triptorelin / Generic mfg. 
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  • ||||||||||  finasteride / Generic mfg.
    Review, Journal:  Anti-androgen drugs in the treatment of obsessive-compulsive disorder: a systematic review. (Pubmed Central) -  Jan 27, 2021   
    There is still a need for further large randomized blinded clinical trials to evaluate the effectiveness of anti-androgens in OCD patients. It is recommended that gender, comorbidities and subscales of Yale-Brown Obsessive-Compulsive Score (Y-BOCS) be considered in designing the studies and interpreting their results.
  • ||||||||||  triptorelin / Generic mfg.
    Trial completion, Phase classification:  Comparative Validation of the Triptorelin Test for the Diagnosis of CPP in Girls (clinicaltrials.gov) -  Jan 6, 2021   
    P3,  N=46, Completed, 
    It will focus on planned total duration of triptorelin at initiation, main reasons of choice according to circumstances of prescription, formulation and route of administration, and their reasons of choice. Active, not recruiting --> Completed | Phase classification: P4 --> P3
  • ||||||||||  triptorelin / Generic mfg.
    [VIRTUAL] Ipamorelin Acetate for the management of postoperative ileus () -  Dec 26, 2020 - Abstract #ASHP2020ASHP_2816;    
    Recruiting --> Completed Since this study provides the first evidence of the safety and initial data regarding efficacy of ipamorelin, and considering the limited options for treatment of POI, future research is needed to further assess ipamorelin in the recovery of GI function in postoperative open-laparotomy patients.
  • ||||||||||  triptorelin / Generic mfg.
    Journal:  Does the risk of arterial hypertension increase in the course of triptorelin treatment? (Pubmed Central) -  Dec 19, 2020   
    Although the etiology of this adverse event is not known and only some hypotheses can be made, clinicians should be aware that arterial hypertension might appear during triptorelin treatment in childhood with CPP. Therefore, they should routinely monitor the arterial blood pressure of patients under treatment.
  • ||||||||||  doxycycline / Generic mfg., Pierre Fabre, everolimus / Generic mfg., sirolimus / Generic mfg.
    Clinical, Journal:  The efficacy and safety of pharmacological treatments for lymphangioleiomyomatosis. (Pubmed Central) -  Nov 22, 2020   
    Doxycycline and triptorelin were not recommended for the treatment of LAM because no beneficial outcomes were consistently observed. The efficacy and safety of combination therapy remain to be further explored.
  • ||||||||||  Elonva (corifollitropin alfa) / Organon
    Enrollment open:  DUO_STIM_FRESH: Double Stimulation Followed by a Fresh Embryo Transfer (clinicaltrials.gov) -  Nov 9, 2020   
    P4,  N=112, Recruiting, 
    Trial completion date: Oct 2021 --> Jul 2022 | Trial primary completion date: Oct 2021 --> Jul 2022 Not yet recruiting --> Recruiting
  • ||||||||||  prednisolone / Generic mfg., triptorelin / Generic mfg.
    [VIRTUAL] Diagnosis and treatment of precocious puberty in the Mexican population: a case report () -  Nov 5, 2020 - Abstract #ISGEI2020ISGE-I_712;    
    In natural history, the CPP conditions a shorter size than the expected, a decreased in bone mineral density, conditioning a higher risk of osteoporosis, a precocious development of secondary sexual characters, an menarche at less age than habitual, with the consequent early ovary fail, predisposing CV an cancer, coupled with psychosocial problems.The essential points for the diagnostic are the clinical data that they present, mainly oriented on the tanner scale. In Mexican population, we don’t count with a specific scale to classify the sexual character development.
  • ||||||||||  [VIRTUAL] Functional test with gonadotropin-releasing hormone analog in the diagnosis of female central hypogonadism () -  Nov 5, 2020 - Abstract #ISGEI2020ISGE-I_648;    
    a functional test with subcutaneous administration of 0.1 mg triptorelin had a high diagnostic value for the determination of hypothalamo-pituitary genesis of hypogonadism (including cases with “normal” basal gonadotropins’ levels) in female patients with intact pituitary region and in the absence of other amenorrhea reasons. Stimulated LH level ≤35 ME/l can be considered as diagnostic criterion in this situation with sensitivity 77.3% and specificity 90.0%.
  • ||||||||||  triptorelin / Generic mfg.
