morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Opioid Discharge Prescriptions After Inpatient Surgery: Risks of Rebound Refills by Length of Stay. (Pubmed Central) -  Jul 28, 2022   
    Therefore, we do not believe that the addition of diazepam to the postoperative regimen is warranted. Despite concerns of increased refills, patients discharged by POD 2-3 were not associated with "rebound refills." A patient-centered 5x-multiplier standardization of discharge opioid prescriptions is feasible in all inpatient surgery patients, even those discharged following a short inpatient stay.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Less Is More: A Multimodal Pain Management Strategy Is Associated With Reduced Opioid Use in Hospitalized Trauma Patients. (Pubmed Central) -  Jul 28, 2022   
    Despite concerns of increased refills, patients discharged by POD 2-3 were not associated with "rebound refills." A patient-centered 5x-multiplier standardization of discharge opioid prescriptions is feasible in all inpatient surgery patients, even those discharged following a short inpatient stay. The implementation of a multimodal pain management protocol in trauma patients targeting scheduled nonopioid medications and patient education is feasible and is associated with reduced opioid amount prescribed on discharge, without compromising pain control.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Toward Zero Prescribed Opioids for Outpatient General Surgery Procedures: A Prospective Cohort Trial. (Pubmed Central) -  Jul 28, 2022   
    The implementation of a multimodal pain management protocol in trauma patients targeting scheduled nonopioid medications and patient education is feasible and is associated with reduced opioid amount prescribed on discharge, without compromising pain control. Our study demonstrates that patient education and preoperative interventions can result in zero opioids prescribed after common general surgery procedures with equivalent patient satisfaction and pain scores.
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Journal:  The erector spinae block: a novel approach to pain management in acute appendicitis. (Pubmed Central) -  Jul 27, 2022   
    After being consented both for the procedure and for research, she received a right-sided erector spinae block with 20 mL's of 0.2% ropivacaine (2 mg/mL) at the L1 vertebral level. After approximately 15 min, she stated that she had a reduction in her pain from a 6/10 to a 1/10 that persisted throughout the rest of her stay in the emergency department.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Peri-Operative Pain and Opioid Use in Opioid-Naïve Patients Following Inpatient Head and Neck Surgery. (Pubmed Central) -  Jul 27, 2022   
    Average daily pain and total daily opioid consumption (as morphine milligram equivalents, MME) and quantity of opioids prescribed at discharge were compared...HNC patients, particularly those with shorter LOA, may be prescribed opioids in excess of their post-operative needs, highlighting the need the for improved pain management algorithms in this patient population. Future work aims to use prospective surveys to better define post-operative and outpatient pain and opioid requirements following HNC surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Age-related changes in peripheral nociceptor function. (Pubmed Central) -  Jul 27, 2022   
    The anti-allodynic effects of intraplantar injection of kappa and delta opioid receptor agonists, salvinorin-A and D-Pen,D-Pen]enkephalin (DPDPE), respectively, were greater in aged than young rats, whereas mu opioid receptor agonists, [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO) and morphine, were not effective in aged rats...Thus, age-related changes in nociceptors generally favor increased pain signaling in aged versus young rats, suggesting that changes in nociceptor sensitivity may play a role in the increased incidence of pain in the elderly population. These results also suggest that development of peripherally-restricted kappa or delta opioid receptor agonists may provide safer and effective pain relief for the elderly.
  • ||||||||||  morphine sulphate / Generic mfg.
    THE IMPACT OF A MULTIMODAL PAIN REGIMEN ON ANALGESIA PRESCRIBING AT AN ACADEMIC HOSPITAL (Grand Ballroom) -  Jul 24, 2022 - Abstract #AAST2022AAST_140;    
    Opioid morphine milligram equivalents (MME) varied widely, with an overall average of 38.6±33.3 daily, but decreased in all groups over the study period... Implementation of a multimodal pain protocol by a single division can facilitate the rapid spread of non-opioid adjunctive pain medication use and decrease opioid utilization throughout surgical specialties in a hospital.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Prenatal exposure to morphine enhances excitability in locus coeruleus neurons. (Pubmed Central) -  Jul 24, 2022   
    In addition, resting membrane potential, rise slope, and amplitude of action potentials were not changed by prenatal morphine exposure. Together, the current findings show a significant enhancement in excitability of the LC neurons following prenatal morphine exposure, which may affect the release of norepinephrine to other brain regions and/or cognitive performances of the offspring.
  • ||||||||||  Exparel (bupivacaine liposome injectable suspension) / Pacira
    Journal:  Liposomal bupivacaine in posterior spine surgery: A piece of the puzzle for postoperative pain. (Pubmed Central) -  Jul 24, 2022   
    Demographics, clinical characteristics, and total morphine milligram equivalents did not differ significantly between the groups...Treatment with LB was associated with lower pain levels at 24 h (5.2 treatment, 6.4 control, p = 0.04) and 48-72 h (4.9 treatment, 6.6 control, p = 0.007) after surgery. LB improved patient perception of pain in the acute postoperative time period.Intraoperative LB injection, coupled with focused early mobilization efforts and multimodal pain control, may lead to improved patient-reported outcomes, shorter length of stay, and decreased risk of perioperative complications.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion:  U/S-guided Continuous Quadratus Lumborum Block III in Percutaneous Nephrolithotomy (clinicaltrials.gov) -  Jul 23, 2022   
    P=N/A,  N=45, Completed, 
    We report the restoration of inflammatory and oxidant-antioxidant system parameters, c-fos, bdnf and opioid receptor oprm1 as the possible mechanisms involved in the ameliorative effect of MOR against PTZ-induced epileptogenic process in zebrafish embryos. Active, not recruiting --> Completed
  • ||||||||||  tramadol hydrochloride / Generic mfg.
