 |
15 Diseases |  |
4 Trials |
|
4 Trials |  |
335 News |  |
| 1234» |
- Eight-teen years of triptan use in Korea: A nationwide population-based study () - Jun 18, 2024 - Abstract #AHS2024AHS_253;
Despite the exponential growth in the volume of triptan prescriptions, the proportion of migraine patients receiving triptans remains low, and there is significant variability in prescribing practices across medical specialties. Efforts to reduce the gap in treatment approaches among doctors through more education are needed.
- || Akineton (biperiden) / Endo, AbbVie
Clinical, Retrospective data, Review, Journal: Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis. (Pubmed Central) - Mar 7, 2024
Cyproheptadine, clonazepam, zolmitriptan, and valproate did not yield significant effects...Trazodone, mianserin, and propranolol appeared as effective alternatives with slightly less favorable efficacy and tolerance profiles. These findings should assist prescribers in selecting an appropriate medication for treating AIA.
- | zolmitriptan / Generic mfg., nitroglycerin / Generic mfg.
Preclinical, Journal: Development of an innovative turn-on fluorescent probe for targeted in-vivo detection of nitric oxide in rat brain extracts as a biomarker for migraine disease. (Pubmed Central) - Feb 18, 2024
Furthermore, this study sheds light on the potential role of zolmitriptan (ZOLM), an antimigraine medication, in modulating NO levels in the brain of rats with nitroglycerin-induced migraine, emphasizing its significant impact on reducing NO levels. The obtained results could have significant implications for understanding how ZOLM affects NO levels and may aid in the development of more targeted and effective migraine treatment strategies.
- | Retrospective data, Journal: Safety and Tolerability of Combining CGRP Monoclonal Antibodies with Gepants in Patients with Migraine: A Retrospective Study. (Pubmed Central) - Feb 16, 2024
The findings of this study demonstrate that combining CGRP mAbs with gepants is a safe and well-tolerated treatment approach for migraine. Future studies are warranted to further validate these findings and explore long-term outcomes.
- | buspirone/zolmitriptan (JM-010) / Bukwang Pharma
Journal: Buspirone and Zolmitriptan Combination for Dyskinesia: A Randomized, Controlled, Crossover Study. (Pubmed Central) - Feb 5, 2024
P2
Future studies are warranted to further validate these findings and explore long-term outcomes. In this proof-of-concept study, addition of buspirone/zolmitriptan to the patients' PD medication regimen significantly reduced dyskinesia severity without worsening motor function.
- | carbidopa/levodopa / Generic mfg., zolmitriptan / Generic mfg., dextromethorphan / Generic mfg.
Journal: Beneficial effect of 5-HT1b/1d agonist on Parkinson's disease by modulating glutamate and reducing deposition of ?-synuclein. (Pubmed Central) - Jan 21, 2024
PD was induced in rats by reserpine at 5?mg/kg ip for 3 days and thereafter the rats were provided with the following treatments for 4 days, zolmitriptan (ZLM) group (30?mg/kg ip); STD group (levodopa?+?carbidopa, 200?+?5?mg/kg ip); ZLM?+?GA group (zolmitriptan, 30?mg/kg ip and glutamic acid, 1.5?mg/kg); ZLM?+?DX group (zolmitriptan, 30?mg/kg ip and dextromethorphan, 20?mg/kg ip). This study concludes by stating that
- || zolmitriptan / Generic mfg.
Clinical, Journal: Efficacy of Oxygen Treatment Using Home Oxygen Concentrators for the Treatment of Cluster Headaches: A Randomized, Crossover, Multicenter Study. (Pubmed Central) - Jan 5, 2024
Oxygen treatment administered using two home oxygen concentrators resulted in better pain relief than oral zolmitriptan in patients with episodic CHs. Our results suggest that home oxygen concentrators are capable of efficiently supplying oxygen in a similar manner to using an oxygen tank.
