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15 Diseases |  |
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- zolmitriptan / Generic mfg.
[VIRTUAL] Consistency of the Efficacy of Single Use and Repeated Use of M207 ( Intracutaneous Microneedle Zolmitriptan) for the Acute Treatment of Migraine; Results for Pain Freedom , Pain Relief, and Sustained Pain Freedom and Pain Relief () - May 25, 2020 - Abstract #AHS2020AHS_42;
Efficacy rates for most pain parameters following M207 treatment were similar for the single-use trial, and the repeated use over one year open-label trial. Together, these results suggest that the 42% pain freedom ;and 80% pain relief at 2 hour results seen in the placebo-controlled trial are good estimates of the efficacy of M207 over time.
- || zolmitriptan / Generic mfg.
Hola Patricia,soy migrañoso desde los 8-10 años,ahora con 40 tengo crisis casi cada semana casi siempre al levantarme y localizadas en ojo sien,lo trato con zolmitriptan.Voy a probar a dormir con ferula x si esta relacionado con el bruxismo,lo aconsejas??gracias (Twitter) - May 6, 2020
- Incidence of Abortive Migraine Medication Fills after Initiation of a Calcitonin Gene-Related Peptide (CGRP) Inhibitor for Migraine Prophylaxis () - May 6, 2020 - Abstract #AMCP2020AMCP_181;
Additional claims data are needed to determine statistical significance in number of claims for abortive migraine medications before and after CGRP inhibitor initiation. Sponsorship: Highmark, Inc
- Analgin (metamizole) / Sedico, eletriptan / Generic mfg., zolmitriptan / Generic mfg.
[VIRTUAL] Dialysis headache: 4 cases of a tertiary headache centre (Room: Screen B4) - Apr 9, 2020 - Abstract #EAN2020EAN_1945;
There is not a specific pattern for DH, besides its temporal profile and its relation to HD. Response to triptans in one suggests a migraine-type pathophysiology.
- ||||| zolmitriptan intracutaneous microneedle system (C213) / Zosano
Enrollment closed, Enrollment change: Double-Blind Comparison of the Efficacy and Safety of C213 to Placebo for the Acute Treatment of Cluster Headaches (clinicaltrials.gov) - Mar 31, 2020
P2/3, N=20, Active, not recruiting, Sponsor: Zosano Pharma Corporation
Response to triptans in one suggests a migraine-type pathophysiology. Recruiting --> Active, not recruiting | N=120 --> 20
- | zolmitriptan / Generic mfg.
Journal: 5-HT1D receptors inhibit the monosynaptic stretch reflex by modulating C fibre activity. (Pubmed Central) - Feb 29, 2020
In chronic spinal rats, numerous 5-HT receptor agonists, including zolmitriptan, methylergonovine, and 5-HT, inhibited the MSR with a potency highly correlated to their binding affinity to 5-HT receptors and not other 5-HT receptors...5-HT1D receptor labelling was not found on large proprioceptive afferents or alpha-motoneurons of the MSR. Thus, serotonergic inhibition of the MSR must act indirectly by modulating C fibre activity, opening up new possibilities for modulating reflex function and clonus via pain related pathways.
- | zolmitriptan / Generic mfg.
Preclinical, Journal: In-vitro and in-vivo respiratory deposition of a developed metered dose inhaler formulation of an anti-migraine drug. (Pubmed Central) - Feb 16, 2020
Zolmitriptan MDI formulation was developed using micronized zolmitriptan powder without further modification or particle engineering. The developed formulation using HFA 134a propellant could be favorable alternative, with enhanced bioavailability, to zolmitriptan oral tablet for acute migraine treatment.
- | zolmitriptan / Generic mfg., sumatriptan succinate / Generic mfg.
Journal: Orofacial Pain and Menstrually Related Migraine. (Pubmed Central) - Feb 15, 2020
A thorough history and examination, as well as an understanding of migraine headaches, is necessary to differentiate odontogenic pain and migraine headaches. Key Words: menstrually related migraine, orofacial pain, ICHD-3, headache.
- || zolmitriptan / Generic mfg.
Clinical, Journal: A case of severe headache attributed to vertebral artery dissection. (Pubmed Central) - Feb 8, 2020
Key Words: menstrually related migraine, orofacial pain, ICHD-3, headache. The possibility of vertebral artery dissection should be considered in the differential diagnosis of severe secondary headaches, and prompt diagnosis and treatment based on detailed MRI and magnetic resonance angiography examinations should be performed.
