- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Transcriptomic Analysis of Long Non-coding RNA-MicroRNA-mRNA Interactions in the Nucleus Accumbens Related to Morphine Addiction in Mice. (Pubmed Central) - Jun 22, 2022
The correlation between the relative expression of lncRNAs, miRNAs and mRNAs was analyzed to further validate predicted ceRNA networks, and the Lnc15qD3-miR-139-3p-Lrp2 ceRNA regulatory interaction was determined. These results suggest that the comprehensive network represents a new insight into the lncRNA-mediated ceRNA regulatory mechanisms underlying morphine addiction and provide new potential diagnostic and prognostic biomarkers for morphine addiction.
- |||||||||| methamphetamine / Generic mfg.
Journal: A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects. (Pubmed Central) - Jun 22, 2022
These effects may involve targeting of genes important for the synaptic transmission, such as Grin1 (NMDAR subunit 1). Our findings demonstrate an important role for NAc novel-m009C in regulating METH reward, reveal a novel molecular regulator of the actions of METH on brain reward circuitries and provide a new strategy for treating METH addiction based on the modulation of small non-coding RNAs.
- |||||||||| morphine sulphate / Generic mfg.
Journal: The Basolateral Amygdala to Ventral Hippocampus Circuit Controls Anxiety-Like Behaviors Induced by Morphine Withdrawal. (Pubmed Central) - Jun 22, 2022
Furthermore, combined treatment of inhibition of the BLA to vHip circuit and KOR antagonists mitigated anxiety-like behaviors and prevented stress-induced CPP reinstatement after morphine withdrawal. These results revealed a previously unknown circuit associated with the emotional component of opioid withdrawal and indicated that restoration of synaptic deficits with KOR antagonists might be effective in the treatment of anxiety associated with morphine withdrawal.
- |||||||||| morphine sulphate / Generic mfg.
Erector spinae plane (ESP) blocks and day case thoracoscopy (TP-25 in thematic poster area) - Jun 22, 2022 - Abstract #ERS2022ERS_4128;
Patients used an average of 3.33mg oral morphine (SEM 2.35) in hospital, and 3mg (SEM 2) on post-op day 1...Conclusions ESP blocks provide good peri and post procedural analgesia. We now propose to formally test this via a trial.
- |||||||||| morphine sulphate / Generic mfg., levomepromazine / Generic mfg., midazolam hydrochloride / Generic mfg.
Palliative care for Continuous Positive Airway Pressure (CPAP) withdrawal in patients with COVID-19 (TP-5 in thematic poster area) - Jun 22, 2022 - Abstract #ERS2022ERS_3753;
In our experience, some patients required higher than usual doses of sedation whilst CPAP was withdrawn. Table 1: Minimum and maximum total doses of sedative drugs Drug Number of patients Minimum dose (mg) Maximum dose (mg) Midazolam 27 2.5 127.5 Morphine 26 1 127.5 Levomepromazine 18 2.5 75 Phenobarbitone 1 - 200
- |||||||||| morphine sulphate / Generic mfg.
