morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    MANAGING ANXIETY-RELATED SEVERE RESPIRATORY ALKALOSIS WITH LOW-DOSE MORPHINE: A CASE REPORT (Convention Center Exhibit Hall: Poster Area 2) -  Jul 31, 2024 - Abstract #CHEST2024CHEST_2675;    
    Morphine and other opioids have a well-documented role in decreasing the respiratory drive, and so do other psychiatric medications, including benzodiazepines [1, 2]. A randomized-control trial is warranted to compare morphine with medications to safely depress the respiratory drive.
  • ||||||||||  morphine sulphate / Generic mfg.
    LATE ONSET POSTPOLIO SYNDROME (PPS) WITH RECURRENT RESPIRATORY FAILURE AND SEVERE DYSPHAGIA: A CASE REPORT (Convention Center 258 B) -  Jul 31, 2024 - Abstract #CHEST2024CHEST_1847;    
    After receiving morphine for abdominal pain, she became obtunded and hypercarbic (pH 6.97, PCO2 >125 mmHg, PO2 199 mmHg, bicarbonate 37 mEq/L), requiring intubation... We report an 80-year-old woman with a late and severe onset of PPS, emphasizing the importance of vigilance in recognizing and managing respiratory and bulbar complications in poliomyelitis survivors.
  • ||||||||||  LACTIC ALKALOSIS: A DECEPTIVE NAME FOR A DECEPTIVE LAB FINDING (Convention Center Exhibit Hall: Poster Area 4) -  Jul 31, 2024 - Abstract #CHEST2024CHEST_1728;    
    She was admitted to Oncology with subsequently negative cardiac and infectious workup for her dyspnea and was started on empiric steroids for possible carmustine pneumonitis...She was not taking nicotine replacement, beta agonists, or progesterone containing medications...She was given morphine as needed to suppress her respiratory drive with subsequent rapid improvement in her lactate level to 1.9... Patients with alkalosis may develop compensatory lactic acid generation, and in cases such as this one with central neurogenic hyperventilation an elevated lactic acid level may be misleading and invite inappropriate diagnostic anchoring.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    RECURRENT RIGHT-SIDED MSSA EMPYEMA SECONDARY TO SILENT ASPIRATIONS DUE TO EXCESSIVE ANALGESIA: A CASE REPORT (Convention Center Exhibit Hall: Poster Area 2) -  Jul 31, 2024 - Abstract #CHEST2024CHEST_1191;    
    Clinicians should be cautious in prescribing high-dose opioids, favoring multimodal analgesia to optimize pain control while minimizing respiratory compromise. Awareness of such associations is crucial for early diagnosis, targeted interventions, and improved patient outcomes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Surgery:  Preoperative Oxybutynin Reduces Postoperative Opioid Use Following Common Pediatric Urology Surgeries. (Pubmed Central) -  Jul 31, 2024   
    There was no statistical difference between the groups in terms of age, procedure type, anesthesia block, postoperative drain, or intraoperative morphine milligram equivalents per kilogram...For pediatric patients with an indwelling urinary drain after urologic surgery, a single preoperative dose of oxybutynin was significantly associated with lower postoperative utilization of opioids. This relatively low risk intervention can be easily implemented.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Review, Journal:  Opioid-Based Haptens: Development of Immunotherapy. (Pubmed Central) -  Jul 31, 2024   
    Immunotherapy for opioid addiction includes the induction of anti-drug vaccines which are composed of a hapten, a carrier protein, and adjuvants. In this review we survey the design of opioid haptens, the development of the opioid radioimmunoassay, and the results of immunotherapy for OUDs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Sex differences in morphine sensitivity of neuroligin-3 knockout mice. (Pubmed Central) -  Jul 31, 2024   
    Together, our data reveal that knockout of neuroligin-3 has both common and distinct effects on morphine sensitivity in female and male mice. These results also support the notion that female sex can confer resilience against the impact of autism-associated gene variants.