- || zolmitriptan / Generic mfg., sumatriptan succinate / Generic mfg.
Clinical, Journal: The efficacy of the second generation triptan migrepam in the treatment of migraine attacks: results of the comparative study (Pubmed Central) - Feb 3, 2020
As a result of therapy, a similar pattern of influence of the studied drugs on the intensity of pain and accompanying symptoms is shown. The more significant effect of migrepam on the characteristics of daily functioning, which is accompanied by a higher subjective assessment of the effectiveness of the relief of migraine attacks by the patients, is noted.
- || ibuprofen / Generic mfg.
Clinical, Journal: Practice guideline update summary: Acute treatment of migraine in children and adolescents: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. (Pubmed Central) - Jan 31, 2020
The more significant effect of migrepam on the characteristics of daily functioning, which is accompanied by a higher subjective assessment of the effectiveness of the relief of migraine attacks by the patients, is noted. Recommendations for the treatment of acute migraine in children and adolescents focus on the importance of early treatment, choosing the route of administration best suited to the characteristics of the individual migraine attack, and providing counseling on lifestyle factors that can exacerbate migraine, including trigger avoidance and medication overuse.
- dihydroergotamine mesylate injection / Generic mfg., zolmitriptan / Generic mfg.
Water-insoluble Mucoadhesive Formulation Enables Consistent and Rapid Intranasal Absorption of Drugs, Including Granisetron, Zolmitriptan and Dihydroergotamine () - Jan 21, 2020 - Abstract #AAN2020AAN_1617;
Recommendations for the treatment of acute migraine in children and adolescents focus on the importance of early treatment, choosing the route of administration best suited to the characteristics of the individual migraine attack, and providing counseling on lifestyle factors that can exacerbate migraine, including trigger avoidance and medication overuse. The water-insoluble mucoadhesive formulation technology enables consistent and rapid Intranasal absorption of drugs including granisetron, zolmitriptan and DHE.
- | zolmitriptan / Generic mfg., sumatriptan succinate / Generic mfg.
Journal: Availability of Effective Evidence-Based Symptomatic Treatments for Cluster Headache in the EU Countries-A Survey of the European Headache Alliance and European Headache Federation. (Pubmed Central) - Jan 18, 2020
Only 47% of the EU population had unrestricted access to effective CH treatments, with unacceptable inequalities between eastern countries and the rest of Europe. Headache societies and patient associations should pressure European and national health authorities to improve the availability of effective symptomatic treatments for CH.
- | sarpogrelate (KW21027) / KunWha Pharma, zolmitriptan / Generic mfg.
Preclinical, Journal: Evaluation of Isolated Vascular Response to 5HT1A, 5HT1B1D & 5HT2A Receptors Agonist & Antagonist in Chronic Endotoxemic Rats. (Pubmed Central) - Dec 6, 2019
In first, DOI2 hydrochloride used as an agonist and sarpogrelate hydrochloride as an antagonist of 5HT2A receptor...In third, Zolmitriptan used as an agonist and GR127935 hydrochloride as an antagonist of 5HT1B1D receptor...PCR studies revealed enhanced 5HT1A receptor and diminished 5HT1B1D and 5HT2A receptor genes expression, while histopathological studies showed inflamed, damaged endothelium in endotoxemic aorta. Our data supports enhanced vasodilation and impaired vasoconstriction during endotoxemia.
- | zolmitriptan / generics
Journal: Preparation and Evaluation of Optimized Zolmitriptan Niosomal Emulgel. (Pubmed Central) - Nov 22, 2019
Our data supports enhanced vasodilation and impaired vasoconstriction during endotoxemia. Optimized F11 represents a promising formulation for transdermal drug delivery system to treat both topical and systemic diseases.
- | zolmitriptan intracutaneous microneedle system (C213) / Zosano
Enrollment open: Double-Blind Comparison of the Efficacy and Safety of C213 to Placebo for the Acute Treatment of Cluster Headaches (clinicaltrials.gov) - Oct 17, 2019
P2/3, N=120, Recruiting, Sponsor: Zosano Pharma Corporation
Optimized F11 represents a promising formulation for transdermal drug delivery system to treat both topical and systemic diseases. Not yet recruiting --> Recruiting
- | zolmitriptan / generics, sumatriptan succinate / generics
Review, Journal: Orally Inhaled Migraine Therapy: Where are we now? (Pubmed Central) - Oct 4, 2019
Orally inhaled therapies have the potential to offer faster onset of action with fewer side effects compared to existing therapies, yet development has stalled. Despite emerging therapies such as calcitonin gene-related peptide antagonists, there are still good opportunities for repositioning migraine drugs via the inhaled route.