Prognostic factors in locally advanced non-small cell lung cancer (TP-22 in thematic poster area) - Jun 22, 2022 - Abstract #ERS2022ERS_2692;
In univariate analysis, the factors interfering with overall survival were: age (p=0.048), initial PS (p=0.024) and its evolution (p=0.026), histologic type (p=0.015), stage of the disease (p=0.02), lymph node extension (p=0.001), surgery (p=0.018), concurrent chemo-radiotherapy (p=0.008), time to consultation under 60 days (p=0.008) and dose of morphine over 150 mg/day (p=0.001)...Several modifiable and exogenous factors to natural evolution of locally advanced lung cancer have an impact on overall survival. Managing and improving patient journey times throughout their care is a priority
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Long-term, high-dose opioid prescribing for chronic non-cancer pain in primary care. (Pubmed Central) - Jun 22, 2022
This study offers confirmation that a significant group of patients are prescribed long-term opioid medication for chronic pain at doses which are unlikely to be effective in reducing pain but are likely to have harmful consequences. The findings offer a simple, reliable and practical method of data extraction to identify these patients individually from routinely collected prescribing data, which will help in monitoring and treating individuals and establishing the problem prevalence.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Long-term Risk of Overdose or Mental Health Crisis After Opioid Dose Tapering. (Pubmed Central) - Jun 21, 2022
Participants were US adults who underwent opioid dose tapering from 2008 to 2017 after a 12-month baseline period of stable daily dosing of 50 morphine milligram equivalents or higher and who had at least 1 month of long-term follow-up during a postinduction period beginning 12 months after taper initiation...In conditional negative binomial regression analyses, adjusted incidence rate ratios for the postinduction period compared with the pretaper period were 1.57 (95% CI, 1.42-1.74) for overdose or withdrawal and 1.52 (95% CI, 1.35-1.71) for mental health crisis. These findings suggest that opioid tapering was associated with increased rates of overdose, withdrawal, and mental health crisis extending up to 2 years after taper initiation.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Review, Journal: How can I manage anaesthesia in obese patients? (Pubmed Central) - Jun 19, 2022
For any obese patient, the implementation of difficult intubation protocols and the use of protective ventilation (low tidal volume 6-8mL/kg of ideal body weight, moderate positive end-expiratory pressure of 10cmH20, recruitment manoeuvres in absence of contra-indications), with morphine sparing and semi-seated positioning as much as possible are recommended, associated with a close postoperative monitoring...The occurrence of intraoperative awareness is indeed more frequent in the obese patient than in the non-obese patient. Appropriate prophylaxis against venous thromboembolism and early mobilisation are recommended, if possible included in an early rehabilitation protocol, to further reduce postoperative complications.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Opioid Prescribing Behaviors Among Surgical Intensive Care Unit Attending Physicians. (Pubmed Central) - Jun 19, 2022
Milligram morphine equivalents (MME) per patient-ICU-day provided by eleven surgical intensivists were analyzed...Despite no significant differences in age, sex, or Elixhauser Comorbidity Index, there was a 45% difference between the high- and low-prescribing physicians in the LVG (253.7 vs 175.4 MME/pt-ICU-day; P = .008). This difference was not observed for patients in the SVG (74.3 vs 93.1 MME/pt-ICU-day; P = .141) nor based on intensivist specialty (LVG: 217.9 vs 209.5 MME/pt-ICU-day; P = .8) (SVG: 79.0 vs 93.3 MME/pt-ICU-day; P = .288).
- |||||||||| MoxDuo IR (morphine + oxycodone) / QRxPharma, AbbVie
Review, Journal: Oxycodone for cancer-related pain. (Pubmed Central) - Jun 19, 2022
Our conclusions are consistent with other reviews and suggest that, while the reliability of the evidence base is low, given the absence of important differences within this analysis, it seems unlikely that larger head-to-head studies of oxycodone versus morphine are justified, although well-designed trials comparing oxycodone to other strong analgesics may well be useful. For clinical purposes, oxycodone or morphine can be used as first-line oral opioids for relief of cancer pain in adults.
- |||||||||| morphine sulphate / Generic mfg.
Retrospective data, Journal: Prospective Implementation of Standardized Post-Hepatectomy Care Pathways to Reduce Opioid Prescription Volume after Inpatient Surgery. (Pubmed Central) - Jun 18, 2022
Implementation of post-hepatectomy care pathways was associated with a 50% reduction in last 24-hour OME, which, combined with a standardized discharge calculation, was associated with an overall 75% reduction in discharge opioid volumes and tripled opioid-free discharges. These data suggest that no-cost, reproducible pathways can be considered in abdominal operations with similar incisions/length of stay to decrease variation in opioid dosing while prioritizing patient-centric opioid needs.
- |||||||||| remifentanil / Generic mfg., morphine sulphate / Generic mfg., rocuronium / Generic mfg.
Is NOL index variation with surgical incision able to predict opioid consumption? (Poster eBoard 1) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1582;
The DNOL value at the begin of the surgery was compared by linear correlation test to the remifentanil and postoperative morphine consumption (indexed). There was neither a significant correlation between the D NOL and remifentanil consumption (Pearson r :0.2628, p : 0.4093, r2:0.06904), nor between the DNOL and 24 hour morphine consumption (Pearson r: 0.03710, r2:0,001377, p : 0.989).Conclusion(s): Despite the fact that the NOL seems to be useful for optimizing opioid consumption during general anesthesia, its initial increase after surgical incision is not predictive for individual analgesic titration during and after general anesthesia, at least not in this particular population.
