cyclosporin A microemulsion / Generic mfg. 
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  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Observational data, Journal:  Response to Single Agent Cyclosporin in Patients with Non-Severe Aplastic Anaemia. (Pubmed Central) -  Sep 12, 2024   
    Overall response rates at 3, 6, and 12 months indicate the potential of CSA as a viable treatment option, particularly in resource-constrained settings. Despite some patients experiencing treatment-related complications, CSA demonstrated a generally tolerable safety profile.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  Effect of magnesium level before allogeneic hematopoietic cell transplantation on outcome in acute leukemia. (Pubmed Central) -  Sep 10, 2024   
    In general, there is a correlation between high magnesium levels and superior outcomes, including less and milder acute graft-versus-host disease, which does not affect cyclosporine-A levels. These findings provide valuable information for identifying the risk of poor prognosis in patients preparing for transplantation.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Preclinical, Journal:  Effect of cyclosporin A on respiratory viral replication in fully differentiated ex (Pubmed Central) -  Sep 1, 2024   
    The research provides novel insights into CsA's effects on respiratory viruses, emphasizing the need for understanding drug-virus interactions in optimizing therapeutic approaches for transplant recipients and advancing knowledge on immunosuppressive treatments' implications on respiratory viral infections. Limitations include the model's inability to assess T lymphocyte activation, suggesting the necessity for further comprehensive studies to decipher the intricate dynamics of immunosuppressive treatments on respiratory viral infections.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  A rare case of late-onset immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome confused with IgA vasculitis nephropathy. (Pubmed Central) -  Aug 27, 2024   
    Although his kidney responded well to glucocorticoid combined with cyclosporine A treatment regimen, enteropathy and severe food allergy still progressed afterwards as evidenced by villous atrophy on gastrointestinal endoscopy examination...The case expanded the phenotypic spectrum of IPEX syndrome, suggesting high phenotypic heterogeneity despite similar genotypes. It also put emphasis on the significance of kidney biopsy to differentiate IgA vasculitis nephropathy from other immune disorders.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Review, Journal:  A review of landmark studies on maintenance immunosuppressive regimens in kidney transplantation. (Pubmed Central) -  Aug 23, 2024   
    Immunosuppressive medications play a pivotal role in kidney transplantation, and the calcineurin inhibitors (CNIs), including cyclosporine A (CsA) and tacrolimus (TAC), are considered as the backbone of maintenance immunosuppressive regimens...In this review, we discuss the historical development of maintenance immunosuppressive regimens in kidney transplantation, covering the early era of transplantation, the CNI-sparing era, and the current era where the alloimmune response, rather than CNI nephrotoxicity, appears to be the major contributor to late allograft failure. Our goal is to provide a chronological overview of the development of maintenance immunosuppressive regimens and summarize the most recent information for clinicians caring for kidney transplant recipients (KTRs).
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  Cornea-SELEX for aptamers targeting the surface of eyes and liposomal drug delivery. (Pubmed Central) -  Aug 23, 2024   
    Aptamer-functionalized liposomes loaded with cyclosporine A (CsA) were developed as a treatment for dry eye diseases...In a rabbit dry eye disease model, Cornea-S1 CsA liposomes demonstrated equivalence in sustaining corneal integrity and tear break-up time when compared to commercial CsA eye drops while utilizing a lower dosage of CsA. The aptamers obtained from cornea-SELEX can serve as a general ligand for ocular drug delivery, suggesting a promising avenue for the treatment of various eye diseases and even other diseases.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening. (Pubmed Central) -  Aug 21, 2024   
    The aptamers obtained from cornea-SELEX can serve as a general ligand for ocular drug delivery, suggesting a promising avenue for the treatment of various eye diseases and even other diseases. ICA inhibits the activation of excessive autophagy and thus improves mitochondrial dysfunction by blocking the mPTP opening.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg., sirolimus / Generic mfg.
    Journal:  Pharmacomicrobiomics: Immunosuppressive Drugs and Microbiome Interactions in Transplantation. (Pubmed Central) -  Aug 21, 2024   
    The available evidence in transplantation is limited and driven by small studies of heterogeneous designs. Larger clinical studies are needed, but the potential for future clinical application of the pharmacomicrobiome in avoiding poor outcomes is high.
  • ||||||||||  verapamil / Generic mfg., cyclosporin A microemulsion / Generic mfg.
