- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Solid-state analysis of amorphous solid dispersions: Why DSC and XRPD may not be regarded as stand-alone techniques. (Pubmed Central) - Jun 8, 2020
In addition, the limiting factors of (m)DSC were defined as the well-described heat-induced sample alteration upon heating, the interfering of residual solvent evaporation with other thermal events and the coinciding of enthalpy recovery with melting events. In all of these cases, the application of a single analytical technique would have led to erroneous conclusions, whilst the combination of (m)DSC and XRPD elucidated the true phases of the ASD.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, Ocaliva (obeticholic acid) / Intercept, Lacromid (bezafibrate) / Remedica
[VIRTUAL] Comparative effects of second-line therapy with obeticholic acid or fibrates in primary biliary cholangitis patients (Poster Area) - May 30, 2020 - Abstract #EASLILCI2020EASL-ILC-I-1023;
Second-line therapy with obeticholic acid or fibrates improve hepatic biochemistry with infrequent adverse events in patients with primary biliary cholangitis non- responders to UDCA. Fibrates are associated with higher decrease in alkaline phosphatase while obeticholic acid with higher transaminases improvement.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Preclinical, Journal: Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice. (Pubmed Central) - May 28, 2020
These data indicate that fenofibrate alters the pancreatic lipidome to a more anti-inflammatory and anti-apoptotic state. The beneficial effects on islet sympathetic nerve fibres and blood glucose homeostasis indicate that fenofibrate could be used as a therapeutic approach to improve blood glucose homeostasis and prevent diabetes-associated pathologies.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, Lacromid (bezafibrate) / Remedica
Clinical, Journal, Real-World Evidence: Delivering Benefits at Speed through Real-World Repurposing of Off-Patent Drugs: The COVID-19 Pandemic as a Case in Point. (Pubmed Central) - May 27, 2020
Clinical trials to assess efficacy are already underway for famotidine, dipyridamole, and sildenafil, and further trials of all these agents will be important in due course. These examples also reveal the unlimited opportunity to future-proof our healthcare systems by proactively mining, synthesizing, cataloging, and evaluating the off-label treatment opportunities of thousands of safe, well established, and affordable generic drugs.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Emerging Fixed-Dose Combination Treatments for Hyperlipidemia. (Pubmed Central) - May 19, 2020
Statins, ezetimibe, and fibrates have established their efficacy and safety in the treatment of hypercholesterolemia and hypertriglyceridemia...Moreover, complementary mechanisms of action of the combined hypolipidemic drugs may also provide additional benefits such as improvement in carbohydrate metabolism. As a result, fixed-dose combinations of hypolipidemic agents may provide an attractive option for the effective and safe management of hypercholesterolemia.
- |||||||||| simvastatin / Generic mfg., Triglide (fenofibrate) / Vectura, Shionogi, Nexletol (bempedoic acid) / Esperion Therap, Otsuka
Journal: Bempedoic acid (Nexletol) for lowering LDL-cholesterol. (Pubmed Central) - May 19, 2020
This evidence supports a previously unknown role for PPAR-α in behavior regulation and suggests new strategies for the treatment of neuropsychopathologies characterized by deficient neurosteroidogenesis, including posttraumatic stress disorder and major depressive disorder. No abstract available
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
[VIRTUAL] Optimal Utilisation of Statins in Real-World Settings () - May 18, 2020 - Abstract #ADA2020ADA_2361;
In the population between 40 and 75, a majority were on low-intensity statins with relatively very few progressing to moderate and high-intensity statin. The low uptake of statins and low dose use indicates the need to increase awareness of appropriate patient selection and correct dose of statin use in the clinic population including referral and tertiary care clinics.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, sirolimus / Generic mfg., Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo
First report of post‐transplant autoimmune hyperlipidaemia and treatment with rituximab () - May 14, 2020 - Abstract #BSH2020BSH_100;
Our case is the first reported case of such an autoimmune phenomenon post‐allograft. Further work is required to elucidate the frequency of such autoimmune phenomenon in the transplant population.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: PPARα suppresses Th17 cell differentiation through IL-6/STAT3 /RORγt pathway in experimental autoimmune myocarditis. (Pubmed Central) - May 11, 2020
Importantly, in vivo activation of PPARα ameliorates EAM by suppressing Th17 cell differentiation through reducing the expression of RORγt and phosphorylated STAT3 that are upregulated in EAM hearts. These results imply that PPARα suppresses Th17 cell differentiation through IL-6/STAT3/RORγt signaling pathway and suggest that PPARα may become a molecular target for treating autoimmune myocarditis.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Clinical, Journal: EFFICACY OF INSULIN, HEPARIN AND FENOFIBRATE COMBINATION TREATMENT IN SEVERE HYPERTRIGLYCERIDEMIA: DOUBLE CENTER EXPERIENCE. (Pubmed Central) - May 8, 2020
Potential toxicities related to insulin, heparin and fenofibrate combination treatment including hypoglycemia, hemorrhage, rise in creatine kinase levels, hepato - and nephrotoxicity were not observed. In this trial involving patients with SH, our data suggest that insulin, heparin and fenofibrate combination therapy was safe and effective.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Preclinical, Journal: Red cabbage (Brassica oleracea L.) extract reverses lipid oxidative stress in rats. (Pubmed Central) - May 1, 2020
Herein, we investigated the effect of red cabbage aqueous extract (RC) or fenofibrate (FF) in oxidative stress induced by Triton WR-1339 in rats...The TBARS and PC levels increased in the liver, cerebral cortex and hippocampus of hyperlipidemic rats were decreased by the treatments with RC or FF. These findings demonstrated that RC is a potential therapy to treat diseases not only involving dyslipidemic condition but also oxidative stress.