- |||||||||| morphine sulphate / Generic mfg.
Epidural versus intrathecal analgesia in laparoscopic colorectal surgery: a retrospective study (Poster eBoard 3) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1320;
Yet in laparoscopic rectal surgery, epidural analgesia provided improved pain control, without affecting the length of stay. These findings suggest that a randomized controlled trial comparing epidural analgesia and intrathecal analgesia for rectal surgery is warranted.
- |||||||||| morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Interpectoral-pectoserratus plane (PECS II) block in patients undergoing trans-axillary thoracic outlet decompression surgery; a prospective double-blind, randomized, placebo-controlled trial (Poster eBoard 3) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1319;
There was no difference in NRS on the PACU at the start (ropivacaine 6.2 ± 3.0 vs placebo 4.9 ± 3.2, p=.08), or the end (ropivacaine 3.9 ± 1.7 vs placebo 4.1 ± 1.6, p=.77), and on the ward on POD 0 (ropivacaine 4.6 ± 2.0 vs placebo 4.6 ± 2.0, p=.10) and POD 1 (ropivacaine 3.6 ± 2.0 vs placebo 3.9 ± 1.8, p=.53). There was no difference in postoperative morphine consumption at the PACU (ropivacaine 8.9 mg ± 6.0 vs placebo 9.7 mg ± 7.1, p=.62) and on the ward (ropivacaine 9.6 mg ± 9.4 vs placebo 11.6 mg ± 8.5, p=.39).Conclusion(s): The interpectoral-pectoserratus plane block is not effective for postoperative analgesia in patients with neurogenic thoracic outlet syndrome undergoing trans-axillary thoracic outlet decompression surgery.
- |||||||||| morphine sulphate / Generic mfg.
Absence of analgesic benefit of a Pecs II block vs. surgical field infiltration for open biceps tenodesis (Poster eBoard 2) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1168;
There were no differences in terms of reaction to incision, postoperative paresthesia/anesthesia on skin distal to surgical dressing, or postoperative pain scores.While Reynold et al. showed a benefit compared to a sham block, surgical infiltration seems simpler and yields comparable analgesia.Conclusion(s): While the preoperative higher pain scores in the Pecs could be a confounder, the theoretical advantage of the Pecs 2 block over surgical infiltration for open biceps tenodesis was not supported by this study, with similar opioid consumption and NRS scores in the Pecs 2 group.
- |||||||||| morphine sulphate / Generic mfg.
Israeli national survey of general anesthesia for cesarean delivery (Poster eBoard 4) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1148;
In this national survey we emphasize the importance of the presence of highly qualified anesthesiology personnel during the surgery, benefits from use of short-acting opiates during induction, availability of video-laryngoscopes, ventilation of patient during RSI and availability of institutional difficult airway protocols. We observed underuse of intraoperative anesthesia-depth monitoring and poor postoperative pain control.
- |||||||||| Impact of perioperative analgesia in prostatectomy patients on early quality of recovery: a 3-arms randomized active-controlled phase IV trial (Poster eBoard 2) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1082;
All groups received ketorolac (iv, 90mg/day) for 48 hours, metamizol (iv/po, 4g/day) and fentanyl (iv) or oxycodone (po) on request.Primary outcome: Change in Quality of Recovery 15 (QoR-15) score on day 1 compared to baseline.Secondary outcomes: QoR-15 at hospital discharge, PONV, pain scores, return of gastrointestinal function, morphine equivalents.Results and From 06/2018 to 12/2020, we included 133 patients (SSS, 40; TAP, 45; SA, 48)...There were no significant differences in the other secondary outcomes.Conclusion(s): Differences in QoR-Scores on postoperative day 1 compared to preoperative did not differ between the groups. Only in the subgroup undergoing open prostatectomy, QoR-scores at hospital discharge where lower in the group receiving systemic analgesia compared to additional spinal anaesthesia..
