morphine sulphate / Generic mfg. 
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 7 Diseases   379 Trials   379 Trials   12426 News 


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  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Review, Journal:  Enhanced Recovery After Surgery for Pediatric Cleft Repair: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Sep 10, 2022   
    The present study sought to assess the impact of ERAS protocols following primary palatoplasty. Our results indicate decreased hospital length of stay, postoperative opioid consumption, and time to feeding, without increasing readmission rates or complication rates.
  • ||||||||||  methadone / Generic mfg.
    Trial completion date, Trial primary completion date:  Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone Therapy (clinicaltrials.gov) -  Sep 10, 2022   
    P1,  N=16, Recruiting, 
    There was also an observed significant decrease in the discharge opioid medication doses prescribed. Trial completion date: Aug 2022 --> May 2023 | Trial primary completion date: Jul 2022 --> Apr 2023
  • ||||||||||  morphine sulphate / Generic mfg., midazolam hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
    Trial completion date, Trial primary completion date:  Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support (clinicaltrials.gov) -  Sep 9, 2022   
    P=N/A,  N=20, Recruiting, 
    Trial completion date: Aug 2022 --> May 2023 | Trial primary completion date: Jul 2022 --> Apr 2023 Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Aug 2022 --> Aug 2023
  • ||||||||||  ketamine / Generic mfg.
    Trial completion date, Trial primary completion date:  Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion (clinicaltrials.gov) -  Sep 8, 2022   
    P3,  N=123, Suspended, 
    Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Aug 2022 --> Aug 2023 Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2023
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date:  Ultrasound Guided Erector Spinae Plane Block vs Intrathecal Morphine (clinicaltrials.gov) -  Sep 8, 2022   
    P4,  N=120, Recruiting, 
    Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2023 Trial completion date: Jun 2022 --> Sep 2022 | Trial primary completion date: Jun 2022 --> Sep 2022
  • ||||||||||  glibenclamide / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Pharmacognostic evaluation of Artemisia maritima L. a highly medicinal specie of genus Artemisia. (Pubmed Central) -  Sep 7, 2022   
    The mechanism underlined in-vivo analgesic responses was carried out which revealed that naloxone (morphine and tramadol antagonist) showed no prominent effect while Glibenclamide pretreatment minutely modified the analgesic action. These observations clearly indicted the absence of opiod receptors and involvement of ATP sensitive potassium channels.
  • ||||||||||  dexamethasone / Generic mfg., methylprednisolone acetate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Perineural Methylprednisolone Depot Formulation Decreases Opioid Consumption After Total Knee Arthroplasty. (Pubmed Central) -  Sep 7, 2022   
    This study aimed to investigate the effects of adding methylprednisolone acetate (MPA) to adductor canal blocks (ACB) and interspace between the popliteal artery and capsule of the posterior knee (iPACK) blocks on postoperative opioid consumption...The primary outcome was cumulative opioid consumption (oral milligram morphine equivalent, OME) during hospitalization for up to three days...Compared to perineural DEX alone, the addition of MPA further decreases postoperative opioid consumption without clinically significant changes on FSG and WBC. III.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid sparing effects of the bupivacaine pleural catheter in surgical decompression of the thoracic outlet. (Pubmed Central) -  Sep 7, 2022   
    Intraoperative placement of a bupivacaine infusion pleural catheter significantly reduced opioid use during the index hospitalization and opioid prescribing at discharge. Anesthetic infusion pleural catheters should be the treatment modality of choice for postoperative pain management in patients undergoing thoracic outlet decompression.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Opioid Dependence and Over-Prescription of Opioids in Patients With Co-Existing IBD and IBS (Crown Ballroom) -  Sep 4, 2022 - Abstract #ACG2022ACG_3865;    
    83.2% of patients in the IBD+IBS group and 62.6% of patients in the control group have been prescribed opioids (OR [2.87-3.03], p< 0.0001). Opioids were more commonly prescribed in the IBD+IBS cohort including morphine (48.5 vs 29.1%), Hydromorphone (44.7 vs 24.8%), Oxycodone (46.0 vs 27.2%) and Hydrocodone (58.4 vs 35.7%).
  • ||||||||||  morphine sulphate / Generic mfg.
    A Rare Case of SARS-CoV-2-Induced Cholangiopathy (Crown Ballroom) -  Sep 4, 2022 - Abstract #ACG2022ACG_3303;    
    Antibiotics, IVF and morphine were initiated for presumed gallstone pancreatitis/acute cholecystitis/choledocholithiasis...Though the time of Covid-19 infection is unclear, intrahepatic cholestasis due to pancreatitis/medication and Covid-19 are all contributing factors in our patients' disease progression. Making an accurate diagnosis of Covid-19 cholangiopathy is prudent as it may progress to cirrhosis, especially if a patient has underlying liver pathology.
