morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Cigarette Smoke and Morphine Promote Treg Plasticity to Th17 via Enhancing Trained Immunity. (Pubmed Central) -  Oct 1, 2022   
    We demonstrated that (1) SM + M, M, and SM upregulated the transcripts of cytokines, chemokines, and clusters of differentiation (CDs) and modulated the transcripts of kinases and phosphatases in Tregs; (2) SM + M, M, and SM upregulated the transcripts of immunometabolism genes, trained immunity genes, and histone modification enzymes; (3) SM + M increased the transcripts of Th17 transcription factor (TF) RORC and Tfh factor CXCR5 in Tregs; M increased the transcripts of T helper cell 1 (Th1) TF RUNX3 and Th1-Th9 receptor CXCR3; and SM inhibited Treg TGIF1 transcript; (4) six genes upregulated in SM + M Tregs were matched with the top-ranked Th17 pathogenic genes; and 57, 39 genes upregulated in SM + M Tregs were matched with groups II and group III Th17 pathogenic genes, respectively; (5) SM + M upregulated the transcripts of 70 IPA-TFs, 11 iTregs-specific TFs, and 4 iTregs-Th17 shared TFs; and (6) SM + M, M, and SM downregulated Treg suppression TF Rel (c-Rel); and 35 SM + M downregulated genes were overlapped with Rel Treg downregulated genes. These results provide novel insights on the roles of SM + M in reprogramming Treg transcriptomes and Treg plasticity to Th17 cells and novel targets for future therapeutic interventions involving immunosuppression in atherosclerotic cardiovascular diseases, autoimmune diseases, transplantation, and cancers.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Journal:  Intravenous Morphine Infusion versus Thoracic Epidural Infusion of Ropivacaine with Fentanyl after the Ravitch Procedure-A Single-Center Cohort Study. (Pubmed Central) -  Oct 1, 2022   
    These results provide novel insights on the roles of SM + M in reprogramming Treg transcriptomes and Treg plasticity to Th17 cells and novel targets for future therapeutic interventions involving immunosuppression in atherosclerotic cardiovascular diseases, autoimmune diseases, transplantation, and cancers. An intravenous infusion of morphine may offer better postoperative analgesia than a thoracic epidural infusion of ropivacaine with fentanyl.
  • ||||||||||  morphine sulphate / Generic mfg., epinephrine / Generic mfg.
    Journal:  Randomized Trial of Bupivacaine versus Liposomal Bupivacaine in Minimally Invasive Lobectomy. (Pubmed Central) -  Sep 30, 2022   
    This information could have clinical relevance in the treatment of postoperative pain. In narcotic naïve patients undergoing minimally invasive lobectomy, short-term narcotic use, postoperative pain scores, length of stay, and long-term narcotic use were similar between bupivacaine and LipoB.
  • ||||||||||  Ergonex (ergotamine/caffeine) / AC Farma
    Journal:  2022 Taiwan Guidelines for Acute Treatment of Migraine. (Pubmed Central) -  Sep 30, 2022   
    Evidence supporting the use of intravenous tramadol or morphine is insufficient; therefore, their use is not recommended...For moderate to severe attacks, oral or nasal spray triptans and ergotamine/caffeine compounds are recommended and should be administered in the early stage of migraine attacks...To prevent medication overuse headache, the use of acute treatment should be limited to a maximum of 2 days per week. Key words: acute migraine treatment, evidence-based medicine, treatment guidelines, triptans, ergotamine, neuromodulation.
  • ||||||||||  morphine sulphate / Generic mfg., naltrexone / Generic mfg.
