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11 Trials |  |
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- Nourianz (istradefylline) / Kyowa Kirin
[VIRTUAL] Risk factors for the onset of dyskinesia in patients with Parkinson's disease exhibiting wearing-off phenomena: A 1-year observational study in Japan (J-FIRST) () - Sep 29, 2021 - Abstract #MDSCongress2021MDS_Congress_939;
Univariate analyses showed that significant risk factors for the onset of dyskinesia were female gender, long duration of PD symptoms, long duration of motor complications, young age of onset, low Movement Disorders Society–Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I Item 3 (depressed mood) score, high MDS-UPDRS Part I Item 7 (sleep problems) score, high modified Hoehn and Yahr stage, high L-dopa dose/L-dopa equivalent dose, and administration of dopamine agonists, a catechol-O-methyltransferase (COMT) inhibitor, zonisamide, and istradefylline [Table1]. This observational study revealed that risk factors for onset of dyskinesia within 1 year in patients with PD exhibiting wearing-off phenomena were female gender and administration of dopamine agonists, a COMT inhibitor, and zonisamide.
- zonisamide / Generic mfg.
[VIRTUAL] Randomised Controlled Trial Comparing Efficacy of Zonisamide 25 mg given in addition to standard treatment with standard treatment alone in Tremor dominant Parkinson's disease- A Pilot study. () - Sep 29, 2021 - Abstract #MDSCongress2021MDS_Congress_711;
Larger studies are required to confirm these findings. Zonisamide in a dose of 25 mg has a safe side effect profile and is well tolerated among Parkinson's disease patients.
- || ganaxolone oral (CCD-1042) / Marinus
Clinical, Journal: The anticonvulsant zonisamide positively modulates recombinant and native glycine receptors at clinically relevant concentrations. (Pubmed Central) - Sep 26, 2021
Furthermore, zonisamide (100 μM) potentiated exogenous homomeric and heteromeric glycine mediated currents from layer II pyramidal cells of the lateral or medial entorhinal cortex. As therapeutic concentrations of zonisamide positively modulate recombinant and native glycine receptors, we propose that the anticonvulsant effects of zonisamide may, at least in part, be mediated via this action.
- zonisamide / Generic mfg.
Airway Management Of A Patient With Zonisamide Induced Toxic Epidermal Necrolysis (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4817;
Fiberoptic laryngoscopy was performed and demonstrated that there was no upper airway involvement. The patient underwent successful awake fiberoptic intubation and was extubated at the end of the procedure.
- || zonisamide / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy. (Pubmed Central) - Sep 22, 2021
P=N/A
Co-administration of zonisamide and levetiracetam had some impact on cannabidiol pharmacokinetic parameters. There was an observed degradation of plasma cannabidiol in long-term storage.
- || zonisamide / Generic mfg.
Clinical, Review, Journal: Zonisamide in Parkinson's disease: a current update. (Pubmed Central) - Sep 19, 2021
Most of the randomized clinical trials used UPDRS III as the primary efficacy point and showed positive results favouring ZNS. This review shows that there is evidence of the efficacy of ZNS in motor symptoms as an adjunctive therapy to levodopa, but for non-motor symptoms, the evidence is lacking and needs further investigation.
- | zonisamide / Generic mfg.
Preclinical, Journal: Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress. (Pubmed Central) - Sep 17, 2021
The combined administration of both compounds was not more effective than each drug alone. This study suggests that doxazosin is reliable at reducing voluntary ethanol intake in mice independently of their history of ethanol dependence and stress exposure.
- || zonisamide / Generic mfg.
Clinical, Retrospective data, Journal: Efficacy and Safety of Zonisamide in Dementia with Lewy Bodies Patients with Parkinsonism: A Post Hoc Analysis of Two Randomized, Double-Blind, Placebo-Controlled Trials. (Pubmed Central) - Sep 17, 2021
This study suggests that doxazosin is reliable at reducing voluntary ethanol intake in mice independently of their history of ethanol dependence and stress exposure. Our findings indicate that zonisamide improved parkinsonism with DLB without deterioration of cognitive function and BPSD.