- |||||||||| Clinical, Journal: Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice. (Pubmed Central) - May 1, 2020
In terms of lipid-lowering medication, statins improve EF in subjects with DM, while data from short-term trials suggest that fenofibrate improves EF; ezetimibe also improves EF but further studies are required in people with DM...Clopidogrel improves EF, but more studies in subjects with DM are required...Phosphodiesterase type 5 inhibitors improve endothelial function locally in the corpus cavernosum. Finally, cilostazol exerts favorable effect on EF, nevertheless, more data in people with DM are required.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα. (Pubmed Central) - Apr 12, 2020
Moreover, formononetin attenuated ANIT-induced inflammatory response by inactivating JNK inflammation pathway in PPARα dependent manner. Taken together, our study demonstrates that formononetin ameliorates hepatic cholestasis by upregulating expression of SIRT1 and activating PPARα, which is an important anti-cholestatic mechanism of formononetin.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review. (Pubmed Central) - Apr 10, 2020
LPG treatment includes fenofibrate, antilipidemic drugs, steroids, LDL aphaeresis, plasma exchange, antiplatelet drugs, anticoagulants, urokinase, and renal transplantation. Recurrence in kidney graft suggests a pathogenic component(s) of extraglomerular humoral complex resulting from abnormal lipoprotein metabolism and presumably associated to ApoE.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Severe Combined Dyslipidemia With a Complex Genetic Basis. (Pubmed Central) - Apr 10, 2020
Conclusion. The multiple genetic "hits" on top of the classical APOE E2/E2 genotype likely explain the more severe dyslipidemia and refractory clinical phenotype.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Simultaneous co-assembly of fenofibrate and ketoprofen peptide for the dual-targeted treatment of nonalcoholic fatty liver disease (NAFLD). (Pubmed Central) - Apr 3, 2020
The multiple genetic "hits" on top of the classical APOE E2/E2 genotype likely explain the more severe dyslipidemia and refractory clinical phenotype. We have developed a co-assembled nanosystem based on fenofibrate and ketoprofen by tactfully utilizing their simultaneous benzophenone interaction, which greatly enhances the bioavailability of fenofibrate and plays a role in the dual-targeted treatment of NAFLD by reducing hepatic lipid accumulation and inflammatory responses.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, metformin / Generic mfg.
Asparaginase Induced Severe Hypertriglyceridemia Requiring Multiple Plasmapheresis Sessions (ENDOExpo) - Apr 1, 2020 - Abstract #ENDO2020ENDO_3803;
This side effect may be explained by multiple mechanisms including increased synthesis of very low-density lipoprotein (VLDL), decreased LPL activity as a result of an increase in the apoCIII/apoCII ratio, and increase in serum chylomicrons. Studies have shown patients who had extreme HTG had a higher frequency of ApoE3/4 phenotype, suggesting that screening for ApoE polymorphism may identify patients at high risk for developing this.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, cyclophosphamide intravenous / Generic mfg.