    Journal:  Sudden sex hormone withdrawal and the effects on body composition in late pubertal adolescents with gender dysphoria. (Pubmed Central) -  Oct 28, 2020   
    Methods Thirty-six healthy, phenotypically and chromosomally normal late and post-pubertal individuals aged 15-17 years with gender dysphoria (transgirls - birth-registered males identifying as female n = 11; and transboys - birth-registered females identifying as male n = 25) underwent Tanita body composition analysis at 0, 6 and 12 months during reproductive hormone suppression with Triptorelin as part of the standard therapeutic protocol...The withdrawal of sex hormone secretion does not appear to have a significant impact on female post-pubertal body composition, in contrast to that seen at the menopause. This suggests that other factors may preserve normal body balance in adolescents in the absence of sex steroids.
  • ||||||||||  triptorelin / Generic mfg.
    Enrollment open:  DEFETOSE: Deferred Versus Fresh Embryo Transfers (clinicaltrials.gov) -  Oct 19, 2020   
    P=N/A,  N=2294, Recruiting, 
    A policy of early salvage radiotherapy could spare men from overtreatment with radiotherapy and the associated adverse events. Not yet recruiting --> Recruiting
  • ||||||||||  Rekovelle (follitropin delta) / Ferring
    Trial completion date, Trial primary completion date:  Follitropin Delta in Long GnRH Agonist and GnRH Antagonist Protocols (BEYOND) (clinicaltrials.gov) -  Oct 19, 2020   
    P3,  N=415, Recruiting, 
    Not yet recruiting --> Recruiting Trial completion date: Dec 2021 --> Sep 2022 | Trial primary completion date: Nov 2020 --> Dec 2021
  • ||||||||||  triptorelin / Generic mfg.
    Trial completion, Trial completion date:  ICSI Versus Conventional IVF in Non-male Factor Couples (clinicaltrials.gov) -  Oct 9, 2020   
    P=N/A,  N=1064, Completed, 
    The aim was to report the novel duplication variant in the NSD-1 in a patient with Sotos syndrome accompanied by a pineal cyst and central precocious puberty, and also to discuss the rationale for treating precocious puberty. Recruiting --> Completed | Trial completion date: Dec 2020 --> Aug 2020
  • ||||||||||  triptorelin / Generic mfg.
    Journal:  Single injections of triptorelin or buserelin acetate in saline solution induce ovulation in mares the same as a single injection of hCG. (Pubmed Central) -  Oct 8, 2020   
    In conclusion, this study contributes to erasing the dogma that has been established since 1975 that a single injection in solution without any long-acting excipient of a GnRH agonist can not induce ovulation in the mare. This study also shows that a injection of 0.1 mg of triptorelin in solution is a good alternative for ovulation induction and is comparable to small doses of buserelin acetate in solution (1 mg) and 1500 IU of the gold standard trigger hCG, mainly in countries where human formulation of buserelin is not available.
  • ||||||||||  Eligard (leuprolide acetate) / TOLMAR, Astellas, Sanofi
    Journal:  Changes in body mass index in boys with central precocious puberty over 2 years of gonadotropin-releasing hormone agonist therapy. (Pubmed Central) -  Oct 8, 2020   
    This study also shows that a injection of 0.1 mg of triptorelin in solution is a good alternative for ovulation induction and is comparable to small doses of buserelin acetate in solution (1 mg) and 1500 IU of the gold standard trigger hCG, mainly in countries where human formulation of buserelin is not available. The BMI SDS in boys with CPP did not significantly change over 2 years of GnRHa therapy.
  • ||||||||||  triptorelin / Generic mfg.
    Biomarker, Clinical, Journal:  Prognostic Factors Influencing Survival Rate of Patients Operated for Prostate-Related Metastatic Spinal Cord Compression (MSCC). (Pubmed Central) -  Oct 7, 2020   
    Poor overall survival rate was also observed in patient over 60 years of age, WHO score > 3, Frankel scale A-B, presence of metastasis, Gleason score > 5, PSA levels > 100 ng/ml, LH-RH analogue (decapeptyl LP 11.25) and anterior corpectomy and fusion...The management of prostate-related MSCC requires a multidisciplinary approach. Surgery has an unequivocal impact on patient quality of life if their combined prognostic scores are satisfactory.