- || zonisamide / Generic mfg.
Clinical, Journal: Case Report of a 67-Year-Old Man with Zonisamide-Induced Ciliochoroidal Effusion Syndrome. (Pubmed Central) - Sep 16, 2021
Our findings indicate that zonisamide improved parkinsonism with DLB without deterioration of cognitive function and BPSD. No abstract available
- || zonisamide / Generic mfg.
Clinical, Journal: Zonisamide safety in pregnancy: Data from the UK and Ireland epilepsy and pregnancy register. (Pubmed Central) - Sep 15, 2021
These data raise concerns about a signal for potential teratogenicity with zonisamide in human pregnancy. Given the low numbers reported, further data will be required to adequately counsel women who use zonisamide in pregnancy.
- || zonisamide / Generic mfg.
Retrospective data, Review, Journal: Efficacy, tolerability, and safety of zonisamide in children with epileptic spasms: A systematic review and meta-analysis. (Pubmed Central) - Sep 15, 2021
But there are only limited studies on epileptic spasms of sufficient quality to give high confidence in meta-analysis. Large controlled trials are needed in this regard to provide high-quality evidence favoring/disfavoring its use in patients with epileptic spasms.
- | zonisamide / Generic mfg.
Journal: Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress. (Pubmed Central) - Sep 11, 2021
Moreover, preapplication of the specific ER stress inducer tunicamycin (10 ng/mL) eliminated the protective effects of ZNS against HG-induced cardiac hypertrophy and ER stress-mediated apoptosis. Our findings suggest that ZNS improves the cardiac diastolic function in diabetic mice and prevents T2DM-induced cardiac hypertrophy by attenuating ER stress-mediated apoptosis.
- || donepezil / Generic mfg.
Retrospective data, Review, Journal: Treatment Efficacy and Acceptabilityof Pharmacotherapies for Dementia with Lewy Bodies: A Systematic Review and Network Meta-Analysis. (Pubmed Central) - Sep 8, 2021
We report the most comprehensive evidence for the selection of pharmacotherapy for treating different clusters of DLB-related symptoms. Due to the limited availability of RCTs on DLB, more well-conducted RCTs are needed for MMA to warrant clinical efficacy in the future.
- | amoxicillin / Generic mfg.
Retrospective data, Journal: Toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in pediatric patients with a focus on newer antiepileptic drugs: A 25-year retrospective study at a single tertiary care center. (Pubmed Central) - Sep 2, 2021
These medications are being used more widely to treat seizures, as well as mood disorders. It is also important for clinicians to be aware of the extremely commonly used medications such as amoxicillin, tetracyclines, NSAIDs, and acetaminophen that can rarely cause SJS and TEN.
- | zonisamide / Generic mfg.
Preclinical, Journal: Zonisamide promotes survival of human-induced pluripotent stem cell-derived dopaminergic neurons in the striatum of female rats. (Pubmed Central) - Aug 25, 2021
In conclusion, ZNS promotes the survival of DA neurons after the transplantation of human-iPS cell-derived DA progenitors in the rat striatum. SLITRK6 is suggested to be involved in this supportive effect of ZNS by modulating the environment of the host brain.
- || Nitredon (nitrazepam) / Remedica
Clinical, Journal: Association of Child Neurology (AOCN) - Indian Epilepsy Society (IES) Consensus Guidelines for the Diagnosis and Management of West Syndrome. (Pubmed Central) - Aug 21, 2021
The choice depends on the preference of the treating physician and the family, based on factors of cost, availability of infrastructure and personnel for daily intramuscular injections, and monitoring side effects. Second line treatment options include anti-epileptic drugs (vigabatrin, sodium valproate, topiramate, zonisamide, nitrazepam and clobazam), ketogenic diet and epilepsy surgery.