- |||||||||| A retrospective review of the postoperative analgesic management of paediatric adeno-tonsillectomies in a non-paediatric tertiary referral hospital in Melbourne (Poster eBoard 5) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_955;
Postoperatively, paracetamol was charted for 99% of patients, although regularly charted in only 74%...Only one child was charted PRN tramadol...Oxycodone use per hour of admission was highest for those patients who received intraoperative fentanyl without a NSAID (0.007mg/kg/hr) and lowest in those patients who received intraoperative long-acting opioid (morphine or oxycodone) +/- fentanyl plus a NSAID (0.004mg/kg/hr).Very poor documentation of pain scores was noted at 6, 12 and 24 hours...Optimising our intraoperative analgesia can promote effective early postoperative pain management. The lack of pain score documentation suggests that further education in this area is essential.Conclusion(s): It may be appropriate to implement a postoperative ‘bundle of care’ in our institution, to more uniformly care for our paediatric adeno-tonsillectomy patients.
- |||||||||| morphine sulphate / Generic mfg.
Dosing error in the administration of intratecal morphine in obstetrics (Poster eBoard 1) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_817;
After 48 hours of treatment and strict monitored surveillance, she presented adequate clinical evolution, allowing discharge from the unit. Medication errors (MEs) are one of the leading causes of preventable harm.1The records of morbidity and mortality in the obstetric population related to MEs are extremely scarce.The early detection of accidental administration of high doses of intrathecal opioids and the prevention of secondary complications, with a close monitored surveillance and the use of antagonists can reduce the probability of serious complications.
- |||||||||| morphine sulphate / Generic mfg.
Thirty years in anesthesiology and reanimation: a bibliometric analysis (Virtual Platform - Poster section) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_721;
The other motor themes were shaped by new anesthetic agents and techniques over the years. ICU themes have become towards mechanical ventilation.
- |||||||||| morphine sulphate / Generic mfg.
Intraoperative magnesium sulfate versus vitamin C for optimal acute postoperative pain management after elective major abdominal surgery (Virtual Platform - Poster section) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_591;
Total morphine consumption was significantly reduced for group C versus group M (p<0.05). Patients in group C experienced statistically less sedation (p<0.05) and they had significantly lower incidence of nausea/vomiting compared to group M (p<0.05).Conclusion(s): According to our findings, intraoperative intravenous infusion of vitamin C contributed to a better control of early postoperative pain by decreasing pain scores, reducing morphine consumption and mitigating the incidence of adverse events compared to magnesium sulfate after elective major abdominal surgery.
- |||||||||| Erector spinae plane block, a viable option for terminal patients with refractory liver metastasis pain (Virtual Platform - Poster section) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_590;
The patient was admitted to the intensive care unit due to uncontrolled pain and was started on transdermal fentanyl (25mcg/hour), dexamethasone (8mg/day), and morphine, 3mg as needed...With the patient’s consent, an echo-guided ESP block was performed at T9 level, with 20mL 0,5% ropivacaine...Hepatic or renal dysfunction limit analgesic options, due to the altered pharmacokinetics. In these cases, regional analgesia plays an important role and should be considered in palliative care patients.
- |||||||||| The contribution of erector spinae plane block in enhanced recovery after surgery to patients undergoing colectomy (Virtual Platform - Poster section) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_505;
P=N/A
Bilateral rectus sheath block can be clinically efective for analgesia in the early postoperative period, as part of a multimodal analgesic regimen. If the patient was randomized in Group RL or RO,Ropivacaine 0.375% (20 ml) was infused at each side 30 minutes before induction of GA and 0.2% (20 ml) 12, 24, 36 and 48 hours after surgery...Regarding OC, total intraoperative remifentanil, postoperative tramadol and morphine administration and mobilization time of the patient was significantly lower in Group RO when compared to CO (p=0.008, p=0.011, p=0.025, p=0.03 respectively)... In this study, we confirmed that ESPB is an effective, simple and safe method which contributes to the reduction of perioperative opioid administration, improvement of quality of perioperative analgesia, and the achievement of enhanced recovery to patients undergoing elective colectomy.
|
