- |||||||||| Ortem (metronidazole topical) / SLA Pharma
Trial completion date, Trial primary completion date: Metronidazole Ointment in Non-healing Pilonidal Sinus Wounds (clinicaltrials.gov) - Jul 14, 2021
P2, N=80, Not yet recruiting,
Trial completion date: May 2021 --> May 2022 | Trial primary completion date: May 2021 --> Feb 2022
- |||||||||| metronidazole topical / SLA Pharma
[VIRTUAL] A Case of Hypopigmented Mycosis Fungioides () - Dec 2, 2020 - Abstract #ASDP2020ASDP_209;
Due to the lack of specific clinical features, as in this case, HMF is difficult to distinguish from many conditions presenting with hypopigmented macules or plaques, such as vitiligo, tinea corporis, and tinea versicolor. Histopathologic examination and ancillary studies are essential to clinch the diagnosis.
- |||||||||| Flagyl (metronidazole) / SLA, metronidazole topical / SLA Pharma
[VIRTUAL] Topical Therapy Pearls () - Nov 26, 2020 - Abstract #FCPANP2020FCPANP_66;
Dr. Kircik ended his talk with the important take away message: vehicles matter.
- |||||||||| Flagyl (metronidazole) / SLA
Journal: Development of an Emulgel for the Treatment of Rosacea Using Quality by Design Approach. (Pubmed Central) - Nov 19, 2020
A metronidazole and niacinamide emulgel, also providing cosmetic assistance, was developed using QbD. The emulgel releases metronidazole faster than the creams, but more gradually than the commercially available gel, providing a realistic time frame of drug delivery in accordance with the expected time of residence of the adhesive emulgel over the affected facial area.
- |||||||||| Flagyl (metronidazole) / SLA
[VIRTUAL] A Rare Culprit in a Case of Budd-Chiari Syndrome () - Sep 15, 2020 - Abstract #ACG2020ACG_2799;
These proteins are known to induce a hypercoagulable state by depressing fibrinolysis, stimulating platelets to release PF4, and encouraging endothelial cellular exposure of tissue factor. Eosinophils have also been demonstrated to express additional tissue factor, which can activate the coagulation pathway via factor VII and X. This case demonstrates the importance of having parasitic infections on the differential as a cause of BCS with eosinophilia.
- |||||||||| Flagyl (metronidazole) / SLA
Journal: 20S proteasome as a drug target in Trichomonas vaginalis. (Pubmed Central) - Aug 7, 2020
In a murine model of vaginal trichomonad infection, proteasome inhibitors eliminated or significantly reduced parasite burden upon topical treatment without any apparent adverse effects. Together, these findings validate the proteasome of T. vaginalis as a therapeutic target for development of a novel class of trichomonacidal agents.
- |||||||||| metronidazole topical / SLA Pharma
Clinical, Review, Journal: Clinical effectiveness of novel rosacea therapies. (Pubmed Central) - Jun 26, 2020
Procedural therapies including pulsed dye laser, radiofrequency, and dual frequency ultrasound are promising as both monotherapies or in combination. Although there are several effective treatment modalities for rosacea management, treatments options should be tailored for the specific clinical scenario.
- |||||||||| metronidazole topical / SLA Pharma, methotrexate / Generic mfg., minocycline / Generic mfg.
[VIRTUAL] Refractory cutaneous-limited facial Rosai Dorfman disease () - Jun 20, 2020 - Abstract #AADVMX2020AAD-VMX_161;
Serial intralesional steroid injections led to temporary improvement in the appearance of her papules, but progression continued. She started 15 mg oral methotrexate weekly and preliminary results are promising.⁴ Gold standard treatments have not been established in RDD, and the cumulative cure rate for all reported treatments is approximately 29%.³ Excision remains the most effective intervention, though challenging to implement in cosmetically sensitive areas.³ This case demonstrates a rare cutaneous variant of RDD and highlights the various treatment modalities used for this chronic, often refractory disease.
- |||||||||| metronidazole topical / SLA Pharma
[VIRTUAL] Metronidazole hypersensitivity in a patient with angioedema and systemic rash () - May 19, 2020 - Abstract #EAACI2020EAACI_1599;
In literature different cases of hypersensitivity reactions to metronidazole are already described. However, most of the systemic reactions to this drug described are not confirmed by allergy testing, except some cases of immediate reactions established by positive skin tests or some delayed reactions established by positive patch tests essentially due to allergic contact dermatitis in patients sensitized to topical metronidazole.
- |||||||||| Flagyl (metronidazole) / SLA
Review, Journal: Bacterial Vaginosis and Surgical Site Infections. (Pubmed Central) - May 7, 2020
Treatment options approved by the FDA include metronidazole, clindamycin, tinidazole, and secnidazole. Given the prevalence of BV and the risks associated with operating on a woman with untreated BV, women undergoing hysterectomy, surgical abortion, and potentially cesarean delivery should be screened for BV, and those who screen positive should be treated with an appropriate antimicrobial agent.