Preclinical, Journal: Nerolidol attenuates cyclophosphamide-induced cardiac inflammation, apoptosis and fibrosis in Swiss Albino mice. (Pubmed Central) - Mar 24, 2020
Histopathological analysis (H & E and Masson's trichrome staining); ultrastructural analysis (transmission electron microscopy) and immunohistochemical analysis were also performed along with mRNA expression and molecular docking to establish the cardioprotective potential of nerolidol. Nerolidol acted as a potent cardioprotective molecule and attenuated CP-induced cardiotoxicity.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Preclinical, Journal: Antiobesity, Regulation of Lipid Metabolism, and Attenuation of Liver Oxidative Stress Effects of Hydroxy-α-sanshool Isolated from Zanthoxylum bungeanum on High-Fat Diet-Induced Hyperlipidemic Rats. (Pubmed Central) - Mar 22, 2020
Wistar rats (n = 48) were randomly divided into six groups: (1) normal diet rats (ND), (2) high-fat diet- (HFD-) treated rats, (3) HFD+fenofibrate-treated rats (HFD+FNB), (4) HFD+low dose of HAS-treated rats (HFD+LD, 9 mg/kg), (5) HFD+middle dose of HAS-treated rats (HFD+MD, 18 mg/kg), and (6) HFD+high dose of HAS-treated rats (HFD+HD, 36 mg/kg)...Immunohistochemistry and Western blotting indicated that HAS stimulation increased the levels of PPARγ and APOE in the liver, as a stress response of the body defense system. These results revealed that HAS exerts antiobesity and hypolipidemic activities in HFD rats by reducing liver oxidative stress and thus could be considered as a potential candidate drug to cure or prevent obesity and hyperlipidemia.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: A Protective Effect of PPARα in Endothelial Progenitor Cells Through Regulating Metabolism. (Pubmed Central) - Mar 19, 2020
Fenofibrate, an agonist of peroxisome proliferator-activated receptor α (PPARα), has shown therapeutic effects on DR in both patients and diabetic animal models...These findings suggest that PPARα is an endogenous regulator of ECFC/CAC metabolism and cell fate. Diabetes-induced down-regulation of PPARα contributes to ECFC/CAC deficiency and retinal vascular degeneration in DR.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Therapeutic plasma exchange for the management of severe gestational hypertriglyceridaemic pancreatitis due to lipoprotein lipase mutation. (Pubmed Central) - Mar 14, 2020
This was initially managed with fasting and insulin infusion and she was commenced on conventional interventions to lower triglycerides, including a fat-restricted diet, heparin, marine oil and gemfibrozil...Fenofibrate and rosuvastatin was commenced to manage her hypertriglyceridaemia postpartum and the importance of preconception counselling for future pregnancies was discussed...Therapeutic plasma exchange (TPE) is an effective intervention for the management of severe gestational hypertriglyceridaemia and should be considered in cases where there is an underlying LPL defect. Preconception counselling and discussion regarding contraception is of paramount importance in women with familial hypertriglyceridaemia.
- |||||||||| micronized fenofibrate / Generic mfg., fenofibrate / Generic mfg.
Biomarker, Trial completion date, Trial primary completion date: Fenofibrate in Type 2 Diabetes (clinicaltrials.gov) - Mar 6, 2020
P4, N=40, Recruiting,
Preconception counselling and discussion regarding contraception is of paramount importance in women with familial hypertriglyceridaemia. Trial completion date: Jun 2020 --> Sep 2020 | Trial primary completion date: Feb 2020 --> Jun 2020
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Clinical, Journal: Management of atherogenic dyslipidemia in the primary care setting in Spain. (Pubmed Central) - Mar 2, 2020
Trial completion date: Jun 2020 --> Sep 2020 | Trial primary completion date: Feb 2020 --> Jun 2020 Physicians have access to general Spanish guidelines and recommendations associated with AD management, however, it is necessary to continue rising awareness about the importance of early detection and optimal control of AD to reduce patients' cardiovascular risk.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: The topography of simulated intestinal equilibrium solubility. (Pubmed Central) - Feb 29, 2020
Overall the approach provides a novel overview of intestinal solubility topography along with greater detail on the impact of the various factors studied, however each matrix requires three hundred and fifty one individual solubility measurements. Further studies will be required to refine the experimental protocol in order the maximise information garnered whilst minimising the number of measurements required.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Review, Journal: An updated review of lipid-modifying therapy. (Pubmed Central) - Feb 24, 2020
Fenofibrate reduces triglycerides and cardiovascular risk in patients with type 2 diabetes when triglycerides are elevated and high-density lipoprotein (HDL) is low...Clinical management requires a focus on the predominant lipid disorder present, namely hypercholesterolaemia, hypertriglyceridaemia or combined hyperlipidaemia. There is an ongoing problem of poor long term persistence on lipid therapy, as well as reduced awareness by practitioners of poor risk factor control.
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