pentostatin / Generic mfg. 
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 76 Diseases   5 Trials   5 Trials   414 News 
6 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
pentostatin / Generic mfg.
REACH3, NCT03112603 / 2016-004432-38: A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation

Checkmark Approved in Korea for acute or chronic GvHD patients aged 12 years and older
May 2022 - May 2022: Approved in Korea for acute or chronic GvHD patients aged 12 years and older
Checkmark CHMP issued a positive opinion for acute or chronic GvHD patients aged 12 years and older
Mar 2022 - Mar 2022: CHMP issued a positive opinion for acute or chronic GvHD patients aged 12 years and older
Checkmark Approved in US for SR-cGVHD
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Completed
3
330
Europe, Canada, Japan, US, RoW
Ruxolitinib, Jakafi, INCB018424, Extracorporeal photopheresis (ECP), Low-dose methotrexate (MTX), Mycophenolate mofetil (MMF), mechanistic Target of Rapamycin (mTOR) inhibitors (everolimus or sirolimus), Infliximab, Rituximab, Pentostatin, Imatinib, Ibrutinib
Incyte Corporation
Graft-versus-host Disease (GVHD)
05/20
12/22
NCT01059786: Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia

Checkmark P2 data in HCL
Nov 2011 - Nov 2011: P2 data in HCL
Active, not recruiting
2
69
US
Pentostatin, Nipent, Rituximab, Rituxan, Bendamustine, Bendeka, Treanda, Acetaminophen, Tylenol, Diphenhydramine, Benadryl, Epinephrine, Adrenaline, Antihistamines, Corticosteroids, Corticoid, Bronchodilators, Broncholytic, Intravenous (IV) Saline
National Cancer Institute (NCI)
Hairy Cell Leukemia
12/22
12/25
NCT02105766: Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

Active, not recruiting
2
56
US
Alemtuzumab, Campath, Sirolimus, Rapamune, Cyclophosphamide, Cytoxan, Pentostatin, Deoxycoformycin, Radiotherapy, Filgrastim, Neupogen
National Heart, Lung, and Blood Institute (NHLBI), National Cancer Institute (NCI), National Institutes of Health Clinical Center (CC)
Sickle Cell Disease, Thalassemia, Stem Cell Transplantation, Graft vs Host Disease
12/23
12/24
NCT03077542: Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Active, not recruiting
1/2
57
US
haploidentical stem cell transplant, Sirolimus, Rapamune, Alemtuzumab, Campth, Pentostatin, Nipent, Cyclophosphamide, Cytoxan, Hydroxyurea, HU, Hydrea, Droxia, Filgrastim, Granulocyte colony-stimulating factor (G-CSF)
National Heart, Lung, and Blood Institute (NHLBI)
Sickle Cell Disease
07/23
08/26
NCT03249831: A Blood Stem Cell Transplant for Sickle Cell Disease

Active, not recruiting
1
3
US
Cyclophosphamide, Cytoxan, Pentostatin, NIPENT, Rabbit anti-thymocyte globulin, Rabbit ATG, Thymoglobulin, Tacrolimus, PROGRAF®, Mycophenolate mofetil, MMF, CellCept®, Myfortic, CD4+ T-cell-depleted Haploidentical Hematopoietic Transplant, CD4+ T-cell depleted HaploHCT, CD4+ T-cell depleted hematopoietic progenitor cell (HPC) product
City of Hope Medical Center, California Institute for Regenerative Medicine (CIRM)
Sickle Cell Disease, Sickle Cell Disorder, Hemoglobinopathies, Thalassemia, Anemia, Sickle Cell
11/24
11/24
NCT05757310: A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia

Recruiting
1
6
US
Anti-Thymocyte Globulin, Antithymocyte Globulin, Antithymocyte Serum, ATG, ATS, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspirate, Human Bone Marrow Aspirate, Bone Marrow Biopsy, Biopsy of Bone Marrow, Biopsy, Bone Marrow, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, Haploidentical Hematopoietic Cell Transplantation, Haploidentical Stem Cell Transplantation, HLA-Haploidentical Hematopoietic Cell Transplantation, Stem Cell Transplantation, Haploidentical, Pentostatin, (R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7, 8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, 2'-Deoxycoformycin, CI-825, Co-Vidarabine, Covidarabine, DCF, Deoxycoformycin, Nipent, PD-81565, Pentostatine, Questionnaire Administration
City of Hope Medical Center, National Cancer Institute (NCI)
Recurrent Severe Aplastic Anemia, Refractory Severe Aplastic Anemia
06/27
06/27

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