- |||||||||| Flagyl (metronidazole) / SLA, metronidazole topical / SLA Pharma, ivermectin / Generic mfg.
Clinical, Journal: Nodular Demodicosis in a Pregnant Woman Treated with Oral Ivermectin and Metronidazole. (Pubmed Central) - May 7, 2020
A Demodex preparation revealed numerous Demodex mites from each pustule that was sampled. Based on the clinical findings and the positive Demodex preparations, the woman was diagnosed with nodular demodicosis.
- |||||||||| Flagyl (metronidazole) / SLA, metronidazole topical / SLA
Journal: A Portable Device for the Generation of Drug-Loaded Three-Compartmental Fibers Containing Metronidazole and Iodine for Topical Application. (Pubmed Central) - Apr 25, 2020
Overall, the portable system has been shown to be capable of not only incorporating the two drugs in distinct layers but also of delivering adequate amounts of drugs for a more effective antibacterial activity. The portability of the device and its ability to generate distinct layers of multiple active ingredients make it promising for further development for wound healing applications in terms of both practical applicability and antimicrobial efficacy.
- |||||||||| Flagyl (metronidazole) / SLA, metronidazole topical / SLA
Journal: Different Types of Gel Carriers as Metronidazole Delivery Systems to the Oral Mucosa. (Pubmed Central) - Mar 25, 2020
The formulated hydrogels and bigels containing micronized MET were considered as better formulations in terms of drug release and antimicrobial activity compared to commercially available metronidazole ointment. An ex vivo permeation study with the use of porcine buccal mucosa demonstrated that the bigel formulation was characterized by higher initial permeability rate providing a fast therapeutic effect with simultaneous moderate retention in mucosal tissue to decrease the risk of local cytotoxicity.
- |||||||||| Flagyl (metronidazole) / SLA, metronidazole topical / SLA
Journal: Design, Formulation, and Physicochemical Evaluation of Vaginal Cream Containing Eucalyptus camaldulensis, Viola odorata, and Mentha piperita extracts for Prevention and Treatment of Trichomoniasis. (Pubmed Central) - Mar 7, 2020
Metronidazole is the drug of choice for the treatment of this infection...Ethyl acetate extract of E. camaldulensis leaves, water fraction of V. odorata root, and hydroalcoholic extract of M. piperita leaves was prepared and used for anti-trichomonas experiments...In the next step, anti-trichomonas effect of selective formulation was tested in vitro. The mixed concentrates containing 2.5 mg/ml E. camaldulensis, 0.06 mg/ml V. odorata, and 1 mg/ml M. piperita showed 100% growth inhibition (GI) during 24 h. Furthermore, the mixture containing 1.25 mg/ml E. camaldulensis, 0.03 mg/ml V. odorata, and 0.5 mg/ml M. piperita showed 92% GI in the first 24 h. The selective formulation passed all of physicochemical test and also showed 100% GI for in vitro anti-trichomonas experiments in the first 24 h. The mixed concentrates containing 2.5 mg/ml E. camaldulensis, 0.06 mg/ml of V. odorata, and 1 mg/ml of M. piperita are the mixture which showed the highest percentage of GI (100%) after 24 h. The selective formulation of vaginal cream containing this mixture of extracts was detected 100% GI in the first 24 h.
- |||||||||| Flagyl (metronidazole) / SLA, metronidazole topical / SLA
PK/PD data, Journal, Combination therapy: Metronidazole-Resistant Trichomoniasis: Beneficial Pharmacodynamic Relationship with High-dose Oral Tinidazole and Vaginal Paromomycin Combination Therapy. (Pubmed Central) - Feb 26, 2020
The mixed concentrates containing 2.5 mg/ml E. camaldulensis, 0.06 mg/ml V. odorata, and 1 mg/ml M. piperita showed 100% growth inhibition (GI) during 24 h. Furthermore, the mixture containing 1.25 mg/ml E. camaldulensis, 0.03 mg/ml V. odorata, and 0.5 mg/ml M. piperita showed 92% GI in the first 24 h. The selective formulation passed all of physicochemical test and also showed 100% GI for in vitro anti-trichomonas experiments in the first 24 h. The mixed concentrates containing 2.5 mg/ml E. camaldulensis, 0.06 mg/ml of V. odorata, and 1 mg/ml of M. piperita are the mixture which showed the highest percentage of GI (100%) after 24 h. The selective formulation of vaginal cream containing this mixture of extracts was detected 100% GI in the first 24 h. No abstract available
- |||||||||| Detection of Helicobacter pylori in children and adolescents: diagnosis and treatment in Jessa Hospital between 2016 and 2019. (Room SANCY) - Feb 24, 2020 - Abstract #BWG2020BWG_119;
Antimicrobial susceptibility testing pointed out resistance against metronidazole in 20% of these patients, while 8% showed resistance against either amoxicillin or levofloxacin...More specifically, these patients were treated with triple therapy, i.e. 4 weeks of omeprazole and 2 weeks of amoxicillin/clarithromycin...The determination of antimicrobial susceptibility allowed clinicians to start a tailor-made treatment regimen which led to successful infection eradication in 83% of the evaluated patients. These data underline the importance of patient-specific therapy and follow-up, as recommended by the most recent ESPGHAN/NASPGHAN guidelines.