- | Retrospective data, Journal: Simultaneous Comparisons of 25 Acute Migraine Medications Based on 10 Million Users' Self-Reported Records From a Smartphone Application. (Pubmed Central) - Jan 3, 2024
Using a big data approach, we analyzed patient-generated real-time records of 10 million migraine attacks and conducted simultaneous head-to-head comparisons of 25 acute migraine medications. Our findings that triptans, ergots, and antiemetics are the most effective classes of medications align with the guideline recommendations and offer generalizable insights to complement clinical practice.
- | zolmitriptan / Generic mfg.
Journal: Evaluation of Dose-Response Relationship of Permeation Enhancer Isopropyl Myristate Release on Drug Release: Release Enhancement Efficiency and Molecular Mechanism. (Pubmed Central) - Dec 24, 2023
Isopropyl myristate (IPM) was used as model enhancer and zolmitriptan (ZOL) was used as model drug to investigate dose-effect relationship in pressure sensitive adhesives (PSA)...According to the mechanism research results, the fluidity of PSA increased linearly with the increase of IPM concentrations, but the interaction between IPM and ZOL reached its strongest point at 6%. In summary, the increase of K value (from 0 to 6% IPM content) was caused by the synergy of increased mobility of PSA and interaction (dipole-dipole and hydrogen-bond) among three components, and when the above two actions were in antagonistic, K no longer increased (6-9% IPM content).
- | zolmitriptan / Generic mfg.
Journal: Xenopus retinal ganglion cell axon extension is unaffected by 5-HT receptor activation during visual system development. (Pubmed Central) - Dec 20, 2023
Zolmitriptan did not significantly alter entopic RGC extension in the contralateral brain. Consequently, RGC axon extension in ectopic but not entopic locations is influenced by altering serotonergic signaling .
- | Journal: Diamine Oxidase Interactions with Anti-Inflammatory and Anti-Migraine Medicines in the Treatment of Migraine. (Pubmed Central) - Dec 9, 2023
However, naproxen reduced DAO protein levels in human enterocyte cultures while not affecting DAO activity. These results suggest that combining anti-inflammatory and anti-migraine drugs with DAO enzyme supplementation for migraine patients with DAO deficiency could be beneficial for healthcare professionals in their daily practice.
- | Journal: Stereoselective Inhibition of High- and Low-Affinity Organic Cation Transporters. (Pubmed Central) - Dec 5, 2023
However, the stereoselectivity of the OCT2 was only moderate with the highest selectivity observed for pramipexole...(R)-Tolterodine and (S)-zolmitriptan inhibited OCT3 11-fold and 25-fold more than their respective counterparts...For the tricyclic antidepressant doxepine, only the (E)-isomer showed an increased risk of drug-drug interactions according to guidelines from regulatory authorities for renal transporters. However, most chiral drugs show only minor stereoselectivity in the inhibition of OCTs in vitro, which is unlikely to translate into clinical consequences.
- Unravelling the role of the putative proton-coupled organic cation antiporter in triptan transport across the blood-brain barrier (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_7786;
J Headache Pain. 2010; 11(1):5-12.
- | zolmitriptan / Generic mfg.
New P1 trial: Pharmacokinetics in Oral and Intranasal Formulations of Zolmitriptan. (clinicaltrials.gov) - Oct 9, 2023
P1, N=8, Completed, Sponsor: Parc de Salut Mar
- | Journal: Clinical characteristics and treatment patterns of patients with episodic cluster headache: results from the United States, United Kingdom and Germany. (Pubmed Central) - Aug 24, 2023
Frequently prescribed acute treatments were sumatriptan, oxygen, and zolmitriptan; oxygen use varied considerably across countries and was prescribed least often in the United States. Frequently prescribed preventive treatments were verapamil,
- | Journal: Drugs for migraine. (Pubmed Central) - Jun 6, 2023
Frequently prescribed preventive treatments were verapamil, No abstract available
- | zolmitriptan / Generic mfg.