    Review, Journal:  Ligand-Free Signaling of G-Protein-Coupled Receptors: Relevance to μ Opioid Receptors in Analgesia and Addiction. (Pubmed Central) -  Sep 30, 2022   
    Antagonists competitively prevent resting MOR (MOR-μ) activation to MOR-μ*, while common antagonists, such as naloxone and naltrexone, also bind to and block ligand-free MOR-μ*, acting as potent inverse agonists...Acting as a 'retrograde addiction modulator', 6BN could represent a novel class of therapeutics for OUD. Further studies need to address regulation of MOR-μ* and, more broadly, the physiological and pharmacological significance of ligand-free signaling in GPCRs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Una causa infrecuente de colestasis extrahepática: colestasis inducida por morfina. (Pubmed Central) -  Sep 30, 2022   
    Conclusión: El síndrome de disfunción del esfínter de Oddi secundario a consumo por tiempo prolongado de opioides es una entidad muy infrecuente. Sin embargo, debe sospecharse ante cuadros de colestasis extrahepáticas en los que no se observe litiasis ni tumores y en pacientes con consumo de opiáceos a altas dosis por tiempo prolongado ya sea por adicción o por tratamiento del dolor crónico.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Opioid-induced respiratory depression and risk factors in a tertiary hospital: A retrospective study. (Pubmed Central) -  Sep 29, 2022   
    Also, fentanyl use remained a significant risk factor for OIRD. In conclusion, monitoring patient receiving opioids with a daily MME dose of ≥150 MME, prescribed Fentanyl, low urea concentration at the baseline, and patients' admissions to the surgery department may mitigate the risk of developing OIRD.
  • ||||||||||  morphine sulphate / Generic mfg., sevoflurane / Generic mfg.
    Journal:  Sevoflurane sparing effect of morphine in tegus (Salvator merianae) - a preliminary study. (Pubmed Central) -  Sep 29, 2022   
    Heart rate, MAP, and esophageal temperature did not differ between groups or within groups over time. Results showed that IM premedication with 10 mg/kg morphine produced a sevoflurane sparing effect in tegus with no significant impact on cardiovascular variables.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Opioid-Free Ureteroscopy: Are Academic Urologists Lagging Behind Private Practice? (Pubmed Central) -  Sep 29, 2022   
    Notably, private practice urologists achieved a median of 0 opioids 2 years prior to academic urologists. These data suggest that, in some circumstances, academic institutions may have been slower to respond to the opioid epidemic.
  • ||||||||||  ketamine / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  No Benefits of Adding Dexmedetomidine, Ketamine, Dexamethasone and Nerve Blocks to an Established Multimodal Analgesic Regimen after Total Knee Arthroplasty. (Pubmed Central) -  Sep 29, 2022   
    These data suggest that, in some circumstances, academic institutions may have been slower to respond to the opioid epidemic. In the presence of periarticular local anesthesia infiltration, intrathecal morphine, single-shot adductor canal block and dexamethasone, the addition of five analgesic interventions-local anesthetic infiltration between the popliteal artery and capsule of the posterior knee, intravenous dexmedetomidine, intravenous ketamine, an additional intravenous dexamethasone dose, and repeated adductor canal block injections-failed to further reduce opioid consumption or pain scores or to improve functional outcomes after total knee arthroplasty.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice. (Pubmed Central) -  Sep 29, 2022   
    Taken together, these data suggest that the GPR171 agonist may be combined with morphine to maintain antinociception while reducing the dose of morphine and therefore reducing side effects and abuse liability. The outcome of this study is clearly an important step toward understanding the functional interactions between opioid receptors and GPR171 and developing safer therapeutics for long-term pain management.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Control of fear by discrete prefrontal GABAergic populations encoding valence-specific information. (Pubmed Central) -  Sep 29, 2022   
    In contrast, an orthogonal population of SST-INs activated by morphine experience exerts opposing control over fear and supports reward-like motivational effects. These results outline an important role for discrete subsets of GABAergic cells in emotional learning and point to an unappreciated capacity for functional specialization among SST-INs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Disease and decision. (Pubmed Central) -  Sep 29, 2022   
    At age 16, I injected morphine for the first time, and then started injecting heroin...I conclude that some labels, even those needed for clinical classification of human behavior, may be pernicious. Clinicians and researchers have an obligation to reflect more deeply on the implications of the disease conceptualization of complex human behaviors such as addiction.
  • ||||||||||  morphine sulphate / Generic mfg., hydrocodone/paracetamol / Generic mfg.
