morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The Interspace Between Popliteal Artery and Posterior Capsule of the Knee (IPACK) Block in Knee Arthroplasty: A Prospective Randomized Trial. (Pubmed Central) -  Jun 11, 2022   
    During ultrasound-guided CPN for patients with inoperable upper abdominal cancers who failed medical management, a volume of 20 mL is as effective as 40 mL of 70% alcohol regarding pain control, opioid consumption, quality of life, and procedure-related complications. The addition of IPACK to the ACB significantly reduced the postoperative morphine consumption and postoperative pain scores compared to the ACB alone without significant difference in mobilization ability in patients undergoing TKA.
  • ||||||||||  remifentanil / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Pain after Interventional Radiology in Oncology: A Case-Control Study from a 5-Year Cohort. (Pubmed Central) -  Jun 11, 2022   
    Severe pain depends on the type and duration of interventional radiology, type of anesthesia, and preoperative use of opiates. Limiting doses of remifentanil and injecting intraoperative analgesics, especially ketoprofen, may reduce the incidence of post-intervention severe pain.
  • ||||||||||  Zynrelef (bupivacaine/meloxicam ER) / Heron Therapeutics
    Journal, Combination therapy:  Proposed- HTX-011 in Combination with Multimodal Analgesic Regimen Minimized Severe Pain and Opioid Use after Total Knee Arthroplasty in an Open-Label Study. (Pubmed Central) -  Jun 11, 2022   
    P3b
    All patients received intraoperative HTX-011 (400 mg bupivacaine/12 mg meloxicam) in combination with an MMA regimen consisting of preoperative acetaminophen, celecoxib, and pregabalin and postoperative acetaminophen and celecoxib until discharge...Mean total opioid consumption was low over 72 hours: 24.8 morphine milligram equivalents (1-2 tablets of oxycodone 10 mg/day)...The treatment regimen was well tolerated, and no added risk was observed with the addition of MMA. HTX-011 with an MMA regimen reduced postoperative pain and opioid use following TKA.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Opioid-Use, COVID-19 Infection, and Their Neurological Implications. (Pubmed Central) -  Jun 10, 2022   
    Our in-vivo and in-vitro unpublished studies show that morphine treatment causes increased expression of ACE2 in murine lung and brain tissue as early as 24 h post treatment...Similarly, gut microbiome alterations have been reported with SARS-CoV-2 infection and may play a role in predicting COVID-19 disease severity. However, there are no studies thus far linking opioid-mediated dysbiosis with the severity of neuron-specific COVID-19 infection.
  • ||||||||||  tramadol hydrochloride / Generic mfg.
    Journal:  Short-term mortality following tramadol poisonings in Denmark. (Pubmed Central) -  Jun 9, 2022   
    The annual number of tramadol poisonings increased from 233 in 2006 to 501 in 2013 and declined to 348 in 2017. In conclusion, despite a lower mortality risk compared to other opioid poisonings, physicians should consider the poisoning and abuse risks when prescribing tramadol.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  BmK DKK13, A Scorpion Toxin, Alleviates Pain Behavior in a Rat Model of Trigeminal Neuralgia by Modulating Voltage-Gated Sodium Channels and MAPKs/CREB Pathway. (Pubmed Central) -  Jun 9, 2022   
    DKK13 (1.0 mg/kg, 2.0 mg/kg and 4.0 mg/kg, i.v.) or morphine (4.0 mg/kg, i.v.) was administered by tail vein once on day 14 after IoN-CCI injury...Western blotting results showed that DKK13 significantly reduced the expression of Nav1.8 and the phosphorylation levels of key proteins of MAPKs/CREB pathway in TG tissues of IoN-CCI rats. In brief, DKK13 has a significant antinociceptive effect on IoN-CCI rats, which may be achieved by changing the dynamic characteristics of Nav1.8 channel and regulating the protein phosphorylation in MAPKs/CREB pathway.
  • ||||||||||  ketorolac / Generic mfg., morphine sulphate / Generic mfg., ketamine / Generic mfg.