Trial completion date, Trial primary completion date: Cocaine and Zolmitriptan (clinicaltrials.gov) - Jun 5, 2023
P1, N=20, Recruiting, Sponsor: William Stoops
No abstract available Trial completion date: Jul 2023 --> Jul 2024 | Trial primary completion date: Jul 2023 --> Jul 2024
- || Review, Journal: The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review. (Pubmed Central) - May 20, 2023
We found that rizatriptan (good tolerability profile with a dose of 5 mg) and sumatriptan (oral administration) had higher efficiency as compared to other triptans. Regardless of type or dose, all triptans are generally well tolerated by patients, but a few adverse effects such as light-headedness (sumatriptan), nasopharyngitis, and, muscular spasms (sumatriptan/ naproxen), somnolence, and dry mouth (rizatriptan), and dizziness (zolmitriptan group) were reported with the triptans.
- Simultaneous Comparisons of 25 Acute Migraine Medications: A Big Data Analysis of 10 Million Patient Self-Reported Treatment Records From A Migraine Smartphone Application (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3806;
Individual medications with the highest ORs were eletriptan(OR 6.1), zolmitriptan(OR 5.7), and sumatriptan(OR 5.2)...Conclusions We analyzed patient-generated real-time records of 10 million migraine attacks and conducted simultaneous head-to-head comparisons of 25 acute migraine medications. Our findings that triptans, ergots and anti-emetics are the most effective classes of medications align with the guideline recommendations and offer generalizable insights to complement clinical practice.
- | sumatriptan succinate / Generic mfg.
Journal: Metabolism of sumatriptan revisited. (Pubmed Central) - Jan 20, 2023
The CYP1A2, CYP2C19, and CYP2D6 isoforms converted this drug into N-desmethyl sumatriptan, which was further demethylated to N,N-didesmethyl sumatriptan by CYP1A2 and CYP2D6. Otherwise, sumatriptan and its two desmethyl metabolites were metabolized by recombinant MAO A but not by MAO B to the corresponding acetaldehyde, with sumatriptan being only a poor substrate for MAO A compared to the N-demethylated and the N,N-didemethylated derivatives.
- prasinezumab (RG7935) / Roche, mesdopetam (IRL790) / Ipsen, tavapadon (CVL-751) / Cerevel Therap
NEW INSIGHT IN THE TREATMENT OF PARKINSONS DISEASE (ONSITE - HALL F1+F2+F3) - Dec 23, 2022 - Abstract #ADPD2023ADPD_877;
The PASADENA study tested prasinezumab and despite the primary end-point was not met positive signals were seen...The ORCHESTRA study with UCB0059, an oral Asyn antibody is also ongoing...A new dopamine agonist, tavapadon. Two different studies on dyskinesia are ongoing with a combination of buspirone and zolmitriptan and another with mesdopetam.
- | HOKUNALIN patch (tulobuterol) / Maruho, Abbott, Nitto Denko
Journal: Mechanistic insights of different release behaviors dominated by drug physicochemical properties in polyisobutylene pressure sensitive adhesive. (Pubmed Central) - Dec 1, 2022
And the trends of in vitro drug release and skin penetration profiles were basically similar. Thus, it was thought that the physicochemical parameters of the drug played a vital role in the drug release behavior of PIB PSAs and would affect the skin penetration process, which provided a reference for the design and application of patches based on PIB PSAs in TDDS.
- || zolmitriptan / Generic mfg.
Clinical, Journal: A multicenter, randomized, double-blind, placebo-controlled, crossover trial to evaluate the efficacy and safety of zolmitriptan nasal spray for the acute treatment of migraine in patients aged 6 to 11 years, with an open-label extension. (Pubmed Central) - Nov 2, 2022
The effect of high-dose ZNS on the primary endpoint of pain-free status at 2 h did not achieve statistical significance. ZNS was safe and well tolerated in this pediatric population.