- ||| Great article! In our practice we use sumatriptan, rizatriptan, zolmitriptan, almotriptan for acute treatment. You may also consider daily prophylactic agent such as ciproheptadine, which in my experience works great! #migraine (Twitter) - Sep 15, 2019
- | dihydroergotamine mesylate injection / generics, zolmitriptan / generics, naratriptan / generics
Journal: Application of Factorial and Doehlert Designs for the Optimization of the Simultaneous Separation and Determination of Antimigraine Drugs in Pharmaceutical Formulations by RP-HPLC-UV. (Pubmed Central) - Sep 13, 2019
The validated method was successfully applied to perform routine analysis of these compounds in different pharmaceutical products such as syrups and tablets. In the presence of some preservatives, it was found that there were no peaks at the related peak locations.
- | zolmitriptan / Generic mfg.
Trial completion: A Four-way Crossover Study of 3 Formulations of M207 With Intranasal Zolmitriptan in Healthy Volunteers (clinicaltrials.gov) - Aug 26, 2019
P1, N=24, Completed, Sponsor: Zosano Pharma Corporation
In the presence of some preservatives, it was found that there were no peaks at the related peak locations. Active, not recruiting --> Completed
- | zolmitriptan intracutaneous microneedle system (C213) / Zosano
New P2/3 trial: Double-Blind Comparison of the Efficacy and Safety of C213 to Placebo for the Acute Treatment of Cluster Headaches (clinicaltrials.gov) - Aug 22, 2019
P2/3, N=120, Not yet recruiting, Sponsor: Zosano Pharma Corporation
- | Journal: Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT receptor and c-Jun. (Pubmed Central) - Aug 21, 2019
RCXTAs exerted significant preventive and therapeutic effects on migraine via increasing the levels of 5-HT and 5-HIAA. Upregulation of the expression of monoamine neurotransmitter 5-HT receptor and downregulation of the expression of c-Jun were the possible mechanisms.
- | Preclinical, Journal: Administration of 5-HT-1B agonist ameliorates pseudodementia induced by depression in rats. (Pubmed Central) - Aug 17, 2019
After the induction of depression, rats were treated with zolmitriptan at a dose of 0.3 mg/kg which resulted in a significant attenuation of depression and depression-associated memory impairment. Results are discussed with reference to the modulation of function of 5-HT-1B receptor following the administration of exogenous agonist.
- | zolmitriptan / Generic mfg.
Clinical, Retrospective data, Journal: Use of Most Bothersome Symptom as a Coprimary Endpoint in Migraine Clinical Trials: A Post-Hoc Analysis of the Pivotal ZOTRIP Randomized, Controlled Trial. (Pubmed Central) - Aug 1, 2019
Results are discussed with reference to the modulation of function of 5-HT-1B receptor following the administration of exogenous agonist. In this study, the use of MBS was feasible and seemed to compare favorably to the previously required 4 co-primary endpoints.
- | zolmitriptan / generics
Journal, IO Biomarker: Zolmitriptan attenuates hepatocellular carcinoma via activation of caspase mediated apoptosis. (Pubmed Central) - Jul 23, 2019
Later, H NMR based serum metabolomics study confirmed that ZOL restored the perturbed metabolites associated with DEN-induced HCC. The antineoplastic potential of ZOL was found comparable or to some degree better than the marketed chemotherapeutics, 5-flurouracil.
- | lasmiditan (COL-144) / Eli Lilly
Journal: Current management: migraine headache. (Pubmed Central) - Jul 11, 2019
Antibodies to CGRP and its receptor are being developed for migraine prevention. All 4 treatments are effective and have, as of yet, no safety concerns.
- | zolmitriptan / generics
PK/PD data, Journal: Pharmacokinetics and Skin Tolerability of Intracutaneous Zolmitriptan Delivery in Swine Using Adhesive Dermally-Applied Microarray (ADAM). (Pubmed Central) - Jun 26, 2019
ADAM zolmitriptan was well-tolerated with a transient mild to moderate erythema response. The findings in these studies, particularly the rapid zolmitriptan absorption profile following intracutaneous administration, provided validation to advance ADAM zolmitriptan development.