    Trial completion date, Trial primary completion date:  ANA01: Anesthetics and Analgesics in Children (clinicaltrials.gov) -  Jun 9, 2022   
    P=N/A,  N=460, Recruiting, 
    In brief, DKK13 has a significant antinociceptive effect on IoN-CCI rats, which may be achieved by changing the dynamic characteristics of Nav1.8 channel and regulating the protein phosphorylation in MAPKs/CREB pathway. Trial completion date: Jun 2023 --> Dec 2023 | Trial primary completion date: Jun 2022 --> Dec 2023
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion. (Pubmed Central) -  Jun 8, 2022   
    In hot-plate assay, the antinociceptive potency of SLL-039 and SLL-1206 increased about 11-and 17.3-fold compared to U50,488H and morphine, respectively, with ED values of 0.4 mg/kg...In comparison with SLL-039, SLL-1206 caused similar antinociceptive responses, but fewer sedation and CPA. In conclusion, our results suggest that SLL-039 and SLL-1206 have potential to be developed as novel analgesic agents, and 4,5-expoxymorphinan scaffold is an attractive structure for the development of selective κ agonists with fewer side effects.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Postoperative pain and opioid use after breast reduction with or without preoperative nerve block. (Pubmed Central) -  Jun 8, 2022   
    Following breast reduction mammoplasty, patients on average consumed < 50% of prescribed opioids, suggesting over-prescription of postoperative opioids for breast reduction recovery. Preoperative nerve block did not improve pain scores or decrease opioid consumption for the first five days after surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  A Novel Prescription Method Reduces Postoperative Opioid Distribution and Consumption: A Randomized Clinical Trial. (Pubmed Central) -  Jun 8, 2022   
    Outcomes included total narcotics dispensed, measured in morphine milligram equivalents (MME) through a prescription monitoring program, patient-reported opioid consumption versus opioid not consumed, and a satisfaction survey...This randomized clinical trial demonstrated that patients obtained and consumed fewer narcotics when postoperative opioids were given in a refill-based prescription method. More research is needed to determine whether this opioid distribution method is reproducible, translatable, and feasible.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The Benefits of Local Anesthesia Used in Mastectomy Without Reconstruction. (Pubmed Central) -  Jun 8, 2022   
    However, a consistent benefit of a specific local anesthetic agent was not demonstrated (LB vs B). A prospective study is warranted to determine the optimal local regimen for this cohort and further inform clinical relevance.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  "Building palliative care capacity in cancer treatment centres: a participatory action research". (Pubmed Central) -  Jun 8, 2022   
    A prospective study is warranted to determine the optimal local regimen for this cohort and further inform clinical relevance. This program illustrates how a transformational change at the organizational and individual level can lead to the development of sustained provision of palliative care services in cancer institutes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Yokukansan Inhibits the Development of Morphine Tolerance by Regulating Presynaptic Proteins in DRG Neurons. (Pubmed Central) -  Jun 8, 2022   
    Furthermore, these changes in presynaptic protein expression were more pronounced at isolectin B4 (IB4)-positive excitatory synapses around the lamina II of the dorsal horn. These results suggest that YKS suppresses the development of morphine tolerance by inhibiting the enhancement of presynaptic function of dorsal root ganglia neurons projecting to spinal dorsal horn neurons caused by continuous morphine administration.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Multiple Opioid Prescribers During the Perioperative Period Increases Opioid Consumption Following Upper Extremity Surgery: A Multicenter Analysis. (Pubmed Central) -  Jun 8, 2022   
    Opioid refills written by non-orthopedic prescribers were written for a significantly greater number of pills (68.4 vs. 27.9, p<.001), for a longer duration (22.2 vs. 6.2 days, p<.001), and for larger total morphine milligram equivalents per prescription (831.4 vs. 169.8, p<.001) compared to those written by orthopedic prescribers...Non-orthopedic providers were the highest prescribers of opioids postoperatively, and they prescribed significantly larger and longer prescriptions. Our findings highlight the value of utilizing PDMP databases to help curtail opioid overprescription and potential adverse opioid-related outcomes following upper extremity surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Surgery:  Erectae Spinae Block Versus Intrathecal Morphine for Postoperative Analgesis in Lumbar Surgeries (clinicaltrials.gov) -  Jun 7, 2022   
    P=N/A,  N=82, Completed, 
    Our findings highlight the value of utilizing PDMP databases to help curtail opioid overprescription and potential adverse opioid-related outcomes following upper extremity surgery. Recruiting --> Completed
  • ||||||||||  morphine sulphate / Generic mfg.
