- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Preclinical, Journal: Fenofibrate rapidly decreases hepatic lipid and glycogen storage in neonatal mice with glycogen storage disease type Ia. (Pubmed Central) - Oct 24, 2020
Moreover, since fenofibrate is a FDA-approved drug that has an excellent safety profile, our findings suggest that fenofibrate could be a potential pharmacological therapy for GSD Ia in neonatal and pediatric patients as well as for adults. These findings also may apply to non-alcoholic fatty liver disease (NAFLD), which shares similar pathological and metabolic changes with GSD Ia.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Exercise as medicine for COVID-19: On PPAR with emerging pharmacotherapy. (Pubmed Central) - Oct 23, 2020
Herein, exercise will be compared to fenofibrate as a possible therapeutic strategy to bolster resilience against (and help manage recovery from) COVID-19. This paper will explore the hypothesis that exercise may be a useful adjuvant in a setting of COVID-19 management/rehabilitation due to its effects on PPARα and vascular endothelial function.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Clinical, Journal: High-rate algal pond for removal of pharmaceutical compounds from urban domestic wastewater under tropical conditions. Case study: Santiago de Cali, Colombia. (Pubmed Central) - Oct 21, 2020
In conclusion, pemafibrate and fenofibrate similarly suppresses microglial activation but through distinct PPARα and SIRT1-dependet pathways. Removal efficiencies were high (>70%) for fenofibric acid, ibuprofen, and paracetamol; medium (30-70%) for gabapentin, lamotrigine, fenofibrate, gemfibrozil, diclofenac, ketoprofen, naproxen, and pentoxifylline; and low (50%) in the ecological hazard posed by most of the compounds, although it is important to note that the hazard from gemfibrozil and ibuprofen remained high even after treatment, indicating the need for complementary treatment.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Biomarker, Clinical, Journal: A Randomised Controlled Trial Assessing the Effects of Peri-operative Fenofibrate Administration on Abdominal Aortic Aneurysm Pathology: Outcomes From the FAME Trial. (Pubmed Central) - Oct 15, 2020
Removal efficiencies were high (>70%) for fenofibric acid, ibuprofen, and paracetamol; medium (30-70%) for gabapentin, lamotrigine, fenofibrate, gemfibrozil, diclofenac, ketoprofen, naproxen, and pentoxifylline; and low (50%) in the ecological hazard posed by most of the compounds, although it is important to note that the hazard from gemfibrozil and ibuprofen remained high even after treatment, indicating the need for complementary treatment. A short course of 145 mg of fenofibrate/day did not lower concentrations of OPN or aortic macrophage density in people with large AAAs.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
[VIRTUAL] Fibrates and CKD Patients: A Controversial Issue (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_1054;
The long term effects of fibrates versus variable renal derangement are yet to be identified. As to lipid profile, shifting from fibrates to statins led to a stastically significant rise in triglycerides but it's clinical impact is yet to be investigated, so established guidelines might need a revision regarding clinical benefits of fibrates versus it's renal injury.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, Lacromid (bezafibrate) / Remedica
Clinical, Journal: Additional fibrate treatment in UDCA-refractory PBC patients. (Pubmed Central) - Oct 11, 2020
The data raise the possibility that fenofibrate could be useful in angiosarcoma therapy, especially considering its well-established clinical safety and tolerability profile. In patients with UDCA-refractory PBC, additional fibrate treatment is associated with a higher probability of ALP normalization and a lower risk of cirrhosis development and hepatic deterioration.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Fenofibrate Reverses Dysfunction of EPCs Caused by Chronic Heart Failure. (Pubmed Central) - Oct 10, 2020
Similar results were also found for tube formation and migration in late EPCs, which were significantly improved by fenofibrate in an AMPK-dependent manner (p < 0.05), suggesting that fenofibrate reversed CACs and late EPC dysfunction in CHF patients. The present findings reveal the potential application of the AMPK agonist fenofibrate to reverse endothelial dysfunction in CHF patients.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells. (Pubmed Central) - Oct 8, 2020