    Journal:  Differing temperature dependencies of functional homologs zebrafish Abcb4 and human ABCB1. (Pubmed Central) -  Aug 21, 2024   
    The differences between zebrafish Abcb4 and human ABCB1 ATPases in temperature sensitivity and activation energy could be important for the comparison of the functional properties of the two transporter proteins in the context of pharmaco-/toxicokinetics. Related to this, our finding that at equal reaction conditions the zebrafish Abcb4 ATPase activity tended to be generally higher than that of human ABCB1 may also be important, as this may point to a higher substrate compound transport rate of Abcb4.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Preclinical, Journal:  Umbilical Cord Blood-Derived Cells Can Reconstruct Hematopoiesis in an Aplastic Anemia Animal Model. (Pubmed Central) -  Aug 20, 2024   
    To explore the efficacy and the mechanism of the umbilical cord-derived cells combined with cyclosporine A (CsA) in treating aplastic anemia (AA) in mice...Treatment with CsA?+?UC-MSC upregulated superoxide dismutase activity compared with CsA?+?UCB-Treg treatment. Adding UC-MSC or UCB-Treg to CsA markedly enhanced the reconstruction of hematopoiesis in AA mice, with UC-MSC eliciting greater efficiency than UCB-Treg. Accordingly, the addition of these cells could further improve immune abnormalities.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  The Cryptococcus neoformans STRIPAK complex controls genome stability, sexual development, and virulence. (Pubmed Central) -  Aug 16, 2024   
    mutants display increased thermotolerance, capsule production, and melanization, and are hypervirulent in a murine infection model. Taken together, these findings reveal that the C. neoformans STRIPAK complex plays an important role in genome stability, vegetative growth, sexual development, and virulence in this prominent human fungal pathogen.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    POST-TRANSPLANT COMPLICATIONS REVEALED BY CYCLOSPORINE A RELATED TRANSPORTERS AND METABOLIC ENZYMES GENE POLYMORPHISMS IN PEDIATRIC PATIENTS WITH HEMATOLOGICAL DISORDERS (315 Hall) -  Aug 15, 2024 - Abstract #SIOP2024SIOP_222;    
    Among these, CYP2C19 (681G>A) did not conform to Hardy-Weinberg equilibrium, while the others did. Univariate and multivariate analysis identified the donor-recipient HLA matching of 9/10-10/10 as an independent protective factor for peri-engraftment syndrome (peri-ES); recipient weight ?26 kg, major or minor ABO blood type mismatch, and mutant type of CYP2C19 (99T>C) as independent risk factors for grades II-IV aGvHD; HLA matching of 9/10-10/10, low mononuclear cell infusion dose, wild-type of CYP2C19 (99T>C), and mutant type of SLCO1B1 (521T>C) as independent protective factors for cGvHD; HLA matching of 9/10-10/10 as an independent protective factor for EBV infection; mutant type of CYP3A5 (219-237C>T) as an independent protective factor for CMV infection; recipient being male, age at transplantation >104 months, wild-type of ABCB1 (1236C>T), and wild-type of SLCO1B1 (1865+4846T>C) as independent risk factors for hemorrhagic cystitis (HC); and HLA matching of 9/10-10/10 as an independent protective factor for capillary leak syndrome (CLS).Conclusions Our study revealed correlations between CsA-related transporters and metabolic enzymes SNPs and post-transplant complications following allo-HSCT, contributing to a better understanding of interindividual difference in efficacy and leading to improved HSCT outcomes.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Trial completion:  Improving Drop Instillation Comfort of a Cyclosporine A Solution (clinicaltrials.gov) -  Aug 9, 2024   
    P=N/A,  N=40, Completed, 
    These findings propose a repurposing strategy for Cyclophilin inhibitors. Recruiting --> Completed
  • ||||||||||  Diquas (diquafosol) / Merck (MSD), Santen
    Journal, IO biomarker:  Diquafosol Improves Corneal Wound Healing by Inducing NGF Expression in an Experimental Dry Eye Model. (Pubmed Central) -  Aug 9, 2024   
    DED has different damage patterns depending on the progression of the lesion. Thus, depending on the type of lesion, eye drops should be selected according to the therapeutic target, focusing on repairing cellular damage when cellular repair is needed or reducing inflammation when inflammation is high and cellular damage is severe.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  Loss of the putative Rab GTPase, Ypt7, impairs the virulence of Cryptococcus neoformans. (Pubmed Central) -  Aug 9, 2024   
    Thus, depending on the type of lesion, eye drops should be selected according to the therapeutic target, focusing on repairing cellular damage when cellular repair is needed or reducing inflammation when inflammation is high and cellular damage is severe. Additionally, Ypt7 was required for robust growth at 39
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  Ivermectin toxicokinetics in rainbow trout (Oncorhynchus mykiss) following P-glycoprotein inhibition. (Pubmed Central) -  Aug 6, 2024   
    The eNOS/GLUT-4 pathway executed the SNAP-mediated cardioprotection. Changes to ivermectin (IVM [22,23-dihydro avermectin B1a?+?22,23-dihydro avermectin B1b]) toxicokinetics (TK) with and without P-glycoprotein (P-gp) inhibition by cyclosporin A (CsA) were examined in rainbow trout (Oncorhynchus mykiss)...P-gp inhibition by CsA did not significantly affect calculated TK parameters (AUC [7.33?