- || Clinical, Review, Journal: Therapeutic Options for Patients with Refractory Status Epilepticus in Palliative Settings or with a Limitation of Life-Sustaining Therapies: A Systematic Review. (Pubmed Central) - Aug 20, 2021
The evidence for the use of ASDs in RSE beyond that in current guidelines is low, but several effective and well-tolerated options are available that should be considered in this patient population. More so than in any other population, advance care planning, advance directives, and medical ethical aspects have to be considered carefully before and during therapy.
- ||||| zonisamide / Generic mfg.
Enrollment change: BuZonE: Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes (clinicaltrials.gov) - Aug 18, 2021
P3, N=26, Active, not recruiting, Sponsor: Rose Research Center, LLC
More so than in any other population, advance care planning, advance directives, and medical ethical aspects have to be considered carefully before and during therapy. N=50 --> 26
- ||| zonisamide / Generic mfg.
Clinical, P3 data, Journal: Effect of zonisamide on parkinsonism in patients with dementia with Lewy bodies: A phase 3 randomized clinical trial. (Pubmed Central) - Aug 14, 2021
N=50 --> 26 Daily administration of 25- or 50-mg zonisamide significantly improved motor function compared with placebo; both doses were safe and well tolerated in patients with DLB.
- || zonisamide / Generic mfg.
Clinical, Journal: Zonisamide Therapy Reduces Metabolic Consequences and Diminishes Nonalcoholic Fatty Liver Disease in Patients with Epilepsy. (Pubmed Central) - Aug 8, 2021
After adjusting for age, sex, time, and the corresponding dependent variable at baseline, the generalized estimating equation analysis revealed that the body weight, BMI, serum levels of HbA1c, triglycerides, hs-CRP, and the index for HSI were significantly declined. These results suggest that ZNS provides benefits in patients with obesity and metabolic syndrome at high vascular risk.
- | gabapentin / Generic mfg.
Journal: Focal Cortical Resection and Hippocampectomy in a Cat With Drug-Resistant Structural Epilepsy. (Pubmed Central) - Aug 7, 2021
This is the first exploratory study of intracranial epilepsy surgery for naturally occurring epilepsy, with modern electroclinical and imaging evidence, in veterinary medicine. Along with the spread of advanced diagnostic modalities and neurosurgical devices in veterinary medicine, epilepsy surgery may be an alternative treatment option for drug-resistant epilepsy in cats.
- | zonisamide / Generic mfg.
Journal: Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel Ca3.1 caused by a mutation responsible for spinocerebellar ataxia. (Pubmed Central) - Aug 7, 2021
Moreover, efonidipine, another T-type calcium channel blocker, had no effect on tremors in our patient with SCA42 and did not improve the abnormal shift in the voltage dependence of the mutant Ca3.1. This indicates that ZNS is distinct from other T-type calcium channel blockers in terms of modulation of the voltage dependence of the mutant Ca3.1.
- | zonisamide / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Z-Comp: Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action (clinicaltrials.gov) - Jul 30, 2021
P3, N=159, Completed, Sponsor: Virginia Commonwealth University
This indicates that ZNS is distinct from other T-type calcium channel blockers in terms of modulation of the voltage dependence of the mutant Ca3.1. Recruiting --> Completed | Trial completion date: Oct 2021 --> Apr 2021 | Trial primary completion date: Oct 2021 --> Apr 2021
- || zonisamide / Generic mfg.
Clinical, Journal: A case of zonisamide-induced toxic epidermal necrolysis with acute respiratory failure. (Pubmed Central) - Jul 24, 2021
Recruiting --> Completed | Trial completion date: Oct 2021 --> Apr 2021 | Trial primary completion date: Oct 2021 --> Apr 2021 No abstract available
- || zonisamide / Generic mfg., carbamazepine / Generic mfg.
