- |||||||||| zonisamide / Generic mfg., levetiracetam / Generic mfg.
[VIRTUAL] When walking becomes seizure: a case report () - Nov 28, 2020 - Abstract #AES2020AES_792; Potential described triggers for spells caused by ambulation include afferent proprioceptive stimuli or more complex cortical motor planning. The key clinical feature that differentiates these reflex seizures from a movement disorder is the altered awareness typical of epileptic events.
- |||||||||| leucovorin calcium / Generic mfg.
[VIRTUAL] Non-Convulsive Status Epilepticus as a Manifestation of Methotrexate-Induced Leukoencephalopathy () - Nov 28, 2020 - Abstract #AES2020AES_580; She showed a gradual progressive improvement in global aphasia, cognitive dysfunction, and right hemiparesis in the weeks, currently she is undergoing rehabilitation treatment in the rehabilitation department. Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
- |||||||||| zonisamide / Generic mfg.
Preclinical, Journal: The effect of zonisamide on memory processes - A preclinical study. (Pubmed Central) - Nov 12, 2020 The findings provide a basis for improved management of "wearing-off" in PD by genotype-guided zonisamide treatment. Zonisamide may impair memory and learning processes in rats but the results are varied and depend on the type of memory.
- |||||||||| zonisamide / Generic mfg.
Review, Journal: Kynurenine pathway in Parkinson's disease-An update. (Pubmed Central) - Nov 3, 2020 Therefore, the present review gives an updated research studies on KP in connection with PD. Moreover, the review emphasizes on the urge for the development of biomarkers and also this would be an initiative in generating an alternative therapeutic approach for PD.
- |||||||||| zonisamide / Generic mfg.
Journal: The absence of NIPA2 enhances neural excitability through BK (big potassium) channels. (Pubmed Central) - Oct 27, 2020 The results indicate that the absence of NIPA2 enhances neural excitability through BK channels. Zonisamide is probably a potential treatment for NIPA2 mutation-induced epilepsy, which may provide a basis for the development of new treatment strategies for epilepsy.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] Glomerular Tip Lesion FSGS: A Rare Case of Nephrotic Syndrome in African Americans (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2128; He trialed hydrochlorothiazide and furosemide without success...Outpatient workup was unrevealing, and was managed with enalapril and torsemide...Cyclosporine caused gastrointestinal upset, and so patient switched to tacrolimus...Resistance to one immunosuppressive treatment is not always associated with resistance to other treatment modalities. PLEX and rituximab should be considered in glomerular tip lesion in African Americans
- |||||||||| zonisamide / Generic mfg., levetiracetam / Generic mfg.
[VIRTUAL] A Case of Lance Adams Syndrome with See-Saw Nystagmus () - Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_1209; Our patient with LAS and associated SSN expands the spectrum of etiology of SSN and to our knowledge this is the first PHM case with combination of SSN. There are many etiologies of SSN, but the proposed mechanism in our case is inactivation of the torsional eye-velocity integrator, the interstitial nucleus of Cajal, with sparing of the torsional fast-phase generator, the rostral interstitial nucleus of MLF.
- |||||||||| zonisamide / Generic mfg.
Review, Journal: Zonisamide add-on therapy for focal epilepsy. (Pubmed Central) - Sep 20, 2020 The included trials evaluated a maximum stable-dose phase of 18 weeks, so results cannot be used to confirm longer periods of efficacy in seizure control. The results cannot be extrapolated to monotherapy, or to people with other seizure types or epilepsy syndromes.
- |||||||||| ondansetron / Generic mfg., amitriptyline / Generic mfg.
Clinical, Review, Journal: Management of cyclic vomiting syndrome in adults: Evidence review. (Pubmed Central) - Sep 19, 2020 The results cannot be extrapolated to monotherapy, or to people with other seizure types or epilepsy syndromes. This evidence review helps inform the accompanying guideline for the management of adults with CVS which is aimed at helping clinicians, patients, and policymakers, and should improve patient outcomes.
- |||||||||| ondansetron / Generic mfg., amitriptyline / Generic mfg.
Clinical, Review, Journal: Guidelines on management of cyclic vomiting syndrome in adults by the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association. (Pubmed Central) - Sep 19, 2020 For acute attacks, the committee conditionally recommends using serotonin antagonists, such as ondansetron, and/or triptans, such as sumatriptan or aprepitant to abort symptoms...The committee recommended screening and treatment for comorbid conditions such as anxiety, depression, migraine headache, autonomic dysfunction, sleep disorders, and substance use with referral to appropriate allied health services as indicated. Techniques like meditation, relaxation, and biofeedback may be offered as complementary therapy to improve overall well-being and patient care outcomes.