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    The forgotten hair growth-promoting immunosuppressant: Tacrolimus stimulates human scalp hair follicle growth ex vivo (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_3847;    
    These data underscore the urgent need for safe therapy options for patients with severe CSU who do not respond to omalizumab. Taken together, these preliminary data show that tacrolimus exerts similar hair growth-stimulatory effects on human scalp HFs as the other main calcineurin inhibitor, cyclosporine A, but likely via different pathways, and thus deserves systematic exploration as a candidate hair growth-stimulatory agent, namely in the management of alopecia areata, FFA and androgenetic alopecia.
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron
    Dupilumab-induced lichen planus in patient with atopic dermatitis: a case report (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_2725;    
    It can also be induced by certain medications, such as antimalarials, beta-blockers, and others. In recent years, there have been various reports of an association between the use of biologics, such as TNF-alpha inhibitors, and the development of lichen planus.
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron, Cibinqo (abrocitinib) / Pfizer
    Therapeutic Success with Abrocitinib in the Treatment of a Teenager with Severe Atopic Dermatitis Poorly Responsive to Dupilumab (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_2142;    
    Initially, we introduced Cyclosporine A (CsA) , but did not obtain a satisfactory response... Our findings of swift and significant improvement in itching, as well as eczematous lesions, after switching from Dupilumab to Abrocitinib, in addition to the resolution of the Dupilumab-associated conjunctivitis, are in accordance with the presented literature.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  Mycoplasma pneumoniae-induced Kawasaki disease via PINK1/Parkin-mediated mitophagy. (Pubmed Central) -  Aug 3, 2024   
    Additionally, neither body weight nor artery tissue were affected due to PINK1 and Parkin suppression Cyclosporin A in Mp-LAMPs-treated mice. These findings indicated that PINK1/Parkin-mediated mitophagy inhibition may be a therapeutic target for MP-induced KD.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  Highly restrictive and directional penetration of the blood cerebral spinal fluid barrier by JCPyV. (Pubmed Central) -  Aug 1, 2024   
    Pretreatment with cyclosporin A, an inhibitor of P-gp, MRP2 and BCRP multidrug resistance transporters, restored viral penetration in cells treated with raft and clathrin dependent transcytosis inhibitors...We found that virus was preferentially released from the cells into the apical (CSF) chamber. These data show clearly that there are two mechanisms of penetration, direct transcytosis which is capable of seeding the CSF with small amounts of virus, and infection followed by directional release of infectious virions into the CSF compartment.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  Highly Drug-Loaded Nanoaggregate Microparticles for Pulmonary Delivery of Cyclosporin A. (Pubmed Central) -  Jul 29, 2024   
    The inhalation toxicity study suggested that pulmonary delivery of NM-2 did not result in lung function damage, inflammatory responses, or tissue lesions. The novel nanoaggregate microparticles for pulmonary drug delivery could effectively enhance the relative bioavailability of CsA and had great potential for clinical application.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg., doxorubicin hydrochloride / Generic mfg.
    Journal:  Cyclosporine A protects podocytes by regulating transgelin in adriamycin-induced podocyte injury. (Pubmed Central) -  Jul 28, 2024   
    The novel nanoaggregate microparticles for pulmonary drug delivery could effectively enhance the relative bioavailability of CsA and had great potential for clinical application. Our findings suggest that CsA protects against podocyte injury by downregulating abnormally high levels of transgelin via upregulation of KLF-4 expression.
  • ||||||||||  Kineret (anakinra) / SOBI
    Review, Journal:  Macrophage Activation Syndrome in Children: Update on Diagnosis and Treatment. (Pubmed Central) -  Jul 27, 2024   
    MAS might be underrecognized in pediatric patients with infectious and inflammatory diseases due to its diverse clinical presentations. Clinical suspicion of MAS is of the utmost importance for early recognition of the disease.
  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  Cyclosporine A in children with ABCA3 deficiency. (Pubmed Central) -  Jul 23, 2024   
    CsA treatment might be helpful for certain patients with ABCA3 deficiency, however, currently strong clinical supporting evidence is lacking. Appropriate trials are necessary to overcome this unmet need.