- | buspirone/zolmitriptan (JM-010) / Bukwang Pharma
Preclinical, Journal: Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats. (Pubmed Central) - Oct 19, 2022
ZNS was safe and well tolerated in this pediatric population. The strong anti-dyskinetic effect found with combined 5-HT1A and 5-HT1B/D agonism renders buspirone and zolmitriptan together a meaningful treatment for LID in PD.
- || Reyvow (lasmiditan) / Eli Lilly, Daiichi Sankyo
Clinical, Retrospective data, Journal: Serotonin Receptor agonist and Risk of Paresthesia in Migraine Patients: A Dose-Response Model-Based (Network) Meta-Analysis. (Pubmed Central) - Oct 11, 2022
The relative risk of paresthesia is higher with the use of Topiramate 200 mg, Lasmiditan 400 mg, and Zolmitriptan 10 mg. In addition, Lasmiditan exhibited a gradual dose-response of relative risk for the manifestation of paresthesia.
- Gocovri (amantadine ER) / Supernus Pharma
Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_8208;
Head-to-head comparison with amantadine showed superior performance of buspirone and zolmitriptan in this rat model. The robust anti-dyskinetic effect resulting from combined 5-HT1A and 5-HT1B/D agonism qualifies buspirone and zolmitriptan as a promising treatment for LID in Parkinson’s disease.
- | zolmitriptan / Generic mfg.
J'ai la paresse de la description mais je m'y connaissais. Introduction savarine, diprivan, zomig , turbuhaler... And so Pourquoi la question d'ailleurs? (Twitter) - Oct 7, 2022
- || rizatriptan / Generic mfg., eletriptan / Generic mfg., zolmitriptan / Generic mfg.
A ver, tengo la mitad de crisis. Pero es que yo tenía unas 24 crisis al mes. Y ahora unas 12-14 depende del mes. Pero ni el maxalt, ni el relpax, ni zomig, me quitan el dolor de las crisis. Me rebajan el dolor, pero no me lo quitan. (Twitter) - Sep 5, 2022
- || zolmitriptan / Generic mfg.
PK/PD data, Preclinical, Journal: Compritol-Based Nanostrucutured Lipid Carriers (NLCs) for Augmentation of Zolmitriptan Bioavailability via the Transdermal Route: In Vitro Optimization, Ex Vivo Permeation, In Vivo Pharmacokinetic Study. (Pubmed Central) - Jul 29, 2022
A histopathological examination revealed the safety of the developed nanoparticles. The declared results highlight the potential of utilizing the proposed NLCs for the transdermal delivery of ZMP to improve the drug bioavailability.
- | zolmitriptan / Generic mfg.
Journal: Evaluation of Brain Targeting Potential of Zolmitriptan Mucoadhesive Nanoparticles for Intranasal Drug Delivery. (Pubmed Central) - Jul 23, 2022
The declared results highlight the potential of utilizing the proposed NLCs for the transdermal delivery of ZMP to improve the drug bioavailability. Thus, the present study confers the significance of nasal drug delivery for brain targeting of zolmitriptan nanoparticles for the treatment of migraine.
- | Journal: Information on migraine drugs in commonly available Indian drug information sources - Whether we satisfied the community needs? (Pubmed Central) - Jul 19, 2022
The information for the antimigraine drugs available from various sources found to so much deficient. Necessary steps need to be taken in case of government public or hard documents to streamline drug information available with them as well the commercial documents as to provide reliable drug information uniformly for promoting rational use of the drug.
- aspirin / Generic mfg., zolmitriptan / Generic mfg.
Internal Carotid Artery Dissection presenting as a new-onset episodic cluster-like headache (A6) - Jul 18, 2022 - Abstract #EAN2022EAN_2411;
Brain MRI imaging showed a rare carotid artery dissection location involving both extracranial and intracranial portions. This case stresses the need to investigate secondary CH.
