morphine sulphate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Post Mortem Analysis of Opioids and Metabolites in Skeletal Tissue. (Pubmed Central) -  Aug 24, 2022   
    As far as the authors know this is the first-time fentanyl and norfentanyl are quantified in skeletal tissue. In conclusion, due to the absence of reference data for drugs in skeletal tissue, these findings are a step forward towards a more thorough understanding of drug concentration found in post-mortem skeletal tissue.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Observational data, Journal:  Opioid Usage and Pain Control in Benign Oropharyngeal Surgery: An Observational Prospective Study. (Pubmed Central) -  Aug 24, 2022   
    Patients were prescribed 38 837 morphine milligram equivalents and used 28 644: approximately 26% went unused, which is the equivalent of 1346 5 mg oxycodone pills...Larger prescriptions may result in increased opioid consumption and may not reduce the amount of refills. More study is needed to confirm these findings.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal, Patient reported outcomes:  Impact of Postoperative Opioid Use on 2-Year Patient-Reported Outcomes in Knee Surgery Patients. (Pubmed Central) -  Aug 24, 2022   
    Total morphine equivalents (TMEs) were calculated from a regional prescription monitoring program...Postoperative refill of opioids was associated with worse 2-year patient-reported outcomes in a dose-dependent fashion. These findings reinforce the importance of counseling patients regarding opioid use and optimizing opioid-sparing pain management postoperatively.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Assessing Impact: Implementing an Opioid Prescription Protocol in Otolaryngology. (Pubmed Central) -  Aug 24, 2022   
    More RCTs are required before recommending routine use of ketamine in select populations. A postoperative opioid prescribing protocol can reduce the amount of opioid prescribed without increasing unplanned contact or opioid refills.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Situational Awareness of Opioid Consumption: The Missing Link to Reducing Dependence After Surgery? (Pubmed Central) -  Aug 24, 2022   
    A tool for collecting and analyzing morphine milligram equivalents (MMEs) can be used to overcome barriers to situational awareness around opioid utilization in the setting of multimodal pain management...Real-time postoperative tracking of MME over the course of an episode of care can be prohibitively labor-intensive, and teams must have practical strategies to overcome this obstacle. In view of the link between the magnitude of opioid prescriptions at discharge and persistent opioid use after cardiac surgery, we believe that improving situational awareness among the patient care team is a vital first step in reducing opioid dependence after cardiac surgery.
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Retrospective data, Journal:  Efficacy of Liposomal Bupivacaine for Sternotomy Pain After Cardiac Surgery: A Retrospective Analysis. (Pubmed Central) -  Aug 24, 2022   
    To determine the efficacy of liposomal bupivacaine compared with bupivacaine or ropivacaine in patients undergoing sternotomy for coronary artery bypass graft (CABG) and/or valve surgery...The primary outcome was opioid utilization in morphine milligram equivalent (MME) from 0 to 72 hours...Based on these findings and previous studies, liposomal bupivacaine should not be routinely used for CABG and/or valve surgery through a median sternotomy given lack of superiority. This helps inform surgical practice to the role of anesthetics as part of the multimodal analgesia regimen.
  • ||||||||||  morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Opioid Prescribing by Dentists in the Veterans Health Administration. (Pubmed Central) -  Aug 24, 2022   
    Nearly 1 in 3 opioids prescribed by Veterans Health Administration dentists exceed guidelines. Prescribing higher potency and quantities of opioids, especially on Fridays and to certain demographic groups, should be addressed as part of dental opioid stewardship programs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Review, Journal:  Erector Spinae Plane Block versus Transversus Abdominis Plane Block for Postoperative Analgesia in Abdominal Surgery: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Aug 24, 2022   
    Meta-analysis revealed that ESPB decreased the opioid consumption and improved the pain scores during the first 24 postoperative hours compared with TAP groups statistically, while the magnitude of this difference did not reach the clinically significant threshold (10 mg of intravenous morphine consumption and 1.3 cm on the VAS scale)...However, it did not improve the patients' satisfaction. Although ESPB does not provide better clinical analgesia than the TAP block, it could be a comparable nerve block technique for abdominal wall analgesia.
  • ||||||||||  morphine sulphate / Generic mfg., dexmedetomidine / Generic mfg.
    Retrospective data, Review, Journal:  Impact of Opioid-Free Anesthesia on Analgesia and Recovery Following Bariatric Surgery: a Meta-Analysis of Randomized Controlled Studies. (Pubmed Central) -  Aug 24, 2022   
    Forest plot revealed a significantly lower pain score (mean difference (MD) =  - 0.96, p = 0.0002; 318 patients), but not morphine consumption (MD =  - 5.85 mg, p = 0.1; 318 patients) at postoperative 24 h in patients with OFA than in those without...• Lower pain score and opioid consumption were noted in the postanesthetic care unit. • OFA correlated with a lower risk of postoperative nausea/vomiting.
  • ||||||||||  morphine sulphate / Generic mfg., amphetamine / Generic mfg., methadone / Generic mfg.
    Journal:  Common opioids and stimulants in autopsy and DUID cases: A comparison of measured concentrations. (Pubmed Central) -  Aug 24, 2022   
    In the DUID group, the opioids heroin/morphine and methadone and the stimulants amphetamine and MDMA were often seen in concentrations above the reported lower comatose-fatal level whereas cocaine was almost always below. Thus, based on our data, the potential for false assessment of intoxication cases when comparing to reported comatose-fatal limits appears greatest on lower end concentrations of heroin/morphine, methadone, amphetamine and MDMA, whereas false assessment of cocaine appears less likely because most control cases are below reported comatose-fatal levels.