Clinical, Journal: Zonisamide Therapy for Patients With Paroxysmal Kinesigenic Dyskinesia. (Pubmed Central) - Jul 24, 2021
We can evaluate the efficacy of zonisamide therapy within one week. Because zonisamide lacks the enzyme-inducing effects of carbamazepine and phenytoin, it may be useful for PKD treatment.
- | pregabalin / Generic mfg.
Observational data, Journal: Seizure freedom and plasma levels of newer generation antiseizure medications. (Pubmed Central) - Jul 21, 2021
Because zonisamide lacks the enzyme-inducing effects of carbamazepine and phenytoin, it may be useful for PKD treatment. Efficacy of newer generation ASMs seems to be reached at the lower part or at times even below the reference ranges in drug responsive patients; this could inform regarding titrations of these treatments.
- || pregabalin / Generic mfg., sirolimus / Generic mfg., gabapentin / Generic mfg.
Review, Journal: Interaction of cannabidiol with other antiseizure medications: A narrative review. (Pubmed Central) - Jul 14, 2021
The existing literature is limited for some ASMs by studies having relatively small cohorts. As increasing numbers of patients use cannabidiol, specialists need to monitor closely for interactions clinically and with blood levels when required.
- | zonisamide / Generic mfg.
Journal: Zonisamide effects on sleep problems and depressive symptoms in Parkinson's disease. (Pubmed Central) - Jul 2, 2021
We showed the beneficial effects of ZNS on motor symptoms and sleep problems in levodopa-treated PD patients with motor fluctuation. ZNS may be more effective for several nonmotor symptoms in PD patients with tremor compared with those without tremor.
- || gabapentin / Generic mfg., carbamazepine / Generic mfg.
Clinical, Review, Journal: Which treatment strategy in patients with epilepsy with focal seizures uncontrolled by the first anti-seizure medication? (Pubmed Central) - Jul 2, 2021
Carbamazepine (CBZ) has negative pharmacokinetic interactions with several ASMs and should not be combined with other SCBs; it could be effectively and safely combined with gabapentin (GBP) and LEV. Valproic acid has enzyme inhibiting properties and can be cautiously used with SCBs; its combination with TPM or zonisamide (ZNS) may be associated with higher toxicity.
- || Fycompa (perampanel) / Eisai
Clinical, Review, Journal: Use of extended-release and immediate-release anti-seizure medications with a long half-life to improve adherence in epilepsy: A guide for clinicians. (Pubmed Central) - Jul 1, 2021
This article is intended as a practical guide for clinicians that provides an overview of the features of ER ASMs and long t IR ASMs that are advantageous in the context of patient adherence and pharmacokinetic "forgiveness" (after missing a dose). In addition, we note that efforts to improve adherence should not depend solely on drug dosing regimens and drug pharmacokinetics, but should be part of a wider strategy that includes therapeutic drug monitoring, improved healthcare provider-patient dialogue, patient education, and the use of "reminder" technology.
- || Vimpat (lacosamide) / UCB, Daiichi Sankyo
Clinical, Journal, HEOR: Investigation of the roles of new antiepileptic drugs' and serum BDNF levels in efficacy and safety monitoring and quality of life: a clinical research. (Pubmed Central) - Jun 30, 2021
Forgetfulness was the most common unwanted effect. Conclussion: While TDM helps the clinician to use more effective and safe NAD, BDNF may assist in TDM for reaching the therapeutic target in epilepsy.
- | zonisamide / Generic mfg., levetiracetam / Generic mfg.
New trial: Modification of Epilepsy Screen Questionnaire and Treatment Feasibility Evaluation (clinicaltrials.gov) - Jun 25, 2021
P=N/A, N=40, Not yet recruiting, Sponsor: National Taiwan University Hospital
- | carbamazepine / Generic mfg.