- ||| zolmitriptan / Generic mfg., Ajovy (fremanezumab) / Otsuka, Teva
No. There's no cure for migraine. It's a disorder of the brain. I'm also on Ajovy and zomig sprays. I've gone from 27 days a month of attacks to 4-5 max. At least I can now medicate for EVERY attack as well! Plus I'm not getting them in this weather which is unbelievable!! (Twitter) - Jul 14, 2022
- || zolmitriptan / Generic mfg.
My question is now he knows what it is can he cure it.. I’ve been on so much different treatments for 40 years and nothing has taken them away fully.. atm I’m on avojy injections and zomig nasel spray but still get them. My dr is running out of things to try (Twitter) - Jul 14, 2022
- | zolmitriptan / Generic mfg., sumatriptan succinate / Generic mfg.
Journal: Two Spectroscopic Methods for Estimation of Anti-migraine Medications; Sumatriptan and Zolmitriptan Based on Nucleophilic Substitution Reaction. (Pubmed Central) - Jul 8, 2022
Statistical analysis of the results obtained from the proposed and comparison methods confirmed that the proposed methods are highly accurate and precise. The suggested methods could be used for the determination of the mentioned drugs in both pure and tablets.
- | zolmitriptan / Generic mfg.
Journal: Development and Characterizations of Pullulan and Maltodextrin-Based Oral Fast-Dissolving Films Employing a Box-Behnken Experimental Design. (Pubmed Central) - May 30, 2022
Zolmitriptan (ZMT) is a potent 5HT1B/1D serotonin receptor agonist frequently used for the treatment of migraine...This study offers a promising strategy for developing ZMT-OFDFs using SCM. ZMT-OFDFs showed remarkable rapid dissolution and fast D-time, which might endeavor ZMT-OFDFs as an auspicious alternative approach to improve patient compliance and shorten the onset time of ZMT in migraine treatment.
- || zolmitriptan / Generic mfg.
@AstraZeneca por que ya no encuentro las pastillas zomig rapilmet en las farmacias de México? Es lo único que me ayuda para la migraña (Twitter) - May 29, 2022
- | zolmitriptan / Generic mfg.
Journal: Nose-to-brain lipid nanocarriers: An active transportation across BBB in migraine management. (Pubmed Central) - May 7, 2022
Zolmitriptan-loaded SLNs via intranasal administration offers a novel approach to effectively circumvent first-pass hepatic metabolism than conventional oral route with 4-fold alleviation in permeation and 2-fold improvement in bioavailability. DATA AVAILABILITY: The data used to support the findings of this study are included within the article.
- | Zeneo Sumatriptan (sumatriptan needle-free injection) / Crossject
Retrospective data, Journal: Network meta-analysis of therapies for cluster headache: Effects of acute therapies for episodic and chronic cluster. (Pubmed Central) - Apr 22, 2022
Additionally, high flow oxygen is likely more effective than zolmitriptan nasal spray, nVNS, and octreotide. Sumatriptan injectable is more likely to be effective when compared to zolmitriptan nasal spray, octreotide, and nVNS.
- | zolmitriptan / Generic mfg.
Journal: Effect of 5-HT 1b/1d agonist on ethanol withdrawal syndrome and ethanol withdrawal induced anxiety. (Pubmed Central) - Apr 8, 2022
Sumatriptan injectable is more likely to be effective when compared to zolmitriptan nasal spray, octreotide, and nVNS. In conclusion, data of investigation reveal that 5-HT 1b/1d receptor involved in the EWS and treatment with its agonist prevents the behavioural changes in EWS by regulating the level of different neurochemicals.
- || zolmitriptan / Generic mfg.
Retrospective data, Review, Journal: Comparative Impact of Pharmacological Therapies on Cluster Headache Management: A Systematic Review and Network Meta-Analysis. (Pubmed Central) - Mar 11, 2022
Pharmacological treatment was shown to be more effective than placebo to manage CH with differences among types of therapies and individual interventions, and it was consistently shown to be associated with the development of adverse events. Thus, individualized therapy approaches should be applied to treat CH in real-world practice.
- || zolmitriptan / Generic mfg.
