (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_2594;    
    Currently, he is managed on fenofibrate 200 mg and rosuvastatin 20 mg daily.In light of this case and drawing from literature, we propose that early TPE not only bears clinical significance in treatment of TGIP, but can also reduce overall costs compared to conventional medical therapy and associated costs, especially in terms of length of stay. This highlights the need for larger-scale studies to compare TPE versus standard medical therapy with direct comparison of mortality, complications, hospital length-of-stay and cost-effectiveness.