  • ||||||||||  morphine sulphate / Generic mfg.
    PHM-13 - Secrets and Lies: The Truth About Buprenorphine (L3/Gracia 3) -  Aug 23, 2022 - Abstract #PAINWeek2022PAINWeek_107;    
    Join us for a dynamic discussion on the complicated simplicities of buprenorphine pharmacology including partial mu opioid agonism, mu opioid receptor affinity, half-life related dosage selections, CYP-450 metabolism and respective interactions, maximum dosage recommendations, morphine milligram equivalent (MME) calculations, and the infamous respiratory depression relative ceiling effects. Dispelling every rumor, secret, or lie, one pharmacological principal at a time, this session will help you help your patients, every day.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open:  Individualized Analgesia for Pediatric Adenotonsillectomy (clinicaltrials.gov) -  Aug 23, 2022   
    P4,  N=128, Recruiting, 
    Initiation date: Jun 2022 --> Sep 2022 Not yet recruiting --> Recruiting
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Assessment of Postoperative Opioid Prescriptions Before and After Implementation of a Mandatory Prescription Drug Monitoring Program. (Pubmed Central) -  Aug 22, 2022   
    The primary outcome was the total quantity of opioid medications (morphine milligram equivalents [MMEs] and number of opioid tablets) prescribed at discharge before and after implementation of the PDMP mandate, with separate analyses by surgical specialty (general, obstetric/gynecologic, and orthopedic) and most common surgical procedure within each specialty (laparoscopic cholecystectomy, cesarean delivery, and knee arthroscopy)...These findings might be explained by prescribers' attempts to meet the mandate exemption and bypass PDMP consultation rather than the PDMP consultation itself. Although policies coupled with EHR alerts may be associated with changes in postoperative opioid prescribing behavior, they need to be well designed to optimize evidence-based opioid prescribing.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Complete opioid cessation after surgery improves patient-reported pain measures among chronic opioid users. (Pubmed Central) -  Aug 22, 2022   
    Complete opioid tapering can be successfully achieved after surgery among patients with chronic opioid use with corresponding improvements in self-reported pain intensity and pain interference. Our results suggest that the highest potential for improving patient-reported outcomes with opioid tapering occurs among patients undergoing orthopedic procedures early after surgical discharge.
  • ||||||||||  Nucynta (tapentadol) / Collegium Pharma, Grunenthal
    Journal:  Prescribing Trend of Tapentadol in a Sydney Local Health District. (Pubmed Central) -  Aug 22, 2022   
    In a Sydney LHD, tapentadol prescriptions increased significantly to become the preferred opioid analgesic. At the hospital's surgical units, off-label prescriptions of tapentadol sustained-release for acute post-operative pain were observed.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal, Adverse events:  Cannabinoid 1 and mu-opioid receptor agonists synergistically inhibit abdominal pain and lack side effects in mice. (Pubmed Central) -  Aug 22, 2022   
    This combination avoided side effects (decreased oxygen saturation and colonic transit) caused by analgesic dose of morphine...Furthermore, a combination of sub-analgesic doses of µ-opioid receptor agonist and CB1R agonist markedly reduce abdominal pain without causing the side effects of high dose opioids. Thus, CB1R agonists, alone or in combination with low-dose opioids, may be a novel and safe treatment strategy for abdominal pain.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Analysis of opiates in urine using microextraction by packed sorbent and gas Chromatography- Tandem mass spectrometry. (Pubmed Central) -  Aug 22, 2022   
    Extraction efficiency varied from 17 to 107%, which did not impair sensitivity, taking into account the low LLOQs obtained (1 ng/ mL for all analytes; and 10 ng/mL for fentanyl). The developed procedure proved to be fast, selective, and accurate for use in routine analysis, with a low volume of sample (250 µL).
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Post-operative opioid dosing relative to preoperative long-acting opioid dose. (Pubmed Central) -  Aug 22, 2022   
    Presynaptic DORs at primary afferent central terminals constitutively inhibit inflammatory and neuropathic pain by restraining glutamatergic input to spinal dorsal horn neurons. Our results suggest that patients with a high intake of long-acting opioids may be more likely to receive PRN opioid doses that are not sufficiently adjusted to their total intake during the first 24 hours after inpatient surgery than patients with a lower intake of long-acting opiods.
  • ||||||||||  morphine sulphate / Generic mfg.
    Local Infiltration of Liposomal Bupivacaine in Isolated Traumatic Rib Fractures (SDCC - 6A - Upper) -  Aug 21, 2022 - Abstract #ACSCLINCON2022ACS_CLINCON_2743;    
    The demographic and clinical characteristics were similar between the two groups... No significant reduction in pain score and opioid requirement were achieved by additional infiltration of LB in patients with isolated traumatic rib fractures.
  • ||||||||||  morphine sulphate / Generic mfg.
    Opioid Consumption Prior To Discharge Predicts Outpatient Opioid Use In Adolescents Undergoing Surgery (SDCC - 6A - Upper) -  Aug 21, 2022 - Abstract #ACSCLINCON2022ACS_CLINCON_2717;    
    For adolescents undergoing surgery, patient reported pain at discharge and cumulative OME used 24- and 48-hours before discharge are associated with outpatient opioid use. Calculating cumulative OME consumption in the 24-hours prior to discharge could be used to tailor outpatient prescriptions and reduce excess opioid prescribing.