Ni caso me hace el INNS, ni de mi migraña, fibromialgia, mi artrosis , lumbalgia,difosis lumbal y profusiones en vértebras, manos y codo operado , espocondiolitis , depresión y ansiedad y fatiga crónica, discapacidad 59%, antralgias en los tobillos a trabajar con el zomig croni (Twitter) - Mar 6, 2022
- || Review, Journal: Drug Treatment of Cluster Headache. (Pubmed Central) - Feb 19, 2022
The efficacy of monoclonal antibodies to the calcitonin gene-related peptide so far has been only demonstrated for episodic cluster headache. Several drug therapies are being investigated including ketamine, onabotulinumtoxinA, lysergic acid, and sodium oxybate.
- | hyoscine butylbromide oral / Generic mfg., dextromethorphan / Generic mfg.
Preclinical, Journal, IO biomarker: Activation of 5-HT 1b/d receptor restores the cognitive function by reducing glutamate release, deposition of β-amyloid and TLR-4 pathway in the brain of scopolamine-induced dementia in rat. (Pubmed Central) - Feb 8, 2022
Several drug therapies are being investigated including ketamine, onabotulinumtoxinA, lysergic acid, and sodium oxybate. In conclusion, ZMT restores the cognitive functions and impaired memory in SPN-induced dementia in the rat by decreasing oxidative stress and Aβ peptide in the brain tissue of rat.
- || sumatriptan succinate / Generic mfg.
Clinical, Retrospective data, Review, Journal: Comparison of New Pharmacologic Agents With Triptans for Treatment of Migraine: A Systematic Review and Meta-analysis. (Pubmed Central) - Jan 12, 2022
For pain freedom or pain relief at 2 hours after the dose, lasmiditan, rimegepant, and ubrogepant were associated with higher ORs compared with placebo but lower ORs compared with most triptans. However, the lack of cardiovascular risks for these new classes of migraine-specific treatments may offer an alternative to triptans.
- | zolmitriptan / Generic mfg., etodolac / Generic mfg.
Preclinical, Journal: Preparation, in vitro and in vivo evaluation of Chitosan-Sodium alginate-Ethyl cellulose polyelectrolyte film as a novel buccal mucosal delivery vehicle. (Pubmed Central) - Dec 18, 2021
The relative bioavailability of the model drugs was 246.00% (Zolmitriptan) and 142.12% (Etodolac) relative to oral administration. The results of this study demonstrate the potential of CS-SA-EC vehicle in buccal mucosa drug delivery.
- || Reyvow (lasmiditan) / Eli Lilly, Daiichi Sankyo
Clinical, Review, Journal: Onset of action in placebo-controlled migraine attacks trials: A literature review and recommendation. (Pubmed Central) - Dec 16, 2021
The results of this study demonstrate the potential of CS-SA-EC vehicle in buccal mucosa drug delivery. Only three non-oral administration forms with a triptan (subcutaneous sumatriptan and nasal zolmitriptan) resulted in an "onset of action" at ≥30 min; in the future, early onset of action should be a priority in the development of new drugs or new administration-forms for the treatment of acute migraine attacks.
- || sumatriptan succinate / Generic mfg.
Clinical, Journal: Twenty-five years of triptans - a nationwide population study. (Pubmed Central) - Dec 16, 2021
In a cohort with access to free clinical consultations and low medication costs, we observed low rates of triptan adherence, likely due to disappointing efficacy and/or unpleasant side effects rather than economic considerations. Triptan success continues to be hindered by poor implementation of clinical guidelines and high rates of treatment discontinuance.
- | zolmitriptan / Generic mfg.
Journal: Metabolic activation of zolmitriptan mediated by CYP2D6. (Pubmed Central) - Dec 16, 2021
Pre-treatment of primary hepatocytes with quinidine was able to reverse ZOL-induced cytotoxicity. The finding facilitates the understanding of the mechanisms involved in ZOL-associated liver adverse reactions.