- |||||||||| zonisamide / Generic mfg.
[VIRTUAL] Acute Hepatitis Secondary to Asymptomatic Epstein-Barr Virus (EBV) Infection () - Sep 15, 2020 - Abstract #ACG2020ACG_2902; Her home medicine includes oral vitamin B12, folic acid, zonisamide (no changes to regimen in 2 years)...EBV hepatitis as a differential in patients with cholestatic hepatitis but without demonstrable biliary obstruction, prompt identification would avoid costly and/or invasive diagnostic procedures. No effective treatment is available for EBV hepatitis.
- |||||||||| Fycompa (perampanel) / Eisai, zonisamide / Generic mfg., clonazepam / Generic mfg.
Journal: Update on current and emerging therapies for dystonia. (Pubmed Central) - Aug 27, 2020 Pallidal deep-brain stimulation is beneficial for medication-refractory primary generalized and possibly focal dystonia such as cervical dystonia. Certain genetic conditions are amenable to specific therapies and future gene-targeted therapies could benefit selected dystonia patients.
- |||||||||| pregabalin / Generic mfg.
Review, Journal: Epilepsy and breastfeeding: from myth to reality (Pubmed Central) - Aug 23, 2020 Lamotrigine, phenobarbital, pregabalin, primidone, tiagabine, eslicarbazepine, brivaracetam, perampanel, zonisamide, lacosamide or the sporadic use of benzodiazepines in low doses are considered quite safe, with a low risk for breastfeeding. The other AEDs present a very low risk for breastfeeding.
- |||||||||| carbamazepine / Generic mfg.
Review, Journal: Antiepileptic drugs as prophylaxis for postcraniotomy seizures. (Pubmed Central) - Aug 15, 2020 The current evidence base is limited due to the different methodologies employed in the trials and inconsistencies in the reporting of outcomes including deaths and adverse events. Further evidence from good-quality, contemporary trials is required in order to assess the clinical effectiveness of prophylactic AED treatment compared to placebo or no treatment, or other AEDs in preventing postcraniotomy seizures in this select group of patients.
- |||||||||| Fycompa (perampanel) / Eisai, zonisamide / Generic mfg.
Journal: An Update on Myoclonus Management. (Pubmed Central) - Aug 11, 2020 Furthermore, due to the etiological heterogeneity of myoclonus, defining the appropriate scope for high quality clinical trials is challenging. In order to advance the field, the myoclonus study group needs to be revived in the US and abroad so that interested investigators can collaborate on multicenter clinical trials for myoclonus treatments.
- |||||||||| zonisamide / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: Evaluation of fecal Lactobacillus populations in dogs with idiopathic epilepsy: a pilot study. (Pubmed Central) - Aug 5, 2020 Further studies are warranted to evaluate the role of the gut microbiome in disease progression and treatment response in dogs with epilepsy. Lactobacilli in culture were not killed or inhibited from growing when exposed to phenobarbital, potassium bromide, zonisamide or levetiracetam, suggesting that antiepileptic drug administration is less likely to be a confounding factor in future studies evaluating the role of Lactobacillus in epilepsy.
- |||||||||| zonisamide / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date: Z-Comp: Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action (clinicaltrials.gov) - Jul 14, 2020 P1, N=160, Recruiting, In addition to collecting data in a regulatory compliant manner, the registry creates a ready for use infrastructure for the conduct of future clinical trials in children and adolescents with migraine. Active, not recruiting --> Recruiting | Trial completion date: Oct 2020 --> Oct 2021 | Trial primary completion date: Oct 2020 --> Oct 2021
- |||||||||| zonisamide / Generic mfg.
Clinical, Journal: Zonisamide for Cluster Headache Prophylaxis: A Case Series. (Pubmed Central) - Jul 11, 2020 Zonisamide appears to be an effective prophylactic treatment for patients with chronic and episodic cluster headache disorders. Further research in this area is clearly warranted.
- |||||||||| zonisamide / Generic mfg.
Review, Journal: Twenty years on: Myoclonus-dystonia and ε-sarcoglycan - neurodevelopment, channel, and signaling dysfunction. (Pubmed Central) - Jul 9, 2020 Further research in this area is clearly warranted. Zonisamide has demonstrated effectiveness at reducing both myoclonus and dystonia, and deep brain stimulation seems to be an effective and long-lasting therapeutic option for medication-refractory cases...Finally, we critically discuss the normal and pathological function of the epsilon-sarcoglycan gene and its product, suggesting a role in the stabilization of the dopaminergic membrane via regulation of calcium homeostasis and in the neurodevelopmental process involving the cerebello-thalamo-pallido-cortical network.