  • ||||||||||  ketamine / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  A randomised comparative study of erector spinae plane block versus low-dose ketamine-dexmedetomidine intravenous infusion as intraoperative opioid-free analgesia for modified radical mastectomy. (Pubmed Central) -  Jul 31, 2024   
    The secondary outcomes were pain scores over 24 hours during rest, duration of analgesia, isoflurane consumption, time to awakening, postoperative nausea and vomiting (PONV), and postoperative serum cortisol level...Group Ket-Dex had lower pain scores at rest, longer analgesia duration, longer awakening time, and lower postoperative serum cortisol levels. Intravenous low-dose ketamine-dexmedetomidine infusion intraoperatively with inhalational-based general anaesthesia provides superior opioid-sparing analgesia to that of ESPB in patients undergoing unilateral non-reconstructive modified radical mastectomy, with less postoperative opioid consumption and stress response.
  • ||||||||||  Observational data, Journal:  Use and misuse of psychoactive medicines: a descriptive cross-sectional study in a densely populated region of Portugal. (Pubmed Central) -  Jul 31, 2024   
    Chronic use of PMed was observed in 25%, especially with sertraline and buprenorphine for opioid use disorder (long-term treatment), and lorazepam (short-term treatment)...Risk of abuse was low for BZDR, whilst four opioids had meaningful doctor shopping indicators - fentanyl, opioid use disorder buprenorphine, morphine and hydromorphone...Prevalence of OA use is low, although with higher risk of misuse than BZDR. Concomitant use of several PMed is frequent.
  • ||||||||||  tramadol hydrochloride / Generic mfg.
    Tramadol for Pain Management Associated with Serotonin Syndrome (Exhibit Hall) -  Jul 31, 2024 - Abstract #PAINWeek2024PAINWeek_241;    
    This recommendation was made based on multiple areas of concern. First, drug-drug interactions between tramadol, sertraline, and quetiapine were noted to increase serotonin in the central nervous system and therefore increase the risk of serotonin syndrome.
  • ||||||||||  morphine sulphate / Generic mfg.
    Subcutaneous Opioids: Under the Skin Irritation or New Standard of Care? (Exhibit Hall) -  Jul 31, 2024 - Abstract #PAINWeek2024PAINWeek_231;    
    Groups were similar in age, BMI, and race; however, the post-intervention group had a higher ratio of females than males. Following the intervention, we observed a decrease in mean number IV opioid administrations (2.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Pharmaceutical Automated Reporting: An Opioid Stewardship Tool (Exhibit Hall) -  Jul 31, 2024 - Abstract #PAINWeek2024PAINWeek_207;    
    9%) patients with at least one opioid-related risk factor and 6590 (62. 4%) triggering multiple risk factors simultaneously.
  • ||||||||||  morphine sulphate / Generic mfg., oxycodone/acetaminophen / Generic mfg., hydrocodone/paracetamol / Generic mfg.
    Opioid Consumption Patterns Before and After Elective Joint Replacement Surgery (Exhibit Hall) -  Jul 31, 2024 - Abstract #PAINWeek2024PAINWeek_202;    
    The average age was 68 years and 59% of patients were female. Over the study period, the total number of opioid prescriptions filled was 43,326.
  • ||||||||||  morphine sulphate / Generic mfg.
    MEDICAID POLICY OVERVIEW OF OPIOID MANAGEMENT FOR SICKLE CELL DISEASE ACROSS STATES (Exhibit Hall) -  Jul 31, 2024 - Abstract #PAINWeek2024PAINWeek_195;    
    First, state-specific PA criteria for SCD for opioid management are limited. As of 2023, only eight states have opioid PAs specific for SCD (Arizona, Connecticut, Florida, Georgia, Indiana, Kansas, Kentucky, and Maryland).
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Effects of morphine to fentanyl interchange in post-anesthesia care unit order sets (Exhibit Hall) -  Jul 31, 2024 - Abstract #PAINWeek2024PAINWeek_169;    
    Patients were screened for inclusion in reverse chronological order until 150 patients were included in both groups. Baseline characteristics were similar except more patients in the pre-intervention group received both fentanyl and morphine in the operating room.