We validated that combined inhibition of ATM and treatment with fenofibrate is synergistic in multiple HGSOC cell lines by inducing senescence. Together, our results suggest that metabolic changes induced by ATM inhibitors are a potential target for the treatment of HGSOC.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, Frumeron (indapamide) / Remedica
Clinical, Review, Journal: Drug treatments in patients with cardiac diseases and epilepsy. (Pubmed Central) - Oct 8, 2020
Together, our results suggest that metabolic changes induced by ATM inhibitors are a potential target for the treatment of HGSOC. Available data show that the treatment of patients with epilepsy and vascular comorbidities is challenging and requires the appropriate knowledge of pharmacological properties of drugs and drug interactions.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: MiR-21 promotes calcium oxalate-induced renal tubular cell injury by targeting PPARA. (Pubmed Central) - Oct 8, 2020
Suppression of miR-21 by miRNA antagomiR or activation of PPAR-α by its selective agonist fenofibrate significantly reduced renal lipid accumulation and protected against renal injury in vivo...In situ hybridization of biopsy samples from patients with nephrocalcinosis revealed that miR-21 was also significantly upregulated compared with normal kidney tissues from patients with renal cell carcinoma who underwent radical nephrectomy. These results suggested that miR-21 promoted calcium oxalate-induced renal tubular cell injury by targeting PPARA, indicating that miR-21 could be a potential therapeutic target and biomarker for nephrolithiasis.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations. (Pubmed Central) - Oct 2, 2020
However, the assay with porcine pancreatin as digestive agent did not predict the in vivo ranking of the assayed formulations better than existing methods. Comparison with a Caco-2 based assay method nonetheless indicates that the in vitro in vivo relationship of this cell-free model could be improved with alternative digestive agents.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Extraction of peroxisome proliferator-activated receptor α agonist-induced lipid metabolism-related and unrelated genes in rat liver and analysis of their genomic location. (Pubmed Central) - Oct 1, 2020
Using the data of Toxicogenomics Database, reliable genes responsive to PPARα agonists, clofibrate, fenofibrate and WY-14,643, in rat liver, were extracted from both in vivo and in vitro data, and sorted by their fold increase...To evaluate possible interaction between neighboring genes in gene expression, the correlation of the fold changes of neighboring genes for 22 drugs with various PPARα agonistic potencies were calculated for the genes showing more than 2.5 fold induction by 3 fibrates in vivo, and their genomic location was compared with that of the human orthologue. In the present study, many candidates of genes other than lipid metabolism were selected, and these could be good starting points to elucidate the mechanism of PPARα agonist-induced rodent-specific toxicity.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Peroxisome proliferator-activated receptor α agonist-induced histidine decarboxylase gene expression in the rat and mouse liver. (Pubmed Central) - Oct 1, 2020
By analysis of the data from the Toxicogenomics Database (TG-GATEs), histidine decarboxylase gene (Hdc) was identified as largely and commonly upregulated by three fibrates, clofibrate, fenofibrate, and WY-14,643, which are known to induce hepatocellular hypertrophy and proliferation via stimulation of peroxisome proliferator-activated receptor α (PPARα) in rodents...Surprisingly, the fibrates caused hepatic hypertrophy but no induction of Hdc mRNA at all in mice. These results revealed that the changes in the histidine catabolism by PPARα agonists might be partially, but not directly, involved in the hepatocyte proliferation in rats, and there is a large genetic distance even between rat and mouse.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Predicting the environmental emissions arising from conventional and nanotechnology-related pharmaceutical drug products. (Pubmed Central) - Sep 30, 2020