- |||||||||| Flagyl (metronidazole) / SLA, metronidazole topical / SLA
Journal: A Validated IVRT Method to Assess Topical Creams Containing Metronidazole Using a Novel Approach. (Pubmed Central) - Feb 8, 2020
Furthermore, another cream containing 0.75% MTZ tested against the reference product was shown to be pharmaceutically equivalent to the reference product. These results confirm the appropriateness of the IVRT method as a valuable tool for use in the development of topical MTZ products intended for local action and indicate the potential for general use with other topical products.
- |||||||||| Flagyl (metronidazole) / SLA, ciprofloxacin / Generic mfg., doxycycline / Generic mfg.
Preclinical, Journal: Lesion Sterilization and Tissue Repair in Nonvital Primary Teeth: An In vivo Study. (Pubmed Central) - Feb 6, 2020
LSTR technique can be considered as an alternative treatment option for nonvital primary teeth avoiding a course of systemic antibiotics to the children. Doxycycline can be used in the drug combination instead of minocycline which also gives higher clinical and radiographic success.
- |||||||||| metronidazole topical / SLA
Journal: The role of topical therapy for perianal fistulizing Crohn's disease: are we forgetting something? (Pubmed Central) - Jan 11, 2020
This article adds a new perspective to the field of regenerative endodontics. Due to the disappoint success rate of current strategy in perianal fistulizing Crohn's disease, the role of rectal inflammation as a causative factor and the fair success rate of topical therapy with mesalazine suppositories in the healing of rectal inflammation without relevant side effects, more studies are advisable in this field.
- |||||||||| Journal: Combined systemic (fluconazole) and topical (metronidazole + clotrimazole) therapy for a new approach to the treatment and prophylaxis of recurrent candidiasis. (Pubmed Central) - Jan 10, 2020
This scheme aims to address the recurrent infection aggressively from the outset by attempting not only to treat acute symptoms, but also to prevent a new event by countering many of the potential risk factors of recurrence, such as the intestinal Candida reservoir, the mycotic biorhythm, the formation of biofilm, the phenotype switching and the presence of infections complicated by the presence of C. non albicans or G. Vaginalis, without interfering, but rather favoring the restoration of the vaginal lactobacillus species. Future clinical studies will be useful to confirm the proposed scheme.
- |||||||||| Flagyl (metronidazole) / SLA, tacrolimus / Generic mfg., metronidazole topical / SLA
Preclinical, Journal: Prediction of the skin permeability of topical drugs using in silico and in vitro models. (Pubmed Central) - Jan 8, 2020
Globally good alignments were found for the studied compounds when comparing models, although discrepancies for some compounds such as tazarotene, tacrolimus, ketoconazole and metronidazole were observed. Overall, the studied in silico and the in vitro models are useful tools to support selection and characterization of research compounds in terms of skin permeability.
- |||||||||| Flagyl (metronidazole) / SLA, tacrolimus / Generic Mfg.
Journal: Crohn's disease initiated with extraintestinal features. (Pubmed Central) - Sep 6, 2019
The perioral lesions were managed with topical 0.03% tacrolimus and oral prednisone 10 mgtwice a day for one month, followed by a tapered regimen of 10 mg/day for another month. The patient's symptoms improved without full remission at the 6-month follow-up.
- |||||||||| Flagyl (metronidazole) / SLA, metronidazole topical / SLA
Journal: Application of conjugated estrogen cream in the treatment of postmenopausal atrophic vaginitis. (Pubmed Central) - Aug 21, 2019
Comparison of estradiol and folliclestimulating hormone levels after treatment in the two groups show that the study group has obvious advantage over the reference group, p<0.05; comparison of vagina cleanliness in the two groups after treatment shows the study group is significantly superior to the reference group, p<0.05; comparison of incidence of adverse reactions in the two groups shows that the study group has lower incidence, with statistical significance in comparison between the groups, p<0.05. Treatment of postmenopausal atrophic vaginitis with combination of conjugated estrogen cream and compound metronidazole suppository can achieve good results with high safety and reliability.
- |||||||||| Flagyl (metronidazole) / SLA
Clinical, Journal: The first case report of kerion-type scalp mycosis caused by Aspergillus protuberus. (Pubmed Central) - Aug 8, 2019
The first case of kerion-type scalp mycosis caused by A. protuberus was described to highlight the importance of mycological examination that helps to recognize rare pathogenic fungi. Any boggy lesion with hair loss over the scalp and non-responsive to antibiotics should be suspected as resulting from fungal infection, and mycological examination should be performed, especially in children.
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