- |||||||||| zonisamide / Generic mfg.
Journal: The Positive Impact of an Extended Intervention on Dosing Accuracy of Student Compounded Suspensions. (Pubmed Central) - Jul 8, 2020 Providing more explicit auditory and visual instructions to pharmacy students regarding the proper shaking and sampling techniques of their compounded suspensions resulted in more consistent and accurate dosing of a zonisamide suspension. By implication, pharmacists providing specific and personalized instructions to patients should reduce their self-dosing inconsistencies at home.
- |||||||||| carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Antiepileptic Drug Exposure in Infants of Breastfeeding Mothers With Epilepsy. (Pubmed Central) - Jul 7, 2020 Overall, antiepileptic drug concentrations in blood samples of infants who were breastfed were substantially lower than maternal blood concentrations. Given the well-known benefits of breastfeeding and the prior studies demonstrating no ill effects when the mother was receiving antiepileptic drugs, these findings support the breastfeeding of infants by mothers with epilepsy who are taking antiepileptic drug therapy.
- |||||||||| pregabalin / Generic mfg., cyclophosphamide intravenous / Generic mfg., Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] A Journey Through the Endless Pursuit: Challenges with Refractory Status Epilepticus (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6886; Patients with NORSE/FIRES present as both a diagnostic and therapeutic challenge, which is illustrated in this case. The paucity of data on these syndromes translates into a lack of data on treatment options, highlighting the need for increased awareness among medical providers, the importance of the existence of a registry and publications of individual case reports that contribute to the literature and foster further investigation.
- |||||||||| carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Treatment of Juvenile Myoclonic Epilepsy in Patients of Child-Bearing Potential. (Pubmed Central) - Jul 4, 2020 Alternatives have emerged, especially lamotrigine and levetiracetam, but also topiramate, zonisamide, and recently perampanel, but none of these AEDs can be considered fully safe in the context of pregnancy...Carbamazepine, oxcarbazepine and phenytoin must be avoided...The consequences of a lifetime of poorly controlled epilepsy need to be balanced against the teratogenic risks of valproate during limited times in a woman's life. The management of JME in WWE should include lifestyle interventions, with avoidance of sleep deprivation, and planned pregnancy.
- |||||||||| zonisamide / Generic mfg., vigabatrin / Generic mfg.
Journal: New insights in phenomenology and treatment of epilepsy in CDKL5 encephalopathy. (Pubmed Central) - Jul 4, 2020 Progressive transition from this seizure type to epileptic spasms in clusters seems to result from increasing expression of the CDKL5 gene, as the child grows older. Five patients responded to the combination of vigabatrin and zonisamide.
- |||||||||| carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Review, Journal: Risks and management of antiepileptic drug induced skin reactions in the adult out-patient setting. (Pubmed Central) - Jun 28, 2020 At the same time our manuscript reviews published data informing best choice and titration of alternative medication when allergy confirmed. Finally we summarize current knowledge on genetic predisposition and other personalized risks of AED allergies identifying gaps in our current understanding.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo, zonisamide / Generic mfg., carbamazepine / Generic mfg.
Journal: Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels. (Pubmed Central) - Jun 11, 2020 Therefore, the present study demonstrated the distinct effects of CBZ, LCM, and ZNS on gliotransmitter release via modulation of astroglial hemichannel function. The different features of the effects of three VDSC-inhibiting anticonvulsants on astroglial transmission associated with hemichannels, at least partially, possibly contributing to the formation of the properties of these three anticonvulsants, including the antiepileptic spectrum and adverse effects regarding mood and cognitive disturbance.
- |||||||||| zonisamide / Generic mfg.
Enrollment open: BuZonE: Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes (clinicaltrials.gov) - May 27, 2020 P3, N=50, Recruiting, The different features of the effects of three VDSC-inhibiting anticonvulsants on astroglial transmission associated with hemichannels, at least partially, possibly contributing to the formation of the properties of these three anticonvulsants, including the antiepileptic spectrum and adverse effects regarding mood and cognitive disturbance. Not yet recruiting --> Recruiting
- |||||||||| zonisamide / Generic mfg.
Enrollment open, Metastases: Role of Zonisamide in Advanced Parkinson's Disease (PD) in Egyptian Population: Pilot Study (clinicaltrials.gov) - May 17, 2020 P=N/A, N=90, Recruiting, These results suggest that pathomechanisms of ADSHE seizure and its cognitive deficit comorbidity, as well as pathophysiology of CBZ-resistant/ZNS-sensitive ADSHE seizures of patients with S284L-mutation. Not yet recruiting --> Recruiting
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