morphine sulphate / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 7 Diseases   379 Trials   379 Trials   12426 News 


«12...8182838485868788899091...217218»
  • ||||||||||  morphine sulphate / Generic mfg., paracetamol / Generic mfg., ibuprofen / Generic mfg.
    Essential Analgesics for Children in Supply System (In-person; Virtual) -  Sep 1, 2022 - Abstract #ISPOREU2022ISPOR_EU_1929;    
    Medicines supply system in Armenia provides only a part of dosage forms and formulations for analgesics recommended by WHO for pain relief in children. There is urgent need for improving availability of dosage forms and formulations of these medicines to improve access to treatment for children.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Treatment Pattern of the Opioid Injection Prescriptions in South Korea (In-person; Virtual) -  Sep 1, 2022 - Abstract #ISPOREU2022ISPOR_EU_518;    
    Although the opioid injection prescription rate in Korea has been decreasing from year to year, it is still maintained at a concerning level. Notably, since the opioid injection rate was shown as a high risk in the elderly and clinics, the management of those is needed.
  • ||||||||||  ketorolac / Generic mfg.
    Trial completion date, Trial primary completion date:  Effect of Ketorolac on Post Adenotonsillectomy Pain (clinicaltrials.gov) -  Sep 1, 2022   
    P4,  N=120, Recruiting, 
    Notably, since the opioid injection rate was shown as a high risk in the elderly and clinics, the management of those is needed. Trial completion date: Aug 2022 --> Aug 2023 | Trial primary completion date: Aug 2022 --> Aug 2023
  • ||||||||||  morphine sulphate / Generic mfg., midazolam hydrochloride / Generic mfg., methamphetamine / Generic mfg.
    Preclinical, Journal:  Midazolam, methamphetamine, morphine and nicotine intake in high-drinking-in-the-dark mice. (Pubmed Central) -  Aug 31, 2022   
    HDID-2 mice, but not HDID-1 mice, consumed more morphine (700 μg/ml) and more nicotine across a range of concentrations than HS/NPT mice. These results demonstrate that the HDID mice can be utilized for tests of voluntary drug consumption other than ethanol and highlight potentially important differences between HDID lines in risk for elevated drug intake.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Inhibition of PSD95-nNOS protein-protein interactions decreases morphine reward and relapse vulnerability in rats. (Pubmed Central) -  Aug 31, 2022   
    Interestingly, ZL006 did not alter acquisition or maintenance of morphine self-administration, but reduced lever pressing in a morphine relapse test after forced abstinence. Our results provide behavioural and neurochemical support for the hypothesis that inhibition of PSD95-nNOS protein-protein interactions decreases morphine reward and relapse-like behaviour, highlighting a previously unreported application for these novel therapeutics in the treatment of opioid addiction.
  • ||||||||||  Chronogesic (sufentanil) / Durect
    Journal:  Stability of Morphine Sulfate-Clonidine and Sufentanil-Clonidine Mixtures. (Pubmed Central) -  Aug 31, 2022   
    For the sufentanil-clonidine mixtures, the results show stability in syringes for seven days at 5 °C. Pump results show stability of seven days for low concentrations and 28 days for high concentrations.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Heterogeneity:  Acetic acid-induced nociception modulates sociability in adult zebrafish: influence on shoaling behavior in heterogeneous groups and social preference. (Pubmed Central) -  Aug 31, 2022   
    For this purpose, using a three-dimensional analysis of heterogeneous shoals, we investigated the main behavioral responses in two 6-min trials: before (baseline) and after a single intraperitoneal (i.p) injection of 10 μL phosphate-buffered saline (PBS) (control), acetic acid 5% (AA), morphine 2.5 mg/kg (MOR) or acetic acid 5% plus morphine 2.5 mg/kg (AA + MOR) in one subject from a four-fish shoal...Overall, our novel findings show that nociception can modulate zebrafish sociability, possibly due to the visual recognition of nocifensive responses. Although future studies are needed to elucidate how nociception modulates zebrafish social behavior, our results contribute to improve the welfare assessment of zebrafish shoals under distinct experimental manipulations.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date:  Sensory Effects of Oral Opioid Treatment in Patients With Chronic Low Back Pain (clinicaltrials.gov) -  Aug 31, 2022   
    P1,  N=100, Recruiting, 
    We believe that this bundle reduced the risk for opioid misuse in our community. Trial completion date: Sep 2021 --> Dec 2022 | Trial primary completion date: Sep 2021 --> Dec 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, IO biomarker:  Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia. (Pubmed Central) -  Aug 30, 2022   
    Furthermore, CBDV attenuated morphine analgesic tolerance as measured by the formalin test by specifically inhibiting chronic morphine-induced glial activation and pro-inflammatory factors expression in the nucleus accumbent. This study confirms that MD2 is a direct binding target of CBDV for the anti-neuroinflammatory effect and implies that CBDV has great translational potential in pain management.