    Retrospective data, Journal, Adverse events:  Incidence of and predictors for serious opioid-related adverse drug events. (Pubmed Central) -  Sep 29, 2022   
    Clinicians and researchers have an obligation to reflect more deeply on the implications of the disease conceptualization of complex human behaviors such as addiction. Once a baseline incidence is known, predictors for serious ORADEs in surgical inpatients are useful in guiding medical-surgical nurses' opioid safety practices, with more frequent focused respiratory assessments before opioid dosing and closer monitoring when opioids are prescribed postoperatively, especially in higher-risk surgical inpatients.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Region-specific macro-indicators for palliative care development in the Eastern Mediterranean Region: a Delphi study. (Pubmed Central) -  Sep 29, 2022   
    Top-scored indicators were: existence of a current national palliative care strategy (R = 8, F = 8, CVI = 1); ratio of specialized services (for adults and children) in the country per population (R = 8, F = 7, CVI = 1); allocation of funds for palliative care in the national health budget by the Ministry of Health or equivalent government agency (R = 8, F = 6, CVI = 1); education for prequalification of doctors/nurses (R = 8, F = 8, CVI = 0.9); and availability of morphine and other strong opioids (R =8, F = 8, CVI= 0.9). A baseline set of 15 region-specific indicators for measuring the development of palliative care were validated by experts in the EMR.
  • ||||||||||  phenytoin / Generic mfg., morphine sulphate / Generic mfg., paracetamol / Generic mfg.
    PK/PD data, Journal:  A Physiologically-Based Pharmacokinetic Model of the Brain Considering Regional Lipid Variance. (Pubmed Central) -  Sep 29, 2022   
    Clearly, knowledge of differentiated drug distribution in the brain is a requisite step in postulating pharmacodynamic and certain disease mechanisms. Significance Statement The application of heterogenous lipid distribution in brain tissue to predict regional variations in drug distribution in the brain via a mathematical model, thus expanding upon the current understanding of mechanisms of drug distribution in the central nervous system.
  • ||||||||||  morphine sulphate / Generic mfg.
    Opiate utilization and predictive factors in patients undergoing surgery for gliomas. (West/Central Hall) -  Sep 28, 2022 - Abstract #SNO2022SNO_274;    
    Clinical data was collected and opiate dose was calculated as morphine equivalent dose (MED)... Nearly half of the patients continued to use opiate beyond the peri-operative setting as outpatient at a higher median MED on median period of 59 days suggesting opportunities for improvement in opiate management post operatively.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial primary completion date:  VPIA: Vital Signs-Integrated Patient-Assisted Intravenous Opioid Analgesia for Post Surgical Pain (clinicaltrials.gov) -  Sep 26, 2022   
    P2/3,  N=40, Active, not recruiting, 
    Nearly half of the patients continued to use opiate beyond the peri-operative setting as outpatient at a higher median MED on median period of 59 days suggesting opportunities for improvement in opiate management post operatively. Trial primary completion date: Aug 2022 --> Dec 2023
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal, Real-world evidence:  Sex-Differences in Pain and Opioid Use Disorder Management: A Cross-Sectional Real-World Study. (Pubmed Central) -  Sep 24, 2022   
    Here, female cases showed an 8% greater substance use disorder (OR 2.04 [1.11-3.76]) and 24% lower tramadol use, while male cases presented a 22% higher fentanyl use (OR 2.97 [1.52-5.81]) and reported the highest number of adverse drug reactions (24%, OR 2.40 [1.12-5.16]) compared with controls. (4) An OUD individual risk profile was evidenced with sex-differences to take into consideration to design equal prevention programs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A Program to Reduce Post-Operative Opioid Prescribing at a Veteran's Affairs Hospital. (Pubmed Central) -  Sep 24, 2022   
    After implementation of opioid prescribing guidelines, morphine milligram equivalents (MME), quantity of pills prescribed, and days prescribed were statistically significantly reduced for procedures with associated guidelines, including cholecystectomy (MME 140.8 vs. 57.5, p = 0.002; quantity 18.8 vs. 8, p = 0.002; days 5.1 vs. 2.8, p = 0.021), inguinal hernia repair (MME 129.9 vs. 45.3, p = 0.002; quantity 17.3 vs. 6.1, p = 0.002; days 5.0 vs. 2.4, p = 0.002), and umbilical hernia repair (MME 128.8 vs. 53.8, p = 0.002; quantity 17.1 vs. 7.8, p = 0.002; days 5.1 vs. 2.5, p = 0.022)...Post-operative opioid prescribing guidelines can steer clinicians toward more conscientious opioid disbursement. There may also be reductions in prescribing opioids for procedures without guidelines as an indirect effect of practice change.