Compared to the conventional product Lipidil® 200, the pharmaceutical product Lipidil 145 One® and Ecocaps take advantage of nanotechnology to improve uptake and bioavailability of the drug in humans...The fish embryo toxicity test revealed a lower aquatic toxicity for the metabolite fenofibric acid and therefore an improved toxicity profile...In a streamlined life cycle assessment, the lowered dose in combination with a lowered drug-to-metabolite ratio observed for Ecocaps led to a reduction of the full life cycle impacts of fenofibrate with a reduction of 18% reduction in the global warming potential, 61% in ecotoxicity, and 15% in human toxicity. The integrated environmental assessment framework highlights the outstanding potential of advanced modeling technologies to determine environmental impacts of pharmaceuticals during early drug development using preclinical in vitro data.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Clinical, Journal: CD44 cells determine fenofibrate-induced microevolution of drug-resistance in prostate cancer cell populations. (Pubmed Central) - Sep 30, 2020
However, they also revealed the resistance of CD44 prostate cancer stem cells to the combined docetaxel/fenofibrate treatment, accompanied by docetaxel/fenofibrate-induced microevolution of hyper-resistant CD44 progenies. Thus, the balance between the sensitivity of CD44 prostate cancer cells to chemotherapeutics and the adaptation of CD44 stem-like cells to metabolic stress determines the response of prostate tumors to metabolic chemotherapy.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
[VIRTUAL] Circulatory markers of diabetic retinopathy caused by Type 2 Diabetes Mellitus (Abstract Channel) - Sep 28, 2020 - Abstract #EURETINA2020EURETINA_847;
Identifying circulatory biomarkers of PDR contributes to greater understanding of mediators of DR and could lead to the development of additional therapeutics.Our study has shown that several biochemical markers especially those looking at dyslipidemia, renal function, ESR and liver function are worth monitoring in T2DM patients and could point towards a diagnosis of retinopathy. Further prospective studies looking at changes in these biochemical markers and the development and progression of retinopathy would be needed to understand the history of disease and further elucidate the use of circulatory biomarkers as predictive markers for sight-threatening disease.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Design, synthesis and evaluation of 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione-Based fibrates as potential hypolipidemic and hepatoprotective agents. (Pubmed Central) - Sep 26, 2020
All the synthesized compounds were preliminarily screened by using the Triton WR-1339-induecd hyperlipidemia model, in which T1 exhibited more potent hypolipidemic property than positive drug fenofibrate (FF)...In the livers of T1-administrated rat, the levels of PPARα related to lipids metabolism were up-regulated. Additional effects such as antioxidant, anti-inflammatory and HS releasing action confirmed and reinforced the activity of T1 as a potential multifunctional hypolipidemic and hepatoprotective agent.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Preclinical, Journal: Large triglyceride-rich lipoproteins in hypertriglyceridemia are associated with the severity of acute pancreatitis in experimental mice. (Pubmed Central) - Sep 25, 2020
Gpihbp1-/- mice with triglyceride levels below 2000 mg/dL had milder pancreatic injury and less incidence of pancreatic necrosis than those with triglyceride levels above 2000 mg/dL, similar to Gpihbp1-/-mice with triglyceride levels above 2000 mg/dL but with fenofibrate administration. These findings demonstrated that hypertriglyceridemia subtypes with large TRL particles could affect acute pancreatitis progression and that chylomicrons showed more cytotoxicity than VLDL by releasing more FFAs.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Review, Journal: Conjugation to Branched Glycerol Oligomers, a Novel Strategy for Extremely Hydrophobic Agents (Pubmed Central) - Sep 23, 2020
Water-solubility of fenofibrate, one of the most hydrophobic medicines in clinical use, was facilitated by a factor of more than 2000, and its lipid-lowering effect in vivo improved more than ten-fold, by simply conjugating with branched glycerol trimer, for instance. Here we will briefly introduce the basic concepts and our successful experiences of applying branched glycerol oligomers including antitumor agents in terms of water-solubility, pharmacological effects, and pharmacokinetics, and merits and current issues will be discussed in this review.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Preclinical, Journal: Fenofibrate impairs liver function and structure more pronounced in old than young rats. (Pubmed Central) - Sep 16, 2020