    Journal:  Tramadol Versus Codeine in Hand Surgery. (Pubmed Central) -  Jul 23, 2022   
    Conclusion Our findings suggest that codeine and tramadol are not equivalent in managing upper extremity pain. Further study is needed to articulate the situations in which physicians and patients are better served by tramadol versus codeine.
  • ||||||||||  Journal:  Adolescent with abdominal pain poorly responsive to analgesia. (Pubmed Central) -  Jul 23, 2022   
    QUESTIONS: What is the diagnosis?Appendicitis.Pancreatitis.Cholecystitis.Gastroenteritis.Which serology would have been most helpful at presentation?Renal function.Coagulation.Amylase and lipase.Gamma glutamyltransferase.What are the acute treatment principles?What is the the most common cause?Idiopathic.Gallstones.Medications.Genetic. Answers can be found on page 2.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Toradol to Reduce Ureteroscopy Symptoms Trial (TRUST). (Pubmed Central) -  Jul 23, 2022   
    Ketorolac during ureteroscopy is associated with a 37% reduction in narcotic requirement and is an independent predictor of decreased peri-operative narcotic needs. These findings show that intra-operative use of ketorolac effectively reduces narcotic requirements and should be considered independently or as part of a multimodal pain control protocol, unless otherwise contraindicated.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Morphine reduces the interest for natural rewards. (Pubmed Central) -  Jul 23, 2022   
    Female mice were more sensitive than male mice to the rewarding effects of morphine. Moreover, both a non-rewarding and a rewarding dose of morphine impaired the interest for naturally rewarding activities, indicating that brain reward systems might be more sensitive to the deleterious than to the rewarding effects of substances of abuse.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Adverse events:  Serious opioid-related adverse outcomes associated with opioids prescribed by dentists. (Pubmed Central) -  Jul 23, 2022   
    Opioid overprescribing was defined as >120 morphine milligram equivalents per Centers for Disease Control and Prevention guidelines...Findings from this study demonstrate that dental prescribing of opioids was associated with adverse outcomes and POU, even when prescriptions were concordant with guidelines. Additional efforts are required to improve analgesic prescribing in dentistry, especially in groups at high risk of opioid-related adverse outcomes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Educational Intervention for Management of Acute Trauma Pain: A Proof-of-Concept Study in Post-surgical Trauma Patients. (Pubmed Central) -  Jul 23, 2022   
    The secondary (explorative) outcome was the change in Morphine Milligram Equivalents (MME) used on the day of the educational intervention while inpatients and prescribed at the time of the hospital discharge...These findings suggest that trauma patients' expectations and understanding of the risks associated with the long-term use of opioids can be modified by a short educational intervention delivered by health providers during the hospitalization. Establishing realistic expectations in managing acute traumatic pain may empower patients with the necessary knowledge to minimize the potential of continuous long-term opioid use, opioid misuse, and the development of post-trauma opioid abuse and/or addiction.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Review:  Ultrasound-Guided Erector Spinae Plane Block in Thoracolumbar Spinal Surgery: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Jul 23, 2022   
    The total morphine consumption within 24 h after surgery was lower in the ESPB group, the mean difference (in mg of morphine) with 95% CI is -9.27 (-11.63, -6.91)...Ultrasound-guided ESPB was superior to placebo in reducing post-operative opioid consumption, pain intensity, post-operative nausea and vomiting, and prolonging the time to first rescue analgesia. There were no ESPB-related serious complications reported.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Trial completion date:  Erector Spinae Plane Block for Post-nephrectomy Pain (clinicaltrials.gov) -  Jul 21, 2022   
    P=N/A,  N=60, Completed, 
    Erector spinae plane block used in conjunction with 'Enhance Recovery After Surgery' and multimodal analgesia protocols provides limited reduction in opioid consumption and no long-term benefits. Recruiting --> Completed | Trial completion date: Nov 2022 --> Jun 2022
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Trial completion date, Trial primary completion date:  Intrathecal Opioids for Colorectal Resection (clinicaltrials.gov) -  Jul 20, 2022   
    P4,  N=85, Recruiting, 
    Recruiting --> Completed | Trial completion date: Nov 2022 --> Jun 2022 Trial completion date: Jun 2022 --> Jun 2023 | Trial primary completion date: Jun 2022 --> Dec 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment status, Head-to-Head:  PENG Block vs Intrathecal Morphine in Total Hip Arthroplasty (clinicaltrials.gov) -  Jul 20, 2022   
    P4,  N=60, Enrolling by invitation, 
    Trial completion date: Jun 2022 --> Jun 2023 | Trial primary completion date: Jun 2022 --> Dec 2022 Recruiting --> Enrolling by invitation
  • ||||||||||  Chirocaine (levobupivacaine) / Purdue, AbbVie
    Journal:  [Translated article]Implementation of a rapid recovery protocol in total knee arthroplasty. A randomized controlled trial. (Pubmed Central) -  Jul 20, 2022   
    P=N/A
    There were no differences in sex, age, implanted prosthesis, hemoglobin drop, need for transfusion, range of motion (ROM) on discharge: C: 82.6º, RP: 85º and at the end of the follow up: C:105.1, RP: 106.6, OKS improvement (C: 17.5 points; RP: 19.3 points), patient satisfaction or re-admissions at the emergency department (C: 7.6%; RP: 10.8%). Significancy was found on time of ischemia (C: 81.29 minutes; RP: 85.35 minutes; p=0.03), need for morphine shots (C: 19.7%; RP: 38.6%; p=0.007), hospital stay (C: 3.84 days; RP: 2.54 days, p<0.0001) and time until ambulation (C: 2.46 days; RP: 0.23 days; p<0.0001) Rapid Recovery protocols can reduce hospital stay without increasing complications or need for readmission.