  • ||||||||||  morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Opioid use after outpatient elective general surgery: quantifying the burden of persistent use. (Pubmed Central) -  Aug 30, 2022   
    Most patients who undergo elective cholecystectomy and hernia repair will fill a prescription for an opioid after surgery, and many will continue to fill opioid prescriptions for considerably longer than clinically anticipated. There is important variability in opioid type, regional prescribing patterns and risk factors that identify strategic targets to reduce the opioid burden in this patient population.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Opioids alter paw placement during walking, confounding assessment of analgesic efficacy in a postsurgical pain model in mice. (Pubmed Central) -  Aug 30, 2022   
    Further investigation of this opioid-induced phenotype revealed that analgesic doses of oxycodone or morphine dose-dependently reduced the hind paw print area in uninjured mice...However, this work reveals an important, previously uncharacterized effect of treatment with analgesic doses of opioids on paw placement. Our characterization of how opioids affect gait has important implications for the use of mice to study opioid pharmacology and suggests that scientists should use caution when using hind paw-directed nociceptive assays to test opioid analgesia in mice.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Characteristics of Patients with Non-Cancer Pain and Perceived Severity of COVID-19 Related Stress. (Pubmed Central) -  Aug 30, 2022   
    Depression/anxiety (p=0.003), using any prescription opioid in the prior three months (p=0.009), higher morphine milligram equivalent used (p=0.005), higher pain severity (p=0.011), and higher pain interference (p=0.0004) were all positively and significantly associated with moderate to severe stress due to COVID-19 related lifestyle changes...Depression, anxiety, pain severity, and pain interference were most strongly and consistently associated with COVID-19 changes in way of life, worsening of emotional/mental health, and worsening pain. Identifying specific stressful experiences that most impacted patients with noncancer pain may inform public health and treatment interventions.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date, Adverse events:  Decreased Neuraxial Morphine After Cesarean Delivery (clinicaltrials.gov) -  Aug 30, 2022   
    P1,  N=96, Recruiting, 
    Identifying specific stressful experiences that most impacted patients with noncancer pain may inform public health and treatment interventions. Trial completion date: Jul 2022 --> Jul 2023 | Trial primary completion date: Jul 2022 --> Jul 2023
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Characterized profiles of gut microbiota in morphine abstinence-induced depressive-like behavior. (Pubmed Central) -  Aug 30, 2022   
    Interestingly, gene function prediction found that the fatty acid metabolism pathway was enriched in the OUTs in the depressive group compared with the non-depressive group after morphine abstinence. Our data suggested that gut microbiota dysbiosis was associated with morphine abstinence-induced depressive behavior, possibly by implicating the fatty acid metabolism pathway.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Association Between State Opioid Prescribing Cap Laws and Receipt of Opioid Prescriptions Among Children and Adolescents. (Pubmed Central) -  Aug 26, 2022   
    Outcomes of interest included receipt of any opioid prescription and, among those with at least 1 opioid prescription, the mean number of opioid prescriptions, mean morphine milligram equivalents (MMEs) per day, and mean days' supply...In this cross-sectional study, no association was observed between state opioid prescribing cap laws and the receipt of opioid prescriptions among children and adolescents. Alternative strategies, such as opioid prescribing guidelines tailored to youths, are needed.
