morphine sulphate / Generic mfg. 
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  • ||||||||||  Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma
    Clinical, Review, Journal:  A critical review of oliceridine injection as an IV opioid analgesic for the management of severe acute pain. (Pubmed Central) -  Jul 6, 2022   
    Recently, oliceridine intravenous injection was approved for use in adults for the management of acute pain severe enough to require an intravenous opioid analgesic and for whom alternative treatments are inadequate. Introduction of this new IV opioid provides a valuable option to manage postoperative pain.
  • ||||||||||  morphine sulphate / Generic mfg., diazepam / Generic mfg.
    Retrospective data, Review, Journal:  Postmortem forensic toxicology cases: A retrospective review from Milan, Italy. (Pubmed Central) -  Jul 6, 2022   
    From the results, acute intoxication at the time of death was confirmed in 54 cases and in 57 cases the toxicological analyses helped in the determination of the cause and manner of death. From this study, the importance of toxicological data among forensic sciences is confirmed.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Evaluation of chloroplast DNA barcoding markers to individualize Papaver somniferum for forensic intelligence purposes. (Pubmed Central) -  Jul 5, 2022   
    This latex contains the alkaloids morphine, codeine, and thebaine that are used for their analgesic properties and/or for synthesizing other opioids...Additionally, ten P. somniferum seed samples from various vendors were sequenced and compared across samples and to published reference data at the various barcode regions of interest. This study showed that the regions trnH-psbA and petA-psbJ have promise for utility in individualization for both inter- and intra-species individualization of P. somniferum.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Incidence and risk factors of chronic opioid use after sleep apnea surgery. (Pubmed Central) -  Jul 2, 2022   
    Additional strategies to monitor for and avoid opioid dependence are urgently needed to prevent chronic opioid use after pulmonary resection. While efforts by different societies are being implemented to control the opioid crisis, we found that perioperative opioid prescription for airway surgery targeting obstructive sleep apnea is an independent risk factor for persistent, prolonged, and inappropriate opioid use.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Impact of Opioid Restriction Legislation on Prescribing Practices for Outpatient Plastic and Reconstructive Surgery. (Pubmed Central) -  Jul 2, 2022   
    In this study, patients managed through ERAS pathways required 46 percent less intraoperative and 31 percent less postoperative narcotics and had a 29 percent reduction in hospital length of stay. This study provides evidence that legislation at the state level restricting postoperative opioid prescriptions is associated with a decrease in opioid prescriptions without an increase in the need for refills in the acute postoperative setting following outpatient plastic surgery procedures.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid Prescription Monitoring in Preoperative and Postoperative Sacroiliac Joint Fusion Patients. (Pubmed Central) -  Jul 2, 2022   
    Quantity of opioid prescriptions received by patients with SI joint pain did not change significantly from 3 months preoperatively to any point postoperatively despite significant improvements in all patient-reported outcome measures. This discordance between long-term opioid requirements and positive clinical outcomes is concerning and warrants further investigation.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Radiomodulation in Mixed, Complex Cancer Pain by Triple Target Irradiation in the Brain: A Preliminary Experience. (Pubmed Central) -  Jul 2, 2022   
    Morphine rescues for cases 1 and 2 were reduced to 84%, and 70% for case 3...Conclusions In complex, for refractory oncological pain of mixed nature (nociceptive, neuropathic, and visceral), very few, if any, treatment alternatives are currently available. We provide a small proof of concept that multitarget intracranial radiosurgery might be effective in ameliorating pain in this population. The doses administered per target are the lowest that have shown effectiveness thus far, a different strategy might be needed as opposed to single target "large" dose approach that has been tried in the past for complex mixed refractory oncological pain. By no means, in our experience, these treatments traduce in elimination of pain, clinical results might make pain to be more bearable and respond better to pain medication.
  • ||||||||||  morphine sulphate / Generic mfg., paracetamol / Generic mfg.
    Review, Journal:  Sterile water injections for management of renal colic pain: a systematic review. (Pubmed Central) -  Jul 1, 2022   
    SWI could be a suitable alternative for management of renal colic pain where alternatives such as non-steroidal anti-inflammatory and opioid drugs are either unavailable or contraindicated. However, further research is required to establish the role of SWI in renal colic pain management.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Journal:  Changes in the Street Prices of Prescription Opioids During the COVID-19 Pandemic. (Pubmed Central) -  Jul 1, 2022   
    Prices of low-potency drugs hydrocodone and morphine increased 9% and 12% per milligram, respectively...Decreased access to opioid analgesics during the pandemic combined with contributors to opioid demand may have led to increases in street prices of prescription opioids. Measures taken to increase access to medications for opioid use disorder were not associated with changes in those drugs' street prices.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Evaluation of Hospitalized Patients Receiving High versus Low-Dose Opioids for Non-Cancer Pain. (Pubmed Central) -  Jun 30, 2022   
    Average oral morphine milligram equivalents (MMEs) administered over the entire LOS was collected, and patients were categorized as high-dose (≥50 MMEs/day) or low-dose (100 MMEs/day, ORAEs occurred in 61% of patients. Hospitalized patients receiving high-dose opioids for non-cancer pain may have an increased incidence of ORAEs.