- | zolmitriptan / generics
Journal: Investigation of Effect of Isopropyl Palmitate on Drug Release from Transdermal Patch and Molecular Dynamics Study. (Pubmed Central) - Jun 7, 2019
...Zolmitriptan (ZOL) was used as a model drug and isopropyl palmitate (IPP) was used as a model enhancer to investigate drug release behaviors in pressure-sensitive adhesives (PSAs)...The results elucidated that IPP increased fluidity of PSAs and vied for drug from PSAs. As a result, the interaction among three components played a major role in changing release behaviors of ZOL, but the increased fluidity only worked in the concentration of less than 10%.
- || zolmitriptan / Generic mfg.
New P1 trial: A Four-way Crossover Study of 3 Formulations of M207 With Intranasal Zolmitriptan in Healthy Volunteers (clinicaltrials.gov) - Jun 6, 2019
P1, N=24, Active, not recruiting, Sponsor: Zosano Pharma Corporation
- | zolmitriptan / generics
Journal: Bursting deep dorsal horn neurons: The pharmacological target for the anti-spastic effects of Zolmitriptan? (Pubmed Central) - May 30, 2019
Deep dorsal horn neurons were classified into bursting, simple or tonic, with bursting neurons showing NMDA and Zolmitriptan sensitivity. Here, we discuss the findings in a methodological framework and propose future experiments of importance for translating the results into physiological settings.
- | metformin / generics
Preclinical, Journal: Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys. (Pubmed Central) - Apr 28, 2019
Compound permeability is a key determinant of K increase by intranasal administration. This route of administration is more beneficial for low-permeable compounds and enhances their delivery to the brain in rodents and non-human primates.
- | zolmitriptan / generics, sumatriptan succinate / generics
Journal, HEOR: Cost-Effectiveness of Reclassifying Triptans in Australia: Application of an Economic Evaluation Approach to Regulatory Decisions. (Pubmed Central) - Apr 18, 2019
Serotonin syndrome, a key concern of the TGA committee, had little impact on the results. Further research is needed regarding pharmacist-only triptan use by migraineurs currently using over-the-counter medicines and by nonmigraineurs, the efficacy of triptans, and the risk of cardiovascular and cerebrovascular AEs and chronic headaches with triptans.
- || zolmitriptan / Generic mfg.
Trial completion: A Study of M207 With Intranasal Zolmitriptan in Healthy Volunteers (clinicaltrials.gov) - Jan 31, 2019
P1, N=24, Completed, Sponsor: Zosano Pharma Corporation
Further research is needed regarding pharmacist-only triptan use by migraineurs currently using over-the-counter medicines and by nonmigraineurs, the efficacy of triptans, and the risk of cardiovascular and cerebrovascular AEs and chronic headaches with triptans. Active, not recruiting --> Completed
- | zolmitriptan / Generic mfg.
Enrollment closed: A Study of M207 With Intranasal Zolmitriptan in Healthy Volunteers (clinicaltrials.gov) - Nov 29, 2018
P1, N=24, Active, not recruiting, Sponsor: Zosano Pharma Corporation
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- | zolmitriptan / Generic mfg.
Enrollment open: A Study of M207 With Intranasal Zolmitriptan in Healthy Volunteers (clinicaltrials.gov) - Nov 5, 2018
P1, N=24, Recruiting, Sponsor: Zosano Pharma Corporation
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting
- | zolmitriptan / Generic mfg.
New P1 trial: A Study of M207 With Intranasal Zolmitriptan in Healthy Volunteers (clinicaltrials.gov) - Oct 17, 2018
P1, N=24, Not yet recruiting, Sponsor: Zosano Pharma Corporation
- | zolmitriptan / Generic mfg.
New P4 trial: Efficacy and Safety of Zolmitriptan by Sublingual Administration (clinicaltrials.gov) - Dec 19, 2017
P4, N=71, Not yet recruiting, Sponsor: Xijing Hospital
- |||||| zolmitriptan / Generic mfg.
Enrollment open: Efficacy & Safety Of Zomig Nasal Spray For Acute Migraine Treatment In Subjects 6 To 11 Years, With OLE (clinicaltrials.gov) - Nov 20, 2017
P3, N=426, Recruiting, Sponsor: IMPAX Laboratories, Inc.
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- |||||||||| zolmitriptan / Generic mfg.
New P3 trial: Efficacy & Safety Of Zomig Nasal Spray For Acute Migraine Treatment In Subjects 6 To 11 Years, With OLE (clinicaltrials.gov) - Sep 7, 2017
P3, N=426, Not yet recruiting, Sponsor: IMPAX Laboratories, Inc.