  • ||||||||||  morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Optimization of an Enhanced Recovery After Surgery protocol for opioid-free pain management following robotic thoracic surgery. (Pubmed Central) -  Aug 26, 2022   
    Essential components of pain management in the original protocol included nonopioid analgesics, intercostal nerve blocks with long-acting liposomal bupivacaine diluted with normal saline, and opioids (ie, scheduled tramadol administration and as-needed schedule II narcotics)...Demographic characteristics, type of robotic procedures, postoperative outcomes, and in-hospital and postdischarge opioids prescribed (ie, milligrams of morphine equivalent [MME]) were extracted from electronic medical records...For anatomic resections: mean, 60.0 MME (range, 0-60.0 MME) versus mean, 105.0 MME (range, 60.0-150.0 MME), and other procedures: mean, 0 MME (range, 0-60 MME) versus mean, 140.0 (range, 60.0-150.0 MME) (P < .00001) with median schedule II opioids prescribed = 0. Small modifications to our protocol for pain management strategies are safe and associated with significant decrease of opioid requirements, particularly schedule II narcotics, during the postoperative period without influencing acute pain levels.
  • ||||||||||  morphine sulphate / Generic mfg.
    Biomarker, Journal:  Post-Mortem Analysis of Heroin Biomarkers, Morphine and Codeine in Stomach Wall Tissue in Heroin-Related Deaths. (Pubmed Central) -  Aug 26, 2022   
    This study provides new data on the distribution of 6-monoacetylmorphine, 6-Acetylcodeine, morphine, and codeine in postmortem stomach wall tissue and suggests the usefulness of alternative matrices for investigating heroin-related fatalities when blood samples are unavailable. In addition, the prevalence of 6-monoacetylmorphine in the stomach wall tissue was higher than that in the liver and kidney tissues.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Current approaches to acute postoperative pain management after major abdominal surgery: a narrative review and future directions. (Pubmed Central) -  Aug 25, 2022   
    Limited research exists on patient quality of recovery using specific analgesic techniques after intra-abdominal surgery. Poorly controlled postoperative pain after major abdominal surgery should be a research priority as it affects patient-centred short-term and long-term outcomes (including quality of life scores, return to function measurements, disability-free survival) and has broad community health and economic implications.
  • ||||||||||  morphine sulphate / Generic mfg., duloxetine / Generic mfg.
    Trial completion, Enrollment change:  Effect of Combined Morphine and Duloxetine on Chronic Pain (clinicaltrials.gov) -  Aug 25, 2022   
    P4,  N=81, Completed, 
    Patient catastrophising negatively affected the experience of pain. Recruiting --> Completed | N=135 --> 81
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Journal:  Surgeon-Performed Saphenous Nerve Block at the Medial Femoral Condyle for Arthroscopic Partial Meniscectomy and Meniscus Repair: A Randomized Control Trial. (Pubmed Central) -  Aug 24, 2022   
    The operating surgeon performed the SNB using a landmark-based approach at the medial femoral epicondyle/adductor hiatus with 5 mL of 1% lidocaine preoperatively and 5 mL of 0.5% ropivacaine postoperatively...No statistically significant difference was detected in the number of patients requiring opioids postoperatively or in the morphine milligram equivalents (MME) provided to patients receiving opioids...However, given our lack of confirmatory testing via ultrasound or nerve stimulation, a true nerve block may not have been achieved in all patients. We believe this adds to the external validity of this study, as these tools may not be readily available in all settings.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Overdose, opioid treatment admissions and prescription opioid pain reliever relationships: United States, 2010-2019. (Pubmed Central) -  Aug 24, 2022   
    Opioid sales (measured as MME (morphine milligram equivalent) per capita) was the independent variable...The guideline, guideline update, CDC's public, medical profession, and intergovernmental communications should be corrected/updated to state no direct correlation has existed between POS to OTA, POD, AOD, and TOD since 2010. Individualized patient care and public health policy should be amended accordingly.