    EMERGENCE OF RESTLESS LEGS SYNDROME DURING OPIOID WITHDRAWAL () -  Jun 6, 2022 - Abstract #SLEEP2022SLEEP_1063;    
    Over one-third of patients in our cohort developed de novo symptoms of RLS at some point during their opioid withdrawal. Physicians supervising individuals undergoing opioid withdrawal should be aware of the potential development of RLS symptoms which may hinder successful opioid withdrawal.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Thoracic epidural anaesthesia vs intrathecal morphine in dogs undergoing major thoracic and abdominal surgery: clinical study. (Pubmed Central) -  Jun 5, 2022   
    Intraoperative rescue analgesia (iRA) was fentanyl 1 μg/kg administered if heart rate or mean arterial pressure increased by 30% above the pre-stimulation level...Side effects were urinary retention in 3/18 (16%) TEA group dogs and 2/18 (11%) ITM group dogs and prolonged sedation in 2/18 (11%) in ITM group dogs. TEA and ITM were effective in managing perioperative pain in dogs undergoing thoracic or cranial abdominal surgery.
  • ||||||||||  ketorolac / Generic mfg., morphine sulphate / Generic mfg.
    Clinical, Review, Journal, Interview:  An interview with Dr. Anne Marie Lynn, A Pioneering Woman in Medicine. (Pubmed Central) -  Jun 4, 2022   
    Through her journal articles, book chapters, national and international lectures, mentoring of residents, fellows, and faculty, and leadership in the Society for Pediatric Anesthesia, she inspired a generation of women and men physicians by demonstrating that gender should not be a barrier to undertaking roles once only held only by men. In 2017, for her many contributions, she was awarded the Society for Pediatric Anesthesia's Myron Yaster lifetime achievement award.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The roles of miR-592-3p and its target gene, TMEFF1, in the nucleus accumbens during the incubation of morphine craving. (Pubmed Central) -  Jun 4, 2022   
    Gallbladder wall thickening was observed in at least one dog in each group, therefore caution is recommended for gallbladder wall thickness ultrasonographic interpretation in dogs when these drugs have been administered. Our findings demonstrated that miR-592-3p can improve the incubation of morphine craving by targeting TMEFF1, and thus, it holds a therapeutic potential to inhibit opioid craving.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Surgical Determinants of Post Operative Pain in Patients Undergoing Laparoscopic Adnexectomy. (Pubmed Central) -  Jun 4, 2022   
    Fascia closure and increased surgical time were significantly associated with immediate postoperative pain and the need for strong opioids consumption. Surgical training to limit prolonged surgeries should be strongly emphasized to lower postoperative pain and limit opioids consumption.
  • ||||||||||  morphine sulphate / Generic mfg., papaverine / Generic mfg., captopril / Generic mfg.
    Journal:  Increasing DESI-MS Ion Signal by Plasma Treatment. (Pubmed Central) -  Jun 4, 2022   
    Under optimal treatment conditions, an improved ion signal intensity is observed without any fragmentation, decomposition, or chemical changes. Ion signals are increased possibly by both increased ionization through protonation of molecules and enhanced subsequent desorption during DESI analysis.
  • ||||||||||  remifentanil / Generic mfg., morphine sulphate / Generic mfg.
    Review, Journal:  Are thyrotropin-releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid-induced respiratory depression? (Pubmed Central) -  Jun 4, 2022   
    In awake and anesthetized rodents, TRH and taltirelin improved morphine- and sufentanil-induced respiratory depression, by causing rapid shallow breathing...In awake and anesthetized humans, a continuous infusion of intravenous TRH with doses up to 8 mg, did not reverse sufentanil- or remifentanil-induced respiratory depression...In conclusion, data from animals and human indicate that TRH is not a viable reversal agent of OIRD in awake or anesthetized humans. Further human studies on the efficacy and safety of TRH's more potent and longer lasting analog taltirelin are needed as this agent seems to be a more promising reversal drug.