  • ||||||||||  Retrospective data, Review, Journal:  Efficacy and Safety of Analgesics and Sedatives during Radiofrequency Catheter Ablation of Atrial Fibrillation: A Network Meta-Analysis. (Pubmed Central) -  Jul 30, 2024   
    In terms of safety, propofol (OR 16.46; 95% CI [1.54 to 175.95]) and midazolam plus fentanyl or its derivatives (OR 7.02; 95% CI [1.33 to 36.99]) significantly increased the incidence of respiratory depression compared with dexmedetomidine plus fentanyl or its derivatives...It is necessary to explore the regimen that can consider both the effectiveness and safety during radiofrequency catheter ablation for atrial fibrillation (AF). This study was registered with PROSPERO, number: CRD42023403661.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Diversity of microglial transcriptional responses during opioid exposure and neuropathic pain. (Pubmed Central) -  Jul 29, 2024   
    However, we found no proliferative transcriptional response associated with opioid-induced microglial activation, consistent with histological data, indicating that the number of microglia remains stable during morphine treatment, whereas their morphological response differs from PNI models. Collectively, these results establish the diversity of pain-associated microglial transcriptomic responses and point towards the targeting of distinct insult-specific microglial responses to treat OIH, PNI, or other central nervous system pathologies.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Characterization and validation of a spontaneous acute and protracted oxycodone withdrawal model in male and female mice. (Pubmed Central) -  Jul 28, 2024   
    Historically, chronic morphine injections have most often been used to produce opioid-dependent animals, and withdrawal signs indicative of dependence were precipitated by administering an opioid antagonist...Spontaneous withdrawal also resulted in mechanical and cold hypersensitivity lasting for 24 and 14?days, respectively, and produced anxiety-like behaviors after 2 and 3?weeks following oxycodone removal. These results help validate a new model of oxycodone dependence, including the temporally distinct emergence of somatic, hyperalgesic, and anxiety-like behaviors, potentially useful for mechanistic and translational studies of opioid dependence.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A bundle of opioid-sparing strategies (BOSS) to eliminate routine opioid prescribing in a urogynecology practice. (Pubmed Central) -  Jul 28, 2024   
    Therefore, these results highlight the therapeutic potential of mGluR5 antagonists in morphine use disorder. A bundle of evidence-based opioid sparing strategies and tiered prescribing based on inpatient use increases the proportion of patients discharged without opioids after minimally invasive pelvic reconstructive surgery without evidence of uncontrolled pain or increased provider workload.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Open Versus Endoscopic Carpal Tunnel Release: A Comparison of Opioid Prescription Patterns and Occupational Therapy Referrals. (Pubmed Central) -  Jul 28, 2024   
    Unadjusted analysis revealed no difference in number of patients requiring refills (6.0% vs 7.1%, P = .44), mean number of refills among those requiring one (1.29 vs 1.23, P = .69), total oral morphine equivalents (45.1 vs 44.7, P = .84), number of patients calling regarding pain (12.8% vs 14.7%, P = .36), OT referrals (12.1% vs 11.4%, P = .71), or average number of OT visits (4.5 vs 4.2, P = .74) for endoscopic and open techniques, respectively...Endoscopic CTR and OCTR did not differ in terms of unadjusted postoperative patient calls for pain, number of opioid refills, or OT referrals. After correcting for individual surgeon practice, endoscopic was associated with decreased odds of requiring postoperative OT.
  • ||||||||||  Retrospective data, Review, Journal, Surgery:  The Impact of Gabapentinoids on Pain-Related Outcomes after Knee and Hip Surgery: A Systematic Review with Meta-Analysis of Randomized Controlled Trials. (Pubmed Central) -  Jul 27, 2024   
    Gabapentinoids, gabapentin, and pregabalin, have been gaining attention in postoperative pain management...The gabapentinoid group required less opioid consumption in morphine equivalents (MD = -6.42 [-9.07, -3.78] mg, p-value < 0.001)...Sedation has not been evaluated in this work and, if performed, this may have influenced the conclusions. An important limitation of this study is that different gabapentinoids, their administration times and dosages, as well as varying intraoperative management protocols, were pooled together.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Dynamic Changes in the Distribution of Hydrocodone and Oxycodone in Florida from 2006 to 2021. (Pubmed Central) -  Jul 26, 2024   
    The data demonstrated pronounced differences in opioid distribution, particularly oxycodone, between Florida counties during the height of the opioid epidemic. Legislative action taken between 2009 and 2011 aligns with the considerable decline in opioid distribution after 2010.