Journal: Pathogenesis and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant α4 subunit of nicotinic ACh receptor. (Pubmed Central) - Jun 22, 2021
Our results suggest that functional abnormalities of S286L-nAChR are associated with intra-frontal and thalamocortical transmission, possibly contributing to the pathogenesis of ADSHE-seizure and comorbidity of S284L-ADSHE. Selective compensation of impaired GABAergic transmission by ZNS (but not by CBZ) in frontal cortex may be involved, at least partially, in CBZ-resistant ADSHE-seizure of S284L-ADSHE patients.
- | Vimpat (lacosamide) / UCB, Daiichi Sankyo
Journal: A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration. (Pubmed Central) - Jun 22, 2021
Altogether, these assays demonstrated that the impact of BCRP on the delivery of zonisamide to the brain is lower after intranasal administration, probably due to direct nose-to-brain transport. Therefore, the intranasal administration of AEDs may be a relevant strategy to avoid the impact of efflux transporters at the BBB and the development of drug resistance.
- || zonisamide / Generic mfg.
#Eisai To Divest Rights For #Zonegran In Europe And Other Regions To #AdvanzPharma https://t.co/kP7UJmpyTV (Twitter) - Jun 16, 2021
- || Fycompa (perampanel) / Eisai, Briviact (brivaracetam) / UCB, lamotrigine liquid oral suspension / OWP Pharma
Clinical, Review, Journal: Pharmacological Management of the Genetic Generalised Epilepsies in Adolescents and Adults. (Pubmed Central) - Jun 10, 2021
The mechanisms underlying genetic generalised epilepsies, including genetic abnormalities, are unclear at present. As the pathophysiology is unravelled, this may lead to the development of novel therapies and improved outcomes for patients with these syndromes.
- gabapentin / Generic mfg.
[VIRTUAL] Case series of headache in children and adolescents with COVID-19 () - Jun 4, 2021 - Abstract #AHS2021AHS_211;
Further understanding of headache characteristics and co-morbidities in this population will inform approach to screening and therapy. Additionaloutcomes data are forthcoming.
- | zonisamide / Generic mfg., thalidomide / Generic mfg.
Journal: Construction of a circRNA-miRNA-mRNA Regulatory Network Reveals Potential Mechanism and Treatment Options for Osteosarcoma. (Pubmed Central) - Jun 4, 2021
And a corresponding drug-protein interaction network was constructed. Overall, we constructed a circRNA-miRNA-mRNA regulatory network to investigate the possible mechanism in osteosarcoma, and predicted that quinacridine, thalidomide and zonisamide could be potential drugs for the treatment of osteosarcoma.
- zonisamide / Generic mfg.
[VIRTUAL] Refractory post hypoxic myoclonus: from Myoclonic Status Epilepticus to Lance- Adams Syndrome (Raum2) - May 30, 2021 - Abstract #EAN2021EAN_2109;
Our case highlights the clinical and neurophysiological development of LAS from MSE as a possible continuum and not two separate entities, as well the therapeutic challenges that it can harbours. The improvement of survival rates after cardiorespiratory events raises the incidence of such severe neurological sequelae and warrants more extensive studies and treatment trials.
- zonisamide / Generic mfg.
[VIRTUAL] The Efficacy of Zonisamide for the Prevention of Migraine - A Systematic Review. (Scientific Theatre) - May 30, 2021 - Abstract #EAN2021EAN_1749;
- Actemra IV (tocilizumab) / Roche, JW Pharma, Kineret (anakinra) / SOBI
[VIRTUAL] Anakinra in the treatment of New-Onset Refractory Status Epilepticus: Our experience from a clinical case (Room Seville) - May 30, 2021 - Abstract #EAN2021EAN_1557;
We report a positive, although incomplete, response to anakinra. More evidence is required to support this indication.
- zonisamide / Generic mfg.
[VIRTUAL] Experience in the initiat ion of zonisamide treatment in a secondary hospital. (Room Seville) - May 30, 2021 - Abstract #EAN2021EAN_1537;
Response rates similar to those described with a high retention rate were obtained from patients who tolerated it. Likewise, the patients who met the indication for focal seizures obtained a better response.