  • ||||||||||  paracetamol / Generic mfg.
    Acetaminophen-Codeine-Induced Pancreatitis in a Young Male Patient (Crown Ballroom) -  Sep 4, 2022 - Abstract #ACG2022ACG_786;    
    Furthermore, the time course of symptom onset and the rapid resolution of symptoms is more fitting with previously documented cases of codeine-associated pancreatitis. Acetaminophen-codeine is one of the most prescribed pain medications, and although rare, DIAP is a possible consequence of its use and should be known by its prescribers.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Do Patient Demographics and Performance Status Influence Opioid Dose in Cancer Pain? (Pubmed Central) -  Sep 4, 2022   
    Main outcome measures were demographics (age, male/female and performance status), oral morphine equivalent daily dose (oMEDD) and adjuvant analgesic use...This highlights the importance of vigilance in opioid prescribing in the elderly in order to balance side effects with under treatment. Although no other significant relationships were observed, future studies comparing objective patient parameters with opioid prescription may uncover other at risk populations.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors. (Pubmed Central) -  Sep 3, 2022   
    Reducing the side chain size of I322 (MOR) transformed naloxone from an inhibitor directly into an agonist of MOR, and I322A also significantly attenuated the potency of MOR on EM-1, confirming that binding deep in the pocket is critical for the agonistic effect of MOR. This finding reveals a dynamic mechanism for the response of MOR to different ligands and provides a basis for the discovery of new ligands for MOR at the atomic level.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Discharge Opioids are Unnecessary Following Radical Cystectomy. (Pubmed Central) -  Sep 3, 2022   
    Age and pathology are predictors of the need for an opioid prescription on discharge. These patients did not have increased follow-up visits, phone calls, or requests for pain medication.
  • ||||||||||  Journal:  Perioperative use of pain medications in vaginal versus laparoscopic pelvic organ prolapse surgery. (Pubmed Central) -  Sep 3, 2022   
    These patients did not have increased follow-up visits, phone calls, or requests for pain medication. Use of pain medication was similar in the intraoperative and immediate postoperative period after pelvic organ prolapse surgery when comparing the vaginal and laparoscopic approaches after controlling for potential confounding factors.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Prefrontal Cortex Response to Prenatal Insult and Postnatal Opioid Exposure. (Pubmed Central) -  Sep 3, 2022   
    The differential expression between the double-challenged group and the baseline saline-treated Controls was less extreme than the individual challenges. The previous findings advance the knowledge about the effects of prenatal MIA and postnatal morphine exposure on the prefrontal cortex pathways.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Enrollment closed:  A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists. (clinicaltrials.gov) -  Sep 2, 2022   
    P2,  N=20, Active, not recruiting, 
    However, further studies should explore the clinical value of preoperative administration and the long-term effect of LP. Recruiting --> Active, not recruiting
  • ||||||||||  PK/PD data, Review, Journal:  A Critical Review on the Pharmacodynamics and Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs and Opioid Drugs Used in Reptiles. (Pubmed Central) -  Sep 1, 2022   
    Most of the existing reports of NSAID used in reptiles did not observe any adverse effects directly associated to the respective NSAID used, with meloxicam being the most well-studied...Fentanyl and morphine were studied in the greatest number of reptile species with analgesic effects observed with the doses used, while adverse effects such as sedation were observed most with butorphanol use...This could have been due to absorption-rate limited disposition. Although current data provided beneficial information, there is an urgent need for future research on NSAID and opioid pharmacology to ensure the safe and effective use of opioids in reptiles.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Impact of Clinical Pharmacist Practitioner-Driven High Opioid Dose Reevaluation in Veterans with Chronic Non-Cancer Pain. (Pubmed Central) -  Sep 1, 2022   
    West Palm Beach VA Healthcare System (WPBVAHCS) has been an outlier for the percentage of Veterans with chronic non-cancer pain receiving ≥90 mg Morphine Equivalent Daily Dosing (MEDD) in Veterans Integrated Service Networks (VISN) 8 since the 2016 fiscal year...Pain CPP's are equipped to provide opioid education, address risk mitigation strategies, reassess pain regimens, and refer for non-pharmacologic modalities. Utilization of Pain CPP resources helps improve OSI metrics while providing safe comprehensive medication management (CMM) for chronic pain.