Although 0.5 % FN decreased serum Chol concentration, it increased serum ALP activity and impaired liver structure in both in both age groups of rats. Thus, FN treatment should be under the control of liver function, especially in older patients.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
[VIRTUAL] Very Severe Hypertriglyceride-Induced Pancreatitis With Quick Resolution on Insulin Therapy Alone () - Sep 15, 2020 - Abstract #ACG2020ACG_820;
Patient was intubated and started on Meropenem for concern over aspiration pneumonia versus necrotizing pancreatitis...Patient was successfully treated for both pancreatitis and pneumonia, and discharged on hospital day 14 on omeprazole and fenofibrate...However, in those cases, it took 6 days of insulin therapy until goal levels were achieved. In this presented case, goal levels were achieved by day 3.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
[VIRTUAL] Lipoprotein Lipase Deficiency as a Rare Cause of Acute Pancreatitis () - Sep 15, 2020 - Abstract #ACG2020ACG_751;
Despite the use of high intensity statin, fenofibrate, diet restriction and insulin pump, triglyceride levels has been very difficult to control...There have been some studies that suggested high dose antioxidant therapy could potentially help lower the level of triglycerides and prevent recurrent episodes of acute pancreatitis in that particular group of patients. It is also critical to make the diagnosis as soon as possible for early medical interventions during childhood and genetic counseling and testing for family members.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, Praluent (alirocumab) / Sanofi, Regeneron
Clinical, Journal: Effect of alirocumab on individuals with type 2 diabetes, high triglycerides, and low high-density lipoprotein cholesterol. (Pubmed Central) - Sep 1, 2020
P4
Trial registration Clinicaltrials.gov, NCT02642159. Registered December 24, 2015, https://clinicaltrials.gov/ct2/show/NCT02642159.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, tacrolimus / Generic mfg., everolimus / Generic mfg.
[VIRTUAL] Outcomes of everolimus after heart transplantation (E-Poster Hall) - Aug 29, 2020 - Abstract #TTS2020TTS_1493;
Frequent indications for EVL were CKD and CAV. Concentration-controlled EVL (C0 target 3.0-6.5 ng/ml) in combination with reduced TAC achieved good efficacy and safety, higher C0 target was associated with frequent infectious complications.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Fibrane the reduced derivative of fenofibrate. (Pubmed Central) - Aug 28, 2020
Concentration-controlled EVL (C0 target 3.0-6.5 ng/ml) in combination with reduced TAC achieved good efficacy and safety, higher C0 target was associated with frequent infectious complications. No abstract available
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Attenuated Lymphatic Proliferation Ameliorates Diabetic Nephropathy and High-Fat Diet-Induced Renal Lipotoxicity. (Pubmed Central) - Aug 27, 2020
We used PPARα agonist, fenofibrate, to unravel the linkage between lipotoxicity and lymphangiogenesis...Enhanced expression of M1 phenotype in RAW264.7 cells correlated with increased lymphatic growth. A causal relationship between lipotoxicity and lymphatic proliferation with a cellular link to macrophage activation can be speculated; pro-inflammatory M1 type macrophage is involved in the development of lymphangiogenesis through stimulation of VEGF-C and by its transdifferentiation into lymphatic endothelial cells.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: A relative permittivity approach for fast drug solubility screening of solvents and excipients in lipid-based delivery. (Pubmed Central) - Aug 20, 2020
Diverse solvents and lipid-based excipients were then experimentally tested for ε and solubility using fenofibrate as model...The novel permittivity approach has demonstrated its usefulness, it has much potential in early development for ranking of suitable excipients, and it gives an initial orientation to design formulations. Future research may clarify further opportunities and limits of the novel approach for LBFs.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Sorry fenofibrate (Twitter) - Aug 20, 2020
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: SPPARM alpha: the Lazarus effect. (Pubmed Central) - Aug 20, 2020
SPPARMα offers a new paradigm for reducing residual cardiovascular risk in T2DM. PROMINENT will be critical to differentiating the first SPPARMα, pemafibrate, as a novel therapeutic class distinct from current fibrates.
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