- || pregabalin / Generic mfg., gabapentin / Generic mfg., carbamazepine / Generic mfg.
Clinical, Review, Journal: Neurocognitive Effects of Antiseizure Medications in Children and Adolescents with Epilepsy. (Pubmed Central) - May 29, 2021
There is limited data for cannabidiol, clobazam, eslicarbazepine acetate, ethosuximide, rufinamide, vigabatrin and zonisamide, although the available evidence suggests these drugs are not associated with severe cognitive impairment. There was too little information to reach conclusions about the effects of brivaracetam, felbamate, gabapentin, pregabalin, retigabine, stiripentol or tiagabine.
- || gabapentin / Generic mfg., carbamazepine / Generic mfg.
Clinical, Review, Journal: Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy. (Pubmed Central) - May 25, 2021
Carbamazepine clearance remains unchanged during pregnancy...Monitoring of clobazam, N-desmethylclobazam, gabapentin, lacosamide, perampanel, and zonisamide during and after pregnancy should be considered...If that is impossible, monitoring of both total and unbound valproate is recommended. More research is needed on the large number of unclear pregnancy-related effects on the pharmacokinetics of antiepileptic drugs.
- || zonisamide / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal, HEOR: Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II). (Pubmed Central) - May 15, 2021
P4
The trial team will disseminate the results through scientific meetings, peer-reviewed publications and patient and public involvement. EudraCT 2012-001884-64; ISRCTN30294119.
- | zonisamide / Generic mfg.
Journal: Zonisamide as treatment option in persistent migraine aura. (Pubmed Central) - May 15, 2021
The patient successfully responded to zonisamide against refractory prolonged aura and remained symptom-free under the ongoing treatment without any relevant side effects. Zonisamide may be considered a new and safe treatment option for patients with persistent migraine aura.
- sertraline / Generic mfg.
[VIRTUAL] Psychiatric Management of Associated Symptoms in CLN3 Disease, Juvenile Onset: A Case Study () - May 2, 2021 - Abstract #APA2021APA_640;
Patient initially was on a main medication regimen of quetiapine 400 mg PO BID and sertraline 50 mg PO daily with limited benefits...Ultimately, sertraline was optimized at 100 mg PO daily and patient’s symptoms were markedly improved on lithium 600mg PO QAM and 300mg PO QHS while on lamotrigine 100mg PO BID and zonisamide per neurology...However, it appears that in this patient, lithium was useful as an adjunct to sertraline to address symptoms of mood, agitation, aggression, and impulsivity. In addition to medication management of symptoms of CLN-3, it is important to keep in mind quality of life for these patients and their caregivers and implement a supportive interdisciplinary team and support groups.
- | Journal: Sulphonamide inhibition profile of Staphylococcus aureus β-carbonic anhydrase. (Pubmed Central) - May 1, 2021
The least efficient inhibitors were zonisamide and dorzolamide. Our work encourages further investigations of SauBCA in an attempt to discover novel drugs against staphylococcal infections.
- || zonisamide / Generic mfg.
Clinical, Journal: Zonisamide as an Adjunctive Treatment to Cognitive Processing Therapy for Veterans With Posttraumatic Stress Disorder and Comorbid Alcohol Use Disorder: A Pilot Study. (Pubmed Central) - Apr 30, 2021
In order to isolate the individual contributions of medication vs psychotherapy a much larger study would need to be conducted. (Am J Addict 2020;00:00-00).
- | zonisamide / Generic mfg.
Journal: Pharmacological management of dementia with Lewy bodies with a focus on zonisamide for treating parkinsonism. (Pubmed Central) - Apr 28, 2021
Two Phase II/III RCTs of DLB patients recently reported a statistically significant improvement in motor function in those receiving zonisamide as an adjunctive treatment to levodopa. New biomarker strategies and validated outcome measures for DLB or prodromal DLB may enhance clinical trial design for the development of specific disease-modifying treatments.