  • ||||||||||  Journal, Video:  Impact of Opioid-Free Anesthesia after video-assisted thoracic surgery: a propensity score study. (Pubmed Central) -  Jun 29, 2022   
    Hospitalized patients receiving high-dose opioids for non-cancer pain may have an increased incidence of ORAEs. Our results suggest that OFA after video-assisted thoracic surgery or robotic-assisted thoracic surgery is safe and is associated with less postoperative morphine cumulative consumption and pain at 48 hours.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Self-reported challenges obtaining ongoing prescription opioids among Australians with chronic non-cancer pain. (Pubmed Central) -  Jun 29, 2022   
    One-third of participants with CNCP reported experiencing challenges obtaining prescriptions for opioids or having their opioid medicines involuntarily reduced. Given increasing restrictions to opioid access, it is important that strategies to reduce opioid-related harms are balanced against the current treatment needs of people prescribed opioids long-term for CNCP.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Peripartum and Postpartum Analgesia and Pain in Women Prescribed Buprenorphine for Opioid Use Disorder Who Deliver by Cesarean Section. (Pubmed Central) -  Jun 29, 2022   
    When compared to matched controls, women taking their pre-hospital dose of buprenorphine undergoing cesarean section utilized more opioid analgesics as measured by morphine milligram equivalents (MME) (mean MME first 48 hours 153.0 mg vs 175.1 mg, respectively, P < .01) but had similar pain scores during delivery hospitalization...Further research is required to fully understand the optimal buprenorphine dosing regimen during surgical hospitalizations. Our results also provide important preliminary evidence that spinal anesthesia containing opioids can be used effectively in individuals with OUD requiring surgical intervention.
  • ||||||||||  morphine sulphate / Generic mfg., alprazolam / Generic mfg.
    Enrollment open:  MAP: Opioid/Benzodiazepine Polydrug Abuse: Aim 3 (clinicaltrials.gov) -  Jun 29, 2022   
    P2,  N=24, Recruiting, 
    Patient adherence and the involvement of all caregivers are essential to the success of such a program. Not yet recruiting --> Recruiting
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Sacroiliac Joint Fusion Using Robotic Navigation: Technical Note and Case Series. (Pubmed Central) -  Jun 28, 2022   
    Robot-navigated SI joint fusion is a feasible and reproducible method for addressing refractory SI joint disease. Further investigation on clinical outcomes and long-term fusion rates is needed, as are studies comparing robot-navigated SI joint fusion with more traditional techniques.
  • ||||||||||  tramadol hydrochloride / Generic mfg.
    Journal:  Tramadol prescribed at discharge is associated with lower odds of chronic opioid use after elective total joint arthroplasty. (Pubmed Central) -  Jun 28, 2022   
    Among patients undergoing elective THA/TKA surgery and discharged with a prescription of opioids, we found that prescription of tramadol combined with another opioid was associated with lower odds of chronic opioid use. This finding must be considered in the context of the tramadol's pharmacology, as well-described genetic differences in metabolism that can make it ineffective in many patients, while for patients with ultrarapid metabolism can cause drug-drug interactions and adverse events, including feelings of high and seizures.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open:  Postoperative Analgesia in Patients Undergoing Elective Lumbar Fusion Operations Under General Anesthesia (clinicaltrials.gov) -  Jun 28, 2022   
    P4,  N=120, Recruiting, 
    This finding must be considered in the context of the tramadol's pharmacology, as well-described genetic differences in metabolism that can make it ineffective in many patients, while for patients with ultrarapid metabolism can cause drug-drug interactions and adverse events, including feelings of high and seizures. Not yet recruiting --> Recruiting
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Journal:  Low Volume Proximal Suprascapular Nerve Block after Arthroscopic Shoulder Surgery - a Randomised, Controlled Trial. (Pubmed Central) -  Jun 25, 2022   
    Despite the fact that this did not result in differences in revision surgery, we conclude that the PFNA, considering the minimal number of implant-related fractures is a viable implant for A1 type trochanteric fractures. In this study, a proximal suprascapular nerve block with only 5 ml ropivacaine resulted in a substantial pain reduction and opioid-sparing effect in patients with VAS of 50 or more after arthroscopic shoulder surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Sex-Related Differences in Pharmacological Response to CNS Drugs: A Narrative Review. (Pubmed Central) -  Jun 25, 2022   
    On the other hand, respiratory and gastrointestinal adverse drug reactions (ADRs) following morphine therapy are more prevalent among female patients...Nonetheless, although for each pharmacological class, studies generally converge to a certain pattern, opposite outcomes are standing in the way of a clear consensus. Hence, the fact that so many studies are yielding conflicting results emphasizes once again the need to address sex-related differences in pharmacological response to drugs.