- | zolmitriptan / Generic mfg., paracetamol / Generic mfg.
New P4 trial: Comparison of Oral Paracetamol and Zolmitriptan Efficacy in the Treatment of Acute Migraine in Emergency Department (clinicaltrials.gov) - May 9, 2017
P4, N=200, Completed, Sponsor: Pamukkale University
- ||| zolmitriptan inhalational (CVT-427) / Acorda
Trial completion: A Study of the Pulmonary Safety and Pharmacokinetics of Zolmitriptan Inhalation Powder (clinicaltrials.gov) - Jan 30, 2017
P1, N=60, Completed, Sponsor: Acorda Therapeutics
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- || zolmitriptan inhalational (CVT-427) / Acorda
Enrollment closed: A Study of the Pulmonary Safety and Pharmacokinetics of Zolmitriptan Inhalation Powder (clinicaltrials.gov) - Dec 22, 2016
P1, N=60, Active, not recruiting, Sponsor: Acorda Therapeutics
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- ||| zolmitriptan inhalational (CVT-427) / Acorda
New P1 trial: A Study of the Pulmonary Safety and Pharmacokinetics of Zolmitriptan Inhalation Powder (clinicaltrials.gov) - Sep 18, 2016
P1, N=60, Recruiting, Sponsor: Acorda Therapeutics
- |||| sumatriptan/naproxen / Generic mfg.
Trial completion, Trial primary completion date: TRXvUsualTrptn: Does Treximet Improve Productivity and Patient Satisfaction Due to Sustained Response and Consistency of Response? (clinicaltrials.gov) - Aug 11, 2016
P4, N=60, Completed, Sponsor: The Cleveland Clinic
Recruiting --> Active, not recruiting Recruiting --> Completed | Trial primary completion date: Dec 2016 --> Aug 2016
- | zolmitriptan inhalational (CVT-427) / Acorda
Trial completion, Enrollment change: Safety and Pharmacokinetics (PK) Study of Single Ascending Doses of CVT-427 (Zolmitriptan Inhalation Powder) In Healthy Adults (clinicaltrials.gov) - Jun 9, 2016
P1, N=21, Completed, Sponsor: Acorda Therapeutics
Recruiting --> Completed | Trial primary completion date: Dec 2016 --> Aug 2016 Active, not recruiting --> Completed | N=32 --> 21
- zolmitriptan inhalational (CVT-427) / Acorda
Enrollment closed: Safety and Pharmacokinetics (PK) Study of Single Ascending Doses of CVT-427 (Zolmitriptan Inhalation Powder) In Healthy Adults (clinicaltrials.gov) - Feb 4, 2016
P1, N=32, Active, not recruiting, Sponsor: Acorda Therapeutics
Active, not recruiting --> Completed | N=32 --> 21 Recruiting --> Active, not recruiting
- | zolmitriptan inhalational (CVT-427) / Acorda
New P1 trial: Safety and Pharmacokinetics (PK) Study of Single Ascending Doses of CVT-427 (Zolmitriptan Inhalation Powder) In Healthy Adults (clinicaltrials.gov) - Nov 21, 2015
P1, N=32, Recruiting, Sponsor: Acorda Therapeutics
- || sumatriptan/naproxen / Generic mfg.
Trial primary completion date: TRXvUsualTrptn: Does Treximet Improve Productivity and Patient Satisfaction Due to Sustained Response and Consistency of Response? (clinicaltrials.gov) - Feb 6, 2015
P4, N=60, Recruiting, Sponsor: The Cleveland Clinic
Recruiting --> Active, not recruiting Trial primary completion date: Dec 2014 --> Dec 2016
- || sumatriptan/naproxen / Generic mfg.
Trial primary completion date: TRXvUsualTrptn: Does Treximet Improve Productivity and Patient Satisfaction Due to Sustained Response and Consistency of Response? (clinicaltrials.gov) - Jun 27, 2014
P4, N=60, Recruiting, Sponsor: The Cleveland Clinic
Trial primary completion date: Dec 2014 --> Dec 2016 Trial primary completion date: Jun 2014 --> Dec 2014
- ||| zolmitriptan / Generic mfg.
Enrollment change: TEENZ: Zomig - Treatment of Acute Migraine Headache in Adolescents (clinicaltrials.gov) - Jan 14, 2014
P4, N=1653, Completed, Sponsor: AstraZeneca
Trial primary completion date: Jun 2014 --> Dec 2014 N=2400 --> 1653