morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Effect of oxytocin pretreatment on the development of morphine tolerance and dependence in rats. (Pubmed Central) -  Jul 15, 2022   
    Clonidine was ineffective on the withdrawal signs but decreased body temperature and increased tail flick latency in the tail immersion test in oxytocin pretreated animals. These results, while producing evidence for a hyperresponsiveness in alpha-2 adrenoceptors, provide contrasting effects on morphine tolerance and dependence, and their partial mediation by opioidergic and adrenergic activation in repeated oxytocin treatment.
  • ||||||||||  morphine sulphate / Generic mfg., zidovudine / Generic mfg., midazolam hydrochloride / Generic mfg.
    Review, Journal:  ATP-binding cassette (ABC) drug transporters in the developing blood-brain barrier: role in fetal brain protection. (Pubmed Central) -  Jul 15, 2022   
    Thus, alterations in regulated transport across the developing BBB may induce long-term changes in brain health and compromise pregnancy outcome. Furthermore, a large portion of neonatal adverse drug reactions are attributed to agents that target or access the nervous system, such as stimulants (e.g., caffeine), anesthetics (e.g., midazolam), analgesics (e.g., morphine) and antiretrovirals (e.g., Zidovudine); thus, understanding brain protection is key for the development of strategies to protect the fetal and neonatal brain.
  • ||||||||||  morphine sulphate / Generic mfg., hydrocodone/paracetamol / Generic mfg.
    Journal:  Laparoscopic guided liposomal bupivacaine injection compared to transversus abdominus plane block for postoperative pain after robotic gynecologic oncology surgery. (Pubmed Central) -  Jul 15, 2022   
    Furthermore, a large portion of neonatal adverse drug reactions are attributed to agents that target or access the nervous system, such as stimulants (e.g., caffeine), anesthetics (e.g., midazolam), analgesics (e.g., morphine) and antiretrovirals (e.g., Zidovudine); thus, understanding brain protection is key for the development of strategies to protect the fetal and neonatal brain. Lap-Taps are comparable to US-Tap for postoperative analgesia during the first 72-h after surgery when performing robotic-assisted gynecologic oncology surgery.
  • ||||||||||  Review, Journal:  Graphene-Based Electrochemical Sensors for Psychoactive Drugs. (Pubmed Central) -  Jul 10, 2022   
    Here, we present a review of developments in the applications of graphene-based sensors in sensing drugs such as cocaine, morphine, methamphetamine, ketamine, tramadol and so forth in the past decade. We compare graphene sensors with other sensors developed from ultrathin two-dimensional materials, such as transition-metal dichalcogenides, hexagonal boron nitrate, and MXenes, to measure drugs directly and indirectly, in various samples.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Preoperative Opioids and the Dose Dependent Effect on Outcomes after Total Hip Arthroplasty. (Pubmed Central) -  Jul 9, 2022   
    Just one 5 mg hydrocodone tablet daily leads to a significant increase in ED visits and readmission, while higher doses are associated with dislocation, superficial infection, periprosthetic joint infection, and revision surgery. Continued education regarding the harmful effects of opioids prescribed for the nonoperative treatment of osteoarthritis is still needed.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Predictors of New Persistent Opioid Use After Benign Hysterectomy in the United States. (Pubmed Central) -  Jul 9, 2022   
    New persistent opioid use after hysterectomy was associated with several patient, operative, and opioid prescription-related factors. Considering these factors may be beneficial in counseling patients and shared decision-making about perioperative prescription to decrease the risk of persistent opioid use.
  • ||||||||||  morphine sulphate / Generic mfg., naltrexone / Generic mfg.
    Journal:  Opioid Antagonist Nanodrugs Successfully Attenuate the Severity of Ischemic Stroke. (Pubmed Central) -  Jul 9, 2022   
    The generated nanoformulations of both opioid antagonists exhibited successful attenuation of morphine- or oxycodone-induced alterations of TJ protein expression and reduced oxidative stress to a greater extent than the parent drugs (non-nano)...Our results demonstrate that the opioid antagonist nanoformulations reduced stroke severity in mice. Overall, this research implements advances in nanotechnology-based repurposing of FDA-approved therapeutics, and the obtained results also suggest underlying pharmacological mechanisms of opioid antagonists, further supporting these opioid antagonists and their respective nanoformulations as potential therapeutic agents for ischemic stroke.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Factors associated with persistent opioid use 6-12 months after primary total knee arthroplasty. (Pubmed Central) -  Jul 9, 2022   
    Pre-operatively, patients with a higher body mass index, more comorbid pain sites and those who had filled an opioid prescription in the last 12 months, were at increased risk of persistent opioid use and a higher oral morphine equivalent daily dose ≥ 6 months after surgery. Strategies need to be developed to limit dose and duration of persistent opioid use in patients following knee arthroplasty surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Caffeine: What Is Its Role in Pain Medicine? (Pubmed Central) -  Jul 9, 2022   
    The mixture of coffee and morphine for pain reduction in individuals with terminal cancer has shown mixed outcomes in studies...Caffeine's usage for migraines and end-stage cancer disease is not well acknowledged. Further research is essential to focus on caffeine's potential role in various forms of pain, including dosage escalation and outcome assessment standardization.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Comparative analysis of opioid use between robotic and open pancreatoduodenectomy. (Pubmed Central) -  Jul 8, 2022   
    A higher percentage of robotic PD patients tapered off of opioids prior to discharge than open surgery counterparts treated with a standardized opioid reduction protocol despite a shorter length of stay. These results provide a rationale for choosing robotic PD when feasible to minimize opioid use.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Accuracy of Spinal Anesthesia Drug Concentrations in Mixtures Prepared by Anesthetists. (Pubmed Central) -  Jul 8, 2022   
    Our results show a high deviation of the obtained from the intended concentrations. Two percent of the samples had bupivacaine concentrations that probably resulted into an insufficient analgesia, and 11% of the samples had morphine concentrations that, according to guidelines, would require a longer monitoring period than with the intended dose.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Opioid Prescriptions Following Otologic Surgery: A Population-Based Study. (Pubmed Central) -  Jul 8, 2022   
    This large comprehensive population study provides insight into the prescribing patterns following otologic surgery. The large amounts prescribed and substantial variation require further study to determine barriers that limit good opioid-prescribing stewardship in the postoperative period.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Postoperative Pain in Adolescent Idiopathic Scoliosis Surgery: A Randomized Controlled Trial. (Pubmed Central) -  Jul 7, 2022   
    P=N/A
    Our findings further support the efficacy of strategies that lower default dispense quantities, although they indicate that caution is warranted when selecting the default. From our results, both techniques can be employed for AIS surgery, but a meticulous approach is essential for the prevention of acute pain for VBT.
  • ||||||||||  tegileridine (SHR8554) / Jiangsu Hengrui Pharma
    Trial completion, Surgery:  A Clinical Study of SHR8554 Injection for the Treatment of Pain After Abdominal Surgery. (clinicaltrials.gov) -  Jul 6, 2022   
    P3,  N=528, Completed, 
    Although the number of patients was too small to draw final conclusions and there were no significant differences in mortality between midazolam and morphine, a significantly higher rate of SAEs was found in the morphine